K J Moise

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi Non-anti-D antibodies in red-cell alloimmunization
    K J Moise
    Division of Maternal Fetal Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, 27599 7570, USA
    Eur J Obstet Gynecol Reprod Biol 92:75-81. 2000
  2. ncbi Management of rhesus alloimmunization in pregnancy
    Kenneth J Moise
    Division of Maternal Fetal Medicine, University of North Carolina School of Medicine, Chapel Hill 27599 7516, USA
    Obstet Gynecol 100:600-11. 2002
  3. ncbi A randomized trial of amnioreduction versus septostomy in the treatment of twin-twin transfusion syndrome
    Kenneth J Moise
    Department of Obstetrics and Gynecology of the University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Am J Obstet Gynecol 193:701-7. 2005
  4. ncbi Umbilical cord stem cells
    Kenneth J Moise
    Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7516, USA
    Obstet Gynecol 106:1393-407. 2005
  5. ncbi Red blood cell alloimmunization in pregnancy
    Kenneth J Moise
    Division of Maternal Fetal Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7516, USA
    Semin Hematol 42:169-78. 2005
  6. ncbi Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. Collaborative Group for Doppler Assessment of the Blood Velocity in Anemic Fetuses
    G Mari
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Conn 06520 8063, USA
    N Engl J Med 342:9-14. 2000
  7. ncbi Correlation between middle cerebral artery peak systolic velocity and fetal hemoglobin after 2 previous intrauterine transfusions
    Giancarlo Mari
    Department of Obstetrics and Gynecology, Wayne State University, Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, MI, USA
    Am J Obstet Gynecol 193:1117-20. 2005
  8. ncbi Fetal splenic rupture following transfusion
    P W Whitecar
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, 214 MacNider Building, CB 7516, Chapel Hill, NC 27599 7516, USA
    Obstet Gynecol 97:824-5. 2001
  9. ncbi Management of Stage I twin-to-twin transfusion syndrome: an international survey
    S Molina
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine and the Texas Children s Fetal Center, Texas Children s Hospital, Houston, TX 77030, USA
    Ultrasound Obstet Gynecol 36:42-7. 2010
  10. ncbi Selective reduction in complicated monochorionic pregnancies: radiofrequency ablation vs. bipolar cord coagulation
    A Roman
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Baylor College of Medicine, USA
    Ultrasound Obstet Gynecol 36:37-41. 2010

Research Grants

  1. ALLOIMMUNIZATION TO PATERNAL LEUKOCYTES FOR HDN
    Kenneth Moise; Fiscal Year: 2002

Detail Information

Publications48

  1. ncbi Non-anti-D antibodies in red-cell alloimmunization
    K J Moise
    Division of Maternal Fetal Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, 27599 7570, USA
    Eur J Obstet Gynecol Reprod Biol 92:75-81. 2000
    ..Review the fetal/neonatal outcome and management of pregnancies associated with alloimmunization to irregular anti-red-cell antibodies...
  2. ncbi Management of rhesus alloimmunization in pregnancy
    Kenneth J Moise
    Division of Maternal Fetal Medicine, University of North Carolina School of Medicine, Chapel Hill 27599 7516, USA
    Obstet Gynecol 100:600-11. 2002
    ..Long-term studies have revealed normal neurologic outcomes in more than 90% of cases. Future therapy will involve selective modulation of the maternal immune system making the need for intrauterine transfusions a rarity...
  3. ncbi A randomized trial of amnioreduction versus septostomy in the treatment of twin-twin transfusion syndrome
    Kenneth J Moise
    Department of Obstetrics and Gynecology of the University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Am J Obstet Gynecol 193:701-7. 2005
    ..Removal of excessive amounts of amniotic fluid through serial amniocenteses (amnioreduction) has been the mainstay of therapy. We sought to compare amnioreduction to intentional perforation of the intervening twin membrane (septostomy)...
