David Moody

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. doi request reprint Metabolic and toxicological considerations of the opioid replacement therapy and analgesic drugs: methadone and buprenorphine
    David E Moody
    University of Utah College of Pharmacy, Department of Pharmacology and Toxicology, Salt Lake City, UT 84108, USA
    Expert Opin Drug Metab Toxicol 9:675-97. 2013
  2. pmc Gender differences in pharmacokinetics of maintenance dosed buprenorphine
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84108, USA
    Drug Alcohol Depend 118:479-83. 2011
  3. pmc Effect of rifampin and nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytes
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84108, USA
    Drug Metab Dispos 37:2323-9. 2009
  4. pmc The in vivo response of novel buprenorphine metabolites, M1 and M3, to antiretroviral inducers and inhibitors of buprenorphine metabolism
    David E Moody
    Department of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, UT 84108, USA
    Basic Clin Pharmacol Toxicol 105:211-5. 2009
  5. ncbi request reprint Determination of naloxone and nornaloxone (noroxymorphone) by high-performance liquid chromatography-electrospray ionization- tandem mass spectrometry
    Wenfang B Fang
    Department of Pharmacology and Toxicology, University of Utah, Center for Human Toxicology, Salt Lake City, Utah 84112, USA
    J Anal Toxicol 33:409-17. 2009
  6. ncbi request reprint A liquid chromatography-electrospray ionization-tandem mass spectrometry method for quantitation of aripiprazole in human plasma
    Shen Nan Lin
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    J Anal Toxicol 33:237-42. 2009
  7. ncbi request reprint An enantiomer-selective liquid chromatography-tandem mass spectrometry method for methadone and EDDP validated for use in human plasma, urine, and liver microsomes
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84108, USA
    J Anal Toxicol 32:208-19. 2008
  8. ncbi request reprint A comparative evaluation of the instant-view 5-panel test card with OnTrak TesTcup Pro 5: comparison with gas chromatography-mass spectrometry
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, 417 Wakara Way, Suite 2111, Salt Lake City, UT 84108, USA
    J Anal Toxicol 30:50-6. 2006
  9. ncbi request reprint Determination of riboflavin by high-performance liquid chromatography with riboflavin-depleted urine as calibration and control matrix
    Meng Chen
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, 20 South 2030 East Room 490, Salt Lake City, UT 84112, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 820:147-50. 2005
  10. ncbi request reprint A high-performance liquid chromatographic-atmospheric pressure chemical ionization-tandem mass spectrometric method for determination of risperidone and 9-hydroxyrisperidone in human plasma
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    J Anal Toxicol 28:494-7. 2004

