O W Moe

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Hypercalciuria from acid load: renal mechanisms
    O W Moe
    Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Nephrol 19:S53-61. 2006
  2. pmc The diurnal variation in urine acidification differs between normal individuals and uric acid stone formers
    Maryann Cameron
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Kidney Int 81:1123-30. 2012
  3. pmc Chronic regulation of the renal Na(+)/H(+) exchanger NHE3 by dopamine: translational and posttranslational mechanisms
    Ming Chang Hu
    Dept of Internal Medicine, Univ of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8885, USA
    Am J Physiol Renal Physiol 304:F1169-80. 2013
  4. pmc Pharmacotherapy of urolithiasis: evidence from clinical trials
    Orson W Moe
    University of Texas Southwestern Medical Center, Dallas, Texas 75380, USA
    Kidney Int 79:385-92. 2011
  5. ncbi request reprint Iron metabolism in end stage renal failure: rationale for re-evaluation of parenteral iron therapy
    Orson W Moe
    Department of Internal Medicine, University of Texas Southwestern Medical Center and Medical Service, Dallas 75390, USA
    Curr Opin Nephrol Hypertens 12:145-51. 2003
  6. ncbi request reprint Pathophysiology of uric acid nephrolithiasis
    Orson W Moe
    Department of Internal Medicine, Center for Mineral Metabolism and Clinical Research, Center of Human Nutrition, University of Texas Southwestern Medical Center, Department of Veteran Affairs Medical Center, Dallas, TX, USA
    Endocrinol Metab Clin North Am 31:895-914. 2002
  7. ncbi request reprint Clinical acid-base pathophysiology: disorders of plasma anion gap
    Orson W Moe
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, 75390 8856, USA
    Best Pract Res Clin Endocrinol Metab 17:559-74. 2003
  8. ncbi request reprint Kidney stones: pathophysiology and medical management
    Orson W Moe
    Charles and Jane Pak Center of Mineral Metabolism and Clinical Research and Department of Internal Medicine University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Lancet 367:333-44. 2006
  9. doi request reprint Posing the question again: does chronic uric acid nephropathy exist?
    Orson W Moe
    Department of Internal Medicine, Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, Dallas, TX 75390 8855, USA
    J Am Soc Nephrol 21:395-7. 2010
  10. ncbi request reprint Genetic hypercalciuria
    Orson W Moe
    Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8855, USA
    J Am Soc Nephrol 16:729-45. 2005

Collaborators

Detail Information

Publications82

  1. ncbi request reprint Hypercalciuria from acid load: renal mechanisms
    O W Moe
    Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Nephrol 19:S53-61. 2006
    ..At least one component of the acid effect is due to renal leak of calcium. This article summarizes the effect of acid on renal handling of calcium in the proximal tubule, thick ascending limb, and distal convoluted tubule...
  2. pmc The diurnal variation in urine acidification differs between normal individuals and uric acid stone formers
    Maryann Cameron
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Kidney Int 81:1123-30. 2012
    ....
  3. pmc Chronic regulation of the renal Na(+)/H(+) exchanger NHE3 by dopamine: translational and posttranslational mechanisms
    Ming Chang Hu
    Dept of Internal Medicine, Univ of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8885, USA
    Am J Physiol Renal Physiol 304:F1169-80. 2013
    ..In summary, chronic DA inhibits NHE3 with mechanisms distinct from its acute action and involves decreased NHE3 translation and increased NHE3 degradation, which are novel mechanisms for NHE3 regulation...
  4. pmc Pharmacotherapy of urolithiasis: evidence from clinical trials
    Orson W Moe
    University of Texas Southwestern Medical Center, Dallas, Texas 75380, USA
    Kidney Int 79:385-92. 2011
    ....