  4. ncbi Umbilical cord stem cells
    Kenneth J Moise
    Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7516, USA
    Obstet Gynecol 106:1393-407. 2005
    ..Directed donation of cord blood should be considered when there is a specific diagnosis of a disease within a family known to be amenable to stem cell transplantation...
  5. ncbi Red blood cell alloimmunization in pregnancy
    Kenneth J Moise
    Division of Maternal Fetal Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7516, USA
    Semin Hematol 42:169-78. 2005
    ..A perinatal survival of greater than 85% with normal neurologic outcome is now expected. Future therapies will target specific immune manipulations in the pregnant patient...
  6. ncbi Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. Collaborative Group for Doppler Assessment of the Blood Velocity in Anemic Fetuses
    G Mari
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Conn 06520 8063, USA
    N Engl J Med 342:9-14. 2000
    ..The purpose of our study was to determine the value of noninvasive measurements of the velocity of blood flow in the fetal middle cerebral artery for the diagnosis of fetal anemia...
  7. ncbi Correlation between middle cerebral artery peak systolic velocity and fetal hemoglobin after 2 previous intrauterine transfusions
    Giancarlo Mari
    Department of Obstetrics and Gynecology, Wayne State University, Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, MI, USA
    Am J Obstet Gynecol 193:1117-20. 2005
    ..The objective of this study was to assess whether the correlation between the MCA-PSV and fetal hemoglobin is maintained in fetuses that had undergone 2 previous intrauterine transfusions...
  8. ncbi Fetal splenic rupture following transfusion
    P W Whitecar
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, 214 MacNider Building, CB 7516, Chapel Hill, NC 27599 7516, USA
    Obstet Gynecol 97:824-5. 2001
    ..Splenic rupture in the newborn is a rare complication in erythroblastosis fetalis. There are no reports of splenic rupture in the fetus affected by hemolytic disease of the newborn...
  9. ncbi Management of Stage I twin-to-twin transfusion syndrome: an international survey
    S Molina
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine and the Texas Children s Fetal Center, Texas Children s Hospital, Houston, TX 77030, USA
    Ultrasound Obstet Gynecol 36:42-7. 2010
    ..To determine practice patterns for evaluation and treatment of Stage I twin-to-twin transfusion syndrome (TTTS) among international physicians...
  10. ncbi Selective reduction in complicated monochorionic pregnancies: radiofrequency ablation vs. bipolar cord coagulation
    A Roman
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Baylor College of Medicine, USA
    Ultrasound Obstet Gynecol 36:37-41. 2010
    ..To compare radiofrequency ablation (RFA) and bipolar cord coagulation (BPC) methods for selective fetal reduction in the treatment of complicated monochorionic (MC) multifetal gestations...
  11. ncbi Twin pregnancy complicated by severe hemolytic disease of the fetus and newborn due to anti-g and anti-C
    Thomas N Trevett
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7516, USA
    Obstet Gynecol 106:1178-80. 2005
    ..We report a case of a twin pregnancy affected by both anti-G and anti-C alloantibodies leading to severe hemolytic disease of the fetus and newborn requiring multiple intrauterine transfusions and prolonged postnatal therapy...
  12. ncbi Management of rhesus alloimmunization in pregnancy
    Kenneth J Moise
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine and the Texas Children s Fetal Center, Texas Children s Hospital, Houston, TX 77030, USA
    Obstet Gynecol 112:164-76. 2008
    ..Long-term studies have revealed normal neurologic outcomes in more than 90% of cases. Future therapy will involve selective modulation of the maternal immune system, making the need for intrauterine transfusions a rarity...
  13. ncbi Chorioamnion plugging and the risk of preterm premature rupture of membranes after laser surgery in twin-twin transfusion syndrome
    R Papanna
    The Texas Children s Fetal Center at Texas Children s Hospital, Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Ultrasound Obstet Gynecol 35:337-43. 2010
    ....
