Research Topics
| A S MontoSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
Vaccines and antiviral drugs in pandemic preparednessArnold S Monto
University of Michigan School of Public Health, Ann Arbor, Michigan 48109 2029, USA
Emerg Infect Dis 12:55-60. 2006..Special questions need to be answered if a highly lethal virus, such as influenza A (H5N1), produces the pandemic. Both vaccines and antiviral drugs will be required for a coordinated strategy...
Response to the 2009 pandemic: effect on influenza control in wealthy and poor countriesArnold S Monto
The School of Public Health, University of Michigan ASM, United States
Vaccine 29:6427-31. 2011..Only by taking a broad view of influenza on an annual basis can vaccine supplies be ensured for all countries of the world...
Invited commentary: Use of selective viral cultures to adjust nonvirologic endpoints in studies of influenza vaccine efficacyArnold S Monto
Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory Street, Room 3080 SPH I, Ann Arbor, MI 48109-2029, USA
Am J Epidemiol 158:312-5. 2003
Detection and control of influenza outbreaks in well-vaccinated nursing home populationsArnold S Monto
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109 2029, USA
Clin Infect Dis 39:459-64. 2004..Recommendations for outbreak control in institutions such as nursing homes advises use of antiviral drugs to reduce influenza transmission...
Seasonal influenza vaccines: evolutions and future trendsArnold S Monto
University of Michigan School of Public Health, Department of Epidemiology, Ann Arbor, MI 48104, USA
Expert Rev Vaccines 8:383-9. 2009..Such data will be necessary to inform decisions on making selections for use...
Detection of influenza viruses resistant to neuraminidase inhibitors in global surveillance during the first 3 years of their useArnold S Monto
University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
Antimicrob Agents Chemother 50:2395-402. 2006..The frequency of variants with decreased sensitivity to the NAIs did not increase significantly during this period, but continued surveillance is required, especially in regions with higher NAI use...
Epidemiology of pandemic influenza: use of surveillance and modeling for pandemic preparednessArnold S Monto
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA
J Infect Dis 194:S92-7. 2006..Models previously used to estimate hospitalizations and mortality associated with past epidemics and pandemics have evolved to estimate the burden and required surge capacity of future pandemics of different severities...
Seasonal and pandemic influenza: a 2007 update on challenges and solutionsArnold S Monto
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, USA
Clin Infect Dis 46:1024-31. 2008..These initiatives will also help control outbreaks of seasonal influenza...
Antivirals and influenza: frequency of resistanceArnold S Monto
Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109 2025, USA
Pediatr Infect Dis J 27:S110-2. 2008..Resistance does emerge, but not at the same frequency as with the M2 inhibitors. Resistant viruses also appear less fit and thus less able to spread. However, as use increases, resistance needs to be carefully monitored...
The risk of seasonal and pandemic influenza: prospects for controlArnold S Monto
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109 2029, USA
Clin Infect Dis 48:S20-5. 2009..Stockpiles of antiviral drugs are being established for therapeutic and perhaps preventive use for pandemic influenza...
Epidemiology of influenzaArnold S Monto
Department of Epidemiology, University of Michigan School of Public Health, 109 Observatory Street, Ann Arbor, MI 48109, USA
Vaccine 26:D45-8. 2008..Younger individuals experience the highest frequency of illnesses caused by all subtypes. This has resulted in suggested strategies for community control by vaccinating children...
Influenza control in the 21st century: Optimizing protection of older adultsArnold S Monto
University of Michigan School of Public Health, Ann Arbor, 48109 2029, USA
Vaccine 27:5043-53. 2009..While it is clear that vaccines with greater immunogenicity are required for older adults, and that adjuvanted vaccines may offer a short-term solution, further research is required to exploit the many other new technologies...
Comparative efficacy of inactivated and live attenuated influenza vaccinesArnold S Monto
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
N Engl J Med 361:1260-7. 2009..The efficacy of influenza vaccines may vary from year to year, depending on a variety of factors, and may differ for inactivated and live attenuated vaccines...
