Research Topics
| Shyam MohapatraSummaryAffiliation: University of South Florida Country: USA Publications
Research Grants
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Detail Information
Publications
ERK-1/2 activity is required for efficient RSV infectionXiaoyuan Kong
The Joy McCann Culverhouse Airways Disease Research Center, Division of Allergy and Immunology, Department of Internal Medicine, MDC 19, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
FEBS Lett 559:33-8. 2004..Inhibition of ERK pathways significantly decreases RSV infection of these cells compared to controls. These results demonstrate that the activation of the ERK-1/2 is required in RSV-induced early gene expression...- Thiolated chitosan/DNA nanocomplexes exhibit enhanced and sustained gene deliveryDongwon Lee
Department of Internal Medicine, University of South Florida College of Medicine and James A Haley Veteran s Hospital, 12901 Bruce B Downs Blvd, Tampa, Florida 33612, USA
Pharm Res 24:157-67. 2007..Herein, we report on a highly effective gene delivery system utilizing a 33-kDa thiol-modified chitosan derivative... 
New perspectives on central and peripheral immune responses to acute traumatic brain injuryMahasweta Das
Nanomedicine Research Center, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
J Neuroinflammation 9:236. 2012....- Modulation of lung inflammation by vessel dilator in a mouse model of allergic asthmaXiaoqin Wang
Division of Allergy and Immunology, University of South Florida, Tampa, FL 33612, USA
Respir Res 10:66. 2009..In this report, we evaluated the effects of vessel dilator (VD), another N-terminal natriuretic peptide covering amino acids 31-67 of proANF, on acute lung inflammation in a mouse model of allergic asthma... - Natriuretic peptide receptor a as a novel target for prostate cancerXiaoqin Wang
Department of Molecular Medicine, University of South Florida, Tampa, FL 33612, USA
Mol Cancer 10:56. 2011..However, the direct role of NPRA signaling in prostate cancer remains unclear... - Chitosan Interferon-gamma Nanogene Therapy for Lung Disease: Modulation of T-Cell and Dendritic Cell Immune ResponsesXiaoyuan Kong
Division of Allergy and Immunology, Culverhouse Airway Disease Research and Nanomedicine Center, University of South Florida College of Medicine, Tampa, FL
Allergy Asthma Clin Immunol 4:95-105. 2008..CIN therapy results in a reduction in proinflammatory CD8+ T cells and decreases the number and antigen-presenting activity of dendritic cells... - Lateral fluid percussion injury of the brain induces CCL20 inflammatory chemokine expression in ratsMahasweta Das
Department of Internal Medicine, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
J Neuroinflammation 8:148. 2011..Due to the high incidence of head trauma in the sports field, battlefield and automobile accidents identification of the molecular signals involved in TBI progression is critical for the development of novel therapeutics... - Plasmid-encoded NP73-102 modulates atrial natriuretic peptide receptor signaling and plays a critical role in inducing tolerogenic dendritic cellsWeidong Zhang
Department of Internal Medicine, Division of Allergy and Immunology, University of South Florida College of Medicine, Tampa, FL 33612, USA
Genet Vaccines Ther 9:3. 2011..abstract:.. - Immunotherapy for allergies and asthma: present and futureShyam S Mohapatra
Department of Internal Medicine, Division of Allergy and Immunology, University of South Florida College of Medicine, Tampa, FL, USA
Curr Opin Pharmacol 10:276-88. 2010..This review discusses the pros and cons of recent developments in both currently practiced and experimental IT approaches... - Epidemiologic, experimental, and clinical links between respiratory syncytial virus infection and asthmaShyam S Mohapatra
Department of Internal Medicine, Division of Allergy and Immunology, University of South Florida College of Medicine, James A Haley Veterans Hospital, 12901 Bruce B Downs Blvd, Tampa, Florida 33612, USA
Clin Microbiol Rev 21:495-504. 2008..Studies to date demonstrate that there is a significant association between RSV infection and childhood asthma and that preventing severe primary RSV infections can decrease the risk of childhood asthma... - Intranasal gene transfer by chitosan-DNA nanospheres protects BALB/c mice against acute respiratory syncytial virus infectionMukesh Kumar
Division of Allergy and Immunology-Joy McCann Culverhouse Airway Disease Center, James A. Haley Veterans Administration Hospital and University of South Florida College of Medicine, Tampa, FL 33612, USA
Hum Gene Ther 13:1415-25. 2002..Together, these results demonstrate the potential of IGT against acute RSV infection... - Intranasal IL-12 produces discreet pulmonary and systemic effects on allergic inflammation and airway reactivityHiroto Matsuse
Department of Internal Medicine, Joy McCann Culverhouse Airway Disease Research Center, Tampa, FL 33612, USA
Int Immunopharmacol 3:457-68. 2003..Thus, intranasal delivery of IL-12 may provide an approach for the treatment of asthma and may be useful as an adjuvant in local nasal immunotherapy (IT) and in asthma... - Adenovirus-mediated interferon gamma gene therapy for allergic asthma: involvement of interleukin 12 and STAT4 signalingAruna K Behera
Division of Allergy and Immunology, Joy McCann Culverhouse Airway Disease Center, University of South Florida College of Medicine, Tampa, FL 33620, USA
Hum Gene Ther 13:1697-709. 2002..Thus, these results demonstrate that mucosal Ad-IFN-gamma gene transfer can effectively attenuate established allergen-induced airway inflammation and AHR, predominantly through an IL-12- and STAT4-dependent mechanism... 
