M Monick

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Effects of Eyjafjallajökull volcanic ash on innate immune system responses and bacterial growth in vitro
    Martha M Monick
    Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Environ Health Perspect 121:691-8. 2013
  2. pmc Cigarette smoking decreases global microRNA expression in human alveolar macrophages
    Joel W Graff
    Department of Medicine, University of Iowa, Iowa City, Iowa, USA
    PLoS ONE 7:e44066. 2012
  3. pmc Coordinated DNA methylation and gene expression changes in smoker alveolar macrophages: specific effects on VEGF receptor 1 expression
    Robert A Philibert
    Departments of Psychiatry, The University of Iowa, Iowa City, IA, USA
    J Leukoc Biol 92:621-31. 2012
  4. ncbi request reprint A phosphatidylcholine-specific phospholipase C regulates activation of p42/44 mitogen-activated protein kinases in lipopolysaccharide-stimulated human alveolar macrophages
    M M Monick
    Department of Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
    J Immunol 162:3005-12. 1999
  5. ncbi request reprint Respiratory syncytial virus synergizes with Th2 cytokines to induce optimal levels of TARC/CCL17
    Martha M Monick
    Department of Internal Medicine, University of Iowa Carver College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
    J Immunol 179:1648-58. 2007
  6. ncbi request reprint Inhibition of Rho family GTPases results in increased TNF-alpha production after lipopolysaccharide exposure
    Martha M Monick
    Division of Pulmonary, Critical Care, and Occupational Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Room 100, Ekstein Medical Research Building, Iowa City, IA 52242, USA
    J Immunol 171:2625-30. 2003
  7. ncbi request reprint Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin
    Martha M Monick
    University of Iowa Roy J and Lucille A Carver College of Medicine and Veterans Affairs Medical Center, Iowa City, Iowa 52240, USA
    J Biol Chem 278:53035-44. 2003
  8. ncbi request reprint Intracellular thiols contribute to Th2 function via a positive role in IL-4 production
    Martha M Monick
    Department of Internal Medicine, University of Iowa, Roy J and Lucille A Carver College of Medicine, and Veterans Administration Medical Center, Iowa City, IA 52242, USA
    J Immunol 171:5107-15. 2003
  9. ncbi request reprint Activation of the epidermal growth factor receptor by respiratory syncytial virus results in increased inflammation and delayed apoptosis
    Martha M Monick
    Department of Internal Medicine, University of Iowa Carver College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
    J Biol Chem 280:2147-58. 2005
  10. ncbi request reprint Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus
    Martha M Monick
    Division of Pulmonary, Critical Care, and Occupational Medicine, Room 100, EMRB, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Respir Cell Mol Biol 30:844-52. 2004

Research Grants

Collaborators

Detail Information

Publications54

  1. pmc Effects of Eyjafjallajökull volcanic ash on innate immune system responses and bacterial growth in vitro
    Martha M Monick
    Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Environ Health Perspect 121:691-8. 2013
    ..Epidemiological studies have observed an increase in respiratory infections in subjects and populations exposed to volcanic eruptions...
  2. pmc Cigarette smoking decreases global microRNA expression in human alveolar macrophages
    Joel W Graff
    Department of Medicine, University of Iowa, Iowa City, Iowa, USA
    PLoS ONE 7:e44066. 2012
    ..The comprehensive mRNA and miRNA expression profiles described here provide insight into gene expression regulation that may underlie the adverse effects cigarette smoking has on alveolar macrophages...
  3. pmc Coordinated DNA methylation and gene expression changes in smoker alveolar macrophages: specific effects on VEGF receptor 1 expression
    Robert A Philibert
    Departments of Psychiatry, The University of Iowa, Iowa City, IA, USA
    J Leukoc Biol 92:621-31. 2012
    ..In conclusion, chronic cigarette smoke exposure altered DNA methylation in specific gene promoter regions in human alveolar macrophages...
  4. ncbi request reprint A phosphatidylcholine-specific phospholipase C regulates activation of p42/44 mitogen-activated protein kinases in lipopolysaccharide-stimulated human alveolar macrophages
    M M Monick
    Department of Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
    J Immunol 162:3005-12. 1999
    ..As an aggregate, these studies support the hypothesis that one way by which LPS activates the ERK kinases is via activation of PC-PLC and that activation of a PC-PLC is an important component of macrophage activation by LPS...
