Thomas Montine

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Quantitative in vivo biomarkers of oxidative damage and their application to the diagnosis and management of Alzheimer's disease
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    J Alzheimers Dis 8:359-67. 2005
  2. pmc Apolipoprotein C-I is an APOE genotype-dependent suppressor of glial activation
    Eiron Cudaback
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    J Neuroinflammation 9:192. 2012
  3. pmc Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein
    Jinghua Jin
    Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    J Neuroinflammation 4:2. 2007
  4. ncbi request reprint Lack of beta-methylamino-l-alanine in brain from controls, AD, or Chamorros with PDC
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Neurology 65:768-9. 2005
  5. pmc Fatty acid oxidation in the pathogenesis of Alzheimer's disease
    Thomas J Montine
    Department of Pathology, University of Washington, Box 359791, Seattle, WA 98104, USA
    Am J Pathol 166:1283-9. 2005
  6. pmc Liquid chromatography with tandem mass spectrometry-based proteomic discovery in aging and Alzheimer's disease
    Thomas J Montine
    Department of Pathology, University of Washington, Harborview Medical Center, Seattle, Washington 98104, USA
    NeuroRx 3:336-43. 2006
  7. ncbi request reprint F(2)-isoprostanes as biomarkers of late-onset Alzheimer's disease
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    J Mol Neurosci 33:114-9. 2007
  8. pmc Therapeutic targets in prostaglandin E2 signaling for neurologic disease
    P J Cimino
    Division of Neuropathology, University of Washington School of Medicine, Box 359791, Harborview Medical Center, Seattle, WA 98104, USA
    Curr Med Chem 15:1863-9. 2008
  9. ncbi request reprint Catalysis of catechol oxidation by metal-dithiocarbamate complexes in pesticides
    Vanessa A Fitsanakis
    Departments of Pathology and Pharmacology and Centers for Molecular Toxicology and Molecular Neurosciences, Vanderbilt University Medical Center, Nashville, TN, USA
    Free Radic Biol Med 33:1714-23. 2002
  10. ncbi request reprint Neuronal oxidative damage from activated innate immunity is EP2 receptor-dependent
    Thomas J Montine
    Department of Pathology, Vanderbilt University, Nashville, Tennessee, USA
    J Neurochem 83:463-70. 2002

Detail Information

Publications89

  1. ncbi request reprint Quantitative in vivo biomarkers of oxidative damage and their application to the diagnosis and management of Alzheimer's disease
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    J Alzheimers Dis 8:359-67. 2005
    ..In addition, measurement of CSF F2-IsoPs can increase the accuracy of laboratory-based classification of geriatric dementias, and have been used to assess objectively the response to anti-oxidant interventions in AD...
  2. pmc Apolipoprotein C-I is an APOE genotype-dependent suppressor of glial activation
    Eiron Cudaback
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    J Neuroinflammation 9:192. 2012
    ..Here we tested the hypothesis that APOE-genotype dependent innate immunomodulation may be mediated in part by apoC-I...
  3. pmc Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein
    Jinghua Jin
    Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    J Neuroinflammation 4:2. 2007
    ..It has been demonstrated that aggregated alpha-synuclein potently activates microglia and causes neurotoxicity. However, the mechanisms by which aggregated alpha-synuclein activates microglia are not understood fully...
  4. ncbi request reprint Lack of beta-methylamino-l-alanine in brain from controls, AD, or Chamorros with PDC
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Neurology 65:768-9. 2005
    ..In contrast to others, they detected no free BMAA in any of these samples...
  5. pmc Fatty acid oxidation in the pathogenesis of Alzheimer's disease
    Thomas J Montine
    Department of Pathology, University of Washington, Box 359791, Seattle, WA 98104, USA
    Am J Pathol 166:1283-9. 2005
    ..If successful, these interventions are unlikely to cure AD, but may check its explosive growth and hopefully reduce its incidence and prevalence in the elderly...
  6. pmc Liquid chromatography with tandem mass spectrometry-based proteomic discovery in aging and Alzheimer's disease
    Thomas J Montine
    Department of Pathology, University of Washington, Harborview Medical Center, Seattle, Washington 98104, USA
    NeuroRx 3:336-43. 2006
    ..As protocols and methods for improved quantitative high-throughput proteomics constantly improve, this approach will likely continue to provide deeper insight into human brain aging and neurodegenerative diseases...
  7. ncbi request reprint F(2)-isoprostanes as biomarkers of late-onset Alzheimer's disease
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    J Mol Neurosci 33:114-9. 2007
    ..CSF F(2)-IsoPs may be used to assist in diagnosis and aid in objective assessment of disease progression and response to therapeutics in patients with AD...
