Alexander Mogilner

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Mechanism of shape determination in motile cells
    Kinneret Keren
    Department of Biochemistry, Technion Israel Institute of Technology, Haifa 32000, Israel
    Nature 453:475-80. 2008
  2. pmc Regulation of actin dynamics in rapidly moving cells: a quantitative analysis
    Alex Mogilner
    Department of Mathematics and Institute of Theoretical Dynamics, University of California, Davis, California 95616 USA
    Biophys J 83:1237-58. 2002
  3. ncbi request reprint Quantitative modeling in cell biology: what is it good for?
    Alex Mogilner
    Department of Neurobiology, Physiology and Behavior, University of California, Davis, 95616, USA
    Dev Cell 11:279-87. 2006
  4. pmc Quantitative analysis of an anaphase B switch: predicted role for a microtubule catastrophe gradient
    Dhanya K Cheerambathur
    Department of Molecular and Cellular Biology, University of California at Davis, Davis, CA 95616, USA
    J Cell Biol 177:995-1004. 2007
  5. pmc Finding the cell center by a balance of dynein and myosin pulling and microtubule pushing: a computational study
    Jie Zhu
    Department of Neurobiology, University of California Davis, Davis, CA 95616, USA
    Mol Biol Cell 21:4418-27. 2010
  6. pmc Actomyosin-dependent cortical dynamics contributes to the prophase force-balance in the early Drosophila embryo
    Patrizia Sommi
    Human Physiology Section, Department of Physiology, University of Pavia, Pavia, Italy
    PLoS ONE 6:e18366. 2011
  7. pmc Computational estimates of membrane flow and tension gradient in motile cells
    Ben Fogelson
    Department of Neurobiology, Physiology and Behavior and Department of Mathematics, University of California, Davis, Davis, California, United States of America
    PLoS ONE 9:e84524. 2014
  8. pmc Mesoscopic model of actin-based propulsion
    Jie Zhu
    Department of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, California, USA
    PLoS Comput Biol 8:e1002764. 2012
  9. doi request reprint Cell polarity: quantitative modeling as a tool in cell biology
    Alex Mogilner
    Department of Neurobiology, Physiology, and Behavior, University of California, Davis, CA 95616, USA
    Science 336:175-9. 2012
  10. pmc Modeling cellular processes in 3D
    Alex Mogilner
    Department of Neurobiology, Physiology and Behavior, University of California, Davis, CA 95616, USA
    Trends Cell Biol 21:692-700. 2011

Research Grants

  1. Dynamics of Mitotic Spindle Morphogenesis
    Alexander Mogilner; Fiscal Year: 2003
  2. Dynamics of Mitotic Spindle Morphogenesis.
    Alexander Mogilner; Fiscal Year: 2005
  3. Dynamics of Mitotic Spindle Morphogenesis.
    Alexander Mogilner; Fiscal Year: 2006
  4. Modeling mitotic spindle assembly
    Alexander Mogilner; Fiscal Year: 2007
  5. Modeling mitotic spindle assembly
    Alexander Mogilner; Fiscal Year: 2010
  6. Dynamics of Mitotic Spindle Morphogenesis.
    Alexander Mogilner; Fiscal Year: 2004
  7. Modeling mitotic spindle assembly
    Alexander Mogilner; Fiscal Year: 2009

