ROBERT MOONEY

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. doi request reprint Tendon repair is compromised in a high fat diet-induced mouse model of obesity and type 2 diabetes
    Michael A David
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, United States of America Department of Biomedical Engineering, University of Rochester, Rochester, New York, United States of America
    PLoS ONE 9:e91234. 2014
  2. pmc High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury
    Robert A Mooney
    Department of Pathology and Laboratory Medicine, Box 626, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Res Ther 13:R198. 2011
  3. ncbi request reprint The leukocyte common antigen-related protein LAR: candidate PTP for inhibitory targeting
    Robert A Mooney
    Department of Pathology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Curr Top Med Chem 3:809-19. 2003
  4. doi request reprint Maternal serum alpha-fetoprotein values in type 1 and type 2 diabetic patients
    Loralei L Thornburg
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Strong Memorial Hospital, University of Rochester, Rochester, NY, USA
    Am J Obstet Gynecol 199:135.e1-5. 2008
  5. ncbi request reprint Plasma amino acids profiles in children with autism: potential risk of nutritional deficiencies
    Georgianne L Arnold
    Department of Pediatrics, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Autism Dev Disord 33:449-54. 2003
  6. ncbi request reprint Interleukin-6 depletion selectively improves hepatic insulin action in obesity
    Peter J Klover
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Endocrinology 146:3417-27. 2005
  7. pmc Expression of the leucocyte common antigen-related (LAR) tyrosine phosphatase is regulated by cell density through functional E-cadherin complexes
    Javelle R Symons
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem J 365:513-9. 2002
  8. ncbi request reprint Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice
    Peter J Klover
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Diabetes 52:2784-9. 2003
  9. ncbi request reprint Interleukin-6 induces cellular insulin resistance in hepatocytes
    Joseph J Senn
    Graduate Program in Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Diabetes 51:3391-9. 2002
  10. pmc Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling
    Alicia H Clementi
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Biochim Biophys Acta 1792:1062-72. 2009

Research Grants

Collaborators

  • Georgianne L Arnold
  • Susan L Hyman
  • Devereux N Saller
  • L L Thornburg
  • Peter J Klover
  • Alicia H Clementi
  • Joseph J Senn
  • Michael A David
  • Melanie J Chagnon
  • Teresa A Zimmers
  • Leonidas G Koniaris
  • Jeffrey P Baliff
  • David A Pearce
  • Bruno M Polliotti
  • Irena A Nowak
  • Khyrie H Jones
  • Hani A Awad
  • Jason A Inzana
  • Javelle R Symons
  • Michael J Zuscik
  • Robert H Pierce
  • Nico Van Rooijen
  • Allison M Gaudy
  • Mounib Elchebly
  • Alan Cheng
  • Michel L Tremblay
  • Andre Marette
  • Luce Dombrowski
  • Noriko Uetani
  • Timothy M Curran
  • A Gordon Fry
  • Christopher Cox
  • Richard K Miller
  • Richard W Furlanetto
  • Subrata Chattopadhyay
  • Karin McCall
  • Charles M LeVea

