Research Topics
| David MoodySummaryAffiliation: University of Utah Country: USA Publications
Research Grants
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Detail Information
Publications
Gender differences in pharmacokinetics of maintenance dosed buprenorphineDavid E Moody
Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84108, USA
Drug Alcohol Depend 118:479-83. 2011..Buprenorphine N-dealkylation to norbuprenorphine is primarily performed by CYP3A. We therefore asked whether gender-dependent differences occur in the pharmacokinetics of buprenorphine...- Effect of rifampin and nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytesDavid E Moody
Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84108, USA
Drug Metab Dispos 37:2323-9. 2009.... 
The in vivo response of novel buprenorphine metabolites, M1 and M3, to antiretroviral inducers and inhibitors of buprenorphine metabolismDavid E Moody
Department of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, UT 84108, USA
Basic Clin Pharmacol Toxicol 105:211-5. 2009..These results provide further information on the in vivo response of novel secondary metabolites of buprenorphine to metabolic inhibitors and inducers...
Determination of naloxone and nornaloxone (noroxymorphone) by high-performance liquid chromatography-electrospray ionization- tandem mass spectrometryWenfang B Fang
Department of Pharmacology and Toxicology, University of Utah, Center for Human Toxicology, Salt Lake City, Utah 84112, USA
J Anal Toxicol 33:409-17. 2009..These results demonstrate a new method suitable for both in vivo and in vitro metabolism and pharmacokinetic studies of naloxone...- A liquid chromatography-electrospray ionization-tandem mass spectrometry method for quantitation of aripiprazole in human plasmaShen Nan Lin
Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
J Anal Toxicol 33:237-42. 2009..All measured concentrations were well within the quantitative range of 2 to 400 ng/mL... - An enantiomer-selective liquid chromatography-tandem mass spectrometry method for methadone and EDDP validated for use in human plasma, urine, and liver microsomesDavid E Moody
Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84108, USA
J Anal Toxicol 32:208-19. 2008.... - A comparative evaluation of the instant-view 5-panel test card with OnTrak TesTcup Pro 5: comparison with gas chromatography-mass spectrometryDavid E Moody
Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, 417 Wakara Way, Suite 2111, Salt Lake City, UT 84108, USA
J Anal Toxicol 30:50-6. 2006..e., false positives) sympathomimetic amines. In summary, the Instant-View Test Card was less precise than the TesTcup at or near the cutoff; with clinical samples, however, the percent accuracies of the two devices were similar... - Determination of riboflavin by high-performance liquid chromatography with riboflavin-depleted urine as calibration and control matrixMeng Chen
Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, 20 South 2030 East Room 490, Salt Lake City, UT 84112, USA
J Chromatogr B Analyt Technol Biomed Life Sci 820:147-50. 2005..999) was acceptable over the range of 10-5000 ng/ml. The intra-assay and inter-assay CVs were 3.3% and 9%, respectively. Subsequent stability studies found that urine riboflavin was stable for up to 6 months at 4 or -20 degrees C... - A high-performance liquid chromatographic-atmospheric pressure chemical ionization-tandem mass spectrometric method for determination of risperidone and 9-hydroxyrisperidone in human plasmaDavid E Moody
Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
J Anal Toxicol 28:494-7. 2004..6% of target with %CVs not exceeding 6.7%. Analytes were stable in plasma after 24 h at room temperature, 2 freeze-thaw cycles, and 490 days at -20 degrees C... - A liquid chromatographic-electrospray-tandem mass spectrometric method for quantitation of quetiapine in human plasma and liver microsomes: application to study in vitro metabolismShen Nan Lin
Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
J Anal Toxicol 28:443-8. 2004..Quetiapine is extensively metabolized by CYP 3A4 and CYP 2D6 and to a lesser extent by CYP 3A7, CYP 3A5, and CYP 2C19... - Quantitative analysis of selegiline and three metabolites (N-desmethylselegiline, methamphetamine, and amphetamine) in human plasma by high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometryMatthew H Slawson
Department of Pharmacology and Toxicology, University of Utah Health Sciences Center, Salt Lake City 84112, USA
J Anal Toxicol 26:430-7. 2002..Methanolic stock solutions were stable for at least 6 h when kept at room temperature or at least 90 days when kept at -20 degrees C... - Stability of plasma gamma-hydroxybutyrate determined by gas chromatography-positive ion chemical ionization-mass spectrometryMeng Chen
Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
J Anal Toxicol 27:445-8. 2003..It was also found to be stable in processed samples stored at room temperature for 5 days and for 15 days at -20 degrees C... - Detection and time course of cocaine N-oxide and other cocaine metabolites in human plasma by liquid chromatography/tandem mass spectrometryShen Nan Lin
University of Utah Center for Human Toxicology, 20S 2030E, Room 490, Salt Lake City, Utah 84112 9457, USA