Collaborators

Detail Information

Publications43

  1. pmc Mechanism of shape determination in motile cells
    Kinneret Keren
    Department of Biochemistry, Technion Israel Institute of Technology, Haifa 32000, Israel
    Nature 453:475-80. 2008
    ..Our model provides a simple biochemical and biophysical basis for the observed morphology and behaviour of motile cells...
  2. pmc Regulation of actin dynamics in rapidly moving cells: a quantitative analysis
    Alex Mogilner
    Department of Mathematics and Institute of Theoretical Dynamics, University of California, Davis, California 95616 USA
    Biophys J 83:1237-58. 2002
    ..Our results suggest that to achieve rapid motility, some tuning of parameters affecting actin dynamics must be operating in the cell...
  3. ncbi request reprint Quantitative modeling in cell biology: what is it good for?
    Alex Mogilner
    Department of Neurobiology, Physiology and Behavior, University of California, Davis, 95616, USA
    Dev Cell 11:279-87. 2006
    ....
  4. pmc Quantitative analysis of an anaphase B switch: predicted role for a microtubule catastrophe gradient
    Dhanya K Cheerambathur
    Department of Molecular and Cellular Biology, University of California at Davis, Davis, CA 95616, USA
    J Cell Biol 177:995-1004. 2007
    ..The resulting redistribution of ipMT plus ends to the overlap zone, together with the suppression of minus-end depolymerization at the poles, could constitute a mechanical switch that initiates spindle elongation...
  5. pmc Finding the cell center by a balance of dynein and myosin pulling and microtubule pushing: a computational study
    Jie Zhu
    Department of Neurobiology, University of California Davis, Davis, CA 95616, USA
    Mol Biol Cell 21:4418-27. 2010
    ..Simulations demonstrate that the force-balance centering mechanism is robust yet versatile. We use the experimental observations to reverse engineer the characteristic forces and centrosome mobility...
  6. pmc Actomyosin-dependent cortical dynamics contributes to the prophase force-balance in the early Drosophila embryo
    Patrizia Sommi
    Human Physiology Section, Department of Physiology, University of Pavia, Pavia, Italy
    PLoS ONE 6:e18366. 2011
    ..Myosin II is known to contribute to the dynamics of the cell cortex but how this influences the prophase force-balance is unclear...
  7. pmc Computational estimates of membrane flow and tension gradient in motile cells
    Ben Fogelson
    Department of Neurobiology, Physiology and Behavior and Department of Mathematics, University of California, Davis, Davis, California, United States of America
    PLoS ONE 9:e84524. 2014
    ..We estimate the influence of intracellular membrane transport and actin growth and contraction on the tension gradient, and discuss possible 'tank tread' flow at ventral and dorsal surfaces. ..
  8. pmc Mesoscopic model of actin-based propulsion
    Jie Zhu
    Department of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, California, USA
    PLoS Comput Biol 8:e1002764. 2012
    ..To summarize, we propose that both microscopic polymerization ratchets and macroscopic stresses of the deformable actin network are responsible for the force and movement generation...
  9. doi request reprint Cell polarity: quantitative modeling as a tool in cell biology
    Alex Mogilner
    Department of Neurobiology, Physiology, and Behavior, University of California, Davis, CA 95616, USA
    Science 336:175-9. 2012
    ..We argue that a quantitative model is a tool that has to fit an experimental study, and the model's value should be judged not by how complex and detailed it is, but by what could be learned from it...
  10. pmc Modeling cellular processes in 3D
    Alex Mogilner
    Department of Neurobiology, Physiology and Behavior, University of California, Davis, CA 95616, USA
    Trends Cell Biol 21:692-700. 2011
    ....
  11. doi request reprint Cell polarity: tension quenches the rear
    Alex Mogilner
    Department of Neurobiology, Physiology and Behavior and Department of Mathematics, University of California, Davis, CA 95616, USA
    Curr Biol 22:R48-51. 2012
    ....
  12. ncbi request reprint Modeling mitosis
    Alex Mogilner
    Laboratory of Cell and Computational Biology, Center for Genetics and Development, University of California, Davis, CA 95616, USA
    Trends Cell Biol 16:88-96. 2006
    ..We discuss some limitations of the application of modeling to other aspects of mitosis and the feasibility of building more comprehensive system-level models...
  13. pmc The shape of motile cells
    Alex Mogilner
    Department of Neurobiology, Physiology and Behavior, University of California, Davis, CA 95616, USA
    Curr Biol 19:R762-71. 2009
    ..Focusing on several different cell types, including keratocytes and fibroblasts, we discuss how dynamic cell morphology emerges from the interplay between the different motility modules and the environment...
  14. pmc Towards a quantitative understanding of mitotic spindle assembly and mechanics
    Alex Mogilner
    Department of Neurobiology, Physiology and Behavior, and Department of Mathematics, University of California, Davis, CA 95616, USA
    J Cell Sci 123:3435-45. 2010
    ....
  15. pmc Actin disassembly 'clock' and membrane tension determine cell shape and turning: a mathematical model
    A Mogilner
    Department of Neurobiology, Physiology and Behavior, University of California, Davis, CA 95616 USA
