E R Mohler

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Carotid stenting for atherothrombosis
    Emile R Mohler
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Heart 93:1147-51. 2007
  2. pmc Endothelial function and weight loss: comparison of low-carbohydrate and low-fat diets
    Emile R Mohler
    Department of Medicine, Cardiovascular Division, Section of Vascular Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 21:504-9. 2013
  3. doi request reprint Progression of asymptomatic peripheral artery disease over 1 year
    Emile R Mohler
    Department of Medicine, Cardiovascular Division, Section of Vascular Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Vasc Med 17:10-6. 2012
  4. pmc Hypercholesterolemia suppresses Kir channels in porcine bone marrow progenitor cells in vivo
    Emile R Mohler
    Department of Medicine, Cardiovascular Division, Section of Vascular Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biochem Biophys Res Commun 358:317-24. 2007
  5. ncbi request reprint A randomized, double-blind trial comparing the effects of amlodipine besylate/benazepril HCl vs amlodipine on endothelial function and blood pressure
    Emile R Mohler
    Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 8:692-8. 2006
  6. ncbi request reprint Impaired exercise-induced blood volume in type 2 diabetes with or without peripheral arterial disease measured by continuous-wave near-infrared spectroscopy
    Emile R Mohler
    Cardiovascular Division, Vascular Medicine Section, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Diabetes Care 29:1856-9. 2006
  7. ncbi request reprint Aortic valve calcium content does not predict aortic valve area
    Emile R Mohler
    Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Heart Valve Dis 15:322-8. 2006
  8. ncbi request reprint Effect of statin treatment on aortic valve and coronary artery calcification
    Emile R Mohler
    Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, University Hospital, Philadelphia 19104, USA
    J Heart Valve Dis 16:378-86. 2007
  9. ncbi request reprint Utility and barriers to performance of the ankle-brachial index in primary care practice
    Emile R Mohler
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Vasc Med 9:253-60. 2004
  10. ncbi request reprint Mechanisms of aortic valve calcification
    Emile R Mohler
    Cardiovascular Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Cardiol 94:1396-402, A6. 2004

Research Grants

  1. CARDIAC VALVE CALCIFICATION
    Emile Mohler; Fiscal Year: 2003
  2. Research career training in vascular medicine
    Emile Mohler; Fiscal Year: 2007

Detail Information

Publications82

  1. pmc Carotid stenting for atherothrombosis
    Emile R Mohler
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Heart 93:1147-51. 2007
    ..This is a review of the current understanding of carotid atherothrombosis and data regarding percutaneous approaches for those with this condition...
  2. pmc Endothelial function and weight loss: comparison of low-carbohydrate and low-fat diets
    Emile R Mohler
    Department of Medicine, Cardiovascular Division, Section of Vascular Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 21:504-9. 2013
    ..A 2-year prospective study (n = 121) was conducted to examine: (1) the effect of obesity and weight loss (either a low-carbohydrate or and low-fat diet) on flow mediated vasodilatation (FMD), a measure of endothelial function...
  3. doi request reprint Progression of asymptomatic peripheral artery disease over 1 year
    Emile R Mohler
    Department of Medicine, Cardiovascular Division, Section of Vascular Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Vasc Med 17:10-6. 2012
    ....
  4. pmc Hypercholesterolemia suppresses Kir channels in porcine bone marrow progenitor cells in vivo
    Emile R Mohler
    Department of Medicine, Cardiovascular Division, Section of Vascular Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biochem Biophys Res Commun 358:317-24. 2007
    ..We further asses the hypercholesterolemia sensitivity of Kir channels in BM-SP cells, which may play a key role in hypercholesterolemia-mediated regulation of EPCs...
  5. ncbi request reprint A randomized, double-blind trial comparing the effects of amlodipine besylate/benazepril HCl vs amlodipine on endothelial function and blood pressure
    Emile R Mohler
    Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 8:692-8. 2006
    ..6/-12.3 mm Hg) than with monotherapy (-14.8/-9.1 mm Hg). A highly positive correlation between change in systolic blood pressure and change in percent of flow-mediated vasodilation was demonstrated only for combination treatment...