  5. ncbi request reprint Iron metabolism in end stage renal failure: rationale for re-evaluation of parenteral iron therapy
    Orson W Moe
    Department of Internal Medicine, University of Texas Southwestern Medical Center and Medical Service, Dallas 75390, USA
    Curr Opin Nephrol Hypertens 12:145-51. 2003
    ..In this article we will examine the basis for using chronic high dose parenteral iron therapy in dialysis patients...
  6. ncbi request reprint Pathophysiology of uric acid nephrolithiasis
    Orson W Moe
    Department of Internal Medicine, Center for Mineral Metabolism and Clinical Research, Center of Human Nutrition, University of Texas Southwestern Medical Center, Department of Veteran Affairs Medical Center, Dallas, TX, USA
    Endocrinol Metab Clin North Am 31:895-914. 2002
    ..A novel renal manifestation of insulin resistance is a mild defect in ammonium excretion, which is not severe enough to disturb acid-base homeostasis, but is sufficient to set up the chemical milieu for uric acid nephrolithiasis...
  7. ncbi request reprint Clinical acid-base pathophysiology: disorders of plasma anion gap
    Orson W Moe
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, 75390 8856, USA
    Best Pract Res Clin Endocrinol Metab 17:559-74. 2003
    ....
  8. ncbi request reprint Kidney stones: pathophysiology and medical management
    Orson W Moe
    Charles and Jane Pak Center of Mineral Metabolism and Clinical Research and Department of Internal Medicine University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Lancet 367:333-44. 2006
    ..Manipulation of inhibitors and epithelial factors is important and needs further investigation. Advances in the management of nephrolithiasis depend on combined efforts of clinicians and scientists to understand the pathophysiology...
  9. doi request reprint Posing the question again: does chronic uric acid nephropathy exist?
    Orson W Moe
    Department of Internal Medicine, Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, Dallas, TX 75390 8855, USA
    J Am Soc Nephrol 21:395-7. 2010
    ..Human epidemiologic data are quite varied, but positive studies do exist. Pathophysiologic models of biology for this entity are sparse in animals and nonexistent in humans...
  10. ncbi request reprint Genetic hypercalciuria
    Orson W Moe
    Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8855, USA
    J Am Soc Nephrol 16:729-45. 2005
    ..Finally, the problem is set in perspective of the current database, technologic advances and limitations are highlighted, and prospects of further advances in the field are speculated upon...
  11. ncbi request reprint Uric acid nephrolithiasis: proton titration of an essential molecule?
    Orson W Moe
    Charles and Jane Pak Center of Mineral Metabolism and Clinical Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8855, USA
    Curr Opin Nephrol Hypertens 15:366-73. 2006
    ..This commentary examines the rationales behind the existence of uric acid in urine and body fluids in vertebrate evolution...
  12. ncbi request reprint ET(B) receptor activation causes exocytic insertion of NHE3 in OKP cells
    Y Peng
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Am J Physiol Renal Physiol 280:F34-42. 2001
    ..These studies demonstrate that ET-1 induces net trafficking of NHE3 to the apical membrane that is mediated by enhanced exocytic insertion and is required for increased NHE3 activity...
  13. ncbi request reprint Renal cortical mitochondrial aconitase is regulated in hypo- and hypercitraturia
    J Z Melnick
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
    Kidney Int 54:160-5. 1998
    ..The present studies examined the regulation of mitochondrial aconitase (m-aconitase), the first step in mitochondrial citrate metabolism, in these conditions...
  14. pmc Effect of renal lipid accumulation on proximal tubule Na+/H+ exchange and ammonium secretion
    I Alexandru Bobulescu
    Dept of Internal Medicine, Univ of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 294:F1315-22. 2008
    ..These findings suggest that renal steatosis decreases ammonium secretion in the proximal tubule, in part by reducing NHE3 activity and by impairing the regulation of NHE3 by specific agonists...