  8. pmc Therapeutic targets in prostaglandin E2 signaling for neurologic disease
    P J Cimino
    Division of Neuropathology, University of Washington School of Medicine, Box 359791, Harborview Medical Center, Seattle, WA 98104, USA
    Curr Med Chem 15:1863-9. 2008
    ..However promising these preclinical studies are, they have yet to be followed by clinical trials targeting any EP receptor in neurologic diseases...
  9. ncbi request reprint Catalysis of catechol oxidation by metal-dithiocarbamate complexes in pesticides
    Vanessa A Fitsanakis
    Departments of Pathology and Pharmacology and Centers for Molecular Toxicology and Molecular Neurosciences, Vanderbilt University Medical Center, Nashville, TN, USA
    Free Radic Biol Med 33:1714-23. 2002
    ..Our results point to the potential for manganese- and zinc-containing EBDC pesticides to promote oxidative stress in catecholaminergic regions of the brain...
  10. ncbi request reprint Neuronal oxidative damage from activated innate immunity is EP2 receptor-dependent
    Thomas J Montine
    Department of Pathology, Vanderbilt University, Nashville, Tennessee, USA
    J Neurochem 83:463-70. 2002
    ..These results suggest the EP2 receptor as a therapeutic target to limit oxidative damage from activation of innate immunity in cerebrum...
  11. ncbi request reprint Parkinson disease: PD biomarkers-use of α-synuclein reaches new levels
    Thomas J Montine
    Department of Pathology, University of Washington, 300 9th Avenue, Seattle, WA 98104, USA
    Nat Rev Neurol 7:308-9. 2011
    ..Some of this promise is now being realized in Alzheimer disease, and progress in Parkinson disease is accelerating...
  12. pmc Increased cerebrospinal fluid F2-isoprostanes are associated with aging and latent Alzheimer's disease as identified by biomarkers
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA, USA
    Neuromolecular Med 13:37-43. 2011
    ..01). These results show that CSF F(2)-IsoPs increased across the human lifespan and that this age-related increase in free radical injury to brain persisted after culling those with laboratory evidence of latent AD...
  13. ncbi request reprint Lipid peroxidation in aging brain and Alzheimer's disease
    Thomas J Montine
    Department of Pharmacology, Pathology, and Medicine and the Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN, USA
    Free Radic Biol Med 33:620-6. 2002
    ....
  14. ncbi request reprint Pharmacologic suppression of neuronal oxidative damage and dendritic degeneration following direct activation of glial innate immunity in mouse cerebrum
    Dejan Milatovic
    Department of Pathology, University of Washington, Harborview Medical Center, Seattle, Washington 98104, USA
    J Neurochem 87:1518-26. 2003
    ....
  15. ncbi request reprint Microglial EP2 is critical to neurotoxicity from activated cerebral innate immunity
    Feng Shiun Shie
    Department of Pathology, University of Washington, Seattle, Washington, USA
    Glia 52:70-7. 2005
    ..EP2 should be considered as a therapeutic target for suppression of microglial innate immunity-mediated damage in neurodegenerative diseases...
  16. pmc Different patterns of cerebral injury in dementia with or without diabetes
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, USA
    Arch Neurol 66:315-22. 2009
    ..Diabetes mellitus (DM) increases the risk of dementia in the elderly. However, its underlying mechanisms, its connection with Alzheimer disease and vascular cognitive impairment, and effects of therapy remain unclear...
  17. ncbi request reprint Mouse cerebral prostaglandins, but not oxidative damage, change with age and are responsive to indomethacin treatment
    Kathleen S Montine
    Department of Pathology, Vanderbilt University Medical Center, C3321 A Medical Center North, Nashville, TN 37232, USA
    Brain Res 930:75-82. 2002
    ..These results suggest that indomethacin may influence the initiation of AD by reducing cerebral PG elevation that may occur in middle age, but that it is unlikely to have a direct effect on levels of oxidative damage...
  18. pmc Detergent-insoluble EAAC1/EAAT3 aberrantly accumulates in hippocampal neurons of Alzheimer's disease patients
    Kevin Duerson
    Geriatric Research Education and Clinical Center, VA Medical Center, 1660 S Columbian Way, Seattle, WA 98108, USA
    Brain Pathol 19:267-78. 2009
    ....
  19. ncbi request reprint Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer's disease and correlation with APOE
    Joseph F Pulliam
    Department of Pathology, University of Kentucky, Lexington, Kentucky 40536, USA
    Am J Med Genet B Neuropsychiatr Genet 119:48-53. 2003
    ....
  20. pmc Protection of hippocampal neurogenesis from toll-like receptor 4-dependent innate immune activation by ablation of prostaglandin E2 receptor subtype EP1 or EP2
    C Dirk Keene
    Department of Pathology, University of Washington, Box 359791, Seattle, WA 98104, USA
    Am J Pathol 174:2300-9. 2009
    ....
