Satdarshan P Monga

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. Min Q, Molina L, Li J, Adebayo Michael A, Russell J, Preziosi M, et al. β-Catenin and Yes-Associated Protein 1 Cooperate in Hepatoblastoma Pathogenesis. Am J Pathol. 2019;189:1091-1104 pubmed publisher
    ..Thus, we demonstrate that β-catenin point mutants can also collaborate with YAP1 in HB development, albeit with a distinct molecular profile from the deletion mutant, which may have implications in both biology and therapy. ..
  2. Adebayo Michael A, Ko S, Tao J, Moghe A, Yang H, Xu M, et al. Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations. Cell Metab. 2019;: pubmed publisher
    ..Thus, mTORC1 inhibitors could be highly relevant in the treatment of liver tumors that are β-catenin mutated and GS positive. ..
  3. Jiang A, Okabe H, Popovic B, Preziosi M, Pradhan Sundd T, Poddar M, et al. Loss of Wnt Secretion by Macrophages Promotes Hepatobiliary Injury after Administration of 3,5-Diethoxycarbonyl-1, 4-Dihydrocollidine Diet. Am J Pathol. 2019;189:590-603 pubmed publisher
    ..In conclusion, this study shows that a lack of macrophage Wnt secretion leads to more DDC-induced hepatic injury due to impaired hepatocyte proliferation and increased M1 macrophages, which promotes immune-mediated cell injury. ..
  4. Pradhan Sundd T, Vats R, Russell J, Singh S, Michael A, Molina L, et al. Dysregulated Bile Transporters and Impaired Tight Junctions During Chronic Liver Injury in Mice. Gastroenterology. 2018;155:1218-1232.e24 pubmed publisher
    ..We used qLIM to study chronic liver injury, induced by a choline-deficient or DDC diet, in mice. Progression of chronic liver injury was accompanied by loss of bile transporters and tight junction proteins. ..
  5. Molina L, Bell D, Tao J, Preziosi M, Pradhan Sundd T, Singh S, et al. Hepatocyte-Derived Lipocalin 2 Is a Potential Serum Biomarker Reflecting Tumor Burden in Hepatoblastoma. Am J Pathol. 2018;188:1895-1909 pubmed publisher
    ..In conclusion, Lcn2 expressed in hepatocytes appears to be dispensable for the pathogenesis of HB. However, transformed hepatocytes secrete serum Lcn2, making Lcn2 a valuable biomarker for HB. ..
  6. Monga S. Role of Wnt/?-catenin signaling in liver metabolism and cancer. Int J Biochem Cell Biol. 2011;43:1021-9 pubmed publisher
  7. Russell J, Ko S, Saggi H, Singh S, Poddar M, Shin D, et al. Bromodomain and Extraterminal (BET) Proteins Regulate Hepatocyte Proliferation in Hepatocyte-Driven Liver Regeneration. Am J Pathol. 2018;188:1389-1405 pubmed publisher
    ..In both models, Wnt signaling was prominently suppressed by JQ1. Our results show that BET proteins regulate hepatocyte proliferation-driven liver regeneration, and Wnt signaling is particularly sensitive to BET protein inhibition. ..
  8. Zhou L, Pradhan Sundd T, Poddar M, Singh S, Kikuchi A, Stolz D, et al. Mice with Hepatic Loss of the Desmosomal Protein γ-Catenin Are Prone to Cholestatic Injury and Chemical Carcinogenesis. Am J Pathol. 2015;185:3274-89 pubmed publisher
    ..However, after insults like BDL, these compensations at desmosomes fail, and KO show enhanced injury. Also, γ-catenin negatively regulates tumor growth by affecting Wnt signaling. ..
  9. Monga S. β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis. Gastroenterology. 2015;148:1294-310 pubmed publisher
    ..We discuss how alterations in β-catenin activity contribute to liver disease and how these might be used in diagnosis and prognosis, as well as in the development of therapeutics. ..

