MAURICIO S MONTAL

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Beltless translocation domain of botulinum neurotoxin A embodies a minimum ion-conductive channel
    Audrey Fischer
    Section of Neurobiology, Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093 0366, USA
    J Biol Chem 287:1657-61. 2012
  2. pmc Botulinum neurotoxin devoid of receptor binding domain translocates active protease
    Audrey Fischer
    Section of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America
    PLoS Pathog 4:e1000245. 2008
  3. pmc Molecular template for a voltage sensor in a novel K+ channel. III. Functional reconstitution of a sensorless pore module from a prokaryotic Kv channel
    Jose S Santos
    Section of Neurobiology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    J Gen Physiol 132:651-66. 2008
  4. pmc Molecular template for a voltage sensor in a novel K+ channel. II. Conservation of a eukaryotic sensor fold in a prokaryotic K+ channel
    Alicia Lundby
    Section of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA
    J Gen Physiol 128:293-300. 2006
  5. pmc Molecular template for a voltage sensor in a novel K+ channel. I. Identification and functional characterization of KvLm, a voltage-gated K+ channel from Listeria monocytogenes
    Jose S Santos
    Section of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA
    J Gen Physiol 128:283-92. 2006
  6. ncbi request reprint Botulinum neurotoxin: a marvel of protein design
    Mauricio Montal
    Section of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, California 92093 0366, USA
    Annu Rev Biochem 79:591-617. 2010
  7. ncbi request reprint The structure of the M2 channel-lining segment from the nicotinic acetylcholine receptor
    M Montal
    Section of Neurobiology, Division of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0366, USA
    Biochim Biophys Acta 1565:287-93. 2002
  8. ncbi request reprint Structure-function correlates of Vpu, a membrane protein of HIV-1
    M Montal
    Section of Neurobiology, Division of Biological Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0366, USA
    FEBS Lett 552:47-53. 2003
  9. ncbi request reprint Protein folds in channel structure
    M Montal
    Department of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0366, USA
    Curr Opin Struct Biol 6:499-510. 1996
  10. ncbi request reprint Structural and functional modularity of voltage-gated potassium channels
    C D Patten
    Department of Physics, University of California at San Diego, La Jolla, CA, USA
    FEBS Lett 463:375-81. 1999

Research Grants

  1. Modular Design of Voltage-Gated Channel Proteins
    MAURICIO S MONTAL; Fiscal Year: 2010
  2. Modular Design of Voltage-Gated Channel Proteins
    Mauricio Montal; Fiscal Year: 2006
  3. Modular Design of Voltage-Gated Channel Proteins
    Mauricio Montal; Fiscal Year: 2005
  4. Modular Design of Voltage-Gated Channel Proteins
    Mauricio Montal; Fiscal Year: 2004
  5. Modular Design of Voltage-Gated Channel Proteins
    Mauricio Montal; Fiscal Year: 2003
  6. DE NOVO DESIGN OF FUNCTIONAL CHANNEL PROTEINS
    Mauricio Montal; Fiscal Year: 2002
  7. DE NOVO DESIGN OF FUNCTIONAL CHANNEL PROTEINS
    Mauricio Montal; Fiscal Year: 2000
  8. DE NOVO DESIGN OF FUNCTIONAL CHANNEL PROTEINS
    Mauricio Montal; Fiscal Year: 1999
  9. DE NOVO DESIGN OF FUNCTIONAL CHANNEL PROTEINS
    Mauricio Montal; Fiscal Year: 1993
  10. Modular Design of Voltage-Gated Channel Proteins
    MAURICIO S MONTAL; Fiscal Year: 2011