Seasonal influenza vaccinations: specialized products for different target groupsArnold S Monto
Dept of Epidemiology, University of Michigan School of Public Health, Ann Arbor, 48109 2029, USA
Vaccine 28:D14-23. 2010..We will also consider different strategies for vaccine use which might be applied to traditional or future vaccines to improve population protection...
Seasonal influenza and vaccination coverageArnold S Monto
Dept of Epidemiology, University of Michigan School of Public Health, Ann Arbor, 48109 2029, USA
Vaccine 28:D33-44. 2010....
The role of antivirals in the control of influenzaArnold S Monto
School of Public Health, The University of Michigan, 109 Observatory Street, Ann Arbor, MI 48109 2029, USA
Vaccine 21:1796-800. 2003..Their availability will depend entirely on the creation of stockpiles of these agents well in advance of the arrival of the pandemic...
The seasonality of rhinovirus infections and its implications for clinical recognitionArnold S Monto
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA
Clin Ther 24:1987-97. 2002..Isolation of rhinoviruses occurs in a distinct and consistent seasonal pattern that can be used to help determine whether an acute respiratory illness is caused by a rhinovirus...
Influenza vaccine effectiveness among elderly nursing home residents: a cohort studyA S Monto
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
Am J Epidemiol 154:155-60. 2001..Given the number of eligible homes and the cohort methodology used, the results support continuation of current policy, encouraging use of vaccine in all nursing home residents...
Randomized, placebo-controlled studies of inhaled zanamivir in the treatment of influenza A and B: pooled efficacy analysisA S Monto
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA
J Antimicrob Chemother 44:23-9. 1999..001). These results highlight the groups likely to show greatest benefit from zanamivir treatment, and confirm the clinical relevance of the treatment benefit...
Acute respiratory infections (ARI) in children: prospects for preventionA S Monto
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor 48109, USA
Vaccine 16:1582-8. 1998..The introduction and use of new vaccines in those regions will require demonstration of cost effectiveness and acceptance by policy makers...
Effect of zanamivir on duration and resolution of influenza symptomsA S Monto
Department of Epidemiology, University of Michigan School of Public Health, Ann Arhor, USA
Clin Ther 22:1294-305. 2000..Administration by inhalation results in direct delivery to the respiratory tract, the principal site of viral replication...
Efficacy and safety of the neuraminidase inhibitor zanamivirin the treatment of influenza A and B virus infectionsA S Monto
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
J Infect Dis 180:254-61. 1999..It was well tolerated. These results suggest that zanamivir can significantly reduce the duration and overall symptomatic effect of influenza...
Zanamivir in the prevention of influenza among healthy adults: a randomized controlled trialA S Monto
School of Public Health, University of Michigan, Ann Arbor 48109 2029, USA
JAMA 282:31-5. 1999..It has also been shown to prevent influenza infection and disease in an experimental model...
Individual and community impact of influenzaA S Monto
School of Public Health, University of Michigan, Ann Arbor, USA
Pharmacoeconomics 16:1-6. 1999..The actual impact of influenza is likely to be within this range of estimates, but recent vaccination studies suggest the possibility of much higher rates of morbidity than previously estimated...
Interrupting the transmission of respiratory tract infections: theory and practiceA S Monto
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor 48109, USA
Clin Infect Dis 28:200-4. 1999..Results of these experiences can in turn strengthen the development of transmission theory...
Development of a predictive index for picornavirus infectionsArnold S Monto
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
Clin Infect Dis 36:253-8. 2003..The model was simplified for clinical use by creating a whole-number index: the lowest possible score (-3) indicates a 15% chance of picornavirus infection and the highest (7) indicates a 69% chance of picornavirus infection...
Zanamivir prophylaxis: an effective strategy for the prevention of influenza types A and B within householdsArnold S Monto
School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor 48109, USA
J Infect Dis 186:1582-8. 2002..Zanamivir was well tolerated and was effective in preventing influenza types A and B within households where the index patient was not treated...