More Information

Publications18

  1. Delgado E, Okabe H, Preziosi M, Russell J, Alvarado T, Oertel M, et al. Complete response of Ctnnb1-mutated tumours to β-catenin suppression by locked nucleic acid antisense in a mouse hepatocarcinogenesis model. J Hepatol. 2015;62:380-7 pubmed publisher
    ..Thus, we provide the in vivo proof of concept that β-catenin suppression in HCC will be of significant therapeutic benefit, provided the tumours display Wnt activation via mechanisms like CTNNB1 mutations. ..
  2. Tao J, Xu E, Zhao Y, Singh S, Li X, Couchy G, et al. Modeling a human hepatocellular carcinoma subset in mice through coexpression of met and point-mutant ?-catenin. Hepatology. 2016;64:1587-1605 pubmed publisher
    ..Hepatology 2016;64:1587-1605). ..
  3. Preziosi M, Singh S, Valore E, Jung G, Popovic B, Poddar M, et al. Mice lacking liver-specific β-catenin develop steatohepatitis and fibrosis after iron overload. J Hepatol. 2017;67:360-369 pubmed publisher
    ..Administration of an antioxidant prevented hepatic injury in this model. ..
  4. Kikuchi A, Pradhan Sundd T, Singh S, Nagarajan S, Loizos N, Monga S. Platelet-Derived Growth Factor Receptor α Contributes to Human Hepatic Stellate Cell Proliferation and Migration. Am J Pathol. 2017;187:2273-2287 pubmed publisher
    ..Our findings support a distinct contribution of PDGFRα signaling to HSC proliferation and migration and provide evidence that inhibition of PDGFRα signaling could alter the pathogenesis of hepatic fibrosis. ..
  5. Puliga E, Min Q, Tao J, Zhang R, Pradhan Sundd T, Poddar M, et al. Thyroid Hormone Receptor-β Agonist GC-1 Inhibits Met-β-Catenin-Driven Hepatocellular Cancer. Am J Pathol. 2017;187:2473-2485 pubmed publisher
    ..GC-1 does not promote β-catenin activation in HCC. Thus, GC-1 may be safe for use in inducing regeneration during chronic hepatic insufficiency. ..
  6. Wang G, Wang H, Singh S, Zhou P, Yang S, Wang Y, et al. ADAR1 Prevents Liver Injury from Inflammation and Suppresses Interferon Production in Hepatocytes. Am J Pathol. 2015;185:3224-37 pubmed publisher
    ..It inhibits the production of type I interferons and other inflammatory cytokines. Our findings may provide novel insight in the pathogenesis of liver diseases caused by excessive inflammatory responses, including autoimmune hepatitis. ..
  7. Yang J, Cusimano A, Monga J, Preziosi M, Pullara F, Calero G, et al. WNT5A inhibits hepatocyte proliferation and concludes β-catenin signaling in liver regeneration. Am J Pathol. 2015;185:2194-205 pubmed publisher
    ..We also provide evidence that the Wnt5a/Frizzled-2 axis suppresses β-catenin signaling in hepatocytes in an autocrine manner, thereby contributing to timely conclusion of the LR process. ..
  8. Lee J, Yang J, Newell P, Singh S, Parwani A, Friedman S, et al. ?-Catenin signaling in hepatocellular cancer: Implications in inflammation, fibrosis, and proliferation. Cancer Lett. 2014;343:90-7 pubmed publisher
    ..Also, ?-catenin mutations and cirrhosis do not appear to cooperate in HCC pathogenesis in mice and men...
  9. request reprint
    Monga S, Micsenyi A, Germinaro M, Apte U, Bell A. beta-Catenin regulation during matrigel-induced rat hepatocyte differentiation. Cell Tissue Res. 2006;323:71-9 pubmed
    ..Thus, beta-catenin undergoes multifactorial regulation during matrigel-induced hepatocyte differentiation and maturation; this induces its stabilization and membrane translocation, possibly contributing to hepatocyte differentiation. ..