  6. ncbi request reprint Impaired exercise-induced blood volume in type 2 diabetes with or without peripheral arterial disease measured by continuous-wave near-infrared spectroscopy
    Emile R Mohler
    Cardiovascular Division, Vascular Medicine Section, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Diabetes Care 29:1856-9. 2006
    ..However, the pathophysiology involved in PAD is unclear. This study was conducted to evaluate the hemodynamic response to exercise of patients with and without diabetes and PAD...
  7. ncbi request reprint Aortic valve calcium content does not predict aortic valve area
    Emile R Mohler
    Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Heart Valve Dis 15:322-8. 2006
    ..The study aim was to evaluate the relationship between AVA as measured with echocardiography compared to calcium quantification using electron beam computed tomography (EBT)...
  8. ncbi request reprint Effect of statin treatment on aortic valve and coronary artery calcification
    Emile R Mohler
    Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, University Hospital, Philadelphia 19104, USA
    J Heart Valve Dis 16:378-86. 2007
    ..The study aim was to evaluate the concomitant effect of statin treatment on aortic valve and coronary artery calcification and to compare results with the inflammatory status of the patient...
  9. ncbi request reprint Utility and barriers to performance of the ankle-brachial index in primary care practice
    Emile R Mohler
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Vasc Med 9:253-60. 2004
    ..The ABI is a simple peripheral arterial disease detection tool that can be successfully applied in primary care office practices...
  10. ncbi request reprint Mechanisms of aortic valve calcification
    Emile R Mohler
    Cardiovascular Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Cardiol 94:1396-402, A6. 2004
    ..Current evidence indicates that modification of atherosclerotic risk factors will slow the progression of aortic valve calcification, and valve risk factors should be addressed in all patients who have aortic valve calcification...
  11. ncbi request reprint Cardiovascular function in normotensive offspring of persons with essential hypertension and black race
    Emile R Mohler
    Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Clin Hypertens (Greenwich) 9:506-12. 2007
    ..These same studies demonstrated some early changes in vascular function based on sex...
  12. ncbi request reprint Should troponin and creatinine kinase be routinely measured after vascular surgery?
    Emile R Mohler
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Vasc Med 12:175-81. 2007
    ..9%) for predicting a CVE. The optimum time for measuring cTn-I after surgery with the highest positive predictive value was 24 hours. In conclusion, these data support routine serial measurement of cTn-I after vascular surgery...
  13. doi request reprint The effect of darapladib on plasma lipoprotein-associated phospholipase A2 activity and cardiovascular biomarkers in patients with stable coronary heart disease or coronary heart disease risk equivalent: the results of a multicenter, randomized, double-bl
    Emile R Mohler
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 51:1632-41. 2008
    ..This study examined the effects of darapladib, a selective lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) inhibitor, on biomarkers of cardiovascular (CV) risk...
  14. doi request reprint Diabetes reduces bone marrow and circulating porcine endothelial progenitor cells, an effect ameliorated by atorvastatin and independent of cholesterol
    Emile R Mohler
    Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cytometry A 75:75-82. 2009
    ..These data suggest a model wherein accelerated atherosclerosis seen with DM may, in part, result from reduction in EPCs which may be ameliorated by treatment with a statin...
  15. doi request reprint Combination antiplatelet therapy in patients with peripheral arterial disease: is the best therapy aspirin, clopidogrel, or both?
    Emile R Mohler
    Department of Medicine, Cardiovascular Division, Vascular Medicine Section, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Catheter Cardiovasc Interv 74:S1-6. 2009
    ..Further studies are needed to establish the optimal antiplatelet therapy in the management and prevention of PAD...
  16. doi request reprint Transillumination of the fingers for vascular anomalies: a novel method for evaluating hereditary hemorrhagic telangiectasia
    Emile R Mohler
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Genet Med 11:356-8. 2009
    ..We describe a novel approach for detecting vascular abnormalities deep in the digits by means of a handheld illuminator...
