Research Topics
Genomes and Genes
| M MonickSummaryAffiliation: University of Iowa Country: USA Publications
Research Grants
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Detail Information
Publications
Coordinated DNA methylation and gene expression changes in smoker alveolar macrophages: specific effects on VEGF receptor 1 expressionRobert A Philibert
Departments of Psychiatry, The University of Iowa, Iowa City, IA, USA
J Leukoc Biol 92:621-31. 2012..In conclusion, chronic cigarette smoke exposure altered DNA methylation in specific gene promoter regions in human alveolar macrophages...
A phosphatidylcholine-specific phospholipase C regulates activation of p42/44 mitogen-activated protein kinases in lipopolysaccharide-stimulated human alveolar macrophagesM M Monick
Department of Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
J Immunol 162:3005-12. 1999..As an aggregate, these studies support the hypothesis that one way by which LPS activates the ERK kinases is via activation of PC-PLC and that activation of a PC-PLC is an important component of macrophage activation by LPS...- Constitutive ERK MAPK activity regulates macrophage ATP production and mitochondrial integrityMartha M Monick
Department of Medicine, University of Iowa Carver College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
J Immunol 180:7485-96. 2008..As a composite, these data demonstrate a novel mitochondrial role for ERK in maintaining mitochondrial membrane potential and ATP production in human alveolar macrophages... - Inhibition of Rho family GTPases results in increased TNF-alpha production after lipopolysaccharide exposureMartha M Monick
Division of Pulmonary, Critical Care, and Occupational Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Room 100, Ekstein Medical Research Building, Iowa City, IA 52242, USA
J Immunol 171:2625-30. 2003..When we inhibited ERK, we blocked the lovastatin-induced increase in TNF-alpha production. As a composite, these studies demonstrate a negative role for one or more Rho family GTPases in LPS-induced TNF-alpha production... - Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxinMartha M Monick
University of Iowa Roy J and Lucille A Carver College of Medicine and Veterans Affairs Medical Center, Iowa City, Iowa 52240, USA
J Biol Chem 278:53035-44. 2003..The increased interaction between airway epithelial cells and LPS has the potential to profoundly alter airway inflammation... - Intracellular thiols contribute to Th2 function via a positive role in IL-4 productionMartha M Monick
Department of Internal Medicine, University of Iowa, Roy J and Lucille A Carver College of Medicine, and Veterans Administration Medical Center, Iowa City, IA 52242, USA
J Immunol 171:5107-15. 2003..The sum of these effects may contribute to alterations in the balance between Th1 and Th2 responses in lung diseases associated alterations in intracellular thiol pools... - Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virusMartha M Monick
Division of Pulmonary, Critical Care, and Occupational Medicine, Room 100, EMRB, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
Am J Respir Cell Mol Biol 30:844-52. 2004..The studies are the first evidence linking sphingolipid metabolites to cell survival mechanisms in the context of a viral infection... - Respiratory syncytial virus synergizes with Th2 cytokines to induce optimal levels of TARC/CCL17Martha M Monick
Department of Internal Medicine, University of Iowa Carver College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
J Immunol 179:1648-58. 2007..These findings demonstrate that RSV induces a chemokine TARC that has the potential to recruit Th2 cells to the lung... - Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activityMartha M Monick
Division of Pulmonary, Critical Care, and Occupational Medicine, Roy J and Lucille A Carver College of Medicine, Eckstein Medical Research Building Room 100, University of Iowa, Iowa City, IA 52242, USA
J Immunol 173:123-35. 2004..These studies suggest an important role for sphingolipids in prolonging survival of human alveolar macrophages via distinct survival pathways... - Activation of the epidermal growth factor receptor by respiratory syncytial virus results in increased inflammation and delayed apoptosisMartha M Monick
Department of Internal Medicine, University of Iowa Carver College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