Detail Information

Publications17

  1. doi request reprint Tendon repair is compromised in a high fat diet-induced mouse model of obesity and type 2 diabetes
    Michael A David
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, United States of America Department of Biomedical Engineering, University of Rochester, Rochester, New York, United States of America
    PLoS ONE 9:e91234. 2014
    ..Clinical evidence suggests that tendon strength and repair are compromised. Here, a mouse model of obesity and T2D recapitulates the deleterious effects of this condition on tendon repair...
  2. pmc High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury
    Robert A Mooney
    Department of Pathology and Laboratory Medicine, Box 626, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Res Ther 13:R198. 2011
    ..This study was undertaken to establish a causal relation between the HF diet and accelerated OA progression in a mouse model and to determine the relative roles of weight gain and metabolic dysregulation in this progression...
  3. ncbi request reprint The leukocyte common antigen-related protein LAR: candidate PTP for inhibitory targeting
    Robert A Mooney
    Department of Pathology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Curr Top Med Chem 3:809-19. 2003
    ..However, selective inhibitors of LAR would be valuable reagents to probe the function of LAR, particularly in animal studies where the most susceptible LAR-dependent pathway(s) must be determined...
  4. doi request reprint Maternal serum alpha-fetoprotein values in type 1 and type 2 diabetic patients
    Loralei L Thornburg
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Strong Memorial Hospital, University of Rochester, Rochester, NY, USA
    Am J Obstet Gynecol 199:135.e1-5. 2008
    ..We sought to determine whether type 2 diabetic patients require the same MSAFP adjustments as type 1 diabetic patients...
  5. ncbi request reprint Plasma amino acids profiles in children with autism: potential risk of nutritional deficiencies
    Georgianne L Arnold
    Department of Pediatrics, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Autism Dev Disord 33:449-54. 2003
    ..The high rate of tryptophan and tyrosine deficiency in this group is also of concern given their role as neurotransmitter precursors...
  6. ncbi request reprint Interleukin-6 depletion selectively improves hepatic insulin action in obesity
    Peter J Klover
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Endocrinology 146:3417-27. 2005
    ..In diet-induced obese mice, depletion of IL-6 improved insulin responsiveness in 2-h insulin tolerance tests. In conclusion, these results indicate that IL-6 plays an important and selective role in hepatic insulin resistance of obesity...
  7. pmc Expression of the leucocyte common antigen-related (LAR) tyrosine phosphatase is regulated by cell density through functional E-cadherin complexes
    Javelle R Symons
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem J 365:513-9. 2002
    ..These results suggest that density-dependent regulation of LAR expression is mediated by functional E-cadherin and may play a role in density-dependent contact inhibition by regulating tyrosine phosphorylation in E-cadherin complexes...
  8. ncbi request reprint Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice
    Peter J Klover
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Diabetes 52:2784-9. 2003
    ..These data suggest that chronic IL-6 treatment selectively impairs hepatic insulin signaling in vivo, further supporting a role for IL-6 in hepatic insulin resistance of obesity...
  9. ncbi request reprint Interleukin-6 induces cellular insulin resistance in hepatocytes
    Joseph J Senn
    Graduate Program in Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Diabetes 51:3391-9. 2002
    ..These data suggest that IL-6 plays a direct role in insulin resistance at the cellular level in both primary hepatocytes and HepG2 cell lines and may contribute to insulin resistance and type 2 diabetes...
  10. pmc Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling
    Alicia H Clementi
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Biochim Biophys Acta 1792:1062-72. 2009
    ..One or more additional factors appear to be required, however, for the Kupffer cell-dependent protective effect on insulin receptor signaling in DIO mice...
  11. ncbi request reprint Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes
    Joseph J Senn
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Biol Chem 278:13740-6. 2003
    ..These data suggest that induction of SOCS-3 in liver may be an important mechanism of IL-6-mediated insulin resistance...
  12. ncbi request reprint Counterpoint: Interleukin-6 does not have a beneficial role in insulin sensitivity and glucose homeostasis
    Robert A Mooney
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
    J Appl Physiol 102:816-8; discussion 818-9. 2007
  13. ncbi request reprint New developments in prenatal screening for Down syndrome
    Jeffrey P Baliff
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Am J Clin Pathol 120:S14-24. 2003
    ....
  14. ncbi request reprint Second-trimester maternal serum placental growth factor and vascular endothelial growth factor for predicting severe, early-onset preeclampsia
    Bruno M Polliotti
    Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, New York 11713, USA
    Obstet Gynecol 101:1266-74. 2003
    ..To determine whether alterations in second-trimester maternal serum cytokine concentrations can identify women at risk for developing severe, early-onset preeclampsia...
  15. ncbi request reprint Altered glucose homeostasis in mice lacking the receptor protein tyrosine phosphatase sigma
    Melanie J Chagnon
    McGill Cancer Centre and Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada
    Can J Physiol Pharmacol 84:755-63. 2006
    ....
  16. ncbi request reprint Altered amino acid levels in sera of a mouse model for juvenile neuronal ceroid lipofuscinoses
    David A Pearce
    Clin Chim Acta 332:145-8. 2003
  17. ncbi request reprint Hepatocytes: critical for glucose homeostasis
    Peter J Klover
    Graduate Program in Biochemistry, University of Rochester Medical Center, NY, USA
    Int J Biochem Cell Biol 36:753-8. 2004
    ..Impairments in the insulin signal transduction pathway appear to be critical lesions contributing to insulin resistance and type 2 diabetes...

Research Grants17

  1. SOCS Proteins - Inhibitors of Hepatic Insulin Receptors
    ROBERT MOONEY; Fiscal Year: 2006
    ..SOCS proteins may potentially be an important contributors to regulation of insulin signaling and a possible target for therapeutic intervention in the treatment of insulin resistance and type 2 diabetes. ..
  2. INSULIN ACTION AND LIPOLYSIS IN PERMEABILIZED ADIPOCYTES
    ROBERT MOONEY; Fiscal Year: 1993
    ..e. insulin resistance) tissue response to insulin...
  3. INSULIN ACTION AND PHOSPHOTYROSINE PHOSPHATASES
    ROBERT MOONEY; Fiscal Year: 2003
    ..Results of this work will shed light on this poorly understood yet potentially important interaction. A greater understanding of the importance of cellular influences on insulin action is the goal. ..
  4. SOCS Proteins - Inhibitors of Hepatic Insulin Receptors
    ROBERT MOONEY; Fiscal Year: 2003
    ..SOCS proteins may potentially be an important contributors to regulation of insulin signaling and a possible target for therapeutic intervention in the treatment of insulin resistance and type 2 diabetes. ..