Dougald M Monroe

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint TFPIbeta, a second product from the mouse tissue factor pathway inhibitor (TFPI) gene
    J Y Chang
    Center for Thrombosis and Hemostasis, University of North Carolina, Chapel Hill, USA
    Thromb Haemost 81:45-9. 1999
  2. ncbi request reprint A mouse bleeding model to study oral anticoagulants
    Dougald M Monroe
    University of North Carolina Division of Hematology Oncology, Chapel Hill, NC, USA Duke University Department of Pathology, Durham, NC, USA Electronic address
    Thromb Res 133:S6-8. 2014
  3. doi request reprint The clotting system - a major player in wound healing
    Dougald M Monroe
    Division of Hematology Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7035, USA
    Haemophilia 18:11-6. 2012
  4. ncbi request reprint The tissue factor-factor VIIa complex: procoagulant activity, regulation, and multitasking
    D M Monroe
    Center for Thrombosis and Hemostasis, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Thromb Haemost 5:1097-105. 2007
  5. ncbi request reprint Platelets and thrombin generation
    Dougald M Monroe
    Center for Thrombosis and Hemostasis, University of North Carolina, Chapel Hill 27599 7035, USA
    Arterioscler Thromb Vasc Biol 22:1381-9. 2002
  6. ncbi request reprint Fathers of modern coagulation
    Dougald M Monroe
    UNC Medical School Hematology Oncology, 932 Mary Ellen Jones, CB 7035 Chapel Hill, North Carolina 27599 7035, USA
    Thromb Haemost 98:3-5. 2007
  7. ncbi request reprint Further understanding of recombinant activated factor VII mode of action
    Dougald M Monroe
    Division of Hematology Oncology, Department of Medicine, Center for Thrombosis and Hemostasis, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7035, USA
    Semin Hematol 45:S7-S11. 2008
  8. ncbi request reprint Coagulation factor interaction with platelets
    Dougald M Monroe
    Center for Thrombosis and Hemostasis, University of North Carolina, Chapel Hill, NC, USA
    Thromb Haemost 88:179. 2002
  9. ncbi request reprint The factor VII-platelet interplay: effectiveness of recombinant factor VIIa in the treatment of bleeding in severe thrombocytopathia
    D M Monroe
    Center for Thrombosis and Hemostasis, UNC School of Medicine, Chapel Hill, North Carolina, USA
    Semin Thromb Hemost 26:373-7. 2000
  10. doi request reprint Modeling the action of factor VIIa in dilutional coagulopathy
    Dougald M Monroe
    Division of Hematology Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599 7035, USA
    Thromb Res 122:S7-S10. 2008

Collaborators

Detail Information

Publications58

  1. ncbi request reprint TFPIbeta, a second product from the mouse tissue factor pathway inhibitor (TFPI) gene
    J Y Chang
    Center for Thrombosis and Hemostasis, University of North Carolina, Chapel Hill, USA
    Thromb Haemost 81:45-9. 1999
    ..In addition, heparin does not enhance the inhibition of factor Xa by mouse TFPIbeta although it does accelerate factor Xa inhibition by TFPI...
  2. ncbi request reprint A mouse bleeding model to study oral anticoagulants
    Dougald M Monroe
    University of North Carolina Division of Hematology Oncology, Chapel Hill, NC, USA Duke University Department of Pathology, Durham, NC, USA Electronic address
    Thromb Res 133:S6-8. 2014
    ..We found that the Whinna saphenous vein hemostasis model reliably reflects a hemostatic defect at therapeutic levels of dabigatran. This model can potentially reflect the effects of reversal or bypassing agents. ..
  3. doi request reprint The clotting system - a major player in wound healing
    Dougald M Monroe
    Division of Hematology Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7035, USA
    Haemophilia 18:11-6. 2012
    ..The goal of such treatment would be to avoid a feedback cycle in which bleeding tends to lead to further bleeding. Once initiated, this cycle may be difficult to control...