J Biol Chem 280:2147-58. 2005..This occurred in an EGFR-dependent manner. This study supports an important role for EGFR activity in the lifespan and inflammatory potential of RSV-infected epithelial cells... - Active ERK contributes to protein translation by preventing JNK-dependent inhibition of protein phosphatase 1Martha M Monick
University of Iowa Carver College of Medicine, Veterans Administration Medical Center, Iowa City, IA 52242, USA
J Immunol 177:1636-45. 2006..This new role for ERK in alveolar macrophage homeostasis may help to explain the survival characteristic of these cells within their unique high oxygen and stress microenvironment... - Second messenger pathways in pulmonary host defenseMartha M Monick
Department of Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa, USA
Annu Rev Physiol 65:643-67. 2003..Animal models of sepsis support the central role played by macrophage-derived TNFalpha in sepsis... - Ceramide regulates lipopolysaccharide-induced phosphatidylinositol 3-kinase and Akt activity in human alveolar macrophagesM M Monick
Department of Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
J Immunol 167:5977-85. 2001..We believe that LPS induction of ceramide results in PI 3-kinase activation and represents a novel effector mechanism that promotes survival of human alveolar macrophages in the setting of pulmonary sepsis... - Lipopolysaccharide activates Akt in human alveolar macrophages resulting in nuclear accumulation and transcriptional activity of beta-cateninM M Monick
Department of Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
J Immunol 166:4713-20. 2001..This is the first demonstration that LPS exposure activates AKT, inactivates GSK-3, and causes accumulation and transcriptional activity of beta-catenin in the nucleus of any cell, including alveolar macrophages... - Identification of an autophagy defect in smokers' alveolar macrophagesMartha M Monick
Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
J Immunol 185:5425-35. 2010..This study identifies the autophagy pathway as a potential target for interventions designed to decrease infection rates in smokers and possibly in individuals with high environmental particulate exposure... - Respiratory syncytial virus infection results in activation of multiple protein kinase C isoforms leading to activation of mitogen-activated protein kinaseM Monick
Department of Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
J Immunol 166:2681-7. 2001..Down-regulation of the other PKC isoforms with PMA blocked the late sustained activation of ERK by RSV. These studies suggest that RSV activates multiple PKC isoforms with subsequent downstream activation of ERK kinase... - Interaction of matrix with integrin receptors is required for optimal LPS-induced MAP kinase activationMartha M Monick
Department of Medicine, University of Iowa College of Medicine, and Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
Am J Physiol Lung Cell Mol Physiol 283:L390-402. 2002..These observations demonstrate that, in addition to the TLR receptor complex, optimal LPS signaling requires complementary signals from integrin receptors... - Activation of second messenger pathways in alveolar macrophages by endotoxinM M Monick
Dept of Medicine, University of Iowa College of Medicine and Veterans Administration Medical Centre, Iowa City, USA
Eur Respir J 20:210-22. 2002..The recent discovery of the endotoxin receptor has accelerated the study of signalling in macrophages. This review focuses on the downstream events that occur following exposure of the alveolar macrophage to endotoxin... - Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophagesM M Monick
Department of Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, IA, USA
J Immunol 165:4632-9. 2000..Taken as a whole, these studies suggest that LPS activates ERK kinase, in part, through activation of an atypical PKC isoform, PKC zeta... - Extracellular signal-regulated kinase activation delays hyperoxia-induced epithelial cell death in conditions of Akt downregulationSon V Truong
Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Am J Respir Cell Mol Biol 31:611-8. 2004.... - Specific inhibition of type I interferon signal transduction by respiratory syncytial virusMurali Ramaswamy
University of Iowa Roy J. and Lucille A. Carver College of Medicine, Department of Internal Medicine, 200 Hawkins Drive, C33-GH, Iowa City, IA 52242, USA
Am J Respir Cell Mol Biol 30:893-900. 2004..Decreased antiviral gene expression in RSV-infected airway epithelial cells may allow RSV replication and establishment of a productive viral infection through subversion of IFN-dependent immunity... - Early exposure to IL-4 stabilizes IL-4 mRNA in CD4+ T cells via RNA-binding protein HuRTimur O Yarovinsky
