PETER MOHLER

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Voltage-gated Nav channel targeting in the heart requires an ankyrin-G dependent cellular pathway
    John S Lowe
    Department of Internal Medicine, Division of Cardiology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Cell Biol 180:173-86. 2008
  2. ncbi request reprint Defining the cellular phenotype of "ankyrin-B syndrome" variants: human ANK2 variants associated with clinical phenotypes display a spectrum of activities in cardiomyocytes
    Peter J Mohler
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, USA
    Circulation 115:432-41. 2007
  3. ncbi request reprint Ankyrins and human disease: what the electrophysiologist should know
    Peter J Mohler
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Cardiovasc Electrophysiol 17:1153-9. 2006
  4. pmc Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence
    Peter J Mohler
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
    PLoS ONE 2:e1051. 2007
  5. pmc Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency
    Marina Cerrone
    Division of Cardiology, New York University School of Medicine, New York, NY, USA
    Cardiovasc Res 95:460-8. 2012
  6. ncbi request reprint Molecular basis for PP2A regulatory subunit B56alpha targeting in cardiomyocytes
    Naina Bhasin
    Department of Internal Medicine, Division of Cardiology, University of Iowa Carver College of Medicine, 285 Newton Road, Iowa City, IA 52242, USA
    Am J Physiol Heart Circ Physiol 293:H109-19. 2007
  7. pmc Revisiting ankyrin-InsP3 receptor interactions: ankyrin-B associates with the cytoplasmic N-terminus of the InsP3 receptor
    Crystal F Kline
    Department of Internal Medicine, Division of Cardiology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Cell Biochem 104:1244-53. 2008
  8. ncbi request reprint Targeting and stability of Na/Ca exchanger 1 in cardiomyocytes requires direct interaction with the membrane adaptor ankyrin-B
    Shane R Cunha
    Department of Internal Medicine, Division of Cardiology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 282:4875-83. 2007
  9. ncbi request reprint Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cells
    Krishnakumar Kizhatil
    Howard Hughes Medical Institute and Departments of Cell Biology, Biochemistry, and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 282:2029-37. 2007
  10. ncbi request reprint Weighing in on molecular anchors: the role of ankyrin polypeptides in human arrhythmia
    Crystal F Kline
    Vanderbilt University School of Medicine, Graduate Program in Pathology, Nashville, TN 37232, USA
    Expert Rev Cardiovasc Ther 4:477-85. 2006

