SATDARSHAN SINGH MONGA

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc β-Catenin loss in hepatocytes promotes hepatocellular cancer after diethylnitrosamine and phenobarbital administration to mice
    Prince Kwaku Awuah
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e39771. 2012
  2. pmc Hepatic regenerative medicine: exploiting the liver's will to live
    Satdarshan P S Monga
    Department of Pathology and Medicine, University of Pittsburgh, Pennsylvania Electronic address
    Am J Pathol 184:306-8. 2014
  3. pmc β-Catenin knockdown in liver tumor cells by a cell permeable gamma guanidine-based peptide nucleic acid
    Evan Delgado
    Endowed Chair for Experimental Pathology, Director Division of Experimental Pathology EP, Professor of Pathology EP and Medicine GI, Hepatology and Nutrition, University of Pittsburgh School of Medicine, 200 Lothrop Street S 422 BST, Pittsburgh, PA 15261, USA
    Curr Cancer Drug Targets 13:867-78. 2013
  4. ncbi request reprint Beta-catenin antisense studies in embryonic liver cultures: role in proliferation, apoptosis, and lineage specification
    Satdarshan P S Monga
    Department of Cellular and Molecular Pathology, S421 BST, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Gastroenterology 124:202-16. 2003
  5. pmc Role of Wnt/β-catenin signaling in liver metabolism and cancer
    Satdarshan Pal Singh Monga
    Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15216, United States
    Int J Biochem Cell Biol 43:1021-9. 2011
  6. pmc Mouse fetal liver cells in artificial capillary beds in three-dimensional four-compartment bioreactors
    Satdarshan P S Monga
    Department of Pathology, McGowan Institute for Regenerative Medicine, and the Department of Pharmacy, University of Pittsburgh, SOM, S421 BST, 200 Lothrop St, Pittsburgh PA 15261, USA
    Am J Pathol 167:1279-92. 2005
  7. ncbi request reprint beta-Catenin regulation during matrigel-induced rat hepatocyte differentiation
    Satdarshan P S Monga
    Department of Pathology, School of Medicine, University of Pittsburgh, PA, 15261, USA
    Cell Tissue Res 323:71-9. 2006
  8. ncbi request reprint Wnt'er in liver: expression of Wnt and frizzled genes in mouse
    Gang Zeng
    Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 45:195-204. 2007
  9. ncbi request reprint beta-Catenin is critical for early postnatal liver growth
    Udayan Apte
    Depts of Pathology and Medicine, Univ of Pittsburgh School of Medicine, 200 Lothrop St, S 421 BST, Pittsburgh, PA 15216, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1578-85. 2007
  10. ncbi request reprint Wnt/beta-catenin signaling mediates oval cell response in rodents
    Udayan Apte
    Department of Pathology Cellular and Molecular Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Hepatology 47:288-95. 2008

Research Grants

Collaborators

  • Jing Yang
  • Jörg C Gerlach
  • Stephen C Strom
  • George K Michalopoulos
  • Hong Fu
  • Jeffrey Peters
  • M S Rao
  • Anthony Demetris
  • Janardan Reddy
  • Donna Stolz
  • Youhua Liu
  • Xinping Tan
  • Udayan Apte
  • Amanda Micsenyi
  • Gang Zeng
  • Michael D Thompson
  • Benjamin Cieply
  • Peggy Muller
  • Klaus H Kaestner
  • Jaideep Behari
  • Evan Delgado
  • Sandeep S Sekhon
  • Sarangarajan Ranganathan
  • Prince Kwaku Awuah
  • Sucha Singh
  • Peggy Stock
  • Dongsheng Guo
  • Wade Otruba
  • Aaron Bell
  • Dulabh K Monga
  • Dimple Sodhi
  • Jian Hua Luo
  • William C Bowen
  • Tamara Sneddon
  • Sunny Z Hussain
  • Peter Pediaditakis
  • Danith H Ly
  • Jung M Lee
  • Raman Bahal
  • Amalea Misse
  • Byung Han Rhieu
  • Youzhong Yuan
  • Bowen Liu
  • Shanshan Cui
  • Sonal Khare
  • Jennifer E Foreman
  • Joy Sarkar
  • Farrukh Awan
  • H Eric Xu
  • Nick Loizos
  • Kasturi Haldar
  • Lorenzo Leoni
  • Kojiro Matsumoto
  • Dulabh Monga
  • Kelly Suino-Powell
  • Songtao Yu
  • Yong Xu
  • Chandrashekhar Gandhi
  • Yuzhi Jia
  • Chunsun Dai
  • Juan Carlos Lopez Talavera
  • Emorphia Kotsagrelos
  • Wendy M Mars