  21. ncbi request reprint Analysis of alpha-synuclein-associated proteins by quantitative proteomics
    Yong Zhou
    Department of Pathology and Medicinal Chemistry, University of Washington School of Medicine, Seattle, Washington 98104, USA
    J Biol Chem 279:39155-64. 2004
    ..Furthermore, the protection afforded by hsp70 transfection appeared to be related to suppression of rotenone-induced oxidative stress as well as mitochondrial and proteasomal dysfunction...
  22. ncbi request reprint Proteomic analysis of neurofibrillary tangles in Alzheimer disease identifies GAPDH as a detergent-insoluble paired helical filament tau binding protein
    Qin Wang
    Department of Pathology, Division of Neuropathology, University of Washington, Seattle, Washington 98105, USA
    FASEB J 19:869-71. 2005
    ....
  23. ncbi request reprint F2-isoprostanes in Alzheimer and other neurodegenerative diseases
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Antioxid Redox Signal 7:269-75. 2005
    ..These results indicate that brain lipid peroxidation is a potential therapeutic target early in the course of AD, and that CSF F2-IsoPs may aid in the assessment of antioxidant experimental therapeutics and laboratory diagnosis of AD...
  24. doi request reprint Application of targeted quantitative proteomics analysis in human cerebrospinal fluid using a liquid chromatography matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometer (LC MALDI TOF/TOF) platform
    Sheng Pan
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    J Proteome Res 7:720-30. 2008
    ....
  25. pmc Pharmacologic suppression of oxidative damage and dendritic degeneration following kainic acid-induced excitotoxicity in mouse cerebrum
    Snjezana Zaja-Milatovic
    Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN 37232, United States
    Neurotoxicology 29:621-7. 2008
    ....
  26. ncbi request reprint Suppression of murine cerebral F2-isoprostanes and F4-neuroprostanes from excitotoxicity and innate immune response in vivo by alpha- or gamma-tocopherol
    Dejan Milatovic
    Department of Pathology, University of Washington, Harborview Medical Center, Box 359791, Seattle, WA 98104, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 827:88-93. 2005
    ..These data imply that AT may be more broadly protective of cerebrum from oxidative damage in different disease contexts...
  27. ncbi request reprint Proteomic determination of widespread detergent-insolubility including Abeta but not tau early in the pathogenesis of Alzheimer's disease
    Randall L Woltjer
    Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA, USA
    FASEB J 19:1923-5. 2005
    ..These results are consistent with the amyloid hypothesis of AD and extend it to include widespread protein insolubility, not exclusively Abeta insolubility, early in AD pathogenesis even before the onset of clinical dementia...
  28. ncbi request reprint Cerebrospinal fluid lipoprotein delivery to human neuronal cells is increased in Alzheimer's disease and is dependent on apoE monomer concentration
    Casey N Bassett
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Alzheimers Dis 4:19-30. 2002
    ....
  29. pmc CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases
    Jing Zhang
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
    Am J Clin Pathol 129:526-9. 2008
    ..This first large-scale validation of a proteomic-discovered MAP suggests a panel of 8 CSF proteins that are highly effective at identifying PD and moderately effective at identifying AD...
  30. ncbi request reprint Microglial EP2 as a new target to increase amyloid beta phagocytosis and decrease amyloid beta-induced damage to neurons
    Feng Shiun Shie
    Department of Pathology, University of Washington, Seattle 98104, USA
    Brain Pathol 15:134-8. 2005
    ..These data point to microglial EP2 as a more focused target within the PG pathway for therapy in AD...
  31. pmc PGH2-derived levuglandin adducts increase the neurotoxicity of amyloid beta1-42
    Olivier Boutaud
    Department of Pharmacology, Vanderbilt University, Nashville 37232 6602, Tennessee, USA
    J Neurochem 96:917-23. 2006
    ....
  32. ncbi request reprint Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK
    Izumi Maezawa
    Department of Pathology, University of Washington, Seattle, Washington 98104, USA
    FASEB J 20:797-9. 2006
    ..These findings suggest a new mechanism by which inheritance of different APOE alleles may influence the outcome of neurodegenerative diseases associated with microglial innate immune response...
  33. ncbi request reprint Effect of statins on Alzheimer's disease biomarkers in cerebrospinal fluid
    Robert G Riekse
    Department of Medicine, Division of Geriatric Medicine, University of Washington School of Medicine, and VA Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 10:399-406. 2006
    ..Putative neuroprotective effects of statins may vary in relation to their ability to penetrate into the central nervous system (CNS)...
