Research Topics
| John MonterossoSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Frontoparietal cortical activity of methamphetamine-dependent and comparison subjects performing a delay discounting taskJohn R Monterosso
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90024, USA
Hum Brain Mapp 28:383-93. 2007..Therefore, while apparent inefficiency of cortical processing related to decision-making in MA abusers may contribute to the neural basis of enhanced delay discounting by this population, other factors remain to be identified...
Neural substrates of resisting craving during cigarette cue exposureArthur L Brody
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Los Angeles, CA 90095, USA
Biol Psychiatry 62:642-51. 2007..We sought to determine changes in brain activity in response to cigarette cues when smokers actively resist craving...- The behavioral economics of will in recovery from addictionJohn Monterosso
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA 90024, USA
Drug Alcohol Depend 90:S100-11. 2007..We suggest that the bundling effect can also be discerned in the advice of 12-step programs... - Deficits in response inhibition associated with chronic methamphetamine abuseJohn R Monterosso
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA 90024 1759, USA
Drug Alcohol Depend 79:273-7. 2005..If such differences are established then response inhibition may serve as a marker for investigating MA abuse in basic science and clinical trials... - Effects of acute smoking on brain activity vary with abstinence in smokers performing the N-Back task: a preliminary studyJiansong Xu
Department of Psychiatry, University of California Los Angeles, Los Angeles, CA 90024, USA
Psychiatry Res 148:103-9. 2006..This interaction merits further examination in larger studies specifically designed to consider this issue... - Effect of cigarette smoking on prefrontal cortical function in nondeprived smokers performing the Stroop TaskJiansong Xu
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
Neuropsychopharmacology 32:1421-8. 2007..Even after brief abstinence from smoking, therefore, smokers exhibit compromised functional efficiency in the right FEF and adjacent precentral sulcus in a test of selective attention; and smoking ameliorates this condition... - Brain activity in cigarette smokers performing a working memory task: effect of smoking abstinenceJiansong Xu
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
Biol Psychiatry 58:143-50. 2005..CONCLUSIONS: We conclude that neural processing related to working memory in the left DLPFC is less efficient during acute abstinence from smoking than at smoking satiety... - Cerebral metabolic dysfunction and impaired vigilance in recently abstinent methamphetamine abusersEdythe D London
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90024 1759, USA
Biol Psychiatry 58:770-8. 2005..The links between cognitive impairment and these cerebral abnormalities are not established... - Ventral striatal dopamine release in response to smoking a regular vs a denicotinized cigaretteArthur L Brody
UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095, USA
Neuropsychopharmacology 34:282-9. 2009..Thus, nicotine delivered through cigarette smoking appears to be important for ventral striatal DA release. Study findings also suggest that mood improvement from smoking is specifically related to ventral striatal DA release... - Prefrontal hypoactivation during cognitive control in early abstinent methamphetamine-dependent subjectsLiam J Nestor
Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, USA
Psychiatry Res 194:287-95. 2011..These preliminary findings suggest that hypofunction in cortical areas that are important for executive function underlies cognitive control deficits associated with MA dependence... - Gender effects on mood and cigarette craving during early abstinence and resumption of smokingJiansong Xu
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angles, Los Angeles, CA, USA
Nicotine Tob Res 10:1653-61. 2008..These differences may contribute to the greater likelihood of relapse when women try to quit smoking... - Short-term plasticity of gray matter associated with leptin deficiency and replacementEdythe D London
Department of Psychiatry and Biobehavioral Sciences and Semel Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90024, USA
J Clin Endocrinol Metab 96:E1212-20. 2011..We previously reported that leptin supplementation increased gray matter (GM) concentration in the anterior cingulate gyrus (ACG), cerebellum, and inferior parietal lobule, areas that are also involved in food intake... - Working memory in cigarette smokers: comparison to non-smokers and effects of abstinenceAdrianna Mendrek
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA
Addict Behav 31:833-44. 2006..These findings provide further evidence for a deficit in working memory associated with acute abstinence from smoking, which may contribute to the difficulty of smoking cessation... - Effect of modafinil on learning and task-related brain activity in methamphetamine-dependent and healthy individualsDara G Ghahremani
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
Neuropsychopharmacology 36:950-9. 2011..These results suggest that modafinil may be a suitable pharmacological adjunct for enhancing the efficiency of cognitive-based therapies for MA dependence... - Neural components underlying behavioral flexibility in human reversal learningDara G Ghahremani
Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90065, USA
Cereb Cortex 20:1843-52. 2010..These regions and lateral OFC represent distinct neural components that support behavioral flexibility important for adaptive learning... - Behavioral and neural evidence of incentive bias for immediate rewards relative to preference-matched delayed rewardsShan Luo