Roy J and Lucille A Carver College of Medicine, University of Iowa and Veterans Administration Medical Center, Iowa City, IA 52242, USA
J Immunol 177:4426-35. 2006..Thus, IL-4 plays a positive role in maintaining IL-4 mRNA stability in CD4+ T cells via a HuR-mediated mechanism... - Pleiotropic functions of TNF-alpha determine distinct IKKbeta-dependent hepatocellular fates in response to LPSRana Dajani
Department of Anatomy and Cell Biology, University of Iowa, College of Medicine, 51 Newton Rd, Rm 1 111 BSB, Iowa City, IA 52242, USA
Am J Physiol Gastrointest Liver Physiol 292:G242-52. 2007..In conclusion, our studies demonstrate that induction of NF-kappaB and TNF-alpha balances protective (antiapoptotic) and detrimental (proinflammatory) pathways to determine hepatocellular fates during endotoxemia... - Cigarette smoke induces cellular senescenceToru Nyunoya
Division of Pulmonary, Critical Care, and Occupational Medicine, 100 EMRB, Iowa City, IA 52242, USA
Am J Respir Cell Mol Biol 35:681-8. 2006..This inability to repair lung injury may be an essential feature of emphysema... - Pseudomonas aeruginosa delays Kupffer cell death via stabilization of the X-chromosome-linked inhibitor of apoptosis proteinAlix Ashare
Division of Pulmonary, Critical Care, and Occupational Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
J Immunol 179:505-13. 2007..Transfection with a stable, nondegradable XIAP mutant also protected cells against TNF-alpha-induced cell death. These studies demonstrate that P. aeruginosa delays TNF-alpha-induced Kupffer cell death via stabilization of XIAP... - Respiratory syncytial virus decreases p53 protein to prolong survival of airway epithelial cellsDayna J Groskreutz
Division of Pulmonary, Critical Care, and Occupational Medicine, Department of Pharmacology, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
J Immunol 179:2741-7. 2007..These findings reveal that RSV decreases p53 by enhancing Akt/Mdm2-mediated p53 degradation, thereby delaying apoptosis and prolonging survival of airway epithelial cells... - Cigarette smoke alters respiratory syncytial virus-induced apoptosis and replicationDayna J Groskreutz
Division of Pulmonary, Critical Care, and Occupational Medicine, 100 EMRB, Iowa City, IA 52242, USA
Am J Respir Cell Mol Biol 41:189-98. 2009..Cigarette smoke causes necrosis rather than apoptosis in viral infection, resulting in increased inflammation and enhanced viral replication... - Respiratory syncytial virus limits alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) phosphorylation to maintain translation and viral replicationDayna J Groskreutz
Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa Roy J, Iowa City, IA 52242, USA
J Biol Chem 285:24023-31. 2010..The result is limited phosphorylation of eIF2alpha and continued translation of cellular and viral proteins... - Insulin-like growth factor-1 improves survival in sepsis via enhanced hepatic bacterial clearanceAlix Ashare
Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa Roy J and Lucille A Carver College of Medicine, 200 Hawkins Drive, C 33 GH, Iowa City, IA 52242, USA
Am J Respir Crit Care Med 178:149-57. 2008..Kupffer cell apoptosis is triggered by tumor necrosis factor (TNF)-alpha and activation of the PI-3 kinase pathway prevents TNF-induced Kupffer cell death... - Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defenseSif Hansdottir
Department of Medicine, University of Iowa Carver College of Medicine, and Veterans Administration Medical Center, Iowa City, IA 52242, USA
J Immunol 181:7090-9. 2008..These observations suggest a novel mechanism by which local conversion of inactive to active vitamin D alters immune function in the lung... - Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulationToru Nyunoya
Division of Pulmonary, Critical Care, and Occupational Medicine, Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Am J Respir Crit Care Med 179:279-87. 2009..Both Werner's syndrome and cigarette smoking accelerate aging. No studies have examined the effect of cigarette smoke on Werner's syndrome protein... - Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral stateSif Hansdottir
Department of Medicine, University of Iowa Carver College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242 1081, USA