Anal Chem 75:4335-40. 2003..The resulting time course data provide additional information into kinetic interrelationships between cocaine N-oxidation and cocaine hydrolysis... - A liquid chromatographic-electrospray ionization-tandem mass spectrometric method for determination of buprenorphine, its metabolite, norbuprenorphine, and a coformulant, naloxone, that is suitable for in vivo and in vitro metabolism studiesDavid E Moody
Center for Human Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
Anal Biochem 306:31-9. 2002..These results suggest this method is suitable for both in vivo and in vitro studies of buprenorphine metabolism to norbuprenorphine... - Comparative analysis of sweat patches for cocaine (and metabolites) by radioimmunoassay and gas chromatography-positive ion chemical ionization-mass spectrometryDavid E Moody
Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112 9457, USA
J Anal Toxicol 28:86-93. 2004..RIA offers a cost-effective, sensitive, and specific alternative initial test for cocaine determination in extracts of sweat patches... - Ketoconazole, a cytochrome P450 3A4 inhibitor, markedly increases concentrations of levo-acetyl-alpha-methadol in opioid-naive individualsDavid E Moody
Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112 9437, USA
Clin Pharmacol Ther 76:154-66. 2004..No previous studies have been conducted to determine the effect of in vivo inhibition of CYP3A on the pharmacokinetics and pharmacodynamics of LAAM... - The in vivo glucuronidation of buprenorphine and norbuprenorphine determined by liquid chromatography-electrospray ionization-tandem mass spectrometryWei Huang
Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84108, USA
Ther Drug Monit 28:245-51. 2006..Because urinary elimination is limited ( approximately 11% of daily dose), the role of NBUPG in total clearance of buprenorphine is not yet known... - Novel metabolites of buprenorphine detected in human liver microsomes and human urineYan Chang
University of Utah, Center for Human Toxicology, Department of Pharmacology and Toxicology, 417 Wakara Way, Suite 2111, Salt Lake City, UT 84108, USA
Drug Metab Dispos 34:440-8. 2006..Examination of human urine from subjects taking buprenorphine showed the presence of M1 and M3; most of M1 was conjugated, whereas 60 to 70% of M3 was unconjugated... - Determination of nalmefene by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometryWenfang B Fang
Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
J Anal Toxicol 29:169-74. 2005..Following intravenous injection of 5 mg/kg nalmefene to rabbits, the mean area under curve for 0 to 24 h was 1116 (ng)(mL)(-1)(h), and the mean plasma clearance was 67.9 (mL)(min)(-1)(kg)(-1)... - Glucuronidation of buprenorphine and norbuprenorphine by human liver microsomes and UDP-glucuronosyltransferasesYan Chang
Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84108, USA
Drug Metab Lett 3:101-7. 2009..Scaling of buprenorphine clearance with, or without, correction for the nonspecific microsomal protein binding of buprenorphine (f(u) = 0.42) suggested glucuronidation was a significant route for hepatic clearance of buprenorphine... - Effect of benzodiazepines on the metabolism of buprenorphine in human liver microsomesYan Chang
Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA
Eur J Clin Pharmacol 60:875-81. 2005..CONCLUSION: A single benzodiazepine, midazolam, is a moderate mechanism-based inactivator of buprenorphine N-dealkylation. It is anticipated that repeated exposures to midazolam might alter the in vivo metabolism of buprenorphine... - Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cellsChristopher A Reilly
Department of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
Chem Res Toxicol 16:336-49. 2003..These data suggested that metabolism of capsaicinoids by P450 in cells represented a detoxification mechanism (in contrast to bioactivation)... - Quantitative analysis of naltrexone and 6beta-naltrexol in human, rat, and rabbit plasma by liquid chromatography-electrospray ionization tandem mass spectrometry with application to the pharmacokinetics of Depotrex in rabbitsMatthew H Slawson
Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
J Anal Toxicol 31:453-61. 2007..In rabbits, the parent compound shows dose-dependent pharmacokinetics as seen in humans, but rabbits have much lower unconjugated metabolite, 6beta-naltrexol, than that seen in humans... - Determination of l-alpha-acetylmethadol (LAAM), norLAAM, and dinorLAAM in clinical and in vitro samples using liquid chromatography with electrospray ionization and tandem mass spectrometryWei Huang
Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, 20 S 2030 E Room 490, Salt Lake City, Utah 84112, USA
J Pharm Sci 92:10-20. 2003..An accurate and precise method for determination of LAAM and its metabolites, norLAAM and dinorLAAM, that is suitable for both in vivo and in vitro metabolism studies has been developed and validated...
Research Grants
- Human Metabolism of Anti-Abuse MedicationsDavid Moody; Fiscal Year: 2005..We anticipate these studies will provide the evidence to support clinical studies to more thoroughly test our hypothesis. ..