  5. ncbi request reprint Respiratory syncytial virus synergizes with Th2 cytokines to induce optimal levels of TARC/CCL17
    Martha M Monick
    Department of Internal Medicine, University of Iowa Carver College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
    J Immunol 179:1648-58. 2007
    ..These findings demonstrate that RSV induces a chemokine TARC that has the potential to recruit Th2 cells to the lung...
  6. ncbi request reprint Inhibition of Rho family GTPases results in increased TNF-alpha production after lipopolysaccharide exposure
    Martha M Monick
    Division of Pulmonary, Critical Care, and Occupational Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Room 100, Ekstein Medical Research Building, Iowa City, IA 52242, USA
    J Immunol 171:2625-30. 2003
    ..When we inhibited ERK, we blocked the lovastatin-induced increase in TNF-alpha production. As a composite, these studies demonstrate a negative role for one or more Rho family GTPases in LPS-induced TNF-alpha production...
  7. ncbi request reprint Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin
    Martha M Monick
    University of Iowa Roy J and Lucille A Carver College of Medicine and Veterans Affairs Medical Center, Iowa City, Iowa 52240, USA
    J Biol Chem 278:53035-44. 2003
    ..The increased interaction between airway epithelial cells and LPS has the potential to profoundly alter airway inflammation...
  8. ncbi request reprint Intracellular thiols contribute to Th2 function via a positive role in IL-4 production
    Martha M Monick
    Department of Internal Medicine, University of Iowa, Roy J and Lucille A Carver College of Medicine, and Veterans Administration Medical Center, Iowa City, IA 52242, USA
    J Immunol 171:5107-15. 2003
    ..The sum of these effects may contribute to alterations in the balance between Th1 and Th2 responses in lung diseases associated alterations in intracellular thiol pools...
  9. ncbi request reprint Activation of the epidermal growth factor receptor by respiratory syncytial virus results in increased inflammation and delayed apoptosis
    Martha M Monick
    Department of Internal Medicine, University of Iowa Carver College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
    J Biol Chem 280:2147-58. 2005
    ..This occurred in an EGFR-dependent manner. This study supports an important role for EGFR activity in the lifespan and inflammatory potential of RSV-infected epithelial cells...
  10. ncbi request reprint Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus
    Martha M Monick
    Division of Pulmonary, Critical Care, and Occupational Medicine, Room 100, EMRB, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Respir Cell Mol Biol 30:844-52. 2004
    ..The studies are the first evidence linking sphingolipid metabolites to cell survival mechanisms in the context of a viral infection...
  11. pmc Constitutive ERK MAPK activity regulates macrophage ATP production and mitochondrial integrity
    Martha M Monick
    Department of Medicine, University of Iowa Carver College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
    J Immunol 180:7485-96. 2008
    ..As a composite, these data demonstrate a novel mitochondrial role for ERK in maintaining mitochondrial membrane potential and ATP production in human alveolar macrophages...
  12. ncbi request reprint Second messenger pathways in pulmonary host defense
    Martha M Monick
    Department of Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa, USA
    Annu Rev Physiol 65:643-67. 2003
    ..Animal models of sepsis support the central role played by macrophage-derived TNFalpha in sepsis...
  13. ncbi request reprint Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity
    Martha M Monick
    Division of Pulmonary, Critical Care, and Occupational Medicine, Roy J and Lucille A Carver College of Medicine, Eckstein Medical Research Building Room 100, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 173:123-35. 2004
    ..These studies suggest an important role for sphingolipids in prolonging survival of human alveolar macrophages via distinct survival pathways...
  14. ncbi request reprint Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages
    M M Monick
    Department of Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, IA, USA
    J Immunol 165:4632-9. 2000
    ..Taken as a whole, these studies suggest that LPS activates ERK kinase, in part, through activation of an atypical PKC isoform, PKC zeta...
  15. ncbi request reprint Respiratory syncytial virus infection results in activation of multiple protein kinase C isoforms leading to activation of mitogen-activated protein kinase
    M Monick
    Department of Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
    J Immunol 166:2681-7. 2001
    ..Down-regulation of the other PKC isoforms with PMA blocked the late sustained activation of ERK by RSV. These studies suggest that RSV activates multiple PKC isoforms with subsequent downstream activation of ERK kinase...