    J Phys Condens Matter 22:194118. 2010
    ..We demonstrate that the theory predicts the observed cell shapes. Furthermore, turning of the cells can be explained by biases in the actin distribution. We discuss experimental implications of this hypothesis...
  16. ncbi request reprint On the edge: modeling protrusion
    Alex Mogilner
    Department of Mathematics and Center for Genetics and Development, University of California, Davis, California 95616, USA
    Curr Opin Cell Biol 18:32-9. 2006
    ..By considering these models, their limitations and their relationships to recent biophysical data, progress is being made toward a unified model of protrusion...
  17. ncbi request reprint Cell biology. Shrinking gels pull cells
    Alex Mogilner
    Department of Mathematics and Center for Genetics and Development, University of California, Davis, CA 95616, USA
    Science 302:1340-1. 2003
  18. pmc The physics of filopodial protrusion
    A Mogilner
    Department of Mathematics, Center for Genetics and Development, University of California, Davis, 95616, USA
    Biophys J 89:782-95. 2005
    ....
  19. pmc Mathematics of cell motility: have we got its number?
    Alex Mogilner
    Department of Neurobiology, Physiology and Behavior, University of California, Davis, CA, 95618, USA
    J Math Biol 58:105-34. 2009
    ..We also comment on modeling approaches and open questions...
  20. ncbi request reprint Mutual interactions, potentials, and individual distance in a social aggregation
    A Mogilner
    Dept of Mathematics and Center for Genetics and Development, Univ of California, Davis, CA 95616, USA
    J Math Biol 47:353-89. 2003
    ..When the number of individuals in a group increases, a dichotomy occurs between swarms in which individual distance is preserved versus those in which the physical size of the group is maintained at the expense of greater crowding...
  21. ncbi request reprint Polymer motors: pushing out the front and pulling up the back
    Alex Mogilner
    Department of Mathematics, University of California, Davis, CA 95616, USA
    Curr Biol 13:R721-33. 2003
    ..We discuss several examples of cellular forces generated by the assembly and disassembly of polymer gels...
  22. ncbi request reprint How nematode sperm crawl
    Dean Bottino
    Department of Molecular and Cellular Biology, University of California, Berkeley, CA 94720 3112, USA
    J Cell Sci 115:367-84. 2002
    ..Although the model refers primarily to the locomotion of nematode sperm, it has important implications for the mechanics of actin-based cell motility...
  23. pmc Mechanical stochastic tug-of-war models cannot explain bidirectional lipid-droplet transport
    Ambarish Kunwar
    Department of Neurobiology, Physiology and Behavior, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 108:18960-5. 2011
    ..Neither model agrees well with our in vivo data, suggesting that, in addition to inevitable tugs-of-war between opposite motors, there is an additional level of regulation not included in the models...
  24. ncbi request reprint The hydration dynamics of polyelectrolyte gels with applications to cell motility and drug delivery
    Charles W Wolgemuth
    Departments of Molecular and Cellular Biology and ESPM, University of California, Berkeley, CA 94720 3112, USA
    Eur Biophys J 33:146-58. 2004
    ..Second, we use the model to describe the locomotion of nematode sperm cells. Finally, we describe the swelling dynamics of polyelectrolyte gels used for drug release...
  25. pmc Robust transport by multiple motors with nonlinear force-velocity relations and stochastic load sharing
    Ambarish Kunwar
    Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, CA 95616, USA
    Phys Biol 7:16012. 2010
    ..Finally, our simulations predict that the stochastic effects are responsible for a significant dispersion of velocities generated by the 'tug-of-war' of the multiple opposing motors...
  26. ncbi request reprint Non-local concepts and models in biology
    C T Lee
    Institute of Theoretical Dynamics, University of California, Davis, CA 95616, USA
    J Theor Biol 210:201-19. 2001
    ..We illustrate these arguments by comparing local and non-local models for the aggregation of hypothetical organisms, and we support theoretical ideas with concrete examples from cell biology and animal behavior...
  27. pmc Model of bacterial band formation in aerotaxis
    B C Mazzag
    Department of Mathematics, Humboldt State University, Arcata, California 95521, USA
    Biophys J 85:3558-74. 2003
    ..We make testable predictions about position and density of the bacterial band...
  28. pmc A force balance model of early spindle pole separation in Drosophila embryos
    E N Cytrynbaum
    Center for Genetics and Development, Section of Molecular and Cell Biology, University of California, Davis, California 95616, USA
    Biophys J 84:757-69. 2003
    ....
  29. ncbi request reprint Computational model of dynein-dependent self-organization of microtubule asters
    E N Cytrynbaum
    Laboratory of Cell and Computational Biology, Department of Mathematics and Center for Genetics and Development, University of California, Davis, CA 95616, USA
    J Cell Sci 117:1381-97. 2004
    ..The model provides stringent constraints on rates and concentrations describing microtubule and motor dynamics, and sheds light on the role of polymer dynamics and polymer-motor interactions in cytoskeletal organization...