  4. ncbi request reprint The tissue factor-factor VIIa complex: procoagulant activity, regulation, and multitasking
    D M Monroe
    Center for Thrombosis and Hemostasis, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Thromb Haemost 5:1097-105. 2007
    ..This article reviews current knowledge on the function and regulation of TF and its role in a range of biological processes, including hemostasis, thrombosis and inflammation...
  5. ncbi request reprint Platelets and thrombin generation
    Dougald M Monroe
    Center for Thrombosis and Hemostasis, University of North Carolina, Chapel Hill 27599 7035, USA
    Arterioscler Thromb Vasc Biol 22:1381-9. 2002
    ..Individual differences in platelet thrombin generation might be accounted for by differences in platelet-binding proteins...
  6. ncbi request reprint Fathers of modern coagulation
    Dougald M Monroe
    UNC Medical School Hematology Oncology, 932 Mary Ellen Jones, CB 7035 Chapel Hill, North Carolina 27599 7035, USA
    Thromb Haemost 98:3-5. 2007
  7. ncbi request reprint Further understanding of recombinant activated factor VII mode of action
    Dougald M Monroe
    Division of Hematology Oncology, Department of Medicine, Center for Thrombosis and Hemostasis, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7035, USA
    Semin Hematol 45:S7-S11. 2008
    ..However, the platelet surface may be able to process only a limited amount of FXa, accounting for the observation that some models of non-hemophilic coagulopathy show a plateau in the effect of rFVIIa...
  8. ncbi request reprint Coagulation factor interaction with platelets
    Dougald M Monroe
    Center for Thrombosis and Hemostasis, University of North Carolina, Chapel Hill, NC, USA
    Thromb Haemost 88:179. 2002
  9. ncbi request reprint The factor VII-platelet interplay: effectiveness of recombinant factor VIIa in the treatment of bleeding in severe thrombocytopathia
    D M Monroe
    Center for Thrombosis and Hemostasis, UNC School of Medicine, Chapel Hill, North Carolina, USA
    Semin Thromb Hemost 26:373-7. 2000
    ..Finally, enhanced thrombin generation on platelets would mean that fewer platelets are required for hemostasis...
  10. doi request reprint Modeling the action of factor VIIa in dilutional coagulopathy
    Dougald M Monroe
    Division of Hematology Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599 7035, USA
    Thromb Res 122:S7-S10. 2008
    ..This may suggest a mechanism to account for the efficacy of factor VIIa in reducing blood loss in some settings of dilutional coagulopathy...
  11. ncbi request reprint A possible mechanism of action of activated factor VII independent of tissue factor
    D M Monroe
    Department of Medicine, University of North Carolina, Chapel Hill 27599 7035, USA
    Blood Coagul Fibrinolysis 9:S15-20. 1998
    ..We speculate that this platelet-localized thrombin generation may, in part, account for the clinical efficacy of high-dose FVIIa...
  12. ncbi request reprint High dose factor VIIa improves clot structure and stability in a model of haemophilia B
    Alisa S Wolberg
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, NC 27599 7525, USA
    Br J Haematol 131:645-55. 2005
    ....
  13. doi request reprint Platelet binding and activity of recombinant factor VIIa
    Maureane Hoffman
    Pathology and Laboratory Medicine Service, Durham VA Medical Center, 508 Fulton St, Durham, NC 27705, USA
    Thromb Res 125:S16-8. 2010
    ..Thus, there are still unanswered questions in fully understanding the mechanism of hemostatic action of recombinant FVIIa...
  14. ncbi request reprint The effect of active site-inhibited factor VIIa on tissue factor-initiated coagulation using platelets before and after aspirin administration
    M Kjalke
    Center for Thrombosis and Hemostasis, University of North Carolina at Chapel Hill, USA
    Thromb Haemost 78:1202-8. 1997
    ....
  15. doi request reprint The coagulation cascade in cirrhosis
    Dougald M Monroe
    Carolina Cardiovascular Biology Center, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA
    Clin Liver Dis 13:1-9. 2009
    ..This allows the coagulation system to be more easily tipped into a state favoring either hemorrhage or thrombosis...