  15. ncbi request reprint Characterization of acute inhibition of Na/H exchanger NHE-3 by dopamine in opossum kidney cells
    M R Wiederkehr
    Medical Service, Department of Veteran Affairs Medical Center and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235-8856, USA
    Kidney Int 59:197-209. 2001
    ..2) DA1 is sufficient to inhibit NHE-3, while DA2 is insufficient but plays a synergistic role by altering NHE-3 phosphorylation...
  16. pmc Characterization of the regulation of renal Na+/H+ exchanger NHE3 by insulin
    Daniel G Fuster
    Department of Internal Medicine, University of Texas Southwestern Medical Ctr, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 292:F577-85. 2007
    ..In summary, insulin stimulates NHE3 acutely via yet undefined pathways and mechanisms. The chronic effect of insulin is mediated by the classic PI3K-SGK1 route...
  17. ncbi request reprint OKP cells express the Na-dicarboxylate cotransporter NaDC-1
    Seiji Aruga
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8856, USA
    Am J Physiol Cell Physiol 287:C64-72. 2004
    ..In OKP cells transfected with a green fluorescent protein-oNaDC-1 construct, however, media acidification increases Na-dependent citrate uptake, demonstrating posttranscriptional acid regulation of NaDC-1 activity...
  18. ncbi request reprint Biochemical and stone-risk profiles with topiramate treatment
    Brian J Welch
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Am J Kidney Dis 48:555-63. 2006
    ..This study explores the relationship between topiramate treatment and propensity for kidney stone formation...
  19. ncbi request reprint Effect of high protein diet on stone-forming propensity and bone loss in rats
    Jamshid Amanzadeh
    Center for Mineral Metabolism and Clinical Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    Kidney Int 64:2142-9. 2003
    ..The purpose of this study was to create an animal model of animal protein excess and to evaluate the response of kidney and bone to the dietary protein load...
  20. ncbi request reprint Effects of thyroid hormone on the neonatal renal cortical Na+/H+ antiporter
    M Baum
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA
    Kidney Int 53:1254-8. 1998
    ..001). These data are consistent with a potential role of thyroid hormone in the postnatal increase in Na+/H+ antiporter activity...
  21. ncbi request reprint Acute regulation of Na/H exchanger NHE3 by adenosine A(1) receptors is mediated by calcineurin homologous protein
    Francesca Di Sole
    Department of Internal Medicine, University of Texas Southwestern, Dallas, Texas 75390 8856, USA
    J Biol Chem 279:2962-74. 2004
    ..We conclude that CHPNHE3 interaction is regulated by A(1)R activation and this interaction is a necessary and integral part of the signaling pathway between adenosine and NHE3...
  22. ncbi request reprint Phosphatonin washout in Hyp mice proximal tubules: evidence for posttranscriptional regulation
    Michel Baum
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 9063, USA
    Am J Physiol Renal Physiol 288:F363-70. 2005
    ..These data are consistent with a rapidly reversible posttranscriptional defect in Hyp mice causing a reduction in phosphate transport...
  23. ncbi request reprint Pathophysiologic basis for normouricosuric uric acid nephrolithiasis
    Khashayar Sakhaee
    Center of Mineral Metabolism and Clinical Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8891, USA
    Kidney Int 62:971-9. 2002
    ..Patients with uric acid nephrolithaisis have normal acid-base parameters according conventional clinical tests...
  24. ncbi request reprint Circadian variation in urine pH and uric acid nephrolithiasis risk
    Mary Ann Cameron
    Department of Internal Medicine, Children s Medical Center, TX, USA
    Nephrol Dial Transplant 22:2375-8. 2007
  25. pmc Klotho deficiency causes vascular calcification in chronic kidney disease
    Ming Chang Hu
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    J Am Soc Nephrol 22:124-36. 2011
    ..Klotho ameliorates vascular calcification by enhancing phosphaturia, preserving glomerular filtration, and directly inhibiting phosphate uptake by vascular smooth muscle. Replacement of Klotho may have therapeutic potential for CKD...