Research Grants

  1. Human Metabolism of Anti-Abuse Medications
    David Moody; Fiscal Year: 2005

Detail Information

Publications25

  1. doi request reprint Metabolic and toxicological considerations of the opioid replacement therapy and analgesic drugs: methadone and buprenorphine
    David E Moody
    University of Utah College of Pharmacy, Department of Pharmacology and Toxicology, Salt Lake City, UT 84108, USA
    Expert Opin Drug Metab Toxicol 9:675-97. 2013
    ..They have distinct routes of metabolism (mostly cytochrome P450 dependent), and distinct pharmacologic activity of metabolites. As such, metabolism may play a role in differences in their toxicity...
  2. pmc Gender differences in pharmacokinetics of maintenance dosed buprenorphine
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84108, USA
    Drug Alcohol Depend 118:479-83. 2011
    ..Buprenorphine N-dealkylation to norbuprenorphine is primarily performed by CYP3A. We therefore asked whether gender-dependent differences occur in the pharmacokinetics of buprenorphine...
  3. pmc Effect of rifampin and nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytes
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84108, USA
    Drug Metab Dispos 37:2323-9. 2009
    ....
  4. pmc The in vivo response of novel buprenorphine metabolites, M1 and M3, to antiretroviral inducers and inhibitors of buprenorphine metabolism
    David E Moody
    Department of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, UT 84108, USA
    Basic Clin Pharmacol Toxicol 105:211-5. 2009
    ..These results provide further information on the in vivo response of novel secondary metabolites of buprenorphine to metabolic inhibitors and inducers...
  5. ncbi request reprint Determination of naloxone and nornaloxone (noroxymorphone) by high-performance liquid chromatography-electrospray ionization- tandem mass spectrometry
    Wenfang B Fang
    Department of Pharmacology and Toxicology, University of Utah, Center for Human Toxicology, Salt Lake City, Utah 84112, USA
    J Anal Toxicol 33:409-17. 2009
    ..These results demonstrate a new method suitable for both in vivo and in vitro metabolism and pharmacokinetic studies of naloxone...
  6. ncbi request reprint A liquid chromatography-electrospray ionization-tandem mass spectrometry method for quantitation of aripiprazole in human plasma
    Shen Nan Lin
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    J Anal Toxicol 33:237-42. 2009
    ..All measured concentrations were well within the quantitative range of 2 to 400 ng/mL...
  7. ncbi request reprint An enantiomer-selective liquid chromatography-tandem mass spectrometry method for methadone and EDDP validated for use in human plasma, urine, and liver microsomes
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84108, USA
    J Anal Toxicol 32:208-19. 2008
    ....
  8. ncbi request reprint A comparative evaluation of the instant-view 5-panel test card with OnTrak TesTcup Pro 5: comparison with gas chromatography-mass spectrometry
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, 417 Wakara Way, Suite 2111, Salt Lake City, UT 84108, USA
    J Anal Toxicol 30:50-6. 2006
    ..e., false positives) sympathomimetic amines. In summary, the Instant-View Test Card was less precise than the TesTcup at or near the cutoff; with clinical samples, however, the percent accuracies of the two devices were similar...
  9. ncbi request reprint Determination of riboflavin by high-performance liquid chromatography with riboflavin-depleted urine as calibration and control matrix
    Meng Chen
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, 20 South 2030 East Room 490, Salt Lake City, UT 84112, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 820:147-50. 2005
    ..999) was acceptable over the range of 10-5000 ng/ml. The intra-assay and inter-assay CVs were 3.3% and 9%, respectively. Subsequent stability studies found that urine riboflavin was stable for up to 6 months at 4 or -20 degrees C...
  10. ncbi request reprint A high-performance liquid chromatographic-atmospheric pressure chemical ionization-tandem mass spectrometric method for determination of risperidone and 9-hydroxyrisperidone in human plasma
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    J Anal Toxicol 28:494-7. 2004
    ..6% of target with %CVs not exceeding 6.7%. Analytes were stable in plasma after 24 h at room temperature, 2 freeze-thaw cycles, and 490 days at -20 degrees C...
  11. ncbi request reprint A liquid chromatographic-electrospray ionization-tandem mass spectrometric method for determination of buprenorphine, its metabolite, norbuprenorphine, and a coformulant, naloxone, that is suitable for in vivo and in vitro metabolism studies
    David E Moody
    Center for Human Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    Anal Biochem 306:31-9. 2002
    ..These results suggest this method is suitable for both in vivo and in vitro studies of buprenorphine metabolism to norbuprenorphine...
  12. ncbi request reprint Quantitative analysis of selegiline and three metabolites (N-desmethylselegiline, methamphetamine, and amphetamine) in human plasma by high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry
    Matthew H Slawson
    Department of Pharmacology and Toxicology, University of Utah Health Sciences Center, Salt Lake City 84112, USA
    J Anal Toxicol 26:430-7. 2002
    ..Methanolic stock solutions were stable for at least 6 h when kept at room temperature or at least 90 days when kept at -20 degrees C...
  13. ncbi request reprint Stability of plasma gamma-hydroxybutyrate determined by gas chromatography-positive ion chemical ionization-mass spectrometry
    Meng Chen
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    J Anal Toxicol 27:445-8. 2003