J Immunol 184:965-74. 2010..This suggests that adequate vitamin D levels would contribute to reduced inflammation and less severe disease in RSV-infected individuals... - Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cellsDayna J Groskreutz
Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa Roy J and Lucille A Carver College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
J Immunol 176:1733-40. 2006..These findings are consistent with the hypothesis that RSV infection sensitizes the airway epithelium to subsequent viral and bacterial exposures by up-regulating TLRs and increasing their membrane localization... - Severe bacteremia results in a loss of hepatic bacterial clearanceAlix Ashare
Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa College of Medicine, 200 Hawkins Drive, C 33 GH, Iowa City, IA 52242, USA
Am J Respir Crit Care Med 173:644-52. 2006..Although it has been postulated that liver injury results in impaired clearance of bacteria from the blood, no prior study has evaluated hepatic bacterial clearance during sepsis... - Mitochondrial K(ATP) channel openers activate the ERK kinase by an oxidant-dependent mechanismLobelia Samavati
Department of Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
Am J Physiol Cell Physiol 283:C273-81. 2002..We conclude that mitochondrial K(ATP) channel openers trigger ERK activation via mitochondria-derived ROS... - Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNAMartha M Monick
University of Iowa Roy J and Lucille A Carver College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
J Biol Chem 277:32992-3000. 2002..The data suggest that PI3K inhibition of p38 modulates COX2 expression via destabilization of LPS-induced COX2 mRNA... - Altered IL-4 mRNA stability correlates with Th1 and Th2 bias and susceptibility to hypersensitivity pneumonitis in two inbred strains of miceNoah S Butler
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
J Immunol 169:3700-9. 2002..Moreover, our results indicate that regulation of mRNA stability may serve as an important mechanism underlying Th1/Th2 immune polarization... - First-generation adenovirus vectors shorten survival time in a murine model of sepsisKevin Doerschug
Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
J Immunol 169:6539-45. 2002..Finally, a profound degree of lymphocyte apoptosis was observed in these animals. These observations suggest that prior exposure to first-generation adenovirus gene therapy vectors may worsen the outcome of some forms of sepsis... - Integrin receptors are crucial for the restimulation of activated T lymphocytesTimur O Yarovinsky
Department of Internal Medicine, University of Iowa, Veteran Affairs Medical Center, Iowa City, IA 52242, USA
Am J Respir Cell Mol Biol 28:607-15. 2003..This indicates that matrix proteins may play a major role in regulating T-cell-mediated immune responses in the lung... - Hyperoxia induces macrophage cell cycle arrest by adhesion-dependent induction of p21Cip1 and activation of the retinoblastoma proteinToru Nyunoya
Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa Roy J and Lucille A Carver College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
J Biol Chem 278:36099-106. 2003..The induction of p21Cip1 and activation of retinoblastoma protein occurred via a p53-independent mechanism. These results suggest that adhesion-dependent pathways are required for hyperoxia-induced cell cycle arrest in macrophages... - Adenoviral infection decreases mortality from lipopolysaccharide-induced liver failure via induction of TNF-alpha toleranceTimur O Yarovinsky
Department of Internal Medicine, Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa, 100 EMRB, Iowa City, IA 52242, USA
J Immunol 171:2453-60. 2003..Decreased production of IL-6 and KC in response to exogenous TNF-alpha, in addition to protection from TNF-alpha, suggested that adenoviral infection results in TNF-alpha tolerance... - Respiratory syncytial virus inhibits apoptosis and induces NF-kappa B activity through a phosphatidylinositol 3-kinase-dependent pathwayKarl W Thomas
Department of Internal Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
J Biol Chem 277:492-501. 2002..Blockade of PI 3-K activation resulted in rapid, premature apoptosis and inhibition of RSV-stimulated NF-kappaB-dependent gene transcription... - Anti-inflammatory response is associated with mortality and severity of infection in sepsisAlix Ashare
Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa College of Medicine, 200 Hawkins Dr, C 33 GH, Iowa City, IA 52242, USA
