Lisa Monteggia

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors
    Lisa M Monteggia
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Biol Psychiatry 61:187-97. 2007
  2. ncbi Long-term behavioural and molecular alterations associated with maternal separation in rats
    Melanie Lippmann
    Department of Psychiatry, The University of Texas South Western Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    Eur J Neurosci 25:3091-8. 2007
  3. ncbi Role of GluR1 expression in nucleus accumbens neurons in cocaine sensitization and cocaine-seeking behavior
    Ryan K Bachtell
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Eur J Neurosci 27:2229-40. 2008
  4. pmc NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
    Anita E Autry
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9111, USA
    Nature 475:91-5. 2011
  5. pmc In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival
    M Waseem Akhtar
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 7:e34863. 2012
  6. pmc Role of MeCP2, DNA methylation, and HDACs in regulating synapse function
    Ege T Kavalali
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75390 9111, USA
    J Neurodev Disord 3:250-6. 2011
  7. pmc The role of eukaryotic elongation factor 2 kinase in rapid antidepressant action of ketamine
    Lisa M Monteggia
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Biol Psychiatry 73:1199-203. 2013
  8. pmc Brain-derived neurotrophic factor and neuropsychiatric disorders
    Anita E Autry
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    Pharmacol Rev 64:238-58. 2012
  9. pmc Essential role of brain-derived neurotrophic factor in adult hippocampal function
    Lisa M Monteggia
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 101:10827-32. 2004
  10. pmc Rett syndrome and the impact of MeCP2 associated transcriptional mechanisms on neurotransmission
    Lisa M Monteggia
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Biol Psychiatry 65:204-10. 2009