  34. pmc Parkinson-dementia complex and development of a new stable isotope dilution assay for BMAA detection in tissue
    Laura R Snyder
    Department of Chemistry, University of Washington, Seattle, WA, USA
    Toxicol Appl Pharmacol 240:180-8. 2009
    ..These studies demonstrate the importance of a sensitive and specific assay for tissue BMAA and seriously challenge the proposal that BMAA is accumulating in human brain...
  35. ncbi request reprint Selectively increased oxidative modifications mapped to detergent-insoluble forms of Abeta and beta-III tubulin in Alzheimer's disease
    Angela M Boutte
    Center for Molecular Neuroscience, Vanderbilt University, Nashville, Tennessee, USA
    FASEB J 20:1473-83. 2006
    ..These findings are the first comprehensive assessment of PTMs in AD and point to oxidative modification of beta-III tubulin as a potential contributor to the neuronal cytoskeletal disruption that is characteristic of AD...
  36. ncbi request reprint Mercapturate metabolism of 4-hydroxy-2-nonenal in rat and human cerebrum
    Kathrin R Sidell
    Department of Pathology and the Center for Molecular Toxicology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Neuropathol Exp Neurol 62:146-53. 2003
    ..These data suggest that lipid peroxidation may present a greater toxic burden to cerebrum than to other organs, and that a component of response to injury in late stage AD is a slight increase in MAP activity...
  37. ncbi request reprint In vivo assessment of lipid peroxidation products associated with age-related neurodegenerative diseases
    Joyce J Ou
    Center for Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Exp Neurol 175:363-9. 2002
    ....
  38. ncbi request reprint Formation of highly reactive A-ring and J-ring isoprostane-like compounds (A4/J4-neuroprostanes) in vivo from docosahexaenoic acid
    Samuel S Fam
    Departments of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 277:36076-84. 2002
    ..Thus, these studies have identified novel, highly reactive A/J-ring isoprostane-like compounds that are derived from docosahexaenoic acid in vivo...
  39. ncbi request reprint Quantitative proteomics of cerebrospinal fluid from patients with Alzheimer disease
    Jing Zhang
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
    J Alzheimers Dis 7:125-33; discussion 173-80. 2005
    ....
  40. pmc Neuropathology-based risk scoring for dementia diagnosis in the elderly
    Sebastien Haneuse
    Group Health Center for Health Studies, Seattle, WA 98101, USA
    J Alzheimers Dis 17:875-85. 2009
    ..Evaluation in independent samples will be important to verify our findings...
  41. pmc Cognitive impairment in older adults without dementia: clinical and pathologic outcomes in a community-based sample
    Lucy Y Wang
    Mental Illness Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington, USA
    J Geriatr Psychiatry Neurol 22:256-65. 2009
    ..4 +/- 2.1 vs 3.1 +/- 2.7, P = .02). These observations are consistent with the view that nondemented patients with underlying AD may be more likely to present with memory than nonmemory cognitive impairment...
  42. pmc Visual hallucinations in dementia: a prospective community-based study with autopsy
    Debby Tsuang
    Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, USA
    Am J Geriatr Psychiatry 17:317-23. 2009
    ..This study seeks to investigate the demographic, clinical, and neuropathologic features of community-based dementia subjects with and without visual hallucations...
  43. ncbi request reprint Predicting lewy body pathology in a community-based sample with clinical diagnosis of Alzheimer's disease
    Debby Tsuang
    University of Washington Departments of Psychiatry and Behavioral Sciences, Seattle, WA, USA
    J Geriatr Psychiatry Neurol 19:195-201. 2006
    ..The model also identified other demographic and clinical characteristics that might enhance the prediction of Lewy body pathology...
  44. ncbi request reprint Peripheral F2-isoprostanes and F4-neuroprostanes are not increased in Alzheimer's disease
    Thomas J Montine
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Ann Neurol 52:175-9. 2002
    ..These results should guide the organization of clinical trials now being planned for patients with Alzheimer's disease...
  45. pmc Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA
    PLoS ONE 4:e5424. 2009
    ..We tested hypothesis that reduced CSF BDNF is associated with age-related cognitive decline...
  46. ncbi request reprint Manganese ethylene-bis-dithiocarbamate and selective dopaminergic neurodegeneration in rat: a link through mitochondrial dysfunction
    Jing Zhang
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Neurochem 84:336-46. 2003
    ....
  47. ncbi request reprint Antioxidants significantly affect the formation of different classes of isoprostanes and neuroprostanes in rat cerebral synaptosomes
    Thomas J Montine
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Biochem Pharmacol 65:611-7. 2003
    ..In addition, they suggest that alpha-tocopherol may not be a particularly effective agent to inhibit oxidant stress in the terminal compartment of neurons in the central nervous system...
  48. pmc APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure
    Lynn M Bekris
    Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Am J Med Genet B Neuropsychiatr Genet 153:409-17. 2010
    ....
