D E Moody

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi request reprint Long-term stability of abused drugs and antiabuse chemotherapeutical agents stored at -20 degrees C
    D E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 84112 9457, USA
    J Anal Toxicol 23:535-40. 1999
  2. ncbi request reprint Comparative analysis of sweat patches for cocaine (and metabolites) by radioimmunoassay and gas chromatography-positive ion chemical ionization-mass spectrometry
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112 9457, USA
    J Anal Toxicol 28:86-93. 2004
  3. ncbi request reprint Ketoconazole, a cytochrome P450 3A4 inhibitor, markedly increases concentrations of levo-acetyl-alpha-methadol in opioid-naive individuals
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112 9437, USA
    Clin Pharmacol Ther 76:154-66. 2004
  4. ncbi request reprint A high-performance liquid chromatographic-atmospheric pressure chemical ionization-tandem mass spectrometric method for determination of risperidone and 9-hydroxyrisperidone in human plasma
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    J Anal Toxicol 28:494-7. 2004
  5. ncbi request reprint A liquid chromatographic-electrospray ionization-tandem mass spectrometric method for determination of buprenorphine, its metabolite, norbuprenorphine, and a coformulant, naloxone, that is suitable for in vivo and in vitro metabolism studies
    David E Moody
    Center for Human Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    Anal Biochem 306:31-9. 2002
  6. ncbi request reprint Evaluation of immunoassays for semiquantitative detection of cocaine and metabolites or heroin and metabolites in extracts of sweat patches
    D E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 84112 9457, USA
    J Anal Toxicol 25:190-7. 2001
  7. ncbi request reprint Determination of buprenorphine in human plasma by gas chromatography-positive ion chemical ionization mass spectrometry and liquid chromatography-tandem mass spectrometry
    D E Moody
    Center for Human Toxicology, University of Utah, Salt Lake City 84112, USA
    J Anal Toxicol 21:406-14. 1997
  8. ncbi request reprint A comparative evaluation of the instant-view 5-panel test card with OnTrak TesTcup Pro 5: comparison with gas chromatography-mass spectrometry
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, 417 Wakara Way, Suite 2111, Salt Lake City, UT 84108, USA
    J Anal Toxicol 30:50-6. 2006
  9. ncbi request reprint Urinary excretion of amphetamine and 4'-hydroxyamphetamine by Sprague Dawley and dark Agouti rats
    M Y Law
    Department of Pharmacology and Toxicology, University of Utah, College of Pharmacy, Salt Lake City 84108
    Life Sci 54:1073-9. 1994
  10. ncbi request reprint Quinidine inhibits in vivo metabolism of amphetamine in rats: impact upon correlation between GC/MS and immunoassay findings in rat urine
    D E Moody
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City
    J Anal Toxicol 14:311-7. 1990

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Long-term stability of abused drugs and antiabuse chemotherapeutical agents stored at -20 degrees C
    D E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 84112 9457, USA
    J Anal Toxicol 23:535-40. 1999
    ....
  2. ncbi request reprint Comparative analysis of sweat patches for cocaine (and metabolites) by radioimmunoassay and gas chromatography-positive ion chemical ionization-mass spectrometry
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112 9457, USA
    J Anal Toxicol 28:86-93. 2004
    ..RIA offers a cost-effective, sensitive, and specific alternative initial test for cocaine determination in extracts of sweat patches...
  3. ncbi request reprint Ketoconazole, a cytochrome P450 3A4 inhibitor, markedly increases concentrations of levo-acetyl-alpha-methadol in opioid-naive individuals
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112 9437, USA
    Clin Pharmacol Ther 76:154-66. 2004
    ..No previous studies have been conducted to determine the effect of in vivo inhibition of CYP3A on the pharmacokinetics and pharmacodynamics of LAAM...