  16. ncbi request reprint Lipopolysaccharide activates Akt in human alveolar macrophages resulting in nuclear accumulation and transcriptional activity of beta-catenin
    M M Monick
    Department of Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
    J Immunol 166:4713-20. 2001
    ..This is the first demonstration that LPS exposure activates AKT, inactivates GSK-3, and causes accumulation and transcriptional activity of beta-catenin in the nucleus of any cell, including alveolar macrophages...
  17. ncbi request reprint Active ERK contributes to protein translation by preventing JNK-dependent inhibition of protein phosphatase 1
    Martha M Monick
    University of Iowa Carver College of Medicine, Veterans Administration Medical Center, Iowa City, IA 52242, USA
    J Immunol 177:1636-45. 2006
    ..This new role for ERK in alveolar macrophage homeostasis may help to explain the survival characteristic of these cells within their unique high oxygen and stress microenvironment...
  18. ncbi request reprint Ceramide regulates lipopolysaccharide-induced phosphatidylinositol 3-kinase and Akt activity in human alveolar macrophages
    M M Monick
    Department of Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
    J Immunol 167:5977-85. 2001
    ..We believe that LPS induction of ceramide results in PI 3-kinase activation and represents a novel effector mechanism that promotes survival of human alveolar macrophages in the setting of pulmonary sepsis...
  19. ncbi request reprint Interaction of matrix with integrin receptors is required for optimal LPS-induced MAP kinase activation
    Martha M Monick
    Department of Medicine, University of Iowa College of Medicine, and Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
    Am J Physiol Lung Cell Mol Physiol 283:L390-402. 2002
    ..These observations demonstrate that, in addition to the TLR receptor complex, optimal LPS signaling requires complementary signals from integrin receptors...
  20. ncbi request reprint Activation of second messenger pathways in alveolar macrophages by endotoxin
    M M Monick
    Dept of Medicine, University of Iowa College of Medicine and Veterans Administration Medical Centre, Iowa City, USA
    Eur Respir J 20:210-22. 2002
    ..The recent discovery of the endotoxin receptor has accelerated the study of signalling in macrophages. This review focuses on the downstream events that occur following exposure of the alveolar macrophage to endotoxin...
  21. pmc Identification of an autophagy defect in smokers' alveolar macrophages
    Martha M Monick
    Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 185:5425-35. 2010
    ..This study identifies the autophagy pathway as a potential target for interventions designed to decrease infection rates in smokers and possibly in individuals with high environmental particulate exposure...
  22. ncbi request reprint Extracellular signal-regulated kinase activation delays hyperoxia-induced epithelial cell death in conditions of Akt downregulation
    Son V Truong
    Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Am J Respir Cell Mol Biol 31:611-8. 2004
    ....
  23. ncbi request reprint Specific inhibition of type I interferon signal transduction by respiratory syncytial virus
    Murali Ramaswamy
    University of Iowa Roy J and Lucille A Carver College of Medicine, Department of Internal Medicine, 200 Hawkins Drive, C33 GH, Iowa City, IA 52242, USA
    Am J Respir Cell Mol Biol 30:893-900. 2004
    ..Decreased antiviral gene expression in RSV-infected airway epithelial cells may allow RSV replication and establishment of a productive viral infection through subversion of IFN-dependent immunity...
  24. ncbi request reprint Pseudomonas aeruginosa delays Kupffer cell death via stabilization of the X-chromosome-linked inhibitor of apoptosis protein
    Alix Ashare
    Division of Pulmonary, Critical Care, and Occupational Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    J Immunol 179:505-13. 2007
    ..Transfection with a stable, nondegradable XIAP mutant also protected cells against TNF-alpha-induced cell death. These studies demonstrate that P. aeruginosa delays TNF-alpha-induced Kupffer cell death via stabilization of XIAP...