  49. pmc Cortical serotonin and norepinephrine denervation in parkinsonism: preferential loss of the beaded serotonin innervation
    Tultul Nayyar
    Department of Neurobiology and Neurotoxicology, Meharry Medical College, Nashville, TN 37208, USA
    Eur J Neurosci 30:207-16. 2009
    ....
  50. pmc A patient with Huntington's disease and long-surviving fetal neural transplants that developed mass lesions
    C Dirk Keene
    Department of Pathology, Harborview Medical Center, University of Washington Medical Center, Seattle, 98104, USA
    Acta Neuropathol 117:329-38. 2009
    ..This report, for the first time, highlights the potential for graft overgrowth in a patient receiving fetal neural transplantation...
  51. ncbi request reprint Neuropathology in the adult changes in thought study: a review
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, WA 98104 2420, USA
    J Alzheimers Dis 18:703-11. 2009
    ..This study examines correlations between clinical characteristics including extensive, longitudinal medication histories, and longitudinal cognitive testing against structural and biochemical features of disease...
  52. pmc Suppressed accumulation of cerebral amyloid {beta} peptides in aged transgenic Alzheimer's disease mice by transplantation with wild-type or prostaglandin E2 receptor subtype 2-null bone marrow
    C Dirk Keene
    Harborview Medical Center, Box 359645, 325 Ninth Ave, Seattle, WA 98104, USA
    Am J Pathol 177:346-54. 2010
    ..Our results provide a foundation for an adult stem cell-based therapy to suppress soluble Abeta peptide and plaque accumulation in the cerebrum of patients with AD...
  53. pmc Quantitative proteomic analysis of oligodendrogliomas with and without 1p/19q deletion
    Robert C Rostomily
    Department of Neurological Surgery, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
    J Proteome Res 9:2610-8. 2010
    ..Future analysis of larger patient samples are warranted to further refine biomarker panels to predict biological behavior and assist in the identification of deleted gene products that define the 1p/19q phenotype...
  54. pmc DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease
    Zhen Hong
    Department of Pathology, University of Washington School of Medicine, HMC Box 359635, 325 9th Avenue, Seattle, WA 98104, USA
    Brain 133:713-26. 2010
    ..We have demonstrated that total DJ-1 and alpha-synuclein in human cerebrospinal fluid are helpful diagnostic markers for Parkinson's disease, if variables such as blood contamination and age are taken into consideration...
  55. pmc The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration
    Chang En Yu
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Arch Neurol 67:161-70. 2010
    ..However, it is unclear whether some rare FTD-related GRN variants are pathogenic and whether neurodegenerative disorders other than FTD can also be caused by GRN mutations...
  56. pmc Cerebrospinal fluid biomarkers in mild cognitive impairment and dementia
    Joshua A Sonnen
    Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA 98104 2420, USA
    J Alzheimers Dis 19:301-9. 2010
    ..A multimodal approach that brings independent information from risk factor assessment, neuroimaging, and biomarkers may soon guide physicians in the early diagnosis and management of cognitive impairment in the elderly...
  57. pmc Associations between microinfarcts and other macroscopic vascular findings on neuropathologic examination in 2 databases
    W T Longstreth
    Department of Neurology, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104 2420, USA
    Alzheimer Dis Assoc Disord 23:291-4. 2009
    ..9, 95% CI: 1.4, 6.3). These neuropathologic associations suggest that people whose cranial MRI shows macroinfarcts, hemorrhages, or leukoencephalopathy are more likely also to have microinfarcts...
  58. pmc Blood pressure and brain injury in older adults: findings from a community-based autopsy study
    Lucy Y Wang
    Mental Illness Research and Education Clinical Center, Veterans Affairs Puget Sound Healthcare System, Seattle, Washington 98108, USA
    J Am Geriatr Soc 57:1975-81. 2009
    ..To examine correlations between blood pressure (BP) and dementia-related pathological brain changes in a community-based autopsy sample...
  59. pmc DOCK2 is a microglial specific regulator of central nervous system innate immunity found in normal and Alzheimer's disease brain
    Patrick J Cimino
    Division of Neuropathology, Department of Pathology, the Neurobiology and Behavior Program, University of Washington, Box 359645, Harborview Medical Center, Seattle, WA 98104, USA
    Am J Pathol 175:1622-30. 2009
    ..Together, these results suggest DOCK2 as a COX2 expression-independent therapeutic target for neurodegenerative diseases such as AD...
  60. ncbi request reprint Pathological correlates of dementia in a longitudinal, population-based sample of aging
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, WA, USA
    Ann Neurol 62:406-13. 2007
    ..Our goal was to determine the independent pathological correlates associated with dementia in a typical US population...