  17. pmc High-frequency ultrasound for evaluation of intimal thickness
    Emile R Mohler
    Department of Medicine, Cardiovascular Division, Section of Vascular Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Am Soc Echocardiogr 22:1129-33. 2009
    ..Although atherosclerosis occurs in the intima, this arterial layer is not measured alone because of the limitation in ultrasound resolution with standard-frequency probes...
  18. doi request reprint Effect of darbepoetin alfa on endothelial progenitor cells and vascular reactivity in chronic kidney disease
    Emile R Mohler
    Department of Medicine, Cardiovascular Division, Vascular Medicine Section, University of Pennsylvania School of Medicine, PA, USA
    Vasc Med 16:183-9. 2011
    ....
  19. ncbi request reprint The effect of risk factor changes on peripheral arterial disease and cardiovascular risk
    Emile R Mohler
    Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Curr Drug Targets Cardiovasc Haematol Disord 4:259-63. 2004
    ..Risk factor modification in conjunction with antiplatelet treatment results in decreased heart attack, stroke and peripheral vascular events in patients with PAD...
  20. ncbi request reprint Effects of cilostazol on resting ankle pressures and exercise-induced ischemia in patients with intermittent claudication
    E R Mohler
    University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Vasc Med 6:151-6. 2001
    ..0039) and 0.04 (p = 0.0001) in the cilostazol 100 mg and 50 mg bid groups, respectively. In conclusion, following 24 weeks of treatment, cilostazol increased the ABI at rest and improved the recovery time of ankle pressures post-exercise...
  21. ncbi request reprint Peripheral arterial disease: identification and implications
    Emile R Mohler
    Cardiovascular Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Arch Intern Med 163:2306-14. 2003
    ..Once diagnosed, risk factor modification, symptomatic relief, and secondary prevention strategies with antiplatelet agents form the core of medical management of PAD...
  22. ncbi request reprint Treatment of intermittent claudication with beraprost sodium, an orally active prostaglandin I2 analogue: a double-blinded, randomized, controlled trial
    Emile R Mohler
    University of Pennsylvania School of Medicine, Philadelphia Heart Institute, Room 432, 51 North 39th Street, Philadelphia, PA 19104, USA
    J Am Coll Cardiol 41:1679-86. 2003
    ..In the current study, we hypothesized that beraprost would: 1) improve treadmill exercise performance and quality of life; and 2) decrease rates of ischemic events in patients with intermittent claudication...
  23. ncbi request reprint Management of peripheral arterial disease patients: comparing the ACC/AHA and TASC-II guidelines
    Emile Mohler
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Curr Med Res Opin 24:2509-22. 2008
    ..Peripheral arterial disease (PAD) is a common manifestation of systemic atherosclerosis associated with a high risk of morbidity and mortality from cardiovascular events. Despite this, PAD is often undiagnosed and, therefore, undertreated...
  24. ncbi request reprint Therapeutic thrombin injection of pseudoaneurysms: a multicenter experience
    E R Mohler
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Vasc Med 6:241-4. 2001
    ..This procedure should be considered as the initial therapeutic approach for peripheral pseudoaneurysms...
  25. ncbi request reprint Adenoviral-mediated gene transfer of vascular endothelial growth factor in critical limb ischemia: safety results from a phase I trial
    Emile R Mohler
    Department of Internal Medicine, Section of Vascular Medicine, Division of Cardiology, University of Pennsylvania Health System, Philadelphia, PA, USA
    Vasc Med 8:9-13. 2003
    ..CI-1023 appears to be well tolerated and safe for single-dose administration in patients with critical limb ischemia due to PAD. Further studies are needed to determine the efficacy of this form of therapeutic angiogenesis...
  26. ncbi request reprint A novel ultrasound method for evaluation of collateral development in limb ischemia
    Emile R Mohler
    Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Vasc Med 7:169-75. 2002
    ..This non-invasive method is useful to quantify blood flow, visualize angiogenesis and determine areas of persistent lower limb ischemia, and may have an important role in evaluating new approaches to modulate angiogenesis...