  30. ncbi request reprint Efficient chromosome capture requires a bias in the 'search-and-capture' process during mitotic-spindle assembly
    R Wollman
    Laboratory of Cell and Computational Biology, Center for Genetics and Development, University of California, Davis, Davis, California 95616, USA
    Curr Biol 15:828-32. 2005
    ..We discuss the possibility that a RanGTP gradient introduces a spatial bias into microtubule dynamics and thus improves the efficiency of search-and-capture as a mechanism for spindle assembly...
  31. pmc Early spindle assembly in Drosophila embryos: role of a force balance involving cytoskeletal dynamics and nuclear mechanics
    E N Cytrynbaum
    Laboratory of Cell and Computational Biology, Center for Genetics and Development, University of California, Davis, Davis, CA 95616, USA
    Mol Biol Cell 16:4967-81. 2005
    ..Thus, the force-balance driving early spindle morphogenesis depends upon MT-based motors acting in concert with the cortex and nucleus...
  32. pmc Force generation by actin polymerization II: the elastic ratchet and tethered filaments
    Alex Mogilner
    Department of Mathematics and Center for Genetics and Development, University of California, Davis 95616, USA
    Biophys J 84:1591-605. 2003
    ..We also discuss "symmetry breaking" dynamics observed in ActA-coated bead experiments, and the implications of the model for lamellipodial protrusion in migrating cells...
  33. ncbi request reprint Cell division
    Jonathan M Scholey
    Laboratory of Cell and Computational Biology, Center for Genetics and Development, University of California, Davis, California 95616, USA
    Nature 422:746-52. 2003
    ....
  34. pmc Model of polarization and bistability of cell fragments
    Michael M Kozlov
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Biophys J 93:3811-9. 2007
    ..The model accounts for the observations of the keratocyte fragments' behavior and generates quantitative predictions about relations between the intracellular forces' magnitudes and the cell geometry and motility...
  35. pmc Direct measurement of the lamellipodial protrusive force in a migrating cell
    Marcus Prass
    Institute of Biophysics, University of Bremen, D 28359 Bremen, Germany
    J Cell Biol 174:767-72. 2006
    ..Rather, the curves indicate that the protrusive force generation is a complex multiphase process involving actin and adhesion dynamics...
  36. pmc Emergence of large-scale cell morphology and movement from local actin filament growth dynamics
    Catherine I Lacayo
    Department of Biochemistry, Stanford University, Stanford, California, United States of America
    PLoS Biol 5:e233. 2007
    ....
  37. ncbi request reprint Cooperativity between cell contractility and adhesion
    Igor L Novak
    Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Phys Rev Lett 93:268109. 2004
    ..The model predicts that the focal adhesions propagate by treadmilling with a velocity proportional to the integrin diffusion coefficient...
  38. pmc Stochastic simulation of actin dynamics reveals the role of annealing and fragmentation
    Joseph Fass
    Department of Neurobiology, Physiology and Behavior, University of California, Davis, CA 95616 8633, USA
    J Theor Biol 252:173-83. 2008
    ..The simulations compare well with experimentally measured actin polymerization data and lend additional support to a number of existing theoretical models...
  39. ncbi request reprint A homotetrameric kinesin-5, KLP61F, bundles microtubules and antagonizes Ncd in motility assays
    Li Tao
    Laboratory of Cell and Computational Biology, Center for Genetics and Development, University of California, Davis, Davis, California 95616, USA
    Curr Biol 16:2293-302. 2006
    ..We tested whether purified KLP61F homotetramers and Ncd homodimers can generate a force balance capable of maintaining a constant spindle length in Drosophila embryos...
  40. pmc Weak force stalls protrusion at the leading edge of the lamellipodium
    Sophie Bohnet
    Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    Biophys J 90:1810-20. 2006
    ..We conclude that a weak external force is sufficient to reorient the growing actin network at the leading edge and to stall the protrusion...
  41. pmc Reverse engineering of force integration during mitosis in the Drosophila embryo
    Roy Wollman
    Laboratory of Cell and Computational Biology, Center for Genetics and Development, University of California at Davis, Davis, CA 95616, USA
    Mol Syst Biol 4:195. 2008
    ..Identified differences among the six predicted strategies regarding the mechanisms of prometaphase and anaphase spindle elongation suggest future experiments...
  42. pmc Quantitative analysis of G-actin transport in motile cells
    Igor L Novak
    Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Biophys J 95:1627-38. 2008
    ..We discuss biological implications of the local and global regimes of the G-actin transport...
  43. ncbi request reprint Chemotactic signaling, microglia, and Alzheimer's disease senile plaques: is there a connection?
    Magdalena Luca
    Massachusetts College of Pharmacy and Health Sciences, School of Arts and Sciences, 179 Longwood Avenue, Boston, MA 021 15 5896, USA
    Bull Math Biol 65:693-730. 2003
    ..Using biological parameters from the literature, we compare and discuss the applicability of this model to actual processes in AD...