  25. ncbi request reprint Early exposure to IL-4 stabilizes IL-4 mRNA in CD4+ T cells via RNA-binding protein HuR
    Timur O Yarovinsky
    Roy J and Lucille A Carver College of Medicine, University of Iowa and Veterans Administration Medical Center, Iowa City, IA 52242, USA
    J Immunol 177:4426-35. 2006
    ..Thus, IL-4 plays a positive role in maintaining IL-4 mRNA stability in CD4+ T cells via a HuR-mediated mechanism...
  26. ncbi request reprint Pleiotropic functions of TNF-alpha determine distinct IKKbeta-dependent hepatocellular fates in response to LPS
    Rana Dajani
    Department of Anatomy and Cell Biology, University of Iowa, College of Medicine, 51 Newton Rd, Rm 1 111 BSB, Iowa City, IA 52242, USA
    Am J Physiol Gastrointest Liver Physiol 292:G242-52. 2007
    ..In conclusion, our studies demonstrate that induction of NF-kappaB and TNF-alpha balances protective (antiapoptotic) and detrimental (proinflammatory) pathways to determine hepatocellular fates during endotoxemia...
  27. pmc Insulin-like growth factor-1 improves survival in sepsis via enhanced hepatic bacterial clearance
    Alix Ashare
    Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa Roy J and Lucille A Carver College of Medicine, 200 Hawkins Drive, C 33 GH, Iowa City, IA 52242, USA
    Am J Respir Crit Care Med 178:149-57. 2008
    ..Kupffer cell apoptosis is triggered by tumor necrosis factor (TNF)-alpha and activation of the PI-3 kinase pathway prevents TNF-induced Kupffer cell death...
  28. pmc Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense
    Sif Hansdottir
    Department of Medicine, University of Iowa Carver College of Medicine, and Veterans Administration Medical Center, Iowa City, IA 52242, USA
    J Immunol 181:7090-9. 2008
    ..These observations suggest a novel mechanism by which local conversion of inactive to active vitamin D alters immune function in the lung...
  29. pmc Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation
    Toru Nyunoya
    Division of Pulmonary, Critical Care, and Occupational Medicine, Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Am J Respir Crit Care Med 179:279-87. 2009
    ..Both Werner's syndrome and cigarette smoking accelerate aging. No studies have examined the effect of cigarette smoke on Werner's syndrome protein...
  30. pmc Cigarette smoke alters respiratory syncytial virus-induced apoptosis and replication
    Dayna J Groskreutz
    Division of Pulmonary, Critical Care, and Occupational Medicine, 100 EMRB, Iowa City, IA 52242, USA
    Am J Respir Cell Mol Biol 41:189-98. 2009
    ..Cigarette smoke causes necrosis rather than apoptosis in viral infection, resulting in increased inflammation and enhanced viral replication...
  31. pmc Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state
    Sif Hansdottir
    Department of Medicine, University of Iowa Carver College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242 1081, USA
    J Immunol 184:965-74. 2010
    ..This suggests that adequate vitamin D levels would contribute to reduced inflammation and less severe disease in RSV-infected individuals...
  32. pmc Respiratory syncytial virus limits alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) phosphorylation to maintain translation and viral replication
    Dayna J Groskreutz
    Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa Roy J, Iowa City, IA 52242, USA
    J Biol Chem 285:24023-31. 2010
    ..The result is limited phosphorylation of eIF2alpha and continued translation of cellular and viral proteins...
  33. ncbi request reprint Respiratory syncytial virus decreases p53 protein to prolong survival of airway epithelial cells
    Dayna J Groskreutz
    Division of Pulmonary, Critical Care, and Occupational Medicine, Department of Pharmacology, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    J Immunol 179:2741-7. 2007
    ..These findings reveal that RSV decreases p53 by enhancing Akt/Mdm2-mediated p53 degradation, thereby delaying apoptosis and prolonging survival of airway epithelial cells...
  34. pmc Cigarette smoke induces cellular senescence
    Toru Nyunoya
    Division of Pulmonary, Critical Care, and Occupational Medicine, 100 EMRB, Iowa City, IA 52242, USA
    Am J Respir Cell Mol Biol 35:681-8. 2006
    ..This inability to repair lung injury may be an essential feature of emphysema...
  35. ncbi request reprint Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells
    Dayna J Groskreutz
    Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa Roy J and Lucille A Carver College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
    J Immunol 176:1733-40. 2006
    ..These findings are consistent with the hypothesis that RSV infection sensitizes the airway epithelium to subsequent viral and bacterial exposures by up-regulating TLRs and increasing their membrane localization...