  27. ncbi request reprint Cholesterol reduction with atorvastatin improves walking distance in patients with peripheral arterial disease
    Emile R Mohler
    Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 108:1481-6. 2003
    ..The purpose of this study was to determine whether cholesterol lowering with atorvastatin improves walking performance in patients with intermittent claudication...
  28. ncbi request reprint Coronary artery calcification at electron beam computed tomography is increased in asymptomatic type 2 diabetics independent of traditional risk factors
    Megan L Wolfe
    Department of Medicine, University of Pennsylvania, 421 Curie Boulevard, 815 BRB2 3, Philadelphia, PA 19104, USA
    J Cardiovasc Risk 9:369-76. 2002
    ..We hypothesized that the presence and extent of CAC would be greater in asymptomatic type 2 diabetics than in non-diabetics independent of traditional risk factors...
  29. ncbi request reprint Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent cl
    Sanjay Rajagopalan
    Department of Internal Medicine, Section of Vascular Medicine, Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, USA
    Circulation 108:1933-8. 2003
    ....
  30. doi request reprint Site-specific atherogenic gene expression correlates with subsequent variable lesion development in coronary and peripheral vasculature
    Emile R Mohler
    University of Pennsylvania, Philadelphia, PA 19104, USA
    Arterioscler Thromb Vasc Biol 28:850-5. 2008
    ..We hypothesized that genes in the vasculature related to cholesterol metabolism, inflammation, and insulin signaling pathways are differentially regulated in a site-specific and time-dependent manner...
  31. ncbi request reprint Role of lipoprotein-associated phospholipase A2 in leukocyte activation and inflammatory responses
    Yi Shi
    Department of Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Atherosclerosis 191:54-62. 2007
    ..To explore the biologic role of Lp-PLA2 in atherosclerosis, we examined its expression and contribution to leukocyte activation under proatherogenic conditions...
  32. doi request reprint Following the arterial switch operation, obese children have risk factors for early cardiovascular disease
    Sara K Pasquali
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Congenit Heart Dis 5:16-24. 2010
    ..Obesity may also pose cardiovascular risk. The purpose of this study was to evaluate comorbidities and markers of early cardiovascular disease in obese ASO patients...
  33. ncbi request reprint Effect of acute exercise on endothelial progenitor cells in patients with peripheral arterial disease
    Rebecca Gusic Shaffer
    Department of Medicine, Cardiovascular Division, Flow Cytometry and Cell Sorting Resource Laboratory, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Vasc Med 11:219-26. 2006
    ..Our findings suggest that aging may reduce baseline circulating levels of PCs, but not EPCs or ECs, and that exercise-induced mobilization of subsets may differ depending on age and presence of PAD...
  34. ncbi request reprint Role of cytokines in the mechanism of action of amlodipine: the PRAISE Heart Failure Trial. Prospective Randomized Amlodipine Survival Evaluation
    E R Mohler
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Am Coll Cardiol 30:35-41. 1997
    ..We postulated that TNF-alpha and IL-6 levels may also have predictive value in patients with congestive heart failure (CHF)...
  35. pmc Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis
    S G Chu
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Thromb Haemost 8:148-56. 2010
    ..Platelet activity is a major culprit in atherothrombotic events. MPV, which is widely available in clinical practice, is a potentially useful biomarker of platelet activity in the setting of cardiovascular disease...
  36. pmc Selective PKC beta inhibition with ruboxistaurin and endothelial function in type-2 diabetes mellitus
    Nehal N Mehta
    Cardiovascular Institute, University of Pennsylvania Medical Center, 909 BRB 2 3, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Cardiovasc Drugs Ther 23:17-24. 2009
    ..Prior studies demonstrate beneficial effects of PKC beta inhibition on microvascular parameters, but, to date, no study has examined the effect on macrovascular atherosclerotic readouts...