  61. pmc Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, USA
    Ann Neurol 65:226-9. 2009
    ....
  62. ncbi request reprint Diminished taxol/GTP-stimulated tubulin polymerization in diseased region of brain from patients with late-onset or inherited Alzheimer's disease or frontotemporal dementia with parkinsonism linked to chromosome-17 but not individuals with mild cognitive
    Angela M Boutte
    Center for Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Alzheimers Dis 8:1-6. 2005
    ..Our results show that modification of tubulin function may contribute to intermediate or late stages in the pathogenesis of sporadic and inherited AD as well as FTDP-17...
  63. ncbi request reprint Role of glutathione in intracellular amyloid-alpha precursor protein/carboxy-terminal fragment aggregation and associated cytotoxicity
    Randall L Woltjer
    Department of Pathology, University of Washington, Seattle, 98104, USA
    J Neurochem 93:1047-56. 2005
    ..These data suggest that antioxidants may serve as 'Abeta targeting' therapies that suppress toxic protein aggregation rather than simply acting as downstream radical scavengers...
  64. ncbi request reprint Lewy body pathology in late-onset familial Alzheimer's disease: a clinicopathological case series
    Debby W Tsuang
    Mental Illness Research, Education, and Clinical Centers, Veteran Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 9:235-42. 2006
    ..Lewy body pathology (LBP) is a common finding in Alzheimer's disease (AD), but the pathophysiology for this coexistent pathology remains unclear...
  65. pmc Microglia lacking E Prostanoid Receptor subtype 2 have enhanced Abeta phagocytosis yet lack Abeta-activated neurotoxicity
    Feng Shiun Shie
    Department of Pathology, University of Washington, Box 359645, Harborview Medical Center, 325 9th Ave, Seattle, WA 98104, USA
    Am J Pathol 166:1163-72. 2005
    ..These data demonstrate that blockade of microglial EP2 is a highly desirable mechanism for AD therapy that can maximize neuroprotective actions while minimizing bystander damage to neurons...
  66. ncbi request reprint Quantitative proteomic analysis of age-related changes in human cerebrospinal fluid
    Jing Zhang
    Division of Neuropathology, University of Washington School of Medicine, Box 359635, Harborview Medical Center, Seattle, WA 98104, USA
    Neurobiol Aging 26:207-27. 2005
    ..These data not only expand substantially our current knowledge regarding human CSF proteins, but also supply the necessary information to appropriately interpret protein biomarkers of age-related neurodegenerative diseases...
  67. ncbi request reprint Effects of chemical chaperones on oxidative stress and detergent-insoluble species formation following conditional expression of amyloid precursor protein carboxy-terminal fragment
    Randall L Woltjer
    Department of Pathology, University of Washington, Box 359645, Harborview Medical Center, 300 Ninth Avenue, Seattle, WA 98104, USA
    Neurobiol Dis 25:427-37. 2007
    ..These results suggest that protein misfolding associated with overexpression of APP CTFs promotes oxidative stress and cytotoxicity and contributes to formation of detergent-insoluble species that appear unrelated to cytotoxicity...
  68. pmc Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient
    James B Leverenz
    Department of Veterans Affairs Northwest Network Mental Illness and Parkinson s Disease Research, University of Washington, Seattle, WA 98108, USA
    Brain Pathol 18:220-4. 2008
    ..In addition, this modification allows for more limited sampling of brain regions for classification of LRP. We propose that these modified criteria for the categorization of LRP be utilized in patients with a history of dementia...
  69. ncbi request reprint Advanced glycation endproduct precursor alters intracellular amyloid-beta/A beta PP carboxy-terminal fragment aggregation and cytotoxicity
    Randall L Woltjer
    Department of Pathology, University of Washington, Seattle, Washington 98104, USA
    J Alzheimers Dis 5:467-76. 2003
    ....
  70. ncbi request reprint HIV associated neurodegeneration requires p53 in neurons and microglia
    Gwenn A Garden
    Department of Neurology, Box 356465, University of Washington, Seattle, WA 98195, USA
    FASEB J 18:1141-3. 2004
    ....
  71. ncbi request reprint Proteomic biomarker discovery in cerebrospinal fluid for neurodegenerative diseases
    Jing Zhang
    Department of Pathology, University of Washington, Seattle, Washington 98104, USA
    J Alzheimers Dis 8:377-86. 2005
    ..Great attention has been directed to practical considerations and limitations of several major aspects of proteomic analysis of human CSF...
  72. pmc Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype
    James B Leverenz
    Parkinson s Disease, Mental Illness Research, Education, and Clinical Centers, Veterans Affairs Puget Sound Health Care System, Seattle, Wash, USA
    Arch Neurol 63:370-6. 2006
    ..The origin and significance of Lewy bodies and neurites (Lewy body pathology [LBP]) in Alzheimer disease (AD) are poorly understood...