Regulating the Regulators: microRNA and AsthmaJia Wang Wang
Department of Internal Medicine Division of Translational Medicine and Nanomedicine Research Center1, and Division of Allergy and Immunology2, Department of Molecular Medicine3, University of South Florida College of Medicine, and James A Haley VA Hospital and Medical Research Center4, Tampa, FL 33612
World Allergy Organ J 4:94-103. 2011..Profiling circulating miRNA might provide the highest specificity and sensitivity to diagnose asthma; similarly, correcting potential defects in the miRNA regulation network may lead to new therapeutic modalities to treat this disease...- Respiratory syncytial virus: immunopathology and controlWeidong Zhang
Division of Allergy and Immunology, Department of Internal Medicine, College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
Expert Rev Clin Immunol 2:169-79. 2006..In this review, the biology of RSV infection, its immunopathology, the role of innate and adaptive immunity, as well as the understanding of how to control RSV infection based on prophylactic and therapeutic approaches are discussed... - Role of natriuretic peptide signaling in modulating asthma and inflammationShyam S Mohapatra
Division of Allergy and Immunology JMC Airway Disease Research Center, Department of Internal Medicine, University of South Florida and VA Hospital, Tampa, FL 33612, USA
Can J Physiol Pharmacol 85:754-9. 2007..This report will review and critically evaluate the role of the ANP pathway in asthma and inflammation... - Thiolated chitosan nanoparticles enhance anti-inflammatory effects of intranasally delivered theophyllineDong Won Lee
Division of Allergy and Immunology and Joy McCann Culverhouse Airway Disease Center, Department of Internal Medicine, University of South Florida College of Medicine and James A, Haley Veteran s Hospital, Tampa, FL 33612, USA
Respir Res 7:112. 2006..It was hypothesized that adsorption of theophylline to chitosan nanoparticles modified by the addition of thiol groups would improve theophylline absorption by the bronchial epithelium and enhance its anti-inflammatory effects... - Combined fluticasone propionate and salmeterol reduces RSV infection more effectively than either of them alone in allergen-sensitized miceRajeswari Singam
Division of Allergy and Immunology, Joy McCann Culverhouse Airway Disease Research Center, University of South Florida College of Medicine and James A, Haley VA Hospital, Tampa, FL, USA
Virol J 3:32. 2006..Respiratory syncytial virus (RSV) infection is the major cause of bronchiolitis in infants and is a risk factor for the development of asthma. Allergic asthmatics are more susceptible to RSV infection and viral exacerbation... - Immunobiology of grass pollen allergensShyam S Mohapatra
Department of Internal Medicine, Division of Allergy and Immunology and the James A Haley Veterans Hospital, University of South Florida, College of Medicine, 12901 Bruce B Downs Boulevard, Tampa, FL 33612, USA
Curr Allergy Asthma Rep 5:381-7. 2005..This review is focused on the structure and immunobiology of the grass allergens and highlights how recent advances in the field have contributed to superior diagnosis and immunotherapy for allergy to grass pollens... - An immunocompromised BALB/c mouse model for respiratory syncytial virus infectionXiaoyuan Kong
Department of Internal Medicine, Division of Allergy and Immunology, Joy McCann Culverhouse Airway Disease Research Center, University of South Florida College of Medicine, USA
Virol J 2:3. 2005..BALB/c mice were treated with cyclophosphamide (CYP) and five days later, they were infected with RSV intranasally. Pulmonary RSV titers, inflammation and airway hyperresponsiveness were measured five days after infection... - Mucosal gene expression vaccine: a novel vaccine strategy for respiratory syncytial virusShyam S Mohapatra
Dept of Internal Medicine, Div of Allergy and Immunology, Joy McCann Culverhouse Airway Disease Research Center, University of South Florida College of Medicine VA Hospital, 12901 Bruce B Downs Boulevard, Tampa, FL 33612, USA
Pediatr Infect Dis J 22:S100-3; discussion S103-4. 2003..MGXV-treated mice show no significant change in airway reactivity to methacholine and no apparent pulmonary inflammation. Together these results demonstrate the potential of MGXV against acute RSV infection... - Mechanism of cigarette smoke condensate-induced acute inflammatory response in human bronchial epithelial cellsGary R Hellermann