  37. ncbi request reprint Hypercholesterolemia suppresses inwardly rectifying K+ channels in aortic endothelium in vitro and in vivo
    Yun Fang
    Institute for Medicine and Engineering, Department of Pathology and Laboratory Medicine, University of Pennsylvania, USA
    Circ Res 98:1064-71. 2006
    ..Therefore, we suggest that suppression of Kir current is one of the important factors in hypercholesterolemia-induced endothelial dysfunction...
  38. ncbi request reprint Paradoxical effects of statins on aortic valve myofibroblasts and osteoblasts: implications for end-stage valvular heart disease
    Bing Wu
    Cardiovascular Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Arterioscler Thromb Vasc Biol 25:592-7. 2005
    ..We evaluated the effects of statins on aortic valve myofibroblasts (AVMFs) and osteoblast calcification in vitro...
  39. ncbi request reprint Electron beam computed tomography for the quantification of aortic valvular calcification
    J R Kizer
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Heart Valve Dis 10:361-6. 2001
    ..EBCT holds promise in the longitudinal assessment of valvular calcification progression and its response to potential medical therapies...
  40. ncbi request reprint Cilostazol: treatment of intermittent claudication
    M P Reilly
    Cardiovascular Division, Department of Medicine, School of Medicine, University of Pennsylvania, 432 PHI Bldg, 51 North 39th St, Philadelphia, PA 19104-2699, USA
    Ann Pharmacother 35:48-56. 2001
    ..Clinical trials demonstrating a significant improvement in walking distances with cilostazol therapy suggest that it will be an important tool in improving symptoms and quality of life in patients with intermittent claudication...
  41. pmc Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development
    Robert L Wilensky
    Hospital of the University of Pennsylvania, 3400 Spruce Street, 9 Gates, Philadelphia, Pennsylvania 19104, USA
    Nat Med 14:1059-66. 2008
    ....
  42. ncbi request reprint Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies
    Guoqiang Yu
    University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 10:024027. 2005
    ..The instrument thus provides a method for evaluation of microcirculation and muscle metabolism in patients with vascular diseases...
  43. pmc Emerging diagnostic and therapeutic molecular imaging applications in vascular disease
    Luis H Eraso
    Cardiovascular Division, Vascular Medicine Section, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Vasc Med 16:145-56. 2011
    ..A special emphasis is given to vascular ultrasound applications, considering the important role this imaging platform plays in the clinical and research practice of the vascular medicine specialty...
  44. ncbi request reprint Bone formation in carotid plaques: a clinicopathological study
    Jennifer L Hunt
    University of Pittsburgh Medical Center, Department of Pathology and Laboratory Medicine, Philadelphia, USA
    Stroke 33:1214-9. 2002
    ..The purpose of this study was to determine whether bone formation and extensive dystrophic calcification are associated with stable plaques and protective against ischemic vascular events...
  45. pmc Statistical design of personalized medicine interventions: the Clarification of Optimal Anticoagulation through Genetics (COAG) trial
    Benjamin French
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, Pennsylvania 19104, USA
    Trials 11:108. 2010
    ....
  46. pmc Akt pathway is hypoactivated by synergistic actions of diabetes mellitus and hypercholesterolemia resulting in advanced coronary artery disease
    Damir Hamamdzic
    Cardiovascular Division, Hospital of University of Pennsylvania and Cardiovascular Institute, University of Pennsylvania 19104, USA
    Am J Physiol Heart Circ Physiol 299:H699-706. 2010
    ..Our results revealed a synergistic effect of DM and HC in triggering abnormal Akt signaling, resulting in advanced atherosclerosis...
  47. doi request reprint Cytometric fingerprinting: quantitative characterization of multivariate distributions
    Wade T Rogers
    Cira Discovery Sciences, Inc, Philadelphia, Pennsylvania, USA
    Cytometry A 73:430-41. 2008
    ..CF supports both the generation and testing of hypotheses, eliminates sources of operator bias, and provides an increased level of automation of data analysis...