  73. ncbi request reprint Biomarkers for Alzheimer's disease
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, WA 98104 2499, USA
    Expert Rev Neurother 7:1021-8. 2007
    ..The next 5 years will see standardization of more established approaches, and the combination of different modalities into the most effective means for assessing different stages of AD...
  74. doi request reprint Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease
    George J Siegel
    Neurology 71:383; author reply 383. 2008
  75. ncbi request reprint Mitochondrial effects of lipid-derived neurotoxins
    Matthew J Picklo
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks, ND 58203, USA
    J Alzheimers Dis 12:185-93. 2007
    ..Lastly, we examine the role of mitochondrial aldehyde detoxification pathways and their potential role in the development of AD...
  76. ncbi request reprint Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation
    Richard S Bruno
    Linus Pauling Institute, 571 Weniger Hall, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 40:689-97. 2006
    ....
  77. ncbi request reprint Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice
    Joseph F Quinn
    Portland Veterans Affairs Medical Center, P3 R and D Portland, OR, United States
    Neurobiol Aging 28:213-25. 2007
    ..These data indicate that chronic dietary ALA can reduce hippocampal-dependent memory deficits of Tg2576 mice without affecting beta-amyloid levels or plaque deposition...
  78. ncbi request reprint Quantification of F-ring isoprostane-like compounds (F4-neuroprostanes) derived from docosahexaenoic acid in vivo in humans by a stable isotope dilution mass spectrometric assay
    Erik S Musiek
    Departments of Medicine and Pharmacology, Vanderbilt University, 526 RBB, Nashville, TN 37232, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 799:95-102. 2004
    ....
  79. ncbi request reprint Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease
    Xibin Liang
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:10180-7. 2005
    ....
  80. ncbi request reprint Mechanisms of 4-hydroxynonenal-induced neuronal microtubule dysfunction
    M Diana Neely
    Department of Psychiatry, Vanderbilt University Medical Center, 313 PHV, 1601 23rd Avenue South, Nashville, TN 37212, USA
    Brain Res 1037:90-8. 2005
    ..These and our previous observations strongly support the hypothesis that HNE-adduction to tubulin is the primary mechanism involved in the HNE-induced loss of the highly dynamic neuronal microtubule network...
  81. ncbi request reprint Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicity
    Izumi Maezawa
    Department of Pathology, University of Washington, Seattle, Washington 98104, USA
    J Neurochem 91:1312-21. 2004
    ....
  82. pmc The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis
    Xibin Liang
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA
    Ann Neurol 64:304-14. 2008
    ..We tested whether EP2 signaling participated in disease pathogenesis in the G93A superoxide dismutase (SOD) model of familial ALS...
  83. ncbi request reprint Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders
    Fadi Abdi
    Applied Biosystems, Framingham, MA, USA
    J Alzheimers Dis 9:293-348. 2006
    ....
  84. ncbi request reprint Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits
    Jun Yao
    Department of Psychiatry, New York University, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    J Neurochem 90:1011-8. 2004
    ....
  85. ncbi request reprint Proteomic identification of novel proteins in cortical lewy bodies
    James B Leverenz
    Department of Neurology, School of Medicine, University of Washington, Seattle, WA 98104, USA
    Brain Pathol 17:139-45. 2007
    ..Further investigation of these novel candidates is also necessary to ensure that the potential proteins in cortical LBs are not identified incorrectly because of incomplete current human protein database...
  86. ncbi request reprint Herpes simplex virus type 1 encephalitis is associated with elevated levels of F2-isoprostanes and F4-neuroprostanes
    Dejan Milatovic
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Neurovirol 8:295-305. 2002
    ....
  87. ncbi request reprint Characterization of proteome of human cerebrospinal fluid
    Jing Xu
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Int Rev Neurobiol 73:29-98. 2006
  88. ncbi request reprint Suppression of longitudinal increase in CSF F2-isoprostanes in Alzheimer's disease
    Joseph F Quinn
    Department Neurology, Oregon Health and Sciences University, Portland, OR, USA
    J Alzheimers Dis 6:93-7. 2004
    ....
  89. ncbi request reprint Formation of novel D-ring and E-ring isoprostane-like compounds (D4/E4-neuroprostanes) in vivo from docosahexaenoic acid
    Erin E Reich
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Adv Exp Med Biol 507:519-24. 2002

Research Grants36

  1. Lipid Oxidation Products in Alzheimer's Disease
    Thomas Montine; Fiscal Year: 2006
    ..abstract_text> ..
  2. Proteomic Discovery in Parkinson-Dementia Complex of Guam
    Thomas Montine; Fiscal Year: 2007
    ....