Person-to-person transmission of hepatitis A virus in an urban area of intermediate endemicity: implications for vaccination strategiesJ C Victor
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
Am J Epidemiol 163:204-10. 2006..If vaccine is determined to be highly effective postexposure and if it is feasible, vaccinating household contacts could be a useful additional control strategy...
Clinical signs and symptoms predicting influenza infectionA S Monto
University of Michigan, 3080 SPH 1, 109 Observatory St, Ann Arbor, MI 48109 2029, USA
Arch Intern Med 160:3243-7. 2000..In clinical practice, antiviral use has rarely been guided by antecedent laboratory diagnosis. Defined clinical predictors of an influenza infection can help guide timely therapy and avoid unnecessary antibiotic use...
Ferrets as a transmission model for influenza: sequence changes in HA1 of type A (H3N2) virusM L Herlocher
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA
J Infect Dis 184:542-6. 2001..The results show the value of the ferret model. A/LA resembled the transmission of influenza in humans when under antibody pressure...
Influenza viruses resistant to the antiviral drug oseltamivir: transmission studies in ferretsM Louise Herlocher
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA
J Infect Dis 190:1627-30. 2004..Both the mutant and the wild-type viruses retained their genotypic characteristics...
Occurrence of respiratory virus: time, place and personArnold S Monto
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, USA
Pediatr Infect Dis J 23:S58-64. 2004..Although vaccination and antiviral drugs are virus-specific, factors that promote transmission and thus strategies for limiting outbreaks are similar for various respiratory viruses...
The threat of an avian influenza pandemicArnold S Monto
University of Michigan School of Public Health, Ann Arbor, USA
N Engl J Med 352:323-5. 2005
Reduced reaction frequencies with repeated inactivated or live-attenuated influenza vaccinationSuzanne E Ohmit
University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
Vaccine 27:1050-4. 2009..Reaction reporting peaked on post-vaccination days 0 and 1 following receipt of the inactivated vaccine, and on day 2 following receipt of the live-attenuated vaccine...
Symptomatic predictors of influenza virus positivity in children during the influenza seasonSuzanne E Ohmit
University of Michigan School of Public Health, Ann Arbor, Michigan 48109-2029, USA
Clin Infect Dis 43:564-8. 2006....
Nonpharmaceutical influenza mitigation strategies, US communities, 1918-1920 pandemicHoward Markel
The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Emerg Infect Dis 12:1961-4. 2006..We conclude that several small communities implemented potentially successful attempts at preventing the introduction of influenza...
Prevention of antigenically drifted influenza by inactivated and live attenuated vaccinesSuzanne E Ohmit
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor 48109, USA
N Engl J Med 355:2513-22. 2006..The efficacy of influenza vaccines may decline during years when the circulating viruses have antigenically drifted from those included in the vaccine...
Prevention of symptomatic seasonal influenza in 2005-2006 by inactivated and live attenuated vaccinesSuzanne E Ohmit
University of Michigan School of Public Health, Department of Epidemiology, Ann Arbor, Michigan 48109, USA
J Infect Dis 198:312-7. 2008....
Assessment of development of resistance to antivirals in the ferret model of influenza virus infectionM Louise Herlocher
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA
J Infect Dis 188:1355-61. 2003..Similar to the situation in humans, amantadine use in ferrets rapidly produces antiviral resistance, but zanamivir use does not, although nucleotide changes were observed...
The economic burden of non-influenza-related viral respiratory tract infection in the United StatesA Mark Fendrick
Division of General Internal Medicine, Department of Internal Medicine, School of Medicine, University of Michigan, 300 N Ingalls Bldg, Room 7E06, Ann Arbor, MI 48109 0376, USA
Arch Intern Med 163:487-94. 2003..Our objectives were to obtain an updated incidence of non-influenza-related VRTI in the United States and to quantify the health care resource use (direct costs) and productivity losses (indirect costs) associated with these infections...