  4. ncbi request reprint A high-performance liquid chromatographic-atmospheric pressure chemical ionization-tandem mass spectrometric method for determination of risperidone and 9-hydroxyrisperidone in human plasma
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    J Anal Toxicol 28:494-7. 2004
    ..6% of target with %CVs not exceeding 6.7%. Analytes were stable in plasma after 24 h at room temperature, 2 freeze-thaw cycles, and 490 days at -20 degrees C...
  5. ncbi request reprint A liquid chromatographic-electrospray ionization-tandem mass spectrometric method for determination of buprenorphine, its metabolite, norbuprenorphine, and a coformulant, naloxone, that is suitable for in vivo and in vitro metabolism studies
    David E Moody
    Center for Human Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    Anal Biochem 306:31-9. 2002
    ..These results suggest this method is suitable for both in vivo and in vitro studies of buprenorphine metabolism to norbuprenorphine...
  6. ncbi request reprint Evaluation of immunoassays for semiquantitative detection of cocaine and metabolites or heroin and metabolites in extracts of sweat patches
    D E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 84112 9457, USA
    J Anal Toxicol 25:190-7. 2001
    ..Both the cocaine metabolite RIA and opiate EIA had the ability to detect analytes known to be extracted from sweat patches...
  7. ncbi request reprint Determination of buprenorphine in human plasma by gas chromatography-positive ion chemical ionization mass spectrometry and liquid chromatography-tandem mass spectrometry
    D E Moody
    Center for Human Toxicology, University of Utah, Salt Lake City 84112, USA
    J Anal Toxicol 21:406-14. 1997
    ..The utility of the lower LOQ was demonstrated in 40 plasma samples collected up to 96 h after a sublingual dose of buprenorphine; 10 were quantitatable using GC-PCI-MS and 38 using LC-ESI-MS-MS...
  8. ncbi request reprint A comparative evaluation of the instant-view 5-panel test card with OnTrak TesTcup Pro 5: comparison with gas chromatography-mass spectrometry
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, 417 Wakara Way, Suite 2111, Salt Lake City, UT 84108, USA
    J Anal Toxicol 30:50-6. 2006
    ..e., false positives) sympathomimetic amines. In summary, the Instant-View Test Card was less precise than the TesTcup at or near the cutoff; with clinical samples, however, the percent accuracies of the two devices were similar...
  9. ncbi request reprint Urinary excretion of amphetamine and 4'-hydroxyamphetamine by Sprague Dawley and dark Agouti rats
    M Y Law
    Department of Pharmacology and Toxicology, University of Utah, College of Pharmacy, Salt Lake City 84108
    Life Sci 54:1073-9. 1994
    ..1 and 1.0, than that of the DA male and female rats, 5.9 and 5.0. These results support our hypothesis that P450 2D is involved in hepatic 4'-hydroxylation of amphetamine in rats...
  10. ncbi request reprint Quinidine inhibits in vivo metabolism of amphetamine in rats: impact upon correlation between GC/MS and immunoassay findings in rat urine
    D E Moody
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City
    J Anal Toxicol 14:311-7. 1990
    ..The inhibition of amphetamine metabolism results in an increased ratio of parent drug to metabolite concentration (metabolic ratio) in the urine, which mimics the effect of genetic polymorphisms.(ABSTRACT TRUNCATED AT 250 WORDS)..
  11. ncbi request reprint Enantioselective gas chromatography-negative ion chemical ionization mass spectrometry for methylphenidate in human plasma
    S N Lin
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 84112 9457, USA
    J Anal Toxicol 23:524-30. 1999
    ..The derivatized methylphenidate in extract is stable at 4 degrees C for up to 10 days...
  12. ncbi request reprint Selective involvement of cytochrome P450 2D subfamily in in vivo 4-hydroxylation of amphetamine in rat
    M Y Law
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112 9457, USA
    Drug Metab Dispos 28:348-53. 2000
    ..989) with microsomal P450 2D activity in parallel-treated rats. These studies also substantiate that 4-hydroxylation of amphetamine is selectively performed by the P450 2D subfamily in the rat...