Division of Allergy and Immunology, Joy McCann Culverhouse Airway Disease Center, Department of Internal Medicine, University of South Florida College of Medicine, VA Hospital, Tampa 33612, USA
Respir Res 3:22. 2002..To demonstrate the involvement of tobacco smoking in the pathophysiology of lung disease, the responses of pulmonary epithelial cells to cigarette smoke condensate (CSC) - the particulate fraction of tobacco smoke - were examined... - Natriuretic peptides and genesis of asthma: an emerging paradigm?Shyam S Mohapatra
Division of Allergy and Immunology JMC Airway Disease Research Center, University of South Florida, Tampa, FL 33612, USA
J Allergy Clin Immunol 114:520-6. 2004..Thus natriuretic peptides appear to play a pivotal role in the genesis and control of asthma, and they might provide an important target to modulate allergen-induced immune responses in allergic patients... - American Academy of Allergy, Asthma and Immunology--60th annual meeting. Advances in allergy and asthma therapy: 2003 AAAI updates. 7-12 March 2003, Denver, CO, USAShyam S Mohapatra
University of South Florida, Division of Allergy and Immunology, Tampa, FL 33612, USA
IDrugs 6:423-5. 2003 - Weed pollen allergensShyam S Mohapatra
University of South Florida College of Medicine, James A. Haley Veterans' Hospital, Tampa, Florida, USA
Clin Allergy Immunol 18:207-22. 2004 - Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 geneWeidong Zhang
Division of Allergy and Immunology-Joy McCann Culverhouse Airway Disease Research Center, Department of Internal Medicine, University of South Florida, MDC-19-Rm 2536, 12901 Bruce B. Downs Boulevard, Tampa, Florida 33612, USA
Nat Med 11:56-62. 2005..Thus, siNS1 nanoparticles may provide an effective inhibition of RSV infection in humans... - Nanotechnology Applications to HIV Vaccines and MicrobicidesSandhya Boyapalle
Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, FL
J Glob Infect Dis 4:62-8. 2012..Thus far nanoparticles provide a strong platform to combine protein and DNA based vaccines/microbicides and will facilitate the production, preclinical evaluation and clinical testing in the future... - Initial observations of cell-mediated drug delivery to the deep lungArun Kumar
Department of Internal Medicine, University of South Florida College of Medicine, Tampa, 33612, USA
Cell Transplant 20:609-18. 2011.... - Microbes and asthma: the missing cellular and molecular linksTina Brar
Division of Translational Medicine, Department of Internal Medicine, University of South Florida College of Medicine, Tampa, FL 33612, USA
Curr Opin Pulm Med 18:14-22. 2012.... - Multifunctional magnetic nanoparticles for targeted deliveryArun Kumar
Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida, Tampa, Florida, USA
Nanomedicine 6:64-9. 2010..The authors demonstrate that a simple external magnetic field is sufficient to target a drug to specific sites in the body without the need for functionalized nanoparticles, at least in selected organs and diseases... - The infectious march: the complex interaction between microbes and the immune system in asthmaTerianne Wong
Department of Molecular Medicine, University of South Florida College of Medicine, Bruce B Downs Boulevard, Tampa, FL 33612, USA
Immunol Allergy Clin North Am 30:453-80, v. 2010.... - 2'-5' Oligoadenylate synthetase plays a critical role in interferon-gamma inhibition of respiratory syncytial virus infection of human epithelial cellsAruna K Behera
Division of Allergy and Immunology, Joy McCann Culverhouse Airway Disease Center, University of South Florida College of Medicine and James A Haley Veterans Affairs Hospital, Tampa 33612, USA
J Biol Chem 277:25601-8. 2002..These results provide direct evidence of the involvement of 2-5 AS in IFN-gamma-mediated antiviral activity in these cells... - Respiratory syncytial virus infection activates STAT signaling in human epithelial cellsXiaoyuan Kong
Division of Allergy and Immunology, The Joy McCann Culverhouse Airway Disease Center, Department of Internal Medicine, University of South Florida College of Medicine, Tampa, FL 33612, USA
Biochem Biophys Res Commun 306:616-22. 2003..RSV also activated STAT-3 and IL-6 specific antibodies blocked this activation. Thus, activation of the STAT-1alpha and STAT-3 pathways play a role in RSV infection... - Mechanism of bronchoprotective effects of a novel natriuretic hormone peptideGary Hellermann
Department of Internal Medicine, University of South Florida College of Medicine, Tampa, FL 33612, USA