  48. pmc Recent developments with lipoprotein-associated phospholipase A2 inhibitors
    Ryan J Chauffe
    Pennsylvania Hospital, 1 Pine West, 800 Spruce Street, Philadelphia, PA 19107, USA
    Curr Atheroscler Rep 12:43-7. 2010
    ..This article reviews the most recent developments with Lp-PLA(2) inhibitors...
  49. pmc Association of lower plasma fetuin-a levels with peripheral arterial disease in type 2 diabetes
    Luis H Eraso
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes Care 33:408-10. 2010
    ..Fetuin-A is an inhibitor of vascular calcification and a mediator of insulin resistance. This study evaluated the association of plasma fetuin-A and peripheral arterial disease (PAD)...
  50. doi request reprint Cardiovascular risk in long-term survivors of testicular cancer
    David J Vaughn
    Department of Medicine, Hematology Oncology Division, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cancer 112:1949-53. 2008
    ..A cross-sectional study was performed to objectively assess cardiovascular risk, subclinical atherosclerosis, and endothelial function in long-term survivors of TC...
  51. ncbi request reprint Transforming growth factor-beta1 mechanisms in aortic valve calcification: increased alkaline phosphatase and related events
    Jocelyn N Clark-Greuel
    Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Ann Thorac Surg 83:946-53. 2007
    ..Previous investigations by our group have shown a strong association of transforming growth factor-beta1 (TGF-beta1)-related mechanisms with calcific aortic stenosis in both cell culture and clinical pathology studies...
  52. ncbi request reprint Can atorvastatin improve the response to sildenafil in men with erectile dysfunction not initially responsive to sildenafil? Hypothesis and pilot trial results
    Howard C Herrmann
    Hospital of the University of Pennsylvania, Philadelphia, 19104, USA
    J Sex Med 3:303-8. 2006
    ..Erectile dysfunction (ED) may be one manifestation of a generalized vascular disorder characterized by endothelial dysfunction. Statin drugs may improve endothelial function, even before altering the lipid profile...
  53. ncbi request reprint Therapy insight: peripheral arterial disease and diabetes--from pathogenesis to treatment guidelines
    Emile R Mohler
    Hospital of the University of Pennsylvania, 4th Floor Penn Tower Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Nat Clin Pract Cardiovasc Med 4:151-62. 2007
    ..For patients with critical limb ischemia, diagnostic testing by a vascular specialist will determine whether revascularization or amputation is feasible...
  54. ncbi request reprint Flow cytometric measurement of circulating endothelial cells: the effect of age and peripheral arterial disease on baseline levels of mature and progenitor populations
    Rebecca Gusic Shaffer
    Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Cytometry B Clin Cytom 70:56-62. 2006
    ....
  55. ncbi request reprint The unsung perils of peripheral arterial disease: a malady in search of a patient
    Richard L Dunbar
    University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Prev Cardiol 8:108-13; quiz 114-5. 2005
    ..This article will review the relationship between PAD and other vascular disease, emphasizing the role of PAD in prevention efforts...
  56. pmc Mineral volume and morphology in carotid plaque specimens using high-resolution MRI and CT
    Ronald L Wolf
    Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce St, Philadelphia, PA 19104, USA
    Arterioscler Thromb Vasc Biol 25:1729-35. 2005
    ..The purpose of this study was to assess the performance of high-resolution MRI in evaluation of the quantity and pattern of mineral deposition in carotid endarterectomy (CEA) specimens, with quantitative micro-CT as the gold standard...
  57. ncbi request reprint Platelet factor 4 localization in carotid atherosclerotic plaques: correlation with clinical parameters
    Stephanie Pitsilos
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, 19104, USA
    Thromb Haemost 90:1112-20. 2003
    ..These studies support the rationale for the chronic use of anti-platelet therapy in patients at risk for developing symptomatic atherosclerosis...