  13. ncbi request reprint Differential N-demethylation of l-alpha-acetylmethadol (LAAM) and norLAAM by cytochrome P450s 2B6, 2C18, and 3A4
    J A Neff
    Center for Human Toxicology, University of Utah, Salt Lake City, Utah 84112-9457, USA
    Biochem Biophys Res Commun 284:751-6. 2001
    ..These studies show that the N-demethylation of LAAM and norLAAM is not restricted to P450 3A4, particularly P450s 2B6 and 2C18, and suggest that the mechanism of sequential metabolism for 3A4 differs from that of 2B6 and 2C18...
  14. ncbi request reprint A validated liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry method for quantitation of cocaine and benzoylecgonine in human plasma
    S N Lin
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 84112, USA
    J Anal Toxicol 25:497-503. 2001
    ..v.) cocaine challenge and treament medications. Results from three of these subjects receiving 40 mg (i.v.) cocaine demonstrate the utility of the method...
  15. ncbi request reprint Determination of naloxone and nornaloxone (noroxymorphone) by high-performance liquid chromatography-electrospray ionization- tandem mass spectrometry
    Wenfang B Fang
    Department of Pharmacology and Toxicology, University of Utah, Center for Human Toxicology, Salt Lake City, Utah 84112, USA
    J Anal Toxicol 33:409-17. 2009
    ..These results demonstrate a new method suitable for both in vivo and in vitro metabolism and pharmacokinetic studies of naloxone...
  16. ncbi request reprint Simultaneous determination of delta9-tetrahydrocannabinol and 11-nor-9-carboxy-delta9-tetrahydrocannabinol in human plasma by solid-phase extraction and gas chromatography-negative ion chemical ionization-mass spectrometry
    W Huang
    Center for Human Toxicology, University of Utah, Salt Lake City 84112, USA
    J Anal Toxicol 25:531-7. 2001
    ..33 to 1 h after cessation of smoking...
  17. ncbi request reprint Determination of riboflavin by high-performance liquid chromatography with riboflavin-depleted urine as calibration and control matrix
    Meng Chen
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, 20 South 2030 East Room 490, Salt Lake City, UT 84112, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 820:147-50. 2005
    ..999) was acceptable over the range of 10-5000 ng/ml. The intra-assay and inter-assay CVs were 3.3% and 9%, respectively. Subsequent stability studies found that urine riboflavin was stable for up to 6 months at 4 or -20 degrees C...
  18. pmc The in vivo response of novel buprenorphine metabolites, M1 and M3, to antiretroviral inducers and inhibitors of buprenorphine metabolism
    David E Moody
    Department of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, UT 84108, USA
    Basic Clin Pharmacol Toxicol 105:211-5. 2009
    ..These results provide further information on the in vivo response of novel secondary metabolites of buprenorphine to metabolic inhibitors and inducers...
  19. ncbi request reprint A liquid chromatography-electrospray ionization-tandem mass spectrometry method for quantitation of aripiprazole in human plasma
    Shen Nan Lin
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    J Anal Toxicol 33:237-42. 2009
    ..All measured concentrations were well within the quantitative range of 2 to 400 ng/mL...
  20. ncbi request reprint An enantiomer-selective liquid chromatography-tandem mass spectrometry method for methadone and EDDP validated for use in human plasma, urine, and liver microsomes
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84108, USA
    J Anal Toxicol 32:208-19. 2008
    ....
  21. ncbi request reprint Detection and time course of cocaine N-oxide and other cocaine metabolites in human plasma by liquid chromatography/tandem mass spectrometry
    Shen Nan Lin
    University of Utah Center for Human Toxicology, 20S 2030E, Room 490, Salt Lake City, Utah 84112 9457, USA
    Anal Chem 75:4335-40. 2003
    ..The resulting time course data provide additional information into kinetic interrelationships between cocaine N-oxidation and cocaine hydrolysis...