    ..It was also found to be stable in processed samples stored at room temperature for 5 days and for 15 days at -20 degrees C...
  14. ncbi request reprint Detection and time course of cocaine N-oxide and other cocaine metabolites in human plasma by liquid chromatography/tandem mass spectrometry
    Shen Nan Lin
    University of Utah Center for Human Toxicology, 20S 2030E, Room 490, Salt Lake City, Utah 84112 9457, USA
    Anal Chem 75:4335-40. 2003
    ..The resulting time course data provide additional information into kinetic interrelationships between cocaine N-oxidation and cocaine hydrolysis...
  15. ncbi request reprint Comparative analysis of sweat patches for cocaine (and metabolites) by radioimmunoassay and gas chromatography-positive ion chemical ionization-mass spectrometry
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112 9457, USA
    J Anal Toxicol 28:86-93. 2004
    ..RIA offers a cost-effective, sensitive, and specific alternative initial test for cocaine determination in extracts of sweat patches...
  16. ncbi request reprint A liquid chromatographic-electrospray-tandem mass spectrometric method for quantitation of quetiapine in human plasma and liver microsomes: application to study in vitro metabolism
    Shen Nan Lin
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    J Anal Toxicol 28:443-8. 2004
    ..Quetiapine is extensively metabolized by CYP 3A4 and CYP 2D6 and to a lesser extent by CYP 3A7, CYP 3A5, and CYP 2C19...
  17. ncbi request reprint Ketoconazole, a cytochrome P450 3A4 inhibitor, markedly increases concentrations of levo-acetyl-alpha-methadol in opioid-naive individuals
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112 9437, USA
    Clin Pharmacol Ther 76:154-66. 2004
    ..No previous studies have been conducted to determine the effect of in vivo inhibition of CYP3A on the pharmacokinetics and pharmacodynamics of LAAM...
  18. ncbi request reprint Determination of nalmefene by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry
    Wenfang B Fang
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    J Anal Toxicol 29:169-74. 2005
    ..Following intravenous injection of 5 mg/kg nalmefene to rabbits, the mean area under curve for 0 to 24 h was 1116 (ng)(mL)(-1)(h), and the mean plasma clearance was 67.9 (mL)(min)(-1)(kg)(-1)...
  19. ncbi request reprint The in vivo glucuronidation of buprenorphine and norbuprenorphine determined by liquid chromatography-electrospray ionization-tandem mass spectrometry
    Wei Huang
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84108, USA
    Ther Drug Monit 28:245-51. 2006
    ..Because urinary elimination is limited ( approximately 11% of daily dose), the role of NBUPG in total clearance of buprenorphine is not yet known...
  20. ncbi request reprint Glucuronidation of buprenorphine and norbuprenorphine by human liver microsomes and UDP-glucuronosyltransferases
    Yan Chang
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84108, USA
    Drug Metab Lett 3:101-7. 2009
    ..Scaling of buprenorphine clearance with, or without, correction for the nonspecific microsomal protein binding of buprenorphine (f(u) = 0.42) suggested glucuronidation was a significant route for hepatic clearance of buprenorphine...
  21. ncbi request reprint Novel metabolites of buprenorphine detected in human liver microsomes and human urine
    Yan Chang
    University of Utah, Center for Human Toxicology, Department of Pharmacology and Toxicology, 417 Wakara Way, Suite 2111, Salt Lake City, UT 84108, USA
    Drug Metab Dispos 34:440-8. 2006
    ..Examination of human urine from subjects taking buprenorphine showed the presence of M1 and M3; most of M1 was conjugated, whereas 60 to 70% of M3 was unconjugated...
  22. ncbi request reprint Effect of benzodiazepines on the metabolism of buprenorphine in human liver microsomes
    Yan Chang
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA
    Eur J Clin Pharmacol 60:875-81. 2005
    ..To determine whether enzyme inhibition explains the clinical adverse interaction of benzodiazepines and buprenorphine...
  23. ncbi request reprint Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells
    Christopher A Reilly
    Department of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    Chem Res Toxicol 16:336-49. 2003
    ..These data suggested that metabolism of capsaicinoids by P450 in cells represented a detoxification mechanism (in contrast to bioactivation)...
  24. ncbi request reprint Quantitative analysis of naltrexone and 6beta-naltrexol in human, rat, and rabbit plasma by liquid chromatography-electrospray ionization tandem mass spectrometry with application to the pharmacokinetics of Depotrex in rabbits
    Matthew H Slawson
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    J Anal Toxicol 31:453-61. 2007
    ..In rabbits, the parent compound shows dose-dependent pharmacokinetics as seen in humans, but rabbits have much lower unconjugated metabolite, 6beta-naltrexol, than that seen in humans...
  25. ncbi request reprint Determination of l-alpha-acetylmethadol (LAAM), norLAAM, and dinorLAAM in clinical and in vitro samples using liquid chromatography with electrospray ionization and tandem mass spectrometry
    Wei Huang
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, 20 S 2030 E Room 490, Salt Lake City, Utah 84112, USA
    J Pharm Sci 92:10-20. 2003
    ..An accurate and precise method for determination of LAAM and its metabolites, norLAAM and dinorLAAM, that is suitable for both in vivo and in vitro metabolism studies has been developed and validated...

Research Grants6

  1. Human Metabolism of Anti-Abuse Medications
    David Moody; Fiscal Year: 2005
    ..We anticipate these studies will provide the evidence to support clinical studies to more thoroughly test our hypothesis. ..