  14. ncbi Fetal intraperitoneal transfusion for iatrogenic twin anemia-polycythemia sequence after laser therapy
    C Herway
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine and the Texas Children s Fetal Center, Texas Children s Hospital, Houston, TX 77030, USA
    Ultrasound Obstet Gynecol 33:592-4. 2009
    ..IUT-PTs may be superior to intravascular intrauterine transfusions in the treatment of this condition...
  15. ncbi Ultrasonographic measurement of crown-rump length in high-order multifetal pregnancies
    G R Saade
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA
    Ultrasound Obstet Gynecol 11:438-44. 1998
    ..The mean CRL in multifetal pregnancies increases with GA similarly to that in singletons. The variability of individual measurements increases with the number of fetuses and CRLs are lower in quintuplets...
  16. ncbi Meconium inhibits the contraction of umbilical vessels induced by the thromboxane A2 analog U46619
    L D Montgomery
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Obstet Gynecol 173:1075-8. 1995
    ..It does, however, inhibit the contractile effect of U46619 in both umbilical artery and vein smooth muscle. The inhibitory activity of meconium appears to be concentrated in the lipid fraction...
  17. ncbi Inhaled nitric oxide for primary pulmonary hypertension in pregnancy
    G K Lam
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Obstet Gynecol 98:895-8. 2001
    ..Previous studies have found a 35-50% maternal mortality rate in the peripartum period. To date, most reports have described treatment of these patients with diuretics, digoxin, and calcium-channel blockers...
  18. ncbi Sonographic methods to detect fetal anemia in red blood cell alloimmunization
    P W Whitecar
    Department of Obstetric and Gynecology, University of North Carolina at Chapel Hill 27599 7570, USA
    Obstet Gynecol Surv 55:240-50. 2000
    ..Noninvasive sonographic techniques may reduce the number of invasive procedures that traditionally are used to follow fetuses at risk for anemia and decrease the associated risks from these procedures...
  19. ncbi Combined plasmapheresis and intravenous immune globulin for the treatment of severe maternal red cell alloimmunization
    Michael S Ruma
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of North Carolina, Chapel Hill, NC 27599 7516, USA
    Am J Obstet Gynecol 196:138.e1-6. 2007
    ..The objective of the study was to report the maternal and perinatal outcome in patients with severe red cell alloimmunization in pregnancy who were treated with immunomodulation therapy...
  20. ncbi Determinants of the middle cerebral artery peak systolic velocity in the human fetus
    Amy H Picklesimer
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Obstet Gynecol 197:526.e1-4. 2007
    ..The purpose of this study was to identify physiologic determinants of the peak systolic blood flow velocity (PSV) of the middle cerebral artery (MCA) in the human fetus...
  21. ncbi The impact of gestational age on the sonographic detection of aneuploidy
    Amy H Picklesimer
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Am J Obstet Gynecol 193:1243-7. 2005
    ..The purpose of this study was to identify the influence of gestational age on the detection of sonographic markers of aneuploidy...
  22. ncbi Insulin-like growth factor and interleukin-1beta levels and subsequent fetal size in response to chronic Porphyromonas gingivalis exposure in the pregnant rabbit
    Kim A Boggess
    Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill School of Medicine, 27599, USA
    Am J Obstet Gynecol 193:1219-23. 2005
    ..The purpose of this study was to describe maternal insulin-like growth factor, interleukin-1beta, and fetal size in a rabbit model of Porphyromonas gingivalis exposure...
  23. ncbi Elevated middle cerebral artery peak systolic velocity without fetal anemia in a case of homozygous alpha-thalassemia-1
    Karla Maguire
    Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Prenat Diagn 28:72-4. 2008
  24. ncbi Antenatal maternal administration of phenobarbital for the prevention of exchange transfusion in neonates with hemolytic disease of the fetus and newborn
    Thomas N Trevett
    Divisions of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Am J Obstet Gynecol 192:478-82. 2005
    ..However, EXT can be associated with significant procedure-related morbidity. We hypothesized that maternal oral administration of phenobarbital (PB) to women with HDFN would reduce the rate of EXT...