  58. ncbi request reprint The Chronic Renal Insufficiency Cohort (CRIC) Study: Design and Methods
    Harold I Feldman
    Center for Clinical Epidemiology, Philadelphia, 19104, USA
    J Am Soc Nephrol 14:S148-53. 2003
    ..Insights from CRIC should lead to the formulation of hypotheses regarding therapy that will serve as the basis for targeted interventional trials focused on reducing the burden of CRI and CVD...
  59. ncbi request reprint Safety and effectiveness of Niaspan when added sequentially to a statin for treatment of dyslipidemia
    M L Wolfe
    Department of Medicine, University of Pennsylvania Health System, Philadelphia, USA
    Am J Cardiol 87:476-9, A7. 2001
    ....
  60. ncbi request reprint Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis
    Bo Jian
    Cardiology Research Laboratory, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Ann Thorac Surg 75:457-65; discussion 465-6. 2003
    ....
  61. pmc Aortic pulse pressure is associated with carotid IMT in chronic kidney disease: report from Chronic Renal Insufficiency Cohort
    Stephanie S DeLoach
    Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Am J Hypertens 22:1235-41. 2009
    ....
  62. pmc Sex, aging, and preexisting cerebral ischemic disease in patients with aortic stenosis
    Ping Wang
    Department of Radiology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 90:1230-5. 2010
    ..We tested the hypotheses that increasing age, female sex, coronary artery disease, and the severity of AS are predictive of the severity of preexisting cerebral ischemic lesions...
  63. ncbi request reprint Detection of osteopontin in calcified human aortic valves
    E R Mohler
    Department of Medicine, Indiana University Medical Center, Indianapolis, USA
    Arterioscler Thromb Vasc Biol 17:547-52. 1997
    ..Identification of the cells producing osteopontin in abnormal cardiac valves and of proximate stimuli for its secretion may lead to novel therapeutic strategies to prevent and/or reverse calcific valve disease...
  64. pmc Matrix metalloproteinase-2 is associated with tenascin-C in calcific aortic stenosis
    B Jian
    Cardiology Research Laboratory, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104-4318, USA
    Am J Pathol 159:321-7. 2001
    ..The residual presence of these proteins in severe calcifications is indicative of their involvement in the pathogenesis...
  65. ncbi request reprint Brachial artery: measurement of flow-mediated dilatation with cross-sectional US--technical validation
    Yen Hong Kao
    Department of Radiology, University of Pennsylvania Medical Center, 1 Silverstein, 3400 Spruce St, Philadelphia, PA 19104, USA
    Radiology 228:895-900. 2003
    ..Cross-sectional imaging is more sensitive than longitudinal imaging for measuring flow-mediated dilatation of the brachial artery...
  66. ncbi request reprint Peripheral arterial disease: a guide for nephrologists
    Stephanie S DeLoach
    Department of Medicine, Renal, Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA 19104, USA
    Clin J Am Soc Nephrol 2:839-46. 2007
    ..Often, PAD is overlooked as a source of morbidity and as a cardiovascular risk factor in this population. This review serves as an overview of the epidemiology, screening, diagnosis, and treatment of PAD with an emphasis on CKD...
  67. pmc Evaluation of cuff-induced ischemia in the lower extremity by magnetic resonance oximetry
    Michael C Langham
    Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 55:598-606. 2010
    ....
  68. ncbi request reprint Images in vascular medicine. Distal abdominal aortic occlusion
    Daniel Chen
    Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Vasc Med 8:285-6. 2003
  69. pmc Membrane cholesterol is a biomechanical regulator of neutrophil adhesion
    Hana Oh
    Department of Chemical and Biomolecular Engineering, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, USA
    Arterioscler Thromb Vasc Biol 29:1290-7. 2009
    ..The purpose of this study was to evaluate the role of membrane cholesterol on human neutrophil and HL-60 biomechanics, capture, rolling, and arrest to P-selectin- or IL-1-activated endothelium...
