ROBERT MOONEY

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury
    Robert A Mooney
    Department of Pathology and Laboratory Medicine, Box 626, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Res Ther 13:R198. 2011
  2. ncbi The leukocyte common antigen-related protein LAR: candidate PTP for inhibitory targeting
    Robert A Mooney
    Department of Pathology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Curr Top Med Chem 3:809-19. 2003
  3. ncbi Maternal serum alpha-fetoprotein values in type 1 and type 2 diabetic patients
    Loralei L Thornburg
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Strong Memorial Hospital, University of Rochester, Rochester, NY, USA
    Am J Obstet Gynecol 199:135.e1-5. 2008
  4. ncbi Plasma amino acids profiles in children with autism: potential risk of nutritional deficiencies
    Georgianne L Arnold
    Department of Pediatrics, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Autism Dev Disord 33:449-54. 2003
  5. ncbi Interleukin-6 depletion selectively improves hepatic insulin action in obesity
    Peter J Klover
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Endocrinology 146:3417-27. 2005
  6. ncbi Expression of the leucocyte common antigen-related (LAR) tyrosine phosphatase is regulated by cell density through functional E-cadherin complexes
    Javelle R Symons
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem J 365:513-9. 2002
  7. ncbi Second-trimester maternal serum placental growth factor and vascular endothelial growth factor for predicting severe, early-onset preeclampsia
    Bruno M Polliotti
    Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, New York 11713, USA
    Obstet Gynecol 101:1266-74. 2003
  8. ncbi Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice
    Peter J Klover
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Diabetes 52:2784-9. 2003
  9. ncbi Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling
    Alicia H Clementi
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Biochim Biophys Acta 1792:1062-72. 2009
  10. ncbi New developments in prenatal screening for Down syndrome
    Jeffrey P Baliff
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Am J Clin Pathol 120:S14-24. 2003

Research Grants

  1. SOCS Proteins - Inhibitors of Hepatic Insulin Receptors
    ROBERT MOONEY; Fiscal Year: 2006
  2. INSULIN ACTION AND LIPOLYSIS IN PERMEABILIZED ADIPOCYTES
    ROBERT MOONEY; Fiscal Year: 1993
  3. INSULIN ACTION AND PHOSPHOTYROSINE PHOSPHATASES
    ROBERT MOONEY; Fiscal Year: 2003
  4. SOCS Proteins - Inhibitors of Hepatic Insulin Receptors
    ROBERT MOONEY; Fiscal Year: 2003

Collaborators

  • Georgianne L Arnold
  • Susan L Hyman
  • Devereux N Saller
  • L L Thornburg
  • Peter J Klover
  • Alicia H Clementi
  • Joseph J Senn
  • Melanie J Chagnon
  • Leonidas G Koniaris
  • Teresa A Zimmers
  • Bruno M Polliotti
  • Jeffrey P Baliff
  • David A Pearce
  • Irena A Nowak
  • Javelle R Symons
  • Nico Van Rooijen
  • Allison M Gaudy
  • Robert H Pierce
  • Mounib Elchebly
  • Andre Marette
  • Michel L Tremblay
  • Noriko Uetani
  • Luce Dombrowski
  • Alan Cheng
  • Richard K Miller
  • Karin McCall
  • Subrata Chattopadhyay
  • Christopher Cox
  • A Gordon Fry
  • Richard W Furlanetto
  • Timothy M Curran
  • Charles M LeVea