  26. ncbi request reprint Physicochemical metabolic characteristics for calcium oxalate stone formation in patients with gouty diathesis
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    J Urol 173:1606-9. 2005
    ..We determined why calcium oxalate stones instead of uric acid stones form in some patients with gouty diathesis...
  27. pmc Mechanism of urinary calcium regulation by urinary magnesium and pH
    Olivier Bonny
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Am Soc Nephrol 19:1530-7. 2008
    ..In summary, these data are compatible with the hypothesis that urinary magnesium directly inhibits renal calcium absorption, which can be negated by high luminal pH, and that this regulation likely takes place in the distal tubule...
  28. pmc Glucocorticoids acutely increase cell surface Na+/H+ exchanger-3 (NHE3) by activation of NHE3 exocytosis
    I Alexandru Bobulescu
    Univ of Texas Southwestern Medical Ctr, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 289:F685-91. 2005
    ....
  29. pmc Klotho and kidney disease
    Ming Chang Hu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 7390 8855, USA
    J Nephrol 23:S136-44. 2010
    ..In summary, Klotho is a critical molecule in a wide variety of renal diseases and bears great potential as a diagnostic and prognostic biomarker as well as for therapeutic replacement therapy...
  30. ncbi request reprint Urine composition in type 2 diabetes: predisposition to uric acid nephrolithiasis
    Mary Ann Cameron
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    J Am Soc Nephrol 17:1422-8. 2006
    ..Higher body mass and increased acid intake can contribute to but cannot entirely account for the lower urine pH in patients with type 2 diabetes...
  31. ncbi request reprint Nephrolithiasis in children
    Mary Ann Cameron
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8885, USA
    Pediatr Nephrol 20:1587-92. 2005
    ..Environmental and hereditary factors are summarized to provide a guide in the evaluation of pediatric stone formers...
  32. pmc When EGF is offside, magnesium is wasted
    Shmuel Muallem
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Invest 117:2086-9. 2007
    ..This work is another seminal example of the power of the study of monogenic disorders in the quest to understand human physiology...
  33. pmc The calcineurin homologous protein-1 increases Na(+)/H(+) -exchanger 3 trafficking via ezrin phosphorylation
    Francesca Di Sole
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8885, USA
    J Am Soc Nephrol 20:1776-86. 2009
    ..Taken together, these results demonstrate that CHP1 increases NHE3 abundance and constitutive function in a manner dependent on ezrin phosphorylation...
  34. ncbi request reprint Long-term combined treatment with thiazide and potassium citrate in nephrolithiasis does not lead to hypokalemia or hypochloremic metabolic alkalosis
    Clarita V Odvina
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, and Department of Veterans Affairs Medical Center, Dallas, Texas 75390 8885, USA
    Kidney Int 63:240-7. 2003
    ..This retrospective analysis was conducted to determine if these two potential complications are encountered in patients on long-term potassium citrate and thiazide therapy...
  35. pmc Biochemical and histological assessment of alkali therapy during high animal protein intake in the rat
    Joseph E Zerwekh
    Department of Internal Medicine, Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8885, USA
    Bone 45:1004-9. 2009
    ..In this animal model of high dietary animal protein intake, the major skeletal effect of alkali therapy is to reduce bone resorption, with little or no effect on bone formation...
  36. pmc Reduction of renal triglyceride accumulation: effects on proximal tubule Na+/H+ exchange and urinary acidification
    I Alexandru Bobulescu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 297:F1419-26. 2009
    ....
  37. ncbi request reprint The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistance
    Nicola Abate
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9169, USA
    Kidney Int 65:386-92. 2004
    ....
  38. pmc Metabolic basis for low urine pH in type 2 diabetes
    Naim M Maalouf
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    Clin J Am Soc Nephrol 5:1277-81. 2010
    ..This study was conducted to assess the metabolic basis responsible for the excessive urinary acidity of individuals with type 2 diabetes...
