Vera Y Moiseenkova Bell
Affiliation: University of Pennsylvania
Samanta A, Hughes T, Moiseenkova Bell V. Cryo Electron Microscopy of TRP Channels. Methods Mol Biol. 2019;1987:39-50 pubmed publisher
..Proteins in the presence of various ligands or other macromolecular complexes can also be studied by this method. Here, we present a protocol for the purification and vitrification of TRP channels for single particle cryo-EM. ..
Hughes T, Pumroy R, Yazici A, Kasimova M, Fluck E, Huynh K, et al
. Structural insights on TRPV5 gating by endogenous modulators. Nat Commun. 2018;9:4198 pubmed publisher
..Overall, this investigation provides insight into the endogenous modulation of TRPV5, which has the potential to guide drug discovery. ..
Samanta A, Kiselar J, Pumroy R, Han S, Moiseenkova Bell V. Structural insights into the molecular mechanism of mouse TRPA1 activation and inhibition. J Gen Physiol. 2018;150:751-762 pubmed publisher
..Collectively, our results reveal that channel modulation results in conformational rearrangements in the N-terminal ankyrin repeats, the pre-S1 helix, the TRP-like domain, and the linker regions of the channel. ..
Hughes T, Lodowski D, Huynh K, Yazici A, Del Rosario J, Kapoor A, et al
. Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM. Nat Struct Mol Biol. 2018;25:53-60 pubmed publisher
Samanta A, Hughes T, Moiseenkova Bell V. Transient Receptor Potential (TRP) Channels. Subcell Biochem. 2018;87:141-165 pubmed publisher
..Overall, this superfamily of channels is involved in a vast array of physiological and pathophysiological processes making the study of these channels imperative to our understanding of subcellular biochemistry. ..