  22. ncbi request reprint Stability of plasma gamma-hydroxybutyrate determined by gas chromatography-positive ion chemical ionization-mass spectrometry
    Meng Chen
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    J Anal Toxicol 27:445-8. 2003
    ..It was also found to be stable in processed samples stored at room temperature for 5 days and for 15 days at -20 degrees C...
  23. ncbi request reprint A liquid chromatographic-electrospray-tandem mass spectrometric method for quantitation of quetiapine in human plasma and liver microsomes: application to study in vitro metabolism
    Shen Nan Lin
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    J Anal Toxicol 28:443-8. 2004
    ..Quetiapine is extensively metabolized by CYP 3A4 and CYP 2D6 and to a lesser extent by CYP 3A7, CYP 3A5, and CYP 2C19...
  24. pmc Effect of rifampin and nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytes
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84108, USA
    Drug Metab Dispos 37:2323-9. 2009
    ....
  25. ncbi request reprint Quantitative analysis of selegiline and three metabolites (N-desmethylselegiline, methamphetamine, and amphetamine) in human plasma by high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry
    Matthew H Slawson
    Department of Pharmacology and Toxicology, University of Utah Health Sciences Center, Salt Lake City 84112, USA
    J Anal Toxicol 26:430-7. 2002
    ..Methanolic stock solutions were stable for at least 6 h when kept at room temperature or at least 90 days when kept at -20 degrees C...
  26. ncbi request reprint Immunoassay detection of nordiazepam, triazolam, lorazepam, and alprazolam in blood
    W Huang
    Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 84108
    J Anal Toxicol 17:365-9. 1993
    ..RIA-a, EIA-s, and FPIA-s had cross-reactivity for alprazolam that was equivalent to or slightly better than nordiazepam. RIA-d had enhanced cross-reactivity for alprazolam at 30-300 ng/mL.(ABSTRACT TRUNCATED AT 250 WORDS)..
  27. ncbi request reprint Variables in human liver microsome preparation: impact on the kinetics of l-alpha-acetylmethadol (LAAM) n-demethylation and dextromethorphan O-demethylation
    A C Nelson
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, 20 S 2030 E RM 490, Salt Lake City, UT 84112 9457, USA
    Drug Metab Dispos 29:319-25. 2001
    ..Variation of the methods used to prepare human liver microsomes can significantly affect the recovery and specific activity of microsomal components; however, they do not appear to affect enzyme kinetics...
  28. ncbi request reprint Effect of benzodiazepines on the metabolism of buprenorphine in human liver microsomes
    Yan Chang
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA
    Eur J Clin Pharmacol 60:875-81. 2005
    ..To determine whether enzyme inhibition explains the clinical adverse interaction of benzodiazepines and buprenorphine...
  29. ncbi request reprint Determination of nalmefene by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry
    Wenfang B Fang
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    J Anal Toxicol 29:169-74. 2005
    ..Following intravenous injection of 5 mg/kg nalmefene to rabbits, the mean area under curve for 0 to 24 h was 1116 (ng)(mL)(-1)(h), and the mean plasma clearance was 67.9 (mL)(min)(-1)(kg)(-1)...
  30. ncbi request reprint Glucuronidation of buprenorphine and norbuprenorphine by human liver microsomes and UDP-glucuronosyltransferases
    Yan Chang
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84108, USA
    Drug Metab Lett 3:101-7. 2009
    ..Scaling of buprenorphine clearance with, or without, correction for the nonspecific microsomal protein binding of buprenorphine (f(u) = 0.42) suggested glucuronidation was a significant route for hepatic clearance of buprenorphine...