Collaborators

Detail Information

Publications34

  1. ncbi Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors
    Lisa M Monteggia
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Biol Psychiatry 61:187-97. 2007
    ....
  2. ncbi Long-term behavioural and molecular alterations associated with maternal separation in rats
    Melanie Lippmann
    Department of Psychiatry, The University of Texas South Western Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    Eur J Neurosci 25:3091-8. 2007
    ..Recognition of these adaptations begins to define the brain regions, and neural circuitry, associated with persistent alterations induced by early life stressors and the development of mood disorders...
  3. ncbi Role of GluR1 expression in nucleus accumbens neurons in cocaine sensitization and cocaine-seeking behavior
    Ryan K Bachtell
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Eur J Neurosci 27:2229-40. 2008
    ....
  4. pmc NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
    Anita E Autry
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9111, USA
    Nature 475:91-5. 2011
    ..Our findings indicate that the regulation of protein synthesis by spontaneous neurotransmission may serve as a viable therapeutic target for the development of fast-acting antidepressants...
  5. pmc In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival
    M Waseem Akhtar
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 7:e34863. 2012
    ..Collectively, these data highlight the key in vivo role of MEF2C isoform in the brain and suggest that MEF2A and MEF2D have only subtle roles in regulating hippocampal synaptic function...
  6. pmc Role of MeCP2, DNA methylation, and HDACs in regulating synapse function
    Ege T Kavalali
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75390 9111, USA
    J Neurodev Disord 3:250-6. 2011
    ....
  7. pmc The role of eukaryotic elongation factor 2 kinase in rapid antidepressant action of ketamine
    Lisa M Monteggia
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Biol Psychiatry 73:1199-203. 2013
    ..This article outlines our recent studies on the synaptic mechanisms that underlie ketamine action, in particular the properties of eEF2K as a potential antidepressant target...
  8. pmc Brain-derived neurotrophic factor and neuropsychiatric disorders
    Anita E Autry
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    Pharmacol Rev 64:238-58. 2012
    ..The review also covers a critique of experimental therapies such as BDNF mimetics and discusses the value of BDNF as a target for future drug development...
  9. pmc Essential role of brain-derived neurotrophic factor in adult hippocampal function
    Lisa M Monteggia
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 101:10827-32. 2004
    ..These results establish roles for BDNF in the adult, and demonstrate the strength of this inducible knockout system in studying gene function in the adult brain...
  10. pmc Rett syndrome and the impact of MeCP2 associated transcriptional mechanisms on neurotransmission
    Lisa M Monteggia
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Biol Psychiatry 65:204-10. 2009
    ..In addition, this work will also help delineate a key pathway that regulates properties of neurotransmission in the central nervous system that may underlie additional neuropsychiatric disorders...
  11. pmc The presynaptic active zone protein RIM1alpha is critical for normal learning and memory
    Craig M Powell
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 42:143-53. 2004
    ....
  12. pmc Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behavior
    Anita E Autry
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Biol Psychiatry 66:84-90. 2009
    ..The neurotrophic hypothesis of depression suggests that loss of brain-derived neurotrophic factor (BDNF) may increase susceptibility for depression-like behavior, although direct evidence is lacking...
  13. ncbi Induction of deltaFosB in reward-related brain structures after chronic stress
    Linda I Perrotti
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 24:10594-602. 2004
    ..These findings establish that chronic stress induces DeltaFosB in several discrete regions of the brain. Such induction could contribute to the long-term effects of stress on the brain...
  14. ncbi Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice
    Terry Gemelli
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Biol Psychiatry 59:468-76. 2006
    ..Methyl-CpG binding protein 2 is a transcriptional repressor that is widely expressed in all tissues...
  15. ncbi Neurobiology of depression
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Neuron 34:13-25. 2002
    ..A neurobiologic understanding of depression also requires identification of the genes that make individuals vulnerable or resistant to the syndrome. These advances will fundamentally improve the treatment and prevention of depression...
  16. doi Activity-dependent suppression of miniature neurotransmission through the regulation of DNA methylation
    Erika D Nelson
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 28:395-406. 2008
    ..These results uncover a means by which NMDA receptor-mediated synaptic activity drives DNA demethylation within mature neurons and suppresses basal synaptic function...
  17. pmc MeCP2-mediated transcription repression in the basolateral amygdala may underlie heightened anxiety in a mouse model of Rett syndrome
    Megumi Adachi
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 29:4218-27. 2009
    ..These results suggest a key role for Mecp2 as a transcriptional repressor in the BLA in mediating behavioral features of RTT...
  18. pmc Histone deacetylases 1 and 2 form a developmental switch that controls excitatory synapse maturation and function
    Mohd W Akhtar
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 29:8288-97. 2009
    ..Therefore, we propose that HDAC1 and HDAC2 form a developmental switch that controls synapse maturation and function acting in a manner dependent on the maturational states of neuronal networks...
  19. ncbi Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
    Olivier Berton
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Science 311:864-8. 2006
    ..These results establish an essential role for BDNF in mediating long-term neural and behavioral plasticity in response to aversive social experiences...
  20. ncbi Elucidating the role of brain-derived neurotrophic factor in the brain
    Lisa M Monteggia
    Department of Psychiatry, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    Am J Psychiatry 164:1790. 2007
  21. pmc Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy
    Megumi Adachi
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Biol Psychiatry 63:642-9. 2008
    ....
  22. ncbi Analysis of pyramidal neuron morphology in an inducible knockout of brain-derived neurotrophic factor
    Justin J Hill
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 57:932-4. 2005
    ....
  23. ncbi MeCP2-dependent transcriptional repression regulates excitatory neurotransmission
    Erika D Nelson
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Curr Biol 16:710-6. 2006
    ..Taken together, these results suggest a role for MeCP2 in control of excitatory presynaptic function through regulation of gene expression...
  24. ncbi A neurotrophic model for stress-related mood disorders
    Ronald S Duman
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 59:1116-27. 2006
    ....
  25. pmc MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function
    Ana C Barbosa
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 105:9391-6. 2008
    ..We conclude that MEF2C limits excessive synapse formation during activity-dependent refinement of synaptic connectivity and thus facilitates hippocampal-dependent learning and memory...
  26. ncbi Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia
    Takanori Hashimoto
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 25:372-83. 2005
    ..Decreased TrkB signaling appears to underlie the dysfunction of inhibitory neurons in the PFC of subjects with schizophrenia...
  27. pmc Histone deacetylases govern cellular mechanisms underlying behavioral and synaptic plasticity in the developing and adult brain
    Michael J Morris
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Behav Pharmacol 21:409-19. 2010
    ..Potential HDAC-mediated cellular mechanisms underlying those behaviors are discussed...
  28. pmc Selective impact of MeCP2 and associated histone deacetylases on the dynamics of evoked excitatory neurotransmission
    Erika D Nelson
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurophysiol 106:193-201. 2011
    ..These findings suggest a distinct role for MeCP2 and its cofactors in the regulation of evoked excitatory neurotransmission compared with their essential role in basal synaptic activity...
  29. ncbi Regional, cellular, and subcellular localization of RGS10 in rodent brain
    Jeff L Waugh
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Comp Neurol 481:299-313. 2005
    ..Moreover, enrichment of RGS10 in transcriptionally active regions of the nucleus suggests an unforeseen role of RGS10 in modulating gene expression...
  30. ncbi Reciprocal interaction of serotonin and neuronal activity in regulation of cAMP-responsive element-dependent gene expression
    Melissa A Mahgoub
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, 75390 9070, USA
    J Pharmacol Exp Ther 317:88-96. 2006
    ..Taken together, these results suggest a reciprocal inhibitory interaction between neuronal activity and 5-HT in the regulation of cAMP response element-dependent gene expression in hippocampal neurons...
  31. ncbi Regulation of serotonin-1A receptor function in inducible brain-derived neurotrophic factor knockout mice after administration of corticosterone
    Julie G Hensler
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Biol Psychiatry 62:521-9. 2007
    ....
  32. ncbi Stress and disease: is being female a predisposing factor?
    Jill B Becker
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 27:11851-5. 2007
  33. pmc VGF, a new player in antidepressant action?
    Jessica E Malberg
    PsychoGenics, Inc, Tarrytown, NY 10591, USA
    Sci Signal 1:pe19. 2008
    ..These studies use in vivo approaches to link VGF to the antidepressant-like behavioral effects produced by antidepressant drugs and exercise...
  34. ncbi Repeated administration of amphetamine or cocaine does not alter AMPA receptor subunit expression in the rat midbrain
    Wenxiao Lu
    Department of Neuroscience, FUHS The Chicago Medical School, North Chicago, IL 60064 3095, USA
    Neuropsychopharmacology 26:1-13. 2002
    ..Our results suggest that enhanced responsiveness of VTA dopamine neurons to AMPA after withdrawal from repeated stimulant administration involves mechanisms more complex than increased expression of AMPA receptor subunits...