  16. pmc Wound healing in hemophilia B mice and low tissue factor mice
    Dougald M Monroe
    School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Thromb Res 125:S74-7. 2010
    ..The current data suggests that ongoing coagulation function needs to be maintained to support a normal wound healing process...
  17. ncbi request reprint Perivascular tissue factor is down-regulated following cutaneous wounding: implications for bleeding in hemophilia
    Anna G McDonald
    Duke University, Durham, NC, USA
    Blood 111:2046-8. 2008
    ..Thus, perivascular TF expression is down-regulated during wound healing. This may prevent thrombosis of neovessels during angiogenesis but renders hemophiliacs vulnerable to hemorrhage during healing...
  18. ncbi request reprint Safety profile of recombinant factor VIIa
    Harold R Roberts
    Division of Hematology, Center for Thrombosis and Hemostasis, University of North Carolina at Chapel Hill, USA
    Semin Hematol 41:101-8. 2004
    ..Finally, those situations in which rFVIIa therapy may not be safe, such as disseminated intravascular coagulation (DIC) and sepsis, will also be discussed...
  19. ncbi request reprint Elevated prothrombin results in clots with an altered fiber structure: a possible mechanism of the increased thrombotic risk
    Alisa S Wolberg
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, USA
    Blood 101:3008-13. 2003
    ..We hypothesize that this alteration in fibrin clot structure is an important determinant of the risk of thrombosis...
  20. ncbi request reprint Platelet heterogeneity: variation in coagulation complexes on platelet subpopulations
    Christine L Kempton
    University of North Carolina, Chapel Hill, NC 27599 7035, USA
    Arterioscler Thromb Vasc Biol 25:861-6. 2005
    ....
  21. ncbi request reprint Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease
    Erica M Sparkenbaugh
    Division of Hematology Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC
    Blood 123:1747-56. 2014
    ..Our data indicate that TF, FXa, and thrombin differentially contribute to vascular inflammation in a mouse model of SCD. ..
  22. ncbi request reprint Cutaneous wound healing is impaired in hemophilia B
    Maureane Hoffman
    Laboratory Service 113, Durham Veterans Affairs Medical Center, 508 Fulton St, Durham, NC 27705, USA
    Blood 108:3053-60. 2006
    ..Our findings have significant implications for treatment of patients with hemophilia, and also highlight the importance of rapidly establishing hemostasis following trauma or surgery...
  23. ncbi request reprint A systematic evaluation of the effect of temperature on coagulation enzyme activity and platelet function
    Alisa S Wolberg
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    J Trauma 56:1221-8. 2004
    ..Hypothermia-associated bleeding has been hypothesized to result from dysregulation of enzymatic function, reduced platelet activity, and/or altered fibrinolysis...
  24. doi request reprint A rationally designed heparin, M118, has anticoagulant activity similar to unfractionated heparin and different from Lovenox in a cell-based model of thrombin generation
    Zoya Volovyk
    Duke University Medical Center, Durham, NC 27710, USA
    J Thromb Thrombolysis 28:132-9. 2009
    ..Our data suggest that the ability to inhibit platelet surface IIa generation correlates with the therapeutic level of heparins and confirms similarities between the anticoagulant properties of M118 and UFH...
  25. ncbi request reprint The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients
    Zhi Hong Meng
    Department of Pathology, Duke University Medical Center, Durham, NC 27705, USA
    J Trauma 55:886-91. 2003
    ..High-dose FVIIa has also been used off-label to manage hemorrhage in trauma and surgical patients, many of whom also develop hypothermia and acidosis...
  26. ncbi request reprint The use of recombinant factor VIIa in the treatment of bleeding disorders
    Harold R Roberts
    Division of Hematology Oncology, Department of Medicine and The Carolina Cardiovascular Biology Center, 932 Mary Ellen Jones Bldg, Chapel Hill, NC 27599 7035, USA
    Blood 104:3858-64. 2004
    ..Several questions pertaining to the use of factor VIIa require further investigation, including the mechanism of action; the optimal dose; definitive indications; ultimate safety; and laboratory tests for monitoring therapy...