  31. ncbi request reprint Novel metabolites of buprenorphine detected in human liver microsomes and human urine
    Yan Chang
    University of Utah, Center for Human Toxicology, Department of Pharmacology and Toxicology, 417 Wakara Way, Suite 2111, Salt Lake City, UT 84108, USA
    Drug Metab Dispos 34:440-8. 2006
    ..Examination of human urine from subjects taking buprenorphine showed the presence of M1 and M3; most of M1 was conjugated, whereas 60 to 70% of M3 was unconjugated...
  32. ncbi request reprint The in vivo glucuronidation of buprenorphine and norbuprenorphine determined by liquid chromatography-electrospray ionization-tandem mass spectrometry
    Wei Huang
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84108, USA
    Ther Drug Monit 28:245-51. 2006
    ..Because urinary elimination is limited ( approximately 11% of daily dose), the role of NBUPG in total clearance of buprenorphine is not yet known...
  33. ncbi request reprint Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells
    Christopher A Reilly
    Department of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    Chem Res Toxicol 16:336-49. 2003
    ..These data suggested that metabolism of capsaicinoids by P450 in cells represented a detoxification mechanism (in contrast to bioactivation)...
  34. ncbi request reprint The involvement of cytochrome P450 3A4 in the N-demethylation of L-alpha-acetylmethadol (LAAM), norLAAM, and methadone
    D E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, USA
    Drug Metab Dispos 25:1347-53. 1997
    ..Knowledge of these enzymatic pathways is essential for assessment of the impact of metabolic drug-drug interactions on therapeutic success and/or adverse events...
  35. ncbi request reprint Determination of l-alpha-acetylmethadol (LAAM), norLAAM, and dinorLAAM in clinical and in vitro samples using liquid chromatography with electrospray ionization and tandem mass spectrometry
    Wei Huang
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, 20 S 2030 E Room 490, Salt Lake City, Utah 84112, USA
    J Pharm Sci 92:10-20. 2003
    ..An accurate and precise method for determination of LAAM and its metabolites, norLAAM and dinorLAAM, that is suitable for both in vivo and in vitro metabolism studies has been developed and validated...
  36. ncbi request reprint Urinary excretion of 4-hydroxyamphetamine and amphetamine in male and female Sprague-Dawley and Dark Agouti rats following multiple doses of amphetamine
    M Y Law
    Department of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, 20 S 2030 E, Room 490, Salt Lake City, UT 84112 9457, USA
    Toxicol Lett 117:139-44. 2000
    ..These results suggest that no alternative pathway is induced following multiple doses of amphetamine in normal SD or P450 2D deficient DA rats...
  37. ncbi request reprint Buprenorphine assay and plasma concentration monitoring in HIV-infected substance users
    Robin DiFrancesco
    Pharmacotherapy Research Center, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA
    J Pharm Biomed Anal 44:188-95. 2007
    ..Use of this combined BUP and ARV plasma concentration monitoring approach for a representative patient receiving BUP, atazanavir and efavirenz demonstrated its clinical application...
  38. ncbi request reprint Pharmacokinetics of buprenorphine following intravenous and oral transmucosal administration in dogs
    Lisa A Abbo
    Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA
    Vet Ther 9:83-93. 2008
    ..05), indicating dose proportionality. The results of this study suggest that OTM buprenorphine may be an alternative for pain management in dogs...
  39. ncbi request reprint Interactions between buprenorphine and antiretrovirals. II. The protease inhibitors nelfinavir, lopinavir/ritonavir, and ritonavir
    Elinore F McCance-Katz
    Virginia Commonwealth University, Richmond, USA
    Clin Infect Dis 43:S235-46. 2006
    ..Adjustments of doses of either buprenorphine or NFV, LPV/R, or RTV are not likely to be necessary when these drugs are administered for the treatment of opioid dependence and HIV disease...
  40. ncbi request reprint Interactions between buprenorphine and antiretrovirals. I. The nonnucleoside reverse-transcriptase inhibitors efavirenz and delavirdine
    Elinore F McCance-Katz
    Virginia Commonwealth University, Richmond, USA
    Clin Infect Dis 43:S224-34. 2006
    ..Adjustments of doses of either buprenorphine or EFV or DLV are not likely to be necessary when these drugs are administered for the treatment of opiate dependence and HIV disease...