  39. ncbi request reprint The dopamine precursor L-dihydroxyphenylalanine is transported by the amino acid transporters rBAT and LAT2 in renal cortex
    HENRY QUINONES
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 287:F74-80. 2004
    ..We conclude that rBAT and LAT2 can mediate apical and basolateral l-DOPA uptake into the proximal tubule, respectively. Additional l-DOPA transport mechanisms exist in the renal cortex that remain to be identified...
  40. ncbi request reprint Novel insights into the pathogenesis of uric acid nephrolithiasis
    Naim M Maalouf
    Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    Curr Opin Nephrol Hypertens 13:181-9. 2004
    ..The underlying mechanism(s) responsible for these disturbances remain poorly characterized. This review summarizes previous knowledge and highlights some recent developments in the pathophysiology of low urine pH and hyperuricosuria...
  41. pmc Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective
    Ming Chang Hu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Kidney Int 78:1240-51. 2010
    ..Thus, endogenous Klotho not only serves as an early biomarker for AKI but also functions as a renoprotective factor with therapeutic potential...
  42. ncbi request reprint Low urine pH: a novel feature of the metabolic syndrome
    Naim M Maalouf
    The Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, Dallas, Texas, USA
    Clin J Am Soc Nephrol 2:883-8. 2007
    ..This study examined the association between the metabolic syndrome and urine pH in individuals without a history of nephrolithiasis...
  43. pmc A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC)
    Dan Wang
    Cecil H and Ida Green Center for Reproductive Biology Sciences, Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390 9051, USA
    Proc Natl Acad Sci U S A 104:9325-30. 2007
    ..We propose that the formation of this complex efficiently modulates intracellular pH and bicarbonate levels through the rapid and effective control of sAC and sNHE activities to facilitate sperm motility regulation...
  44. pmc Nephrolithiasis-associated bone disease: pathogenesis and treatment options
    Khashayar Sakhaee
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    Kidney Int 79:393-403. 2011
    ..This manuscript reviews the epidemiology, pathophysiology, and potential treatments of bone disease in patients with nephrolithiasis...
  45. ncbi request reprint Sodium-hydrogen exchange in renal epithelia: mechanisms of acute regulation
    O W Moe
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8856, USA
    Curr Opin Nephrol Hypertens 6:440-6. 1997
    ..This review updates understanding of the renal distribution and highlights some of the recent advances in understanding the mechanisms of acute regulation of sodium-hydrogen exchangers in the kidney...
  46. ncbi request reprint Role of c-SRC and ERK in acid-induced activation of NHE3
    Hirohiko Tsuganezawa
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9003, USA
    Kidney Int 62:41-50. 2002
    ..Incubation of cultured renal epithelial cells in acid media activates c-Src...
  47. pmc Luminal Na(+)/H (+) exchange in the proximal tubule
    I Alexandru Bobulescu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 75390 8856, USA
    Pflugers Arch 458:5-21. 2009
    ..This article discusses the physiology of proximal Na(+)/H(+) exchange, the multiple mechanisms of NHE3 regulation, and the reciprocal relationship between NHE3 and NHE8 at the lumen of the proximal tubule...
  48. ncbi request reprint Ontogeny of NHE8 in the rat proximal tubule
    Amy M Becker
    Dept of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
    Am J Physiol Renal Physiol 293:F255-61. 2007
    ..These data demonstrate that NHE8 does undergo maturational changes on the apical membrane of the rat proximal tubule and may account for the Na(+)-dependent proton flux in neonatal proximal tubules...
  49. ncbi request reprint Etiological role of estrogen status in renal stone formation
    Howard J Heller
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Center for Mineral Metabolism and Clinical Research, USA
    J Urol 168:1923-7. 2002
    ..We examined the contribution of estrogen to kidney stone risk by comparing outpatient evaluations in the 2 genders, and in estrogen treated and untreated postmenopausal women...