Detail Information

Publications27

  1. pmc β-Catenin loss in hepatocytes promotes hepatocellular cancer after diethylnitrosamine and phenobarbital administration to mice
    Prince Kwaku Awuah
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e39771. 2012
    ..Catenin downregulation also made hepatoma cells more sensitive to receptor tyrosine kinases and thus may be exploited for therapeutics...
  2. pmc Hepatic regenerative medicine: exploiting the liver's will to live
    Satdarshan P S Monga
    Department of Pathology and Medicine, University of Pittsburgh, Pennsylvania Electronic address
    Am J Pathol 184:306-8. 2014
    ..This Guest Editorial introduces this month's special Liver Pathobiology Theme Issue, a series of reviews that encompass the discipline of hepatic regenerative medicine. ..
  3. pmc β-Catenin knockdown in liver tumor cells by a cell permeable gamma guanidine-based peptide nucleic acid
    Evan Delgado
    Endowed Chair for Experimental Pathology, Director Division of Experimental Pathology EP, Professor of Pathology EP and Medicine GI, Hepatology and Nutrition, University of Pittsburgh School of Medicine, 200 Lothrop Street S 422 BST, Pittsburgh, PA 15261, USA
    Curr Cancer Drug Targets 13:867-78. 2013
    ....
  4. ncbi request reprint Beta-catenin antisense studies in embryonic liver cultures: role in proliferation, apoptosis, and lineage specification
    Satdarshan P S Monga
    Department of Cellular and Molecular Pathology, S421 BST, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Gastroenterology 124:202-16. 2003
    ..The aim of this study was to investigate the role of beta-catenin, a key component of the Wnt pathway, in liver development as well as its normal distribution in developing liver...
  5. pmc Role of Wnt/β-catenin signaling in liver metabolism and cancer
    Satdarshan Pal Singh Monga
    Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15216, United States
    Int J Biochem Cell Biol 43:1021-9. 2011
    ....
  6. pmc Mouse fetal liver cells in artificial capillary beds in three-dimensional four-compartment bioreactors
    Satdarshan P S Monga
    Department of Pathology, McGowan Institute for Regenerative Medicine, and the Department of Pharmacy, University of Pittsburgh, SOM, S421 BST, 200 Lothrop St, Pittsburgh PA 15261, USA
    Am J Pathol 167:1279-92. 2005
    ..Thus, fetal liver cells can survive, proliferate, differentiate, and function in a three-dimensional perfusion culture system while maintaining a progenitor pool, reflecting an important advance in hepatic tissue engineering...
  7. ncbi request reprint beta-Catenin regulation during matrigel-induced rat hepatocyte differentiation
    Satdarshan P S Monga
    Department of Pathology, School of Medicine, University of Pittsburgh, PA, 15261, USA
    Cell Tissue Res 323:71-9. 2006
    ..Thus, beta-catenin undergoes multifactorial regulation during matrigel-induced hepatocyte differentiation and maturation; this induces its stabilization and membrane translocation, possibly contributing to hepatocyte differentiation...
  8. ncbi request reprint Wnt'er in liver: expression of Wnt and frizzled genes in mouse
    Gang Zeng
    Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 45:195-204. 2007
    ..CONCLUSION: These data indicate that most Wnt and frizzled genes are expressed in the liver and might be playing important roles in liver pathobiology via canonical and noncanonical pathways...
  9. ncbi request reprint beta-Catenin is critical for early postnatal liver growth
    Udayan Apte
    Depts of Pathology and Medicine, Univ of Pittsburgh School of Medicine, 200 Lothrop St, S 421 BST, Pittsburgh, PA 15216, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1578-85. 2007
    ..These data indicate that the activation of beta-catenin is critical for early postnatal liver growth and development...
  10. ncbi request reprint Wnt/beta-catenin signaling mediates oval cell response in rodents
    Udayan Apte
    Department of Pathology Cellular and Molecular Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Hepatology 47:288-95. 2008
    ..A dramatic decrease in the A6-positive oval cell numbers in the absence of beta-catenin demonstrated a critical role of beta-catenin in oval cell biology...
  11. ncbi request reprint Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liver
    Dongsheng Guo
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611 3008, USA
    J Biol Chem 282:36766-76. 2007
    ..These observations, therefore, provide information for the first time to indicate that PPARalpha ligands not only serve as PPARalpha agonists but possibly act as CAR antagonists...
  12. ncbi request reprint Conditional deletion of beta-catenin reveals its role in liver growth and regeneration
    Xinping Tan
    Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Gastroenterology 131:1561-72. 2006
    ..The Wnt/beta-catenin pathway plays a role in liver growth and development. To address this conclusively, we used a conditional knockout approach to delete beta-catenin in the liver...
  13. ncbi request reprint Morpholino oligonucleotide-triggered beta-catenin knockdown compromises normal liver regeneration
    Dimple Sodhi
    Department of Pathology, School of Medicine, University of Pittsburgh, S421 BST, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    J Hepatol 43:132-41. 2005
    ..However, beta-catenin continues to be in hepatocyte nucleus and membrane, secondary to its increased gene expression at 6-72 h...
  14. ncbi request reprint Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes
    Satdarshan P S Monga
    Division of Cellular and Molecular Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Cancer Res 62:2064-71. 2002
    ..Part of the multifunctionality of HGF might be attributable to nuclear beta-catenin and the resulting target gene expression...