  41. ncbi request reprint Buprenorphine duration of action: mu-opioid receptor availability and pharmacokinetic and behavioral indices
    Mark Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences Wayne State University, Detroit, Michigan 48207, USA
    Biol Psychiatry 61:101-10. 2007
    ..This study examined the duration of action of BUP at microORs and correlations with pharmacokinetic and pharmacodynamic outcomes in 10 heroin-dependent volunteers...
  42. ncbi request reprint Relative bioavailability of different buprenorphine formulations under chronic dosing conditions
    Eric C Strain
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 74:37-43. 2004
    ..This study compared the relative buprenorphine bioavailability of these different formulations...
  43. ncbi request reprint Opioid plasma concentrations in methadone-and buprenorphine-maintained patients
    Reinhold Jagsch
    Faculty of Psychology, Clinical and Health Psychology, University of Vienna, Vienna, Austria
    Addict Biol 10:365-71. 2005
    ..No such differences could be evaluated between completers and dropouts in buprenorphine-maintained subjects, neither concerning withdrawal scores nor dose, plasma concentration, concentration-to-dose ratios or intra-individual variation...
  44. ncbi request reprint Developmental toxicity of levo-alpha-acetylmethadol (LAAM) in tolerant rats
    Raymond G York
    International Research and Development Corporation, Mattawan, Michigan, USA
    Int J Toxicol 21:147-59. 2002
    ..Despite maternal and developmental toxicity, there was no evidence of selective fetal toxicity or teratogenic activity attributable to LAAM...
  45. ncbi request reprint Buprenorphine tablet versus liquid: a clinical trial comparing plasma levels, efficacy, and symptoms
    Marek C Chawarski
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    J Subst Abuse Treat 29:307-12. 2005
    ..Measures of withdrawal symptoms or illicit opioid use were not associated with buprenorphine dose, formulation, or plasma buprenorphine levels...
  46. pmc Sublingual buprenorphine for treatment of neonatal abstinence syndrome: a randomized trial
    Walter K Kraft
    Department of Pharmacology and Experimental Therapeutics, Jefferson Medical College, Philadelphia, PA 19107, USA
    Pediatrics 122:e601-7. 2008
    ..Secondary goals were to evaluate efficacy relative to standard therapy and to characterize buprenorphine pharmacokinetics when sublingually administered...
  47. ncbi request reprint Effects of buprenorphine maintenance dose on mu-opioid receptor availability, plasma concentrations, and antagonist blockade in heroin-dependent volunteers
    Mark K Greenwald
    Department of Psychiatry and Behavioral Neurosciences and Addiction Research Institute, Wayne State University, Detroit, MI 48207, USA
    Neuropsychopharmacology 28:2000-9. 2003
    ....
  48. ncbi request reprint An injection depot formulation of buprenorphine: extended bio-delivery and effects
    Stacey C Sigmon
    Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, MD
    Addiction 101:420-32. 2006
    ....
  49. pmc Interaction between buprenorphine and atazanavir or atazanavir/ritonavir
    Elinore F McCance-Katz
    Virginia Commonwealth University, Richmond, VA, USA
    Drug Alcohol Depend 91:269-78. 2007
    ..Atazanavir or atazanavir/ritonavir may increase buprenorphine and buprenorphine metabolite concentrations and might require a decreased buprenorphine dose...
  50. ncbi request reprint Pharmacokinetic interactions between buprenorphine and antiretroviral medications
    R Douglas Bruce
    Yale University AIDS Program, New Haven, CT 06511, USA
    Clin Infect Dis 43:S216-23. 2006
    ..Review of the current state of knowledge regarding specific interactions between buprenorphine and antiretrovirals is followed by a review of the clinical applicability of these interactions...