  36. ncbi request reprint Mitochondrial K(ATP) channel openers activate the ERK kinase by an oxidant-dependent mechanism
    Lobelia Samavati
    Department of Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
    Am J Physiol Cell Physiol 283:C273-81. 2002
    ..We conclude that mitochondrial K(ATP) channel openers trigger ERK activation via mitochondria-derived ROS...
  37. ncbi request reprint Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA
    Martha M Monick
    University of Iowa Roy J and Lucille A Carver College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
    J Biol Chem 277:32992-3000. 2002
    ..The data suggest that PI3K inhibition of p38 modulates COX2 expression via destabilization of LPS-induced COX2 mRNA...
  38. ncbi request reprint Altered IL-4 mRNA stability correlates with Th1 and Th2 bias and susceptibility to hypersensitivity pneumonitis in two inbred strains of mice
    Noah S Butler
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
    J Immunol 169:3700-9. 2002
    ..Moreover, our results indicate that regulation of mRNA stability may serve as an important mechanism underlying Th1/Th2 immune polarization...
  39. ncbi request reprint First-generation adenovirus vectors shorten survival time in a murine model of sepsis
    Kevin Doerschug
    Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
    J Immunol 169:6539-45. 2002
    ..Finally, a profound degree of lymphocyte apoptosis was observed in these animals. These observations suggest that prior exposure to first-generation adenovirus gene therapy vectors may worsen the outcome of some forms of sepsis...
  40. ncbi request reprint Integrin receptors are crucial for the restimulation of activated T lymphocytes
    Timur O Yarovinsky
    Department of Internal Medicine, University of Iowa, Veteran Affairs Medical Center, Iowa City, IA 52242, USA
    Am J Respir Cell Mol Biol 28:607-15. 2003
    ..This indicates that matrix proteins may play a major role in regulating T-cell-mediated immune responses in the lung...
  41. ncbi request reprint Hyperoxia induces macrophage cell cycle arrest by adhesion-dependent induction of p21Cip1 and activation of the retinoblastoma protein
    Toru Nyunoya
    Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa Roy J and Lucille A Carver College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
    J Biol Chem 278:36099-106. 2003
    ..The induction of p21Cip1 and activation of retinoblastoma protein occurred via a p53-independent mechanism. These results suggest that adhesion-dependent pathways are required for hyperoxia-induced cell cycle arrest in macrophages...
  42. ncbi request reprint Adenoviral infection decreases mortality from lipopolysaccharide-induced liver failure via induction of TNF-alpha tolerance
    Timur O Yarovinsky
    Department of Internal Medicine, Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa, 100 EMRB, Iowa City, IA 52242, USA
    J Immunol 171:2453-60. 2003
    ..Decreased production of IL-6 and KC in response to exogenous TNF-alpha, in addition to protection from TNF-alpha, suggested that adenoviral infection results in TNF-alpha tolerance...
  43. ncbi request reprint Respiratory syncytial virus inhibits apoptosis and induces NF-kappa B activity through a phosphatidylinositol 3-kinase-dependent pathway
    Karl W Thomas
    Department of Internal Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
    J Biol Chem 277:492-501. 2002
    ..Blockade of PI 3-K activation resulted in rapid, premature apoptosis and inhibition of RSV-stimulated NF-kappaB-dependent gene transcription...
  44. ncbi request reprint Adenovirus vectors activate survival pathways in lung epithelial cells
    Dawn M Flaherty
    Department of Internal Medicine, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Lung Cell Mol Physiol 287:L393-401. 2004
    ..When we examined induction of the prosurvival pathways, ERK and AKT, in the viral vector-infected cells, we found that there was significant activation of both Akt and ERK...
  45. ncbi request reprint Oxidant-mediated increases in redox factor-1 nuclear protein and activator protein-1 DNA binding in asbestos-treated macrophages
    Dawn M Flaherty
    Department of Internal Medicine, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City, IA 52243, USA
    J Immunol 168:5675-81. 2002
    ..These findings suggest that an exposure associated with fibrotic lung disease, i.e., asbestos, modulates accumulation of nuclear Ref-1 in macrophages, and that this effect is mediated by an oxidant stimulus...