  27. pmc Potent anticoagulant aptamer directed against factor IXa blocks macromolecular substrate interaction
    Bruce Sullenger
    Duke Translational Research Institute, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 287:12779-86. 2012
    ..Thus, aptamers may be useful agents to probe and block substrate-binding sites outside of the active site of an enzyme...
  28. doi request reprint Low intensity laser therapy speeds wound healing in hemophilia by enhancing platelet procoagulant activity
    Maureane Hoffman
    Department of Pathology, Duke University and Durham Veterans Affairs Medical Centers, Durham, North Carolina 27705, USA
    Wound Repair Regen 20:770-7. 2012
    ..These data suggest that trials of LILT as an adjunct to the usual hemostatic therapies in hemophilia are warranted...
  29. pmc Activation of protease-activated receptors 3 and 4 accelerates tissue factor-induced thrombin generation on the surface of vascular smooth muscle cells
    Param Vidwan
    Division of Cardiology, University of North Carolina, Chapel Hill 27599 7075, USA
    Arterioscler Thromb Vasc Biol 30:2587-96. 2010
    ..To determine factors regulating human aortic smooth muscle cells (HASMC) supported tissue factor-induced thrombin generation...
  30. ncbi request reprint Active site-inactivated factors VIIa, Xa, and IXa inhibit individual steps in a cell-based model of tissue factor-initiated coagulation
    M Kjalke
    Center for Thrombosis and Hemostasis, University of North Carolina at Chapel Hill, USA
    Thromb Haemost 80:578-84. 1998
    ..Thrombin then activates platelets, which serve as the physiologically important surface for large-scale thrombin generation...
  31. ncbi request reprint Rethinking the coagulation cascade
    Maureane M Hoffman
    Department of Pathology, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA
    Curr Hematol Rep 4:391-6. 2005
    ..It also highlights how host factors that are not part of the coagulation process per se can influence the effectiveness of coagulation...
  32. ncbi request reprint The multiple roles of tissue factor in wound healing
    Maureane Hoffman
    Pathology and Laboratory Medicine Service, Durham VA Medical Center, Durham, NC 27705, USA
    Front Biosci (Schol Ed) 4:713-21. 2012
    ..The literature in this are remains somewhat sparse, but suggests that modulation of TF expression plays a role in modulating the host response to injury...
  33. doi request reprint Studies on the mechanism of action of the aptamer BAX499, an inhibitor of tissue factor pathway inhibitor
    Jen Yea Chang
    Department of Medicine, University of North Carolina at Chapel Hill, NC 27599, USA
    Thromb Res 130:e151-7. 2012
    ..Diluted prothrombin time assay was used to investigate the effects of BAX499 on factor VIII-deficient plasma collected from hemophilia patients...
  34. ncbi request reprint A cell-based model of thrombin generation
    Harold R Roberts
    School of Medicine, Division of Hematology Oncology, Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, North Carolina 27599 7035, USA
    Semin Thromb Hemost 32:32-8. 2006
    ..We have also shown that activated protein C does not inactivate Va on the platelet surface but rather on endothelial cell surfaces...
  35. ncbi request reprint Activated protein C cleaves factor Va more efficiently on endothelium than on platelet surfaces
    Julie A Oliver
    Duke University and the Durham VA Medical Hospital, Durham, NC, USA
    Blood 100:539-46. 2002
    ..From the studies reported here, we conclude that in vivo, despite the important role of the protein C system in regulating thrombosis, activated protein C does not serve as a primary regulator of platelet-dependent thrombin generation...
  36. ncbi request reprint The effects of activated factor VII in a cell-based model for tissue factor-initiated coagulation
    M Kjalke
    University of North Carolina at Chapel Hill, USA
    Blood Coagul Fibrinolysis 9:S21-5. 1998
    ....
  37. ncbi request reprint Current concepts of hemostasis: implications for therapy
    Harold R Roberts
    Division of Hematology Oncology, Carolina Cardiovascular Biology Center, University of North Carolina School of Medicine, Chapel Hill 27599 7035, USA
    Anesthesiology 100:722-30. 2004
    ..Finally, recombinant factor VIIa has been used off-label as a hemostatic agent in some surgical situations associated with excessive bleeding that is not responsive to conventional therapy...