Collaborators

Detail Information

Publications33

  1. pmc Voltage-gated Nav channel targeting in the heart requires an ankyrin-G dependent cellular pathway
    John S Lowe
    Department of Internal Medicine, Division of Cardiology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Cell Biol 180:173-86. 2008
    ..These data are the first report of a cellular pathway required for Na(v) channel trafficking in the heart and suggest that ankyrin-G is critical for cardiac depolarization and Na(v) channel organization in multiple excitable tissues...
  2. ncbi request reprint Defining the cellular phenotype of "ankyrin-B syndrome" variants: human ANK2 variants associated with clinical phenotypes display a spectrum of activities in cardiomyocytes
    Peter J Mohler
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, USA
    Circulation 115:432-41. 2007
    ..More importantly, there is no cellular explanation for the range of severity of cardiac phenotypes associated with specific ANK2 variants...
  3. ncbi request reprint Ankyrins and human disease: what the electrophysiologist should know
    Peter J Mohler
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Cardiovasc Electrophysiol 17:1153-9. 2006
    ..Moreover, these data define an exciting new field of cardiac "channelopathies" due to defects in proper channel targeting/localization...
  4. pmc Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence
    Peter J Mohler
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
    PLoS ONE 2:e1051. 2007
    ..Together these findings suggest a constellation of traits that we term "ankyrin-B syndrome", which may contribute to both aging-related disorders and enhanced cardiac function...
  5. pmc Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency
    Marina Cerrone
    Division of Cardiology, New York University School of Medicine, New York, NY, USA
    Cardiovasc Res 95:460-8. 2012
    ..We sought to characterize the morphology, histology, and ultrastructural features of PKP2-heterozygous-null (PKP2-Hz) murine hearts and explore the relation between PKP2 abundance, I(Na) function, and cardiac electrical synchrony...
  6. ncbi request reprint Molecular basis for PP2A regulatory subunit B56alpha targeting in cardiomyocytes
    Naina Bhasin
    Department of Internal Medicine, Division of Cardiology, University of Iowa Carver College of Medicine, 285 Newton Road, Iowa City, IA 52242, USA
    Am J Physiol Heart Circ Physiol 293:H109-19. 2007
    ..These new data implicate ankyrin-B as a critical targeting component for PP2A in heart and identify a new class of signaling proteins targeted by ankyrin polypeptides...
  7. pmc Revisiting ankyrin-InsP3 receptor interactions: ankyrin-B associates with the cytoplasmic N-terminus of the InsP3 receptor
    Crystal F Kline
    Department of Internal Medicine, Division of Cardiology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Cell Biochem 104:1244-53. 2008
    ..In summary, our findings demonstrate that the ankyrin-binding site is located on the cytoplasmic face of the InsP(3) receptor, thus validating the feasibility of in vivo ankyrin-InsP(3) receptor interactions...
  8. ncbi request reprint Targeting and stability of Na/Ca exchanger 1 in cardiomyocytes requires direct interaction with the membrane adaptor ankyrin-B
    Shane R Cunha
    Department of Internal Medicine, Division of Cardiology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 282:4875-83. 2007
    ..These results raise exciting new questions regarding potentially dynamic roles for ankyrin proteins in the biogenesis and maintenance of specialized membrane domains in excitable cells...
  9. ncbi request reprint Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cells
    Krishnakumar Kizhatil
    Howard Hughes Medical Institute and Departments of Cell Biology, Biochemistry, and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 282:2029-37. 2007
    ..These results demonstrate that ankyrin-G and beta(2)-spectrin are functional partners in biogenesis of the lateral membrane of epithelial cells...
  10. ncbi request reprint Weighing in on molecular anchors: the role of ankyrin polypeptides in human arrhythmia
    Crystal F Kline
    Vanderbilt University School of Medicine, Graduate Program in Pathology, Nashville, TN 37232, USA
    Expert Rev Cardiovasc Ther 4:477-85. 2006
    ....
  11. pmc Cardiac cytoskeleton and arrhythmia: an unexpected role for protein 4.1R in cardiac excitability
    Shane R Cunha
    Circ Res 103:779-81. 2008
  12. ncbi request reprint Cardiac ankyrins: Essential components for development and maintenance of excitable membrane domains in heart
    Shane R Cunha
    Department of Pathology, Vanderbilt University Medical School, Nashville, TN 37232, USA
    Cardiovasc Res 71:22-9. 2006
    ....
  13. ncbi request reprint Isoform specificity of ankyrin-B: a site in the divergent C-terminal domain is required for intramolecular association
    Khadar M Abdi
    Howard Hughes Medical Institute, and Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Biol Chem 281:5741-9. 2006
    ..Taken together these results suggest a model of an extended and unstructured C-terminal domain folding back to bind and potentially regulate the membrane-binding domain of ankyrin-B...
  14. pmc Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain
    Peter J Mohler
    Department of Pathology, Vanderbilt University, Nashville, Tennessee, USA
    PLoS Biol 3:e423. 2005
    ..Ankyrin-B also is not abundantly expressed in smooth muscle. We propose that the ankyrin-B-based complex is a specialized adaptation of cardiomyocytes with a role for cytosolic Ca2+ modulation...
  15. ncbi request reprint Biochemical assays for studying indirect interactions between CFTR and the cytoskeleton
    Peter J Mohler
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC, USA
    Methods Mol Med 70:383-94. 2002
  16. ncbi request reprint Ankyrins
    Peter J Mohler
    Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, NC 27513, USA
    J Cell Sci 115:1565-6. 2002
  17. ncbi request reprint Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death
    Peter J Mohler
    Howard Hughes Medical Institute and Departments of Cell Biology, Biochemistry, and Neuroscience, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 421:634-9. 2003
    ..Thus, we identify a new mechanism for cardiac arrhythmia due to abnormal coordination of multiple functionally related ion channels and transporters...
  18. ncbi request reprint FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death
    Xander H T Wehrens
    Department of Physiology and Cellular Biophysics, Center for Molecular Cardiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Cell 113:829-40. 2003
    ..6 for RyR2 and increased single-channel activity under conditions that simulate exercise. These data suggest that "leaky" RyR2 channels can trigger fatal cardiac arrhythmias, providing a possible explanation for CPVT...
  19. ncbi request reprint The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes
    Peter J Mohler
    Howard Hughes Medical Institute and Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:10599-607. 2002
    ..C-terminal domains are the most divergent between ankyrin isoforms and are candidates to encode the signal(s) that enable ankyrins to selectively target proteins to diverse cellular sites...
  20. ncbi request reprint Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B
    Peter J Mohler
    Howard Hughes Medical Institute and Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Biol Chem 279:12980-7. 2004
    ..These new results provide the first physiological evidence of a molecular partner required for early post-translational stability of InsP(3)R...
  21. ncbi request reprint Isoform specificity among ankyrins. An amphipathic alpha-helix in the divergent regulatory domain of ankyrin-b interacts with the molecular co-chaperone Hdj1/Hsp40
    Peter J Mohler
    Howard Hughes Medical Institute and Departments of Cell Biology, Biochemistry, and Neurosciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 279:25798-804. 2004
    ....
  22. pmc A cardiac arrhythmia syndrome caused by loss of ankyrin-B function
    Peter J Mohler
    Howard Hughes Medical Institute and Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 101:9137-42. 2004
    ....
  23. ncbi request reprint Ankyrin-based cardiac arrhythmias: a new class of channelopathies due to loss of cellular targeting
    Peter J Mohler
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Curr Opin Cardiol 20:189-93. 2005
    ..The focus is on ankyrins, a family of proteins that localize diverse membrane ion channels and transporters, and recent evidence that mutations affecting functions of ankyrins result in cardiac arrhythmia...
  24. pmc Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes
    Peter J Mohler
    Howard Hughes Medical Institute and Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 101:17533-8. 2004
    ..Together with previous work in neurons, these results in cardiomyocytes suggest that ankyrin-G participates in a common pathway for localization of voltage-gated Na(v) channels at sites of function in multiple excitable cell types...
  25. ncbi request reprint Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes
    Peter J Mohler
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 279:40185-93. 2004
    ..This work also establishes a functional hierarchy in which ankyrin-B determines the localization of beta(2)-spectrin and operates independently of beta(2)-spectrin in its role in organizing membrane-spanning proteins...
  26. ncbi request reprint L-type Ca2+ channel facilitation mediated by phosphorylation of the beta subunit by CaMKII
    Chad E Grueter
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Mol Cell 23:641-50. 2006
    ..These findings reveal a molecular mechanism for targeting CaMKII to LTCCs and facilitating I(Ca) that may modulate Ca(2+) entry in diverse cell types coexpressing CaMKII and the beta(2a) subunit...
  27. ncbi request reprint Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affe
    Stephan E Lehnart
    Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, P and S 9 401 box 22, 630 W 168 St, New York, NY 10032, USA
    Circulation 116:2325-45. 2007
    ....
  28. ncbi request reprint Identification of a novel isoform of microsomal triglyceride transfer protein
    Peter J Mohler
    Department of Internal Medicine, University of Iowa School of Medicine, Iowa City, IA 52242, USA
    J Biol Chem 282:26981-8. 2007
    ..However, in nonlipoprotein-secreting cells, such as the adipocyte, MTP-B may have different localization properties, perhaps reflecting a distinct role in lipid storage and mobilization...
  29. doi request reprint New insights into genetic causes of sinus node disease and atrial fibrillation
    Peter J Mohler
    J Cardiovasc Electrophysiol 19:516-8. 2008
  30. pmc A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation
    Jeffrey R Erickson
    Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1109, USA
    Cell 133:462-74. 2008
    ..Our data demonstrate a dynamic mechanism for CaMKII activation by oxidation and highlight the critical importance of oxidation-dependent CaMKII activation to AngII and ischemic myocardial apoptosis...
  31. ncbi request reprint Calmodulin kinase II inhibition enhances ischemic preconditioning by augmenting ATP-sensitive K+ current
    Jingdong Li
    Departments of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 1081, USA
    Channels (Austin) 1:387-94. 2007
    ..Our study results show CaMKII inhibition enhances beneficial effects of IP by increasing I(KATP)...
  32. ncbi request reprint Defects in ankyrin-based cellular pathways in metazoan physiology
    Peter J Mohler
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Front Biosci 10:2832-40. 2005
    ..This review will provide an overview of the ankyrin family and highlight seminal findings in the field which have linked dysfunction in ankyrin-based pathways with defects in metazoan physiology and human disease...
  33. ncbi request reprint Mechanisms of human arrhythmia syndromes: abnormal cardiac macromolecular interactions
    Peter J Mohler
    Department of Internal Medicine, Division of Cardiology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Physiology (Bethesda) 22:342-50. 2007
    ..The association of genetic defects in regulatory and targeting proteins to inherited arrhythmia syndromes has led to a better understanding of the critical role these proteins play in ion channel modulation...