Research Grants12

  1. Region & Developmental Stage Specific Deletion of MeCP2 in Mouse Brain
    Lisa Monteggia; Fiscal Year: 2007
    ..The proposed studies should increase our understanding of the role of MeCP2 in mediating certain RTT associated behaviors as well as identify neural circuits that mediate these abnormalities. ..
  2. Antidepressants and Intracellular Signaling Linked to BDNF
    Lisa Monteggia; Fiscal Year: 2005
    ..Together, the proposed molecular, cellular, and behavioral studies promise to advance our understanding of the role of BDNF that chronic antidepressants induce in the hippocampus. ..
  3. MeCP2 Dependent Transcriptional Repression & Neurotransmission
    Lisa M Monteggia; Fiscal Year: 2010
    ..Information attained from these studies will provide new insight into the synaptic mechanisms that may be affected in Rett Syndrome as well as related disorders that involve alterations in MeCP2 expression. ..
  4. Antidepressants and Intracellular Signaling Linked to BDNF
    Lisa Monteggia; Fiscal Year: 2009
    ..Together, the proposed molecular, cellular, and behavioral studies promise to advance our understanding of the role of BDNF that chronic antidepressants induce in the hippocampus. ..
  5. MeCP2 Dependent Transcriptional Repression & Neurotransmission
    Lisa Monteggia; Fiscal Year: 2009
    ..Information attained from these studies will provide new insight into the synaptic mechanisms that may be affected in Rett Syndrome as well as related disorders that involve alterations in MeCP2 expression. ..
  6. Antidepressants and Intracellular Signaling Linked to BDNF
    Lisa Monteggia; Fiscal Year: 2006
    ..Together, the proposed molecular, cellular, and behavioral studies promise to advance our understanding of the role of BDNF that chronic antidepressants induce in the hippocampus. ..
  7. Antidepressants and Intracellular Signaling Linked to BDNF
    Lisa Monteggia; Fiscal Year: 2007
    ..Together, the proposed molecular, cellular, and behavioral studies promise to advance our understanding of the role of BDNF that chronic antidepressants induce in the hippocampus. ..
  8. Antidepressants and Intracellular Signaling Linked to BDNF
    Lisa Monteggia; Fiscal Year: 2006
    ..Together, the proposed molecular, cellular, and behavioral studies promise to advance our understanding of the role of BDNF that chronic antidepressants induce in the hippocampus. ..
  9. Antidepressants and Intracellular Signaling Linked to BDNF
    Lisa M Monteggia; Fiscal Year: 2010
    ..abstract_text> ..