Detail Information

Publications16

  1. ncbi High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury
    Robert A Mooney
    Department of Pathology and Laboratory Medicine, Box 626, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Res Ther 13:R198. 2011
    ..This study was undertaken to establish a causal relation between the HF diet and accelerated OA progression in a mouse model and to determine the relative roles of weight gain and metabolic dysregulation in this progression...
  2. ncbi The leukocyte common antigen-related protein LAR: candidate PTP for inhibitory targeting
    Robert A Mooney
    Department of Pathology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Curr Top Med Chem 3:809-19. 2003
    ..However, selective inhibitors of LAR would be valuable reagents to probe the function of LAR, particularly in animal studies where the most susceptible LAR-dependent pathway(s) must be determined...
  3. ncbi Maternal serum alpha-fetoprotein values in type 1 and type 2 diabetic patients
    Loralei L Thornburg
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Strong Memorial Hospital, University of Rochester, Rochester, NY, USA
    Am J Obstet Gynecol 199:135.e1-5. 2008
    ..We sought to determine whether type 2 diabetic patients require the same MSAFP adjustments as type 1 diabetic patients...
  4. ncbi Plasma amino acids profiles in children with autism: potential risk of nutritional deficiencies
    Georgianne L Arnold
    Department of Pediatrics, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Autism Dev Disord 33:449-54. 2003
    ..The high rate of tryptophan and tyrosine deficiency in this group is also of concern given their role as neurotransmitter precursors...
  5. ncbi Interleukin-6 depletion selectively improves hepatic insulin action in obesity
    Peter J Klover
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Endocrinology 146:3417-27. 2005
    ..In diet-induced obese mice, depletion of IL-6 improved insulin responsiveness in 2-h insulin tolerance tests. In conclusion, these results indicate that IL-6 plays an important and selective role in hepatic insulin resistance of obesity...
  6. ncbi Expression of the leucocyte common antigen-related (LAR) tyrosine phosphatase is regulated by cell density through functional E-cadherin complexes
    Javelle R Symons
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem J 365:513-9. 2002
    ..These results suggest that density-dependent regulation of LAR expression is mediated by functional E-cadherin and may play a role in density-dependent contact inhibition by regulating tyrosine phosphorylation in E-cadherin complexes...
  7. ncbi Second-trimester maternal serum placental growth factor and vascular endothelial growth factor for predicting severe, early-onset preeclampsia
    Bruno M Polliotti
    Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, New York 11713, USA
    Obstet Gynecol 101:1266-74. 2003
    ..To determine whether alterations in second-trimester maternal serum cytokine concentrations can identify women at risk for developing severe, early-onset preeclampsia...
  8. ncbi Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice
    Peter J Klover
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Diabetes 52:2784-9. 2003
    ..These data suggest that chronic IL-6 treatment selectively impairs hepatic insulin signaling in vivo, further supporting a role for IL-6 in hepatic insulin resistance of obesity...
  9. ncbi Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling
    Alicia H Clementi
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Biochim Biophys Acta 1792:1062-72. 2009
    ..One or more additional factors appear to be required, however, for the Kupffer cell-dependent protective effect on insulin receptor signaling in DIO mice...
  10. ncbi New developments in prenatal screening for Down syndrome
    Jeffrey P Baliff
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Am J Clin Pathol 120:S14-24. 2003
    ....
  11. ncbi Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes
    Joseph J Senn
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Biol Chem 278:13740-6. 2003
    ..These data suggest that induction of SOCS-3 in liver may be an important mechanism of IL-6-mediated insulin resistance...
  12. ncbi Interleukin-6 induces cellular insulin resistance in hepatocytes
    Joseph J Senn
    Graduate Program in Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Diabetes 51:3391-9. 2002
    ..These data suggest that IL-6 plays a direct role in insulin resistance at the cellular level in both primary hepatocytes and HepG2 cell lines and may contribute to insulin resistance and type 2 diabetes...
  13. ncbi Counterpoint: Interleukin-6 does not have a beneficial role in insulin sensitivity and glucose homeostasis
    Robert A Mooney
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
    J Appl Physiol 102:816-8; discussion 818-9. 2007
  14. ncbi Altered glucose homeostasis in mice lacking the receptor protein tyrosine phosphatase sigma
    Melanie J Chagnon
    McGill Cancer Centre and Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada
    Can J Physiol Pharmacol 84:755-63. 2006
    ....
  15. ncbi Altered amino acid levels in sera of a mouse model for juvenile neuronal ceroid lipofuscinoses
    David A Pearce
    Clin Chim Acta 332:145-8. 2003
  16. ncbi Hepatocytes: critical for glucose homeostasis
    Peter J Klover
    Graduate Program in Biochemistry, University of Rochester Medical Center, NY, USA
    Int J Biochem Cell Biol 36:753-8. 2004
    ..Impairments in the insulin signal transduction pathway appear to be critical lesions contributing to insulin resistance and type 2 diabetes...

Research Grants17

  1. SOCS Proteins - Inhibitors of Hepatic Insulin Receptors
    ROBERT MOONEY; Fiscal Year: 2006
    ..SOCS proteins may potentially be an important contributors to regulation of insulin signaling and a possible target for therapeutic intervention in the treatment of insulin resistance and type 2 diabetes. ..
  2. INSULIN ACTION AND LIPOLYSIS IN PERMEABILIZED ADIPOCYTES
    ROBERT MOONEY; Fiscal Year: 1993
    ..e. insulin resistance) tissue response to insulin...
  3. INSULIN ACTION AND PHOSPHOTYROSINE PHOSPHATASES
    ROBERT MOONEY; Fiscal Year: 2003
    ..Results of this work will shed light on this poorly understood yet potentially important interaction. A greater understanding of the importance of cellular influences on insulin action is the goal. ..
  4. SOCS Proteins - Inhibitors of Hepatic Insulin Receptors
    ROBERT MOONEY; Fiscal Year: 2003
    ..SOCS proteins may potentially be an important contributors to regulation of insulin signaling and a possible target for therapeutic intervention in the treatment of insulin resistance and type 2 diabetes. ..