Preparing for pandemic influenza: should hospitals stockpile oseltamivir?Sandro Cinti
Division of Infectious Diseases, University of Michigan Health System, Ann Arbor, Michigan, USA
Infect Control Hosp Epidemiol 26:852-4. 2005..We think that hospitals should consider stockpiling oseltamivir, and we provide a strategy for doing so at a reasonable cost...
Research findings from nonpharmaceutical intervention studies for pandemic influenza and current gaps in the researchAllison E Aiello
Center for Social Epidemiology and Population Health, Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109, USA
Am J Infect Control 38:251-8. 2010..The current novel influenza A (H1N1) pandemic underscores the importance of influenza research...
Mask use, hand hygiene, and seasonal influenza-like illness among young adults: a randomized intervention trialAllison E Aiello
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA
J Infect Dis 201:491-8. 2010..Our study examined whether use of face masks and hand hygiene reduced the incidence of influenza-like illness (ILI)...
Respiratory illness caused by picornavirus infection: a review of clinical outcomesA S Monto
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA
Clin Ther 23:1615-27. 2001..New treatments should be assessed not only in terms of their ability to produce the desired clinical outcome, but also in terms of their ability to reduce the burden of disease, decrease health care costs, and improve productivity...
Influenza virus carrying an R292K mutation in the neuraminidase gene is not transmitted in ferretsM L Herlocher
Epidemiology, School of Public Health, University of Michigan, 109 Observatory, Ann Arbor, MI 48109, USA
Antiviral Res 54:99-111. 2002....
Diagnostic testing or empirical neuraminidase inhibitor therapy for patients with influenza-like illness: what a difference a day makesSusan G Blitz
Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, USA
Am J Manag Care 8:221-7. 2002..Clinicians must consider these factors when determining cost-effective use of NIs...
Epidemiology of viral respiratory infectionsArnold S Monto
Department of Epidemiology, School of Public Health, University of Michigan at Ann Arbor, Ann Arbor, Michigan, USA
Am J Med 112:4S-12S. 2002....
Demographic and socioeconomic determinants of influenza vaccination disparities among university studentsM Uddin
Center for Social Epidemiology and Population Health, 1415 Washington Heights, Ann Arbor, MI 48109 2029, USA
J Epidemiol Community Health 64:808-13. 2010..We therefore sought to examine the influence of demographic, social and health behaviours on influenza vaccination coverage among college dormitory students...
The increasing prominence of household transmission of hepatitis A in an area undergoing a shift in endemicityJ C Victor
Department of Epidemiology, School of Public Health, The University of Michigan, Ann Arbor, MI 48109, USA
Epidemiol Infect 134:492-7. 2006..0, 95% confidence interval 1.3-3.2). Almaty is experiencing an epidemiological shift in hepatitis A incidence. Feasible and effective prevention strategies using hepatitis A vaccine should be explored...
Hepatitis A vaccine versus immune globulin for postexposure prophylaxisJohn C Victor
University of Michigan, Ann Arbor, USA
N Engl J Med 357:1685-94. 2007....
Prevention and treatment of influenza in high-risk groups: children, pregnant women, immunocompromised hosts, and nursing home residentsRichard J Whitley
University of Alabama at Birmingham, Birmingham, AL, 35233 1711, USA
J Infect Dis 194:S133-8. 2006..The development of additional antiviral drugs is an important recommendation for the future, so that antiviral resistance can be circumvented. Similarly, availability of drugs for children <1 year of age is mandatory...
A comparison of 2 influenza vaccine schedules in 6- to 23-month-old childrenJanet A Englund
Division of Pediatric Infectious Diseases, Allergy, and Rheumatology, University of Washington and Children s Hospital and Regional Medical Center, Seattle, Washington 98105, USA
Pediatrics 115:1039-47. 2005..Trivalent inactivated influenza vaccine (TIV) is recommended for all children ages 6 to 23 months. Delivering 2 doses of TIV at least 4 weeks apart to young children receiving this vaccine for the first time is challenging...