  3. LIPID PEROXIDATION AND APOE IN ALZHEIMERS DISEASE
    Thomas Montine; Fiscal Year: 1999
    ..This new information will aid in laying the foundation for designing rational therapeutic approaches to ameliorate brain oxidative damage in Alzheimer's disease. ..
  4. Pharmaconeuropathology of Brain Aging and Dementia
    Thomas Montine; Fiscal Year: 2005
    ....
  5. Dementia with Lewy Bodies: A Collaborative Study
    Thomas Montine; Fiscal Year: 2006
    ..This resource will be made available for future investigations of DLB. ..
  6. Pharmaconeuropathology of Brain Aging and Dementia
    Thomas Montine; Fiscal Year: 2006
    ....
  7. Pharmaconeuropathology of Brain Aging and Dementia
    Thomas Montine; Fiscal Year: 2007
    ....
  8. Characterization of Dementia with Lewy Bodies: A Collaborative Study
    Thomas Montine; Fiscal Year: 2007
    ..This resource will be made available for future investigations of DLB. ..
  9. Lipid Oxidation Products in Alzheimer's Disease
    Thomas Montine; Fiscal Year: 2007
    ..abstract_text> ..
  10. White matter damage in age-related cognitive decline
    Thomas Montine; Fiscal Year: 2009
    ....
  11. Pharmaconeuropathology of Brain Aging and Dementia
    Thomas Montine; Fiscal Year: 2009
    ....
  12. Toxicants and innate immunity in models of Parkinson's disease
    Thomas Montine; Fiscal Year: 2009
    ....
  13. Toxicants and innate immunity in models of Parkinson's disease
    Thomas J Montine; Fiscal Year: 2010
    ....
  14. White matter damage in age-related cognitive decline
    Thomas J Montine; Fiscal Year: 2010
    ....
  15. Dementia with Lewy Bodies: A Collaborative Study
    Thomas Montine; Fiscal Year: 2005
    ..This resource will be made available for future investigations of DLB. ..
  16. CATECHOL THIOETHERS IN PARKINSON'S DISEASE
    Thomas Montine; Fiscal Year: 2000
    ....
  17. LIPID PEROXIDATION AND APOE IN ALZHEIMERS DISEASE
    Thomas Montine; Fiscal Year: 2000
    ..This new information will aid in laying the foundation for designing rational therapeutic approaches to ameliorate brain oxidative damage in Alzheimer's disease. ..
  18. LIPID PEROXIDATION AND APOE IN ALZHEIMERS DISEASE
    Thomas Montine; Fiscal Year: 2001
    ..This new information will aid in laying the foundation for designing rational therapeutic approaches to ameliorate brain oxidative damage in Alzheimer's disease. ..
  19. CATECHOL THIOETHERS IN PARKINSON'S DISEASE
    Thomas Montine; Fiscal Year: 2001
    ....
  20. LIPID PEROXIDATION AND APOE IN ALZHEIMERS DISEASE
    Thomas Montine; Fiscal Year: 2002
    ..This new information will aid in laying the foundation for designing rational therapeutic approaches to ameliorate brain oxidative damage in Alzheimer's disease. ..
  21. CATECHOL THIOETHERS IN PARKINSON'S DISEASE
    Thomas Montine; Fiscal Year: 2002
    ....
  22. LIPID PEROXIDATION AND APOE IN ALZHEIMERS DISEASE
    Thomas Montine; Fiscal Year: 2002
    ..This new information will aid in laying the foundation for designing rational therapeutic approaches to ameliorate brain oxidative damage in Alzheimer's disease. ..
  23. CATECHOL THIOETHERS IN PARKINSON'S DISEASE
    Thomas Montine; Fiscal Year: 2002
    ....
  24. LIPID PEROXIDATION AND APOE IN ALZHEIMERS DISEASE
    Thomas Montine; Fiscal Year: 2003
    ..This new information will aid in laying the foundation for designing rational therapeutic approaches to ameliorate brain oxidative damage in Alzheimer's disease. ..
  25. CATECHOL THIOETHERS IN PARKINSON'S DISEASE
    Thomas Montine; Fiscal Year: 2003
    ....
  26. Dementia with Lewy Bodies: A Collaborative Study
    Thomas Montine; Fiscal Year: 2003
    ..This resource will be made available for future investigations of DLB. ..
  27. CATECHOL THIOETHERS IN PARKINSON'S DISEASE
    Thomas Montine; Fiscal Year: 2004
    ....
  28. Dementia with Lewy Bodies: A Collaborative Study
    Thomas Montine; Fiscal Year: 2004
    ..This resource will be made available for future investigations of DLB. ..
  29. Pharmaconeuropathology of Brain Aging and Dementia
    Thomas Montine; Fiscal Year: 2009
    ....