Am J Physiol Lung Cell Mol Physiol 288:L633-40. 2005..These data suggest that it is the timing and magnitude of the anti-inflammatory response that predicts severity of infection in a murine model of sepsis... - Adenovirus vectors activate survival pathways in lung epithelial cellsDawn M Flaherty
Department of Internal Medicine, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
Am J Physiol Lung Cell Mol Physiol 287:L393-401. 2004..When we examined induction of the prosurvival pathways, ERK and AKT, in the viral vector-infected cells, we found that there was significant activation of both Akt and ERK... - Oxidant-mediated increases in redox factor-1 nuclear protein and activator protein-1 DNA binding in asbestos-treated macrophagesDawn M Flaherty
Department of Internal Medicine, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City, IA 52243, USA
J Immunol 168:5675-81. 2002..These findings suggest that an exposure associated with fibrotic lung disease, i.e., asbestos, modulates accumulation of nuclear Ref-1 in macrophages, and that this effect is mediated by an oxidant stimulus... - Human alveolar macrophages are deficient in PTEN. The role of endogenous oxidantsDawn M Flaherty
Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
J Biol Chem 281:5058-64. 2006..These data support the hypothesis that alterations in ROS levels contribute to macrophage homeostasis by altering the balance between PI 3-kinase/Akt and the phosphatase, PTEN... - Increased sensitivity to staphylococcal enterotoxin B following adenoviral infectionTimur O Yarovinsky
Division of Pulmonary, Critical Care, and Occupational Medicine, 100 EMRB, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
Infect Immun 73:3375-84. 2005..These data suggest that a preexisting viral infection primes mice for subsequent staphylococcal enterotoxin B exposure, possibly via a gamma-interferon-mediated mechanism... - Macrophages survive hyperoxia via prolonged ERK activation due to phosphatase down-regulationToru Nyunoya
Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
J Biol Chem 280:26295-302. 2005..These data demonstrate that, in hyperoxia-exposed macrophages, sustained activation of ERK due to phosphatase down-regulation permits macrophage survival via effects on the balance between pro- and anti-apoptotic Bcl-2 family proteins... - Antibiotics delay but do not prevent bacteremia and lung injury in murine sepsisKevin C Doerschug
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA, USA
Crit Care Med 32:489-94. 2004..CONCLUSIONS: In this model of sepsis, antibiotics delay but do not prevent acute lung injury and mortality. Even in the presence of antibiotics, acute lung injury is strongly associated with bacteremia and bacteria within the lungs... - Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosisChristopher P Baran
Department of Internal Medicine, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Dorothy M Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio 43210, USA
Am J Respir Crit Care Med 176:78-89. 2007..However, little attention is given to the role of the mononuclear phagocyte survival and recruitment factor, macrophage colony-stimulating factor (M-CSF), in pulmonary fibrosis... - Role of repeated lung injury and genetic background in bleomycin-induced fibrosisMan Pyo Chung
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea
Am J Respir Cell Mol Biol 29:375-80. 2003..This data indicate that healing of injury/fibrosis after bleomycin is complex and can be determined by a number of genetic and environmental factors... - Interferons increase cell resistance to Staphylococcal alpha-toxinTimur O Yarovinsky
Yale University School of Medicine, Department of Immunobiology, TAC S555, 300 Cedar Street, New Haven, CT 06520, USA
Infect Immun 76:571-7. 2008..Our results demonstrate that IFNs may increase cell resistance to staphylococcal alpha-toxin via the regulation of lipid metabolism and suggest that interferons play a protective role during staphylococcal infections...
Research Grants
- Cigarette Smoke and Autophagy/Lysosomal Pathway DysfunctionMartha M Monick; Fiscal Year: 2010..This project investigates the role of autophagy in alveolar macrophage immune dysfunction subsequent to smoke exposure and tests a number of relevant interventions. ..
- Role of EGFR in Viral Infected Lung Epithelial CellsMartha M Monick; Fiscal Year: 2010..Completion of these studies will add to our understanding of mechanisms of RSV infection of airway epithelium and the role of targeted signaling pathways in the subsequent inflammation and life span of infected cells. ..