J Allergy Clin Immunol 113:79-85. 2004..These results suggest a bronchodilatory and anti-inflammatory activity of this peptide... - Natriuretic peptide receptor a as a novel anticancer targetXiaoyuan Kong
Joy McCann Culverhouse Airway Disease and Nanomedicine Research Center, Allergy and Immunology Division, Department of Internal Medicine, University of South Florida College of Medicine, Tampa, FL 33612, USA
Cancer Res 68:249-56. 2008..These results suggest that NPRA is involved in tumor angiogenesis and represents a new target for cancer therapy... - Protein kinase C-alpha activity is required for respiratory syncytial virus fusion to human bronchial epithelial cellsHomero San-Juan-Vergara
The Joy McCann Culverhouse Airways Disease Research Center, Division of Allergy and Immunology, Department of Internal Medicine, College of Medicine, University of South Florida, Tampa, FL 33612, USA
J Virol 78:13717-26. 2004..Also, PKC-alpha colocalizes with virus particles and is required for RSV fusion to the cell membrane. Thus, PKC-alpha could provide a new pharmacological target for controlling RSV infection... - Chitosan nanoparticle-mediated gene transferDongwon Lee
College of Medicine, Department of Internal Medicine, University of South Florida, Tampa, FL, USA
Methods Mol Biol 433:127-40. 2008..Chitosan has been reported to form nanocomplexes with DNA to protect them against DNase degradation and transfer DNA effectively and safely into cells in culture cell as well as in vivo... - Serum total IgE and specific IgE to Dermatophagoides pteronyssinus, but not eosinophil cationic protein, are more likely to be elevated in elderly asthmatic patientsMonroe J King
Joy McCann Culverhouse Airway Disease Center, University of South Florida, Tampa, Florida 33612, USA
Allergy Asthma Proc 25:321-5. 2004..4 microg/L, Pharmacia Diagnostics). The serum of elderly asthmatic patients is more likely to have elevated total IgE and a positive specific IgE to Dp. ECP is elevated in elderly subjects but is not an indicator of asthma... - Curcumin prevents human dendritic cell response to immune stimulantsShawna A Shirley
Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, FL 33612, USA
Biochem Biophys Res Commun 374:431-6. 2008..These data suggest a therapeutic role for curcumin as an immune suppressant... - Development of hyaluronic acid-Fe2O3 hybrid magnetic nanoparticles for targeted delivery of peptidesArun Kumar
Division of Allergy and Immunology, Department of Internal Medicine, College of Medicine, University of South Florida, Tampa, Florida 33612, USA
Nanomedicine 3:132-7. 2007..Results show that these particles delivered peptides at about 100% level. These HA-iron oxide nanoparticles are expected to be useful in developing effective tissue and cell targeting systems... - Atrial natriuretic peptide gene transfer by means of intranasal administration attenuates airway reactivity in a mouse model of allergic sensitizationMukesh Kumar
Division of Allergy and Immunology-Joy McCann Culverhouse Airway Disease Center, University of South Florida College of Medicine and James A. Haley Veteran's Hospital, Tampa 33612, USA
J Allergy Clin Immunol 110:879-82. 2002..Mice administered pANP demonstrated significantly less AHR for 20 days after treatment. The results demonstrate that pANP gene transfer protects against AHR and might be useful in the treatment of asthma... - Nanoparticle-mediated gene delivery: state of the artM Ravi Kumar
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, SASNagar, Mohali, India
Expert Opin Biol Ther 4:1213-24. 2004.... - Modifying allergens and using adjuvants for specific immunotherapyMark Larché
Imperial College London Faculty of Medicine, London, England
Clin Allergy Immunol 18:641-61. 2004
Research Grants
- Chliposome IFN-gamma-pDNA Naoparticle Therapy for AsthmaShyam Mohapatra; Fiscal Year: 2004..The results of the proposed research are expected to advance our knowledge of the mechanisms of asthma and may lead to the development of an effective approach for the prevention and/or treatment of asthma. ..
- Chlipoplex Nanoparticle Prophylactics for RSV InfectionShyam Mohapatra; Fiscal Year: 2004..abstract_text> ..
- Chitosan IFNgamma-pDNA Nanosphere Therapy and Immunopathology of Allergic AsthmaShyam Mohapatra; Fiscal Year: 2006..It is anticipated that the results of these studies will contribute significantly to our knowledge of asthma and CIN therapy may provide a major breakthrough in management of asthma. ..
- An Integrated Nano-Cell Delivery Platform of Theranostics for Lung CancersSubhra Mohapatra; Fiscal Year: 2010....