  38. ncbi request reprint Recombinant activated factor VII: its mechanism of action and role in the control of hemorrhage
    Geoffrey A Allen
    Center for Thrombosis and Hemostasis and Pediatric Hematology Oncology, University of North Carolina School of Medicine, Chapel Hill 27599 7220, USA
    Can J Anaesth 49:S7-14. 2002
    ..We have attempted to reconcile the various proposed mechanisms of action of rFVIIa with its apparent efficacy in such diverse clinical settings...
  39. ncbi request reprint Impact of procoagulant concentration on rate, peak and total thrombin generation in a model system
    G A Allen
    Department of Pediatrics Department of Pathology and Laboratory Medicine Department of Medicine Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC, USA
    J Thromb Haemost 2:402-13. 2004
    ....
  40. ncbi request reprint Role of the gamma-carboxyglutamic acid domain of activated factor X in the presence of calcium during inhibition by antithrombin-heparin
    H C Whinna
    Department of Pathology and Laboratory Medicine, Carolina Cardiovascular Biology Center, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    J Thromb Haemost 2:1127-34. 2004
    ..Recently, Rezaie showed that calcium further enhanced the heparin-catalyzed AT inhibition of FXa by promoting 'ternary complex' formation, and these results showed a role for the gamma-carboxyl-glutamate (Gla)-domain of FXa...
  41. pmc Replacing the first epidermal growth factor-like domain of factor IX with that of factor VII enhances activity in vitro and in canine hemophilia B
    J Y Chang
    Center for Thrombosis and Hemostasis, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7035, USA
    J Clin Invest 100:886-92. 1997
    ....
  42. ncbi request reprint Recombinant human factor VIIa (rFVIIa) can activate factor FIX on activated platelets
    D A Gabriel
    Division of Hematology Oncology, The Bone Marrow Transplant Program and The University of North Carolina School of Medicine, Carolina Center for Cardiovascular Biology, Chapel Hill, NC 27599, USA
    J Thromb Haemost 2:1816-22. 2004
    ....
  43. doi request reprint Wound healing in haemophilia--breaking the vicious cycle
    M Hoffman
    Pathology and Laboratory Medicine Service, Durham VA Medical Center, Durham, NC 27705, USA
    Haemophilia 16:13-8. 2010
    ..Thus, normalizing haemostasis, until the process of angiogenesis has resolved, may be required to prevent re-bleeding and additional tissue damage...
  44. ncbi request reprint Cloning, expression, and characterization of mouse tissue factor pathway inhibitor (TFPI)
    J Y Chang
    Center for Thrombosis and Hemostasis, University of North Carolina at Chapel Hill, 27599 7035, USA
    Thromb Haemost 79:306-9. 1998
    ..Cloning and expression of the mouse TFPI gene will offer useful information and material for coagulation studies performed in a mouse model system...
  45. ncbi request reprint Activated factor VII activates factors IX and X on the surface of activated platelets: thoughts on the mechanism of action of high-dose activated factor VII
    M Hoffman
    Department of Pathology, Durham Veterans Affairs Medical Center, NC 27705, USA
    Blood Coagul Fibrinolysis 9:S61-5. 1998
    ..Activation of FIX and FX on platelet surfaces in thrombocytopenia would result in more thrombin generation per platelet, possibly leading to formation of a stable fibrin network even in the absence of an optimal initial platelet plug...
  46. ncbi request reprint Links between the immune and coagulation systems: how do "antiphospholipid antibodies" cause thrombosis?
    M Hoffman
    Duke University Medical Center, Durham, NC, USA
    Immunol Res 22:191-7. 2000
    ..Antiphospholipid" antibodies against the phospholipid-binding protein beta-2-glycoprotein-1 enhance thrombin generation in this model system, primarily by enhancing procoagulant reactions on tissue factor-bearing cells...