  25. ncbi Impact of maternal-fetal surgery for myelomeningocele on the progression of ventriculomegaly in utero
    Amy Adelberg
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, USA
    Am J Obstet Gynecol 193:727-31. 2005
    ..Intrauterine myelomeningocele (MMC) repair decreases hindbrain herniation and the need for postnatal ventriculoperitoneal shunting. We examined the impact of intrauterine repair on the progression of ventriculomegaly in utero...
  26. ncbi Chronic maternal and fetal Porphyromonas gingivalis exposure during pregnancy in rabbits
    Kim A Boggess
    Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Am J Obstet Gynecol 192:554-7. 2005
    ..This study was undertaken to develop a rabbit model of maternal exposure to Porphyromonas gingivalis and determine whether fetal or placental exposure occurs...
  27. ncbi Use of maternal plasma for noninvasive determination of fetal RhD status
    Terry C Harper
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Am J Obstet Gynecol 191:1730-2. 2004
    ..Therefore, maternal plasma testing for fetal RhD status represents a new tool in the management of the cases of RhD alloimmunization in pregnancy...
  28. ncbi Paternal leukocyte alloimmunization as a treatment for hemolytic disease of the newborn in a rabbit model
    Paul W Whitecar
    Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Am J Obstet Gynecol 187:977-80. 2002
    ..CONCLUSION: Maternal alloimmunization to paternal leukocytes decreases the severity of hemolytic disease and may play a role in the treatment of severe hemolytic disease of the newborn in humans...
  29. ncbi The role of fetal breathing motions compared with gasping motions in pulmonary airway uptake of intra-amniotic iron dextran
    Jason A Pollack
    Division of Obstetrics, Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver, USA
    Am J Obstet Gynecol 189:958-62. 2003
    ....
  30. ncbi Fetal anemia due to non-Rhesus-D red-cell alloimmunization
    Kenneth J Moise
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Semin Fetal Neonatal Med 13:207-14. 2008
    ..Although most diagnostic protocols used in the management of the RhD-alloimmunized pregnancy can be applied in cases of non-RhD sensitization, Kell (K1 and K2) alloimmunization should be managed more conservatively...
  31. ncbi The usefulness of middle cerebral artery Doppler assessment in the treatment of the fetus at risk for anemia
    Kenneth J Moise
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine, and the Texas Children s Fetal Center, Texas Children s Hospital, Houston, TX 77030, USA
    Am J Obstet Gynecol 198:161.e1-4. 2008
    ....
  32. ncbi Noninvasive determination of fetal RhD status using fetal DNA in maternal serum and PCR
    F Z Bischoff
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Soc Gynecol Investig 6:64-9. 1999
    ....
  33. ncbi Amniotic septostomy for the treatment of twin oligohydramnios-polyhydramnios sequence
    G R Saade
    Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston 77555 1062, USA
    Fetal Diagn Ther 13:86-93. 1998
    ..To report our experience with intentional puncture of the intervening membrane ('septostomy') for the treatment of the twin oligohydramnios-polyhydramnios sequence (TOPS)...
  34. ncbi Use of the World Wide Web in research: randomization in a multicenter clinical trial of treatment for twin-twin transfusion syndrome
    K Dorman
    Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill 27599, USA
    Obstet Gynecol 96:636-9. 2000
    ..To describe the process involved in using the World Wide Web to coordinate a randomized, multicenter international trial of treatment for twin-twin transfusion syndrome...
  35. ncbi Minimizing red blood cell contamination while isolating mononuclear cells from whole blood: the next step for the treatment of severe hemolytic disease of the fetus/newborn
    Garrett K Lam
    Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Am J Obstet Gynecol 189:1012-6. 2003
    ..CONCLUSION: Purification of human blood is possible to produce reasonable mononuclear cell yields with minimal rhesus activity, which makes paternal leukocyte therapy a plausible treatment for severe rhesus alloimmunization...