  15. ncbi request reprint beta-Catenin and met deregulation in childhood Hepatoblastomas
    Sarangarajan Ranganathan
    Department of Pathology, S421 BST, Children s Hospital of Pittsburgh, Pennsylvania 15261, USA
    Pediatr Dev Pathol 8:435-47. 2005
    ..In contrast, Met undergoes a prominent decrease after treatment and thus might be important in pathogenesis of hepatoblastoma...
  16. ncbi request reprint Wnt impacts growth and differentiation in ex vivo liver development
    Sunny Z Hussain
    Department of Pediatric Gastroenterology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Exp Cell Res 292:157-69. 2004
    ..The addition of insulin to the combination of HGF and Wnt provided no growth or differentiation advantage. Our results indicate usefulness of Wnt and HGF in hepatocyte cultures and suggest their balance during normal liver development...
  17. pmc Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver
    Xinping Tan
    Department of Pathology, University of Pittsburgh, School of Medicine, Pennsylvania 15261, USA
    Gastroenterology 129:285-302. 2005
    ..Wnt/beta-catenin activation is observed in normal liver development, regeneration, and liver cancer. Our aim was to elucidate the regulation and mechanism of this pathway in liver...
  18. ncbi request reprint Beta-catenin is temporally regulated during normal liver development
    Amanda Micsenyi
    Department of Pathology, University of Pittsburgh, School of Medicine, PA 15261, USA
    Gastroenterology 126:1134-46. 2004
    ..beta-Catenin, a key component of the Wnt pathway, plays an important role in unregulated liver growth in liver tumors, in regulated growth during liver regeneration, and in ex vivo embryonic liver cultures...
  19. pmc Fibroblast growth factor enriches the embryonic liver cultures for hepatic progenitors
    Sandeep S Sekhon
    Department of Internal Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA
    Am J Pathol 164:2229-40. 2004
    ..FGF8 promotes such enrichment and induces a one-step differentiation toward a unipotential hepatocyte progenitor. Thus, FGFs might be useful for enrichment and propagation of developmental hepatic progenitors...
  20. ncbi request reprint Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development
    Xinping Tan
    Department of Pathology, University of Pennsylvania, School of Medicine, Philadelphia, PA, USA
    Hepatology 47:1667-79. 2008
    ..While the stem cell assays demonstrated no intrinsic defect in hematopoiesis, distorted hepatic architecture and deficient hepatocyte compartments resulted in defective endothelial cell organization leading to overall fetal pallor...
  21. pmc siRNA-mediated beta-catenin knockdown in human hepatoma cells results in decreased growth and survival
    Gang Zeng
    Department of Pathology, University of Pittsburgh, SOM, Pittsburgh, PA 15213, USA
    Neoplasia 9:951-9. 2007
    ..Thus, beta-catenin is essential for the survival and growth of hepatoma cells independent of mutations in the beta-catenin gene and provide a proof of principle for the significance of the therapeutic inhibition of beta-catenin in HCC...
  22. ncbi request reprint Activation of Wnt/beta-catenin pathway during hepatocyte growth factor-induced hepatomegaly in mice
    Udayan Apte
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15216, USA
    Hepatology 44:992-1002. 2006
    ..In conclusion, beta-catenin- and HGF-mediated signaling pathways cooperate in hepatocyte proliferation, which may be crucial in liver development, regeneration following partial hepatectomy, and pathogenesis of hepatocellular carcinoma...
  23. ncbi request reprint Platelet-derived growth factor receptor-alpha: a novel therapeutic target in human hepatocellular cancer
    Peggy Stock
    Department of Pathology, University of Pittsburgh School of Medicine, 200 Lothrop Street, S421 BST Pittsburgh, PA 15213, USA
    Mol Cancer Ther 6:1932-41. 2007
    ..PDGFRalpha inhibition in hepatoma cells led to diminution of tumor cell survival and proliferation and thus might be of therapeutic significance...
  24. ncbi request reprint WNT/beta-catenin signaling in liver health and disease
    Michael D Thompson
    Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 45:1298-305. 2007
    ..In addition, areas that are currently deficient or understudied are identified and discussed along with the avenues of translational and clinical relevance...
  25. pmc R-Etodolac decreases beta-catenin levels along with survival and proliferation of hepatoma cells
    Jaideep Behari
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Hepatol 46:849-57. 2007
    ..Here, we examine the effect of Celecoxib, a COX-2-inhibitor and R-Etodolac, an enantiomer of the nonsteroidal anti-inflammatory drug Etodolac, which lacks COX-inhibitory activity, on the Wnt/beta-catenin pathway and human hepatoma cells...
  26. pmc Tyrosine residues 654 and 670 in beta-catenin are crucial in regulation of Met-beta-catenin interactions
    Gang Zeng
    Department of Pathology CMP, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Exp Cell Res 312:3620-30. 2006
    ..Thus, intact 654 and 670 tyrosine residues in beta-catenin are crucial in HGF-mediated beta-catenin translocation, activation and mitogenesis...
  27. pmc Differential mitogenic effects of single chain hepatocyte growth factor (HGF)/scatter factor and HGF/NK1 following cleavage by factor Xa
    Peter Pediaditakis
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261
    J Biol Chem 277:14109-15. 2002
    ..This suggests mandatory maintenance of a steric interaction of the N domain and the first kringle domain for HGF/NK1 to act as an agonist for rat hepatocyte growth but is not required by full-length HGF/SF...