Research Grants12

  1. Dysfunction in Ankyrin-based Pathways and Human Arrythmia
    PETER MOHLER; Fiscal Year: 2006
    ..5 targeting pathway and identification/characterization of ankyrin-G-interacting proteins for effects on ankyrin-G/ Nav1.5 localization and expression. ..
  2. Molecular Mechanisms of Ankyrin-B-based Arrhythmia
    Peter J Mohler; Fiscal Year: 2010
    ....
  3. Dysfunction in Ankyrin-based Pathways and Human Arrythmia
    PETER MOHLER; Fiscal Year: 2009
    ..5 targeting pathway and identification/characterization of ankyrin-G-interacting proteins for effects on ankyrin-G/ Nav1.5 localization and expression. ..
  4. Dysfunction in Ankyrin-based Pathways and Human Arrythmia
    Peter J Mohler; Fiscal Year: 2010
    ..5 targeting pathway and identification/characterization of ankyrin-G-interacting proteins for effects on ankyrin-G/ Nav1.5 localization and expression. ..
  5. Molecular Mechanisms of Ankyrin-B-based Arrhythmia
    PETER MOHLER; Fiscal Year: 2007
    ....
  6. Dysfunction in Ankyrin-based Pathways and Human Arrythmia
    PETER MOHLER; Fiscal Year: 2007
    ..5 targeting pathway and identification/characterization of ankyrin-G-interacting proteins for effects on ankyrin-G/ Nav1.5 localization and expression. ..
  7. Role of spectrin/ankyrin-G complex in myocyte signaling and cardiac excitability
    Peter J Mohler; Fiscal Year: 2011
    ....