  47. ncbi request reprint A cell-based model of hemostasis
    M Hoffman
    Pathology and Laboratory Medicine Service, Durham VA, Medical Center, NC 27705, USA
    Thromb Haemost 85:958-65. 2001
    ..This cell based model explains some aspects of hemostasis that a protein-centric model does not...
  48. ncbi request reprint Tissue factor around dermal vessels has bound factor VII in the absence of injury
    M Hoffman
    Duke University Medical Center, Durham, NC, USA
    J Thromb Haemost 5:1403-8. 2007
    ..Idling' or ongoing low-level activity of the tissue factor (TF) pathway is a postulated mechanism by which the coagulation process can become active without a lag period at sites of injury...
  49. ncbi request reprint Coagulation 2006: a modern view of hemostasis
    Maureane Hoffman
    Pathology and Laboratory Medicine Service 113, Durham Veterans Affairs Medical Center, 508 Fulton Street, Durham, NC 27705, USA
    Hematol Oncol Clin North Am 21:1-11. 2007
    ..Generation of the right amount of thrombin during the coagulation process not only may be essential for effective hemostasis but also may set the stage for effective wound healing...
  50. ncbi request reprint What does it take to make the perfect clot?
    Dougald M Monroe
    Durham Veterans Affairs Medical Center, Department of Pathology, Duke University Medical Center, Durham, NC, USA
    Arterioscler Thromb Vasc Biol 26:41-8. 2006
    ..Our understanding of how specific cellular features control the processes of hemostasis and thrombosis is developing rapidly. This review discusses some aspects of the cellular control of coagulation...
  51. ncbi request reprint Thrombin generation in vascular tissue
    A Pathak
    Division of Cardiology, Hematology and Cardiothoracic Surgery and Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599 7075, USA
    J Thromb Haemost 4:60-7. 2006
    ..Classically, it is thought that the vast majority of thrombin is generated on the surface of platelets, however, thrombotic events occur in patients despite treatment with potent antiplatelet agents...
  52. doi request reprint Major burn injury is not associated with acute traumatic coagulopathy
    Rommel P Lu
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Trauma Acute Care Surg 74:1474-9. 2013
    ....
  53. ncbi request reprint Severe factor VII deficiency caused by mutations abolishing the cleavage site for activation and altering binding to tissue factor
    S Chaing
    Department of Medicine, University of North Carolina at Chapel Hill
    Blood 83:3524-35. 1994
    ..Our results suggest that the first EGF-like domain is required for binding to tissue factor and that the F.VII zymogen lacks activity and requires activation for expression of biologic activity...
  54. ncbi request reprint Functional consequences of an arginine180 to glutamine mutation in factor IX Hilo
    D M Monroe
    Department of Medicine, University of North Carolina, Chapel Hill
    Blood 73:1540-4. 1989
    ..Further, our data suggest that the mutation results in a molecule that interacts with components of the extrinsic pathway to give a prolonged ox brain prothrombin time...
  55. ncbi request reprint Mechanism of action of high-dose factor VIIa: points of agreement and disagreement
    Dougald M Monroe
    Arterioscler Thromb Vasc Biol 23:8-9; discussion 10. 2003
  56. ncbi request reprint Manipulation of prothrombin concentration improves response to high-dose factor VIIa in a cell-based model of haemophilia
    Geoffrey A Allen
    Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Br J Haematol 134:314-9. 2006
    ..Furthermore, these results suggest that increasing plasma prothrombin concentration prior to rFVIIa administration may offer advantages over the use of rFVIIa alone in the treatment of haemophilic bleeding...
  57. ncbi request reprint The action of high-dose factor VIIa (FVIIa) in a cell-based model of hemostasis
    Maureane Hoffman
    Dis Mon 49:14-21. 2003
    ..Our data suggest that in a cellular system high-dose FVIIa acts primarily by enhancing the rate of thrombin generation on platelet surfaces and not by overcoming inhibition by zymogen FVII of TF-dependent activation of FX...
  58. ncbi request reprint More information on patients with factor XI deficiency
    Harold R Roberts
    Anesthesiology 101:1253-4. 2004