Alexander Mogilner

..Our model provides a simple biochemical and biophysical basis for the observed morphology and behaviour of motile cells...

..Our results suggest that to achieve rapid motility, some tuning of parameters affecting actin dynamics must be operating in the cell...

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..The resulting redistribution of ipMT plus ends to the overlap zone, together with the suppression of minus-end depolymerization at the poles, could constitute a mechanical switch that initiates spindle elongation...

..We argue that a quantitative model is a tool that has to fit an experimental study, and the model's value should be judged not by how complex and detailed it is, but by what could be learned from it...

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..By considering these models, their limitations and their relationships to recent biophysical data, progress is being made toward a unified model of protrusion...

..We discuss some limitations of the application of modeling to other aspects of mitosis and the feasibility of building more comprehensive system-level models...

..We also comment on modeling approaches and open questions...

..Focusing on several different cell types, including keratocytes and fibroblasts, we discuss how dynamic cell morphology emerges from the interplay between the different motility modules and the environment...

..We demonstrate that the theory predicts the observed cell shapes. Furthermore, turning of the cells can be explained by biases in the actin distribution. We discuss experimental implications of this hypothesis...

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..We discuss several examples of cellular forces generated by the assembly and disassembly of polymer gels...

..When the number of individuals in a group increases, a dichotomy occurs between swarms in which individual distance is preserved versus those in which the physical size of the group is maintained at the expense of greater crowding...

..Although the model refers primarily to the locomotion of nematode sperm, it has important implications for the mechanics of actin-based cell motility...

..Neither model agrees well with our in vivo data, suggesting that, in addition to inevitable tugs-of-war between opposite motors, there is an additional level of regulation not included in the models...

..Second, we use the model to describe the locomotion of nematode sperm cells. Finally, we describe the swelling dynamics of polyelectrolyte gels used for drug release...

..Finally, our simulations predict that the stochastic effects are responsible for a significant dispersion of velocities generated by the 'tug-of-war' of the multiple opposing motors...

..We illustrate these arguments by comparing local and non-local models for the aggregation of hypothetical organisms, and we support theoretical ideas with concrete examples from cell biology and animal behavior...

..We make testable predictions about position and density of the bacterial band...

..The model provides stringent constraints on rates and concentrations describing microtubule and motor dynamics, and sheds light on the role of polymer dynamics and polymer-motor interactions in cytoskeletal organization...

..We discuss the possibility that a RanGTP gradient introduces a spatial bias into microtubule dynamics and thus improves the efficiency of search-and-capture as a mechanism for spindle assembly...

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..Thus, the force-balance driving early spindle morphogenesis depends upon MT-based motors acting in concert with the cortex and nucleus...

..Rather, the curves indicate that the protrusive force generation is a complex multiphase process involving actin and adhesion dynamics...

..The model predicts that the focal adhesions propagate by treadmilling with a velocity proportional to the integrin diffusion coefficient...

..We also discuss "symmetry breaking" dynamics observed in ActA-coated bead experiments, and the implications of the model for lamellipodial protrusion in migrating cells...

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..We discuss biological implications of the local and global regimes of the G-actin transport...

..Identified differences among the six predicted strategies regarding the mechanisms of prometaphase and anaphase spindle elongation suggest future experiments...

..The simulations compare well with experimentally measured actin polymerization data and lend additional support to a number of existing theoretical models...

..We conclude that a weak external force is sufficient to reorient the growing actin network at the leading edge and to stall the protrusion...

..The model accounts for the observations of the keratocyte fragments' behavior and generates quantitative predictions about relations between the intracellular forces' magnitudes and the cell geometry and motility...

..We tested whether purified KLP61F homotetramers and Ncd homodimers can generate a force balance capable of maintaining a constant spindle length in Drosophila embryos...

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..Using biological parameters from the literature, we compare and discuss the applicability of this model to actual processes in AD...

..The models will allow to test plausible scenarios of mitosis and cell division. They will provide a new interdisciplinary level of understanding and predicting dynamic cell behavior in important biomedical situations. ..

..The modeling framework will be applicable for a number of fundamental mechanochemical processes such as cytokinesis and cell motility, a quantitative understanding of which is important for biomedical applications. ..

..The modeling framework will be applicable for a number of fundamental mechanochemical processes such as cytokinesis and cell motility, quantitative understanding of which is important for biomedical applications. ..

..The modeling framework will be applicable for a number of fundamental mechanochemical processes such as cytokinesis and cell motility, quantitative understanding of which is important for biomedical applications. ..