Collaborators

Detail Information

Publications16

  1. pmc Beltless translocation domain of botulinum neurotoxin A embodies a minimum ion-conductive channel
    Audrey Fischer
    Section of Neurobiology, Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093 0366, USA
    J Biol Chem 287:1657-61. 2012
    ..This notion is consistent with the hypothesis that although each domain of the holotoxin functions individually, each domain serves as a chaperone for the others...
  2. pmc Botulinum neurotoxin devoid of receptor binding domain translocates active protease
    Audrey Fischer
    Section of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America
    PLoS Pathog 4:e1000245. 2008
    ..These findings indicate that, in addition to its individual functions, each module acts as a chaperone for the others, working in concert to achieve productive intoxication...
  3. pmc Molecular template for a voltage sensor in a novel K+ channel. III. Functional reconstitution of a sensorless pore module from a prokaryotic Kv channel
    Jose S Santos
    Section of Neurobiology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    J Gen Physiol 132:651-66. 2008
    ..Collectively, the results indicate that this robust functional module will prove valuable as a molecular template for coupling new sensors and to elucidate PM residue-specific contributions to Kv conduction properties...
  4. pmc Molecular template for a voltage sensor in a novel K+ channel. II. Conservation of a eukaryotic sensor fold in a prokaryotic K+ channel
    Alicia Lundby
    Section of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA
    J Gen Physiol 128:293-300. 2006
    ..We observed significant functional coupling between sites known to interact in Shaker Kv channels, supporting the notion that the KvLm sensor largely retains the fold of its eukaryotic homologue...
  5. pmc Molecular template for a voltage sensor in a novel K+ channel. I. Identification and functional characterization of KvLm, a voltage-gated K+ channel from Listeria monocytogenes
    Jose S Santos
    Section of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA
    J Gen Physiol 128:283-92. 2006
    ....
  6. ncbi request reprint Botulinum neurotoxin: a marvel of protein design
    Mauricio Montal
    Section of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, California 92093 0366, USA
    Annu Rev Biochem 79:591-617. 2010
    ..Understanding the design principles underpinning the function of such a dynamic modular protein remains a challenging task...
  7. ncbi request reprint The structure of the M2 channel-lining segment from the nicotinic acetylcholine receptor
    M Montal
    Section of Neurobiology, Division of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0366, USA
    Biochim Biophys Acta 1565:287-93. 2002
    ..A pentameric M2 helical bundle may, therefore, represent the structural blueprint for the inner bundle that lines the channel of the nicotinic AChR...
  8. ncbi request reprint Structure-function correlates of Vpu, a membrane protein of HIV-1
    M Montal
    Section of Neurobiology, Division of Biological Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0366, USA
    FEBS Lett 552:47-53. 2003
    ....
  9. ncbi request reprint Protein folds in channel structure
    M Montal
    Department of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0366, USA
    Curr Opin Struct Biol 6:499-510. 1996
    ....
  10. ncbi request reprint Structural and functional modularity of voltage-gated potassium channels
    C D Patten
    Department of Physics, University of California at San Diego, La Jolla, CA, USA
    FEBS Lett 463:375-81. 1999
    ..The properties ascribed to the modules are the same whether the modules function in their native context or have been assembled into a chimera...
  11. ncbi request reprint Electrostatic attraction at the core of membrane fusion
    M Montal
    Department of Biology, University of California San Diego, La Jolla 92093, USA
    FEBS Lett 447:129-30. 1999
    ..Thus, the positively charged end of the SNARE complex in concert with Ca2+ may be sufficient to generate a transient 'fusion pore'...
  12. ncbi request reprint Mitochondria, glutamate neurotoxicity and the death cascade
    M Montal
    Department of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0366, USA
    Biochim Biophys Acta 1366:113-26. 1998
    ....
  13. pmc An N-methyl-D-aspartate receptor channel blocker with neuroprotective activity
    K K Tai
    Section of Neurobiology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0366, USA
    Proc Natl Acad Sci U S A 98:3519-24. 2001
    ..Mutagenesis data indicate that the N site, a key asparagine on the M2 transmembrane segment of the NR1 subunit, is the main determinant of the blocker action. The results highlight the potential of this compound as a neuroprotectant...
  14. pmc Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice
    R Planells-Cases
    Department of Biology, University of California San Diego, La Jolla, CA 92093 0366, USA
    Biophys J 78:2878-91. 2000
    ..Death appears to arise from severe hypoxia consequent to the brainstem deficiency of NaChalpha(II). NaChalpha(II) expression is, therefore, redundant for embryonic development but essential for postnatal survival...
  15. ncbi request reprint Characterization of Clostridial botulinum neurotoxin channels in neuroblastoma cells
    A Fisher
    Section of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, 92093 0366, USA
    Neurotox Res 9:93-100. 2006
    ....

Research Grants15

  1. Modular Design of Voltage-Gated Channel Proteins
    MAURICIO S MONTAL; Fiscal Year: 2010
    ..The thrust of our program aims to establish structure-function relationships with a primary emphasis on the modular design of the transmembrane domain in voltage-gated channel proteins. ..
  2. Modular Design of Voltage-Gated Channel Proteins
    Mauricio Montal; Fiscal Year: 2006
    ..These advances may contribute valuable insights to understand mechanisms of disease and provide structural blueprints for drug design. ..
  3. Modular Design of Voltage-Gated Channel Proteins
    Mauricio Montal; Fiscal Year: 2005
    ..These advances may contribute valuable insights to understand mechanisms of disease and provide structural blueprints for drug design. ..
  4. Modular Design of Voltage-Gated Channel Proteins
    Mauricio Montal; Fiscal Year: 2004
    ..These advances may contribute valuable insights to understand mechanisms of disease and provide structural blueprints for drug design. ..
  5. Modular Design of Voltage-Gated Channel Proteins
    Mauricio Montal; Fiscal Year: 2003
    ..These advances may contribute valuable insights to understand mechanisms of disease and provide structural blueprints for drug design. ..
  6. DE NOVO DESIGN OF FUNCTIONAL CHANNEL PROTEINS
    Mauricio Montal; Fiscal Year: 2002
    ..These discoveries may contribute clues to understand mechanisms of disease and provide structural blueprints for drug design. ..
  7. DE NOVO DESIGN OF FUNCTIONAL CHANNEL PROTEINS
    Mauricio Montal; Fiscal Year: 2000
    ..These discoveries may contribute clues to understand mechanisms of disease and provide structural blueprints for drug design. ..
  8. DE NOVO DESIGN OF FUNCTIONAL CHANNEL PROTEINS
    Mauricio Montal; Fiscal Year: 1999
    ..These discoveries may contribute clues to understand mechanisms of disease and provide structural blueprints for drug design. ..
  9. DE NOVO DESIGN OF FUNCTIONAL CHANNEL PROTEINS
    Mauricio Montal; Fiscal Year: 1993
    ....
  10. Modular Design of Voltage-Gated Channel Proteins
    MAURICIO S MONTAL; Fiscal Year: 2011
    ..The thrust of our program aims to establish structure-function relationships with a primary emphasis on the modular design of the transmembrane domain in voltage-gated channel proteins. ..