Research Grants8

  1. Dynamics of Mitotic Spindle Morphogenesis
    Alexander Mogilner; Fiscal Year: 2003
    ..The models will allow to test plausible scenarios of mitosis and cell division. They will provide a new interdisciplinary level of understanding and predicting dynamic cell behavior in important biomedical situations. ..
  2. Dynamics of Mitotic Spindle Morphogenesis.
    Alexander Mogilner; Fiscal Year: 2005
    ..The models will allow to test plausible scenarios of mitosis and cell division. They will provide a new interdisciplinary level of understanding and predicting dynamic cell behavior in important biomedical situations. ..
  3. Dynamics of Mitotic Spindle Morphogenesis.
    Alexander Mogilner; Fiscal Year: 2006
    ..The models will allow to test plausible scenarios of mitosis and cell division. They will provide a new interdisciplinary level of understanding and predicting dynamic cell behavior in important biomedical situations. ..
  4. Modeling mitotic spindle assembly
    Alexander Mogilner; Fiscal Year: 2007
    ..The modeling framework will be applicable for a number of fundamental mechanochemical processes such as cytokinesis and cell motility, a quantitative understanding of which is important for biomedical applications. ..
  5. Modeling mitotic spindle assembly
    Alexander Mogilner; Fiscal Year: 2010
    ..The modeling framework will be applicable for a number of fundamental mechanochemical processes such as cytokinesis and cell motility, quantitative understanding of which is important for biomedical applications. ..
  6. Dynamics of Mitotic Spindle Morphogenesis.
    Alexander Mogilner; Fiscal Year: 2004
    ..The models will allow to test plausible scenarios of mitosis and cell division. They will provide a new interdisciplinary level of understanding and predicting dynamic cell behavior in important biomedical situations. ..
  7. Modeling mitotic spindle assembly
    Alexander Mogilner; Fiscal Year: 2009
    ..The modeling framework will be applicable for a number of fundamental mechanochemical processes such as cytokinesis and cell motility, quantitative understanding of which is important for biomedical applications. ..