  36. ncbi A randomized controlled trial of acupuncture for initiation of labor in nulliparous women
    Terry C Harper
    Department of Obstetrics and Gynecology, University of North Carolina, NC, USA
    J Matern Fetal Neonatal Med 19:465-70. 2006
    ..05). CONCLUSION: Acupuncture is well tolerated among term nulliparous women and holds promise in reducing interventions that occur in post-term pregnancies...
  37. ncbi Radiofrequency ablation for selective reduction in the complicated monochorionic gestation
    Kenneth J Moise
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Obstet Gynecol 198:198.e1-5. 2008
    ..This study was undertaken to describe the efficacy and safety of radiofrequency ablation for selective reduction in the treatment of complicated monochorionic gestations...
  38. ncbi Arginine flux and nitric oxide production during human pregnancy and postpartum
    Linda A Goodrum
    Department of Obstetrics and Gynecology, Children s Nutrition Research Center, Baylor College of Medicine, Houston, Texas 77555 0587, USA
    J Soc Gynecol Investig 10:400-5. 2003
    ..To compare second-trimester, third-trimester, and postpartum arginine flux and nitric oxide production using infusions of the stable isotope L-[(15)N(2)]-arginine in normal human gestation...
  39. ncbi Chorioamnion separation as a risk for preterm premature rupture of membranes after laser therapy for twin-twin transfusion syndrome
    Ramesha Papanna
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine, and the Texas Children s Fetal Center, Texas Children s Hospital, Houston, Texas 77030, USA
    Obstet Gynecol 115:771-6. 2010
    ..To compare the outcomes in chorioamnion membrane separation with nonchorioamnion membrane separation cases after fetoscopic laser photocoagulation of placental anastomoses for the treatment of twin to twin transfusion syndrome...
  40. ncbi Treatment of second trimester fetal cytomegalovirus infection with maternal hyperimmune globulin
    Kenneth J Moise
    Prenat Diagn 28:264-5. 2008
  41. ncbi Diagnosing hemolytic disease of the fetus--time to put the needles away?
    Kenneth J Moise
    N Engl J Med 355:192-4. 2006
  42. ncbi Longitudinal assessment of the middle cerebral artery peak systolic velocity in healthy fetuses and in fetuses at risk for anemia
    Laura Detti
    Departments of Obstetrics and Gynecology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH, USA
    Am J Obstet Gynecol 187:937-9. 2002
    ..Our findings expand the clinical applications to which Doppler ultrasonography can be applied in monitoring pregnancies at risk for fetal anemia...
  43. ncbi Noninvasive prenatal RhD testing
    Kenneth J Moise
    Am J Obstet Gynecol 195:e20; author reply e21. 2006
  44. ncbi Fetal RhD typing with free DNA in maternal plasma
    Kenneth J Moise
    Am J Obstet Gynecol 192:663-5. 2005
  45. ncbi A randomized trial for the treatment of TTTS, too little to answer the question
    Anthony Johnson
    Am J Obstet Gynecol 198:608-9; author reply 609. 2008
  46. ncbi Maternal-fetal surgery for spina bifida: on the brink of a new era?
    Kenneth J Moise
    Am J Obstet Gynecol 189:311. 2003
  47. ncbi Preventability of pregnancy-related deaths: results of a state-wide review
    Cynthia J Berg
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Obstet Gynecol 106:1228-34. 2005
    ..We sought to identify all pregnancy-related deaths in North Carolina and conduct a comprehensive review examining ways in which the number of these deaths could potentially be reduced...
  48. ncbi Neurodevelopmental outcome after laser therapy for twin-twin transfusion syndrome
    Kenneth J Moise
    Am J Obstet Gynecol 194:1208-10. 2006

Research Grants1

  1. ALLOIMMUNIZATION TO PATERNAL LEUKOCYTES FOR HDN
    Kenneth Moise; Fiscal Year: 2002
    ..A monocyte monolayer assay will be performed using the spleens and sensitized red cells of the pups from the three serial breedings to determine the level of phagocytosis of the fetal reticuloendothelial system. ..