Research Grants11

  1. Role of Wnt/Beta-Catenin Signaling in Liver Development
    SATDARSHAN SINGH MONGA; Fiscal Year: 2010
    ..Our proposal will comprehensively examine Wnt signaling in liver biology to eventually improve prognosis of liver diseases. ..
  2. Role of Wnt/Beta-Catenin Signaling in Liver Development
    SATDARSHAN MONGA; Fiscal Year: 2004
    ..Thus this study will be a comprehensive analysis of Wnt/beta-catenin pathway and its interactions with HGF in liver development & growth. ..
  3. BETA-CATENIN AS A THERAPEUTIC TARGET IN HEPATOCELLULAR CANCER
    SATDARSHAN MONGA; Fiscal Year: 2009
    ..Thus this proposal will lay the ground work for initiating clinical studies directed against -catenin in HCC. ..
  4. Role of Wnt/Beta-Catenin Signaling in Liver Development
    SATDARSHAN MONGA; Fiscal Year: 2009
    ..Our proposal will comprehensively examine Wnt signaling in liver biology to eventually improve prognosis of liver diseases. ..
  5. BETA-CATENIN AS A THERAPEUTIC TARGET IN HEPATOCELLULAR CANCER
    SATDARSHAN MONGA; Fiscal Year: 2007
    ..Thus this proposal will lay the ground work for initiating clinical studies directed against ¿-catenin in HCC. ..
  6. Role of Wnt/Beta-Catenin Signaling in Liver Development
    SATDARSHAN MONGA; Fiscal Year: 2007
    ..Thus this study will be a comprehensive analysis of Wnt/beta-catenin pathway and its interactions with HGF in liver development & growth. ..
  7. Role of Wnt/Beta-Catenin Signaling in Liver Development
    SATDARSHAN MONGA; Fiscal Year: 2006
    ..Thus this study will be a comprehensive analysis of Wnt/beta-catenin pathway and its interactions with HGF in liver development & growth. ..
  8. Role of Wnt/Beta-Catenin Signaling in Liver Development
    SATDARSHAN MONGA; Fiscal Year: 2005
    ..Thus this study will be a comprehensive analysis of Wnt/beta-catenin pathway and its interactions with HGF in liver development & growth. ..
  9. BETA-CATENIN AS A THERAPEUTIC TARGET IN HEPATOCELLULAR CANCER
    SATDARSHAN SINGH MONGA; Fiscal Year: 2010
    ..Thus this proposal will lay the ground work for initiating clinical studies directed against -catenin in HCC. ..