Virulence may determine the necessary duration and dosage of oseltamivir treatment for highly pathogenic A/Vietnam/1203/04 influenza virus in miceHui-Ling Yen
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA
J Infect Dis 192:665-72. 2005..CONCLUSIONS. Oseltamivir prophylaxis is efficacious against lethal challenge with VN1203/04 virus in mice. Viral virulence may affect the antiviral treatment schedule...
Neuraminidase inhibitor-resistant influenza viruses may differ substantially in fitness and transmissibilityHui-Ling Yen
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105-2794, USA
Antimicrob Agents Chemother 49:4075-84. 2005..Our results suggest that NAI-resistant influenza virus variants may differ substantially in fitness and transmissibility, depending on different levels of NA functional loss...
Importance of neuraminidase active-site residues to the neuraminidase inhibitor resistance of influenza virusesHui-Ling Yen
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105-2794, USA
J Virol 80:8787-95. 2006..The results of our study may help to optimize the design of NAIs...
Influenza vaccine immunogenicity in 6- to 23-month-old children: are identical antigens necessary for priming?Emmanuel B Walter
Duke Clinical Research Institute, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA
Pediatrics 118:e570-8. 2006....
Immunization with trivalent inactivated influenza vaccine in partially immunized toddlersJanet A Englund
Pediatric ID, Children s Hospital and Regional Medical Center, 4800 Sand Point Way, NE W8851, Seattle, Washington 98105, USA
Pediatrics 118:e579-85. 2006....
Seasonal and pandemic influenza: recommendations for preparedness in the United StatesRichard J Whitley
Department of Pediatric, University of Alabama at Birmingham, Birmingham, AL, 35233 1711, USA
J Infect Dis 194:S155-61. 2006....
Seasonal and pandemic influenza preparedness: a global threatRichard J Whitley
Departments of Pediatrics, Microbiology, Medicine, and Neurosurgery and Center for Biodefense and Emerging Infections, University of Alabama at Birmingham, Birmingham, AL, 35233 1711, USA
J Infect Dis 194:S65-9. 2006....
Editorial commentary: viral susceptibility and the choice of influenza antiviralsArnold S Monto
Clin Infect Dis 47:346-8. 2008
Stockpiling prepandemic influenza vaccines: a new cornerstone of pandemic preparedness plansLance C Jennings
Microbiology Department, Canterbury Health Laboratories, University of Otago, Christchurch, New Zealand
Lancet Infect Dis 8:650-8. 2008..WHO and governments should give urgent consideration to the use of these vaccines for the priming of individuals or communities who would be at greatest risk of infection if an H5N1 influenza pandemic were to emerge...
Antiviral effects on influenza viral transmission and pathogenicity: observations from household-based trialsM Elizabeth Halloran
Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Am J Epidemiol 165:212-21. 2007..Studies of influenza antivirals in transmission units would be improved if randomization schemes were used that allow estimation of the antiviral effect on infectiousness from individual studies...
Antivirals for influenza in healthy adultsArnold S Monto
Lancet 367:1571-2; author reply 1573. 2006
Echinacea purpurea for prevention of experimental rhinovirus coldsSteven J Sperber
Department of Internal Medicine, Hackensack University Medical Center, Hackensack, NJ 07601, USA
Clin Infect Dis 38:1367-71. 2004....
A study of influenza and influenza-related complications among children in a large US health insurance plan databaseJeanne Loughlin
Ingenix Epidemiology Division, Newton, Massachusetts 02466, USA. .com
Pharmacoeconomics 21:273-83. 2003....
Research Grants
- Comparative Study of Influenza Vaccines in AdultsARNOLD MONTO; Fiscal Year: 2006..Results will help to determine how the vaccine may be used as part of the strategy to combat influenza in varying situations. ..