  46. ncbi request reprint Anti-inflammatory response is associated with mortality and severity of infection in sepsis
    Alix Ashare
    Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa College of Medicine, 200 Hawkins Dr, C 33 GH, Iowa City, IA 52242, USA
    Am J Physiol Lung Cell Mol Physiol 288:L633-40. 2005
    ..These data suggest that it is the timing and magnitude of the anti-inflammatory response that predicts severity of infection in a murine model of sepsis...
  47. ncbi request reprint Macrophages survive hyperoxia via prolonged ERK activation due to phosphatase down-regulation
    Toru Nyunoya
    Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 280:26295-302. 2005
    ..These data demonstrate that, in hyperoxia-exposed macrophages, sustained activation of ERK due to phosphatase down-regulation permits macrophage survival via effects on the balance between pro- and anti-apoptotic Bcl-2 family proteins...
  48. pmc Severe bacteremia results in a loss of hepatic bacterial clearance
    Alix Ashare
    Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa College of Medicine, 200 Hawkins Drive, C 33 GH, Iowa City, IA 52242, USA
    Am J Respir Crit Care Med 173:644-52. 2006
    ..Although it has been postulated that liver injury results in impaired clearance of bacteria from the blood, no prior study has evaluated hepatic bacterial clearance during sepsis...
  49. ncbi request reprint Human alveolar macrophages are deficient in PTEN. The role of endogenous oxidants
    Dawn M Flaherty
    Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 281:5058-64. 2006
    ..These data support the hypothesis that alterations in ROS levels contribute to macrophage homeostasis by altering the balance between PI 3-kinase/Akt and the phosphatase, PTEN...
  50. pmc Increased sensitivity to staphylococcal enterotoxin B following adenoviral infection
    Timur O Yarovinsky
    Division of Pulmonary, Critical Care, and Occupational Medicine, 100 EMRB, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    Infect Immun 73:3375-84. 2005
    ..These data suggest that a preexisting viral infection primes mice for subsequent staphylococcal enterotoxin B exposure, possibly via a gamma-interferon-mediated mechanism...
  51. ncbi request reprint Antibiotics delay but do not prevent bacteremia and lung injury in murine sepsis
    Kevin C Doerschug
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA, USA
    Crit Care Med 32:489-94. 2004
    ..To circumvent the effect of antibiotics on cultures, we used polymerase chain reaction to detect bacteria...
  52. pmc Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis
    Christopher P Baran
    Department of Internal Medicine, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Dorothy M Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio 43210, USA
    Am J Respir Crit Care Med 176:78-89. 2007
    ..However, little attention is given to the role of the mononuclear phagocyte survival and recruitment factor, macrophage colony-stimulating factor (M-CSF), in pulmonary fibrosis...
  53. ncbi request reprint Role of repeated lung injury and genetic background in bleomycin-induced fibrosis
    Man Pyo Chung
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea
    Am J Respir Cell Mol Biol 29:375-80. 2003
    ..This data indicate that healing of injury/fibrosis after bleomycin is complex and can be determined by a number of genetic and environmental factors...
  54. pmc Interferons increase cell resistance to Staphylococcal alpha-toxin
    Timur O Yarovinsky
    Yale University School of Medicine, Department of Immunobiology, TAC S555, 300 Cedar Street, New Haven, CT 06520, USA
    Infect Immun 76:571-7. 2008
    ..Our results demonstrate that IFNs may increase cell resistance to staphylococcal alpha-toxin via the regulation of lipid metabolism and suggest that interferons play a protective role during staphylococcal infections...

Research Grants2

  1. Cigarette Smoke and Autophagy/Lysosomal Pathway Dysfunction
    Martha M Monick; Fiscal Year: 2010
    ..This project investigates the role of autophagy in alveolar macrophage immune dysfunction subsequent to smoke exposure and tests a number of relevant interventions. ..
  2. Role of EGFR in Viral Infected Lung Epithelial Cells
    Martha M Monick; Fiscal Year: 2010
    ..Completion of these studies will add to our understanding of mechanisms of RSV infection of airway epithelium and the role of targeted signaling pathways in the subsequent inflammation and life span of infected cells. ..