Department of Psychology, University of Southern California, Los Angeles, California 90089, USA
J Neurosci 29:14820-7. 2009..This discrepancy may mark the contribution of self-control processes that are recruited during decision-making but that are absent when rewards are individually anticipated... - Common substrates of dysphoria in stimulant drug abuse and primary depression: therapeutic targetsKate Baicy
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles California 90024, USA
Int Rev Neurobiol 65:117-45. 2005 - Regional brain abnormalities in 22q11.2 deletion syndrome: association with cognitive abilities and behavioral symptomsCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA 90095, USA
Neurocase 10:198-206. 2004..Although preliminary,these findings suggest a possible underlying pathophysiology of the cognitive deficits seen in this syndrome,and provide insight into complex gene-brain-behavior relationships... - Differences in cortical activity between methamphetamine-dependent and healthy individuals performing a facial affect matching taskDoris E Payer
Neuroscience Interdepartmental Program, University of California, Los Angeles, CA 90024 1759, USA
Drug Alcohol Depend 93:93-102. 2008..Together, the results point to cortical abnormalities that could underlie the socially inappropriate behaviors often shown by individuals who abuse MA... - Differences in regional brain metabolism associated with marijuana abuse in methamphetamine abusersBradley Voytek
Department of Psychiatry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90024, USA
Synapse 57:113-5. 2005 - Methamphetamine dependence and neuropsychological functioning: evaluating change during early abstinenceSara L Simon
Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California 90095 1759, USA
J Stud Alcohol Drugs 71:335-44. 2010..The purpose of this work was to assess neuropsychological functioning of individuals in early abstinence from methamphetamine dependence and to test for cognitive change over the first month of abstinence... - Effects of cigarette smoking and abstinence on Stroop task performanceCatherine P Domier
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, Los Angeles, CA, USA
Psychopharmacology (Berl) 195:1-9. 2007..Selective attention may be important in this regard, but earlier literature presents inconsistent findings on how smoking abstinence and resumption of smoking influence this cognitive function... - Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivityBuyean Lee
Department of Psychiatry, Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90024, USA
J Neurosci 29:14734-40. 2009..12 corrected). The findings suggest that low striatal D(2)/D(3) receptor availability may mediate impulsive temperament and thereby influence addiction... 
Neuroeconomics and the study of addictionJohn Monterosso
Department of Psychology, University of Southern California, Los Angeles, CA 90089 2520, USA
Biol Psychiatry 72:107-12. 2012..We also consider efforts to apply neuroeconomics to the study of self-control and discuss challenges for this area. We argue that neuroeconomic work has the potential to generate breakthrough research in addiction science...- Leptin replacement alters brain response to food cues in genetically leptin-deficient adultsKate Baicy
Department of Psychiatry and Biobehavioral Sciences and Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA
Proc Natl Acad Sci U S A 104:18276-9. 2007..Leptin appears to modulate feeding behavior through these circuits, suggesting therapeutic targets for human obesity... - Smoking reduces conflict-related anterior cingulate activity in abstinent cigarette smokers performing a Stroop taskAllen Azizian
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
Neuropsychopharmacology 35:775-82. 2010..Resumption of smoking may enhance cognitive control in smokers, involving a reduction in ACC response conflict activity together with improvement in conflict resolution involving the dorsolateral prefrontal cortex... - Severity of nicotine dependence moderates performance on perceptual-motor tests of attentionAllen Azizian
Department of Psychiatry and Biobehavioral Sciences, Laboratory of Molecular Neuroimaging, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, USA
Nicotine Tob Res 10:599-606. 2008..The findings suggest that severity of nicotine dependence and slowness in perceptual-motor tasks of attention share an underlying basis... - Building blocks of self-control: increased tolerance for delay with bundled rewardsGeorge Ainslie
Department of Psychiatry, Coatesville Veterans Affairs Medical Center, Temple University, Pennsylvania 19320, USA
J Exp Anal Behav 79:37-48. 2003..Because bundling in humans may be based on the perception that one's current choice is predictive of future choices, the data presented here may demonstrate an important building block of self-control... - Comparing attentional bias to smoking cues in current smokers, former smokers, and non-smokers using a dot-probe taskRonald N Ehrman
Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
Drug Alcohol Depend 67:185-91. 2002..These results support further use of the dot-probe task as a measure of attentional bias in non-abstinent smokers and in individuals undergoing smoking cessation treatment...
Research Grants
- BRAIN SUBSTRATES OF SELF-CONTROL IN ADDICTIONJohn Monterosso; Fiscal Year: 2005DESCRIPTION: (Provided by Applicant) The goal of this K01 proposal is to provide John Monterosso, Ph.D., with the training and support to become an independent investigator in the field of clinical substance abuse research...
- Neural recruitment during self-control of smoking: An fMRI paradigmJohn Monterosso; Fiscal Year: 2007..With the primary procedures already operational and in use, this 2-year project should yield valuable insights into the substrates of self-control, with both basic science and clinical implications. ..