  70. ncbi request reprint Vascular disease, hypertension, and prevention
    Rhondalyn C McLean
    Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 47:D3-8. 2006
  71. ncbi request reprint Drug treatment of intermittent claudication
    Douglas Jacoby
    Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Drugs 64:1657-70. 2004
    ..Amino acids, certain peptides and prostaglandins may have a therapeutic role. Finally, novel approaches including angiogenesis mediated by growth factors, are currently under investigation...
  72. ncbi request reprint Splenic artery aneurysm
    Anthony Shih
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Vasc Med 7:155-6. 2002
  73. ncbi request reprint An unusual case of toe ulceration
    Ramarao Lankipalli
    Department of Medicine, Cardiovascular Division, Vascular Medicine Section, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Vasc Med 11:35-7. 2006
    ..The patient was given the diagnosis of polycythemia vera with iron deficiency. Phlebotomy was performed and aspirin and cytoreductive therapy with hydroxyurea was prescribed with resolution of the toe ulceration...
  74. ncbi request reprint Atherothrombosis--wave goodbye to combined anticoagulation and antiplatelet therapy?
    Emile R Mohler
    N Engl J Med 357:293-6. 2007
  75. ncbi request reprint MR angiography with gadofosveset trisodium for peripheral vascular disease: phase II trial
    Pierre Perreault
    Department of Radiology, CHUM Hospital St Luc, Montreal, Quebec, Canada
    Radiology 229:811-20. 2003
    ..To evaluate the dose response and safety of gadofosveset trisodium-enhanced magnetic resonance (MR) angiography compared with nonenhanced two-dimensional time-of-flight MR angiography and with x-ray angiography as the standard...
  76. ncbi request reprint Carotid intima-media thickness testing by non-sonographer clinicians: the office practice assessment of carotid atherosclerosis study
    Claudia E Korcarz
    University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    J Am Soc Echocardiogr 21:117-22. 2008
    ....
  77. doi request reprint Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascula
    James H Stein
    University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    J Am Soc Echocardiogr 21:93-111; quiz 189-90. 2008
  78. ncbi request reprint Gaps in public knowledge of peripheral arterial disease: the first national PAD public awareness survey
    Alan T Hirsch
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Ste 300, 1300 S 2nd St, Minneapolis, MN 55454, USA
    Circulation 116:2086-94. 2007
    ..Nevertheless, public knowledge of PAD as a morbid and mortal disease has not been previously assessed...
  79. ncbi request reprint Vascular calcification: good, bad or ugly?
    Emile R Mohler
    Vasc Med 7:161-2. 2002
  80. doi request reprint Usefulness of increased skin cholesterol to identify individuals at increased cardiovascular risk (from the Predictor of Advanced Subclinical Atherosclerosis study)
    James H Stein
    University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Am J Cardiol 101:986-91. 2008
    ..SC may be a useful test for cardiovascular risk prediction...
  81. ncbi request reprint Images in vascular medicine. An unusual presentation of cerebral sinus thrombosis
    Christopher C Glisson
    Department of Neurology and Ophthalmology, Michigan State University, East Lansing, Michigan 48824, USA
    Vasc Med 9:225-6. 2004
  82. ncbi request reprint MR angiography of aortoiliac occlusive disease: a phase III study of the safety and effectiveness of the blood-pool contrast agent MS-325
    Mathias Goyen
    Department of Diagnostic and Interventional Radiology, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany mathias goyen de
    Radiology 236:825-33. 2005
    ..03 mmol/kg; effectiveness was defined as accuracy relative to the reference standard, conventional angiography...

Research Grants3

  1. CARDIAC VALVE CALCIFICATION
    Emile Mohler; Fiscal Year: 2003
    ..2. To investigate mechanisms of valve calcification using a cell culture model of calcification. 3. To examine therapeutic strategies to inhibit valve calcification with a bisphosphonate in cell culture. ..
  2. Research career training in vascular medicine
    Emile Mohler; Fiscal Year: 2007
    ..Implementation and replication of this program will provide the future academic leaders in Vascular Medicine who will define the field as a distinct discipline. (End of Abstract) ..