  50. pmc Lipid- and mechanosensitivities of sodium/hydrogen exchangers analyzed by electrical methods
    Daniel Fuster
    Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA
    Proc Natl Acad Sci U S A 101:10482-7. 2004
    ..Expressed in AP-1 cells, however, NHE1 is insensitive to these agents but remains sensitive to volume changes. Thus, changes of hydrophobic mismatch can modulate NHE1 but do not underlie its volume sensitivity...
  51. pmc Endothelin-1/endothelin-B receptor-mediated increases in NHE3 activity in chronic metabolic acidosis
    K Laghmani
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9003, USA
    J Clin Invest 107:1563-9. 2001
    ..In conclusion, metabolic acidosis increases ET-1 expression, which increases NHE3 activity via the ET(B) receptor...
  52. pmc Na+/H+ exchangers in renal regulation of acid-base balance
    I Alexandru Bobulescu
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Semin Nephrol 26:334-44. 2006
    ..This article reviews some important aspects of NHEs in the kidney, with special emphasis on the role of renal NHE3 in the maintenance of acid-base balance...
  53. ncbi request reprint Post-renal transplantation hypophosphatemia: a review and novel insights
    Hrishikesh Ghanekar
    Department of Internal Medicine and Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Curr Opin Nephrol Hypertens 15:97-104. 2006
    ....
  54. ncbi request reprint Recurrent calcium nephrolithiasis associated with primary aldosteronism
    Jason Shey
    Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8885, USA
    Am J Kidney Dis 44:e7-12. 2004
    ..The patient had severe recurrent renal calcium calculi that corrected with adrenalectomy. The clinical physiology of renal calcium and citrate handling in hyperaldosteronism is reviewed...
  55. pmc Characterization of Na+/H+ exchanger NHE8 in cultured renal epithelial cells
    Jianning Zhang
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 293:F761-6. 2007
    ..NHE8 activity is Na+ dependent, displaying a cooperative sigmoidal relationship, and is highly sensitive to 5-(N-ethyl-n-isopropyl)-amiloride (EIPA). NRK cells provide a useful system where NHE8 can be studied in its native environment...
  56. ncbi request reprint Rapid Communication: relative effect of urinary calcium and oxalate on saturation of calcium oxalate
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 8571, USA
    Kidney Int 66:2032-7. 2004
    ..The study compared the effect of urinary calcium with that of oxalate on urinary saturation [relative saturation ratio (RSR)] of calcium oxalate...
  57. ncbi request reprint Expression of epidermal growth factor and surfactant proteins during postnatal and compensatory lung growth
    David J Foster
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9034, USA
    Am J Physiol Lung Cell Mol Physiol 283:L981-90. 2002
    ....
  58. ncbi request reprint Cloning and characterization of the human soluble adenylyl cyclase
    Weidong Geng
    Center for Mineral Metabolism and Clinical Research, Department of Internal Medicine University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 8885, USA
    Am J Physiol Cell Physiol 288:C1305-16. 2005
    ..In summary, hsAC is a divalent cation and HCO(3)(-) sensor, and its HCO(3)(-) sensitivity is modulated by divalent cations...
  59. pmc Na+/H+ exchangers: physiology and link to hypertension and organ ischemia
    I Alexandru Bobulescu
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 77530, USA
    Curr Opin Nephrol Hypertens 14:485-94. 2005
    ..The involvement of NHEs in the pathophysiology of these disorders is incompletely understood. This paper reviews the principal findings and current hypotheses linking NHE dysfunction to hypertension and ischemia...
  60. pmc Steady-state function of the ubiquitous mammalian Na/H exchanger (NHE1) in relation to dimer coupling models with 2Na/2H stoichiometry
    Daniel Fuster
    Department of Physiology and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Gen Physiol 132:465-80. 2008
    ..We conclude that a large fraction of mammalian Na/H activity may occur with a 2Na/2H stoichiometry...
  61. ncbi request reprint Dopamine acutely stimulates Na+/H+ exchanger (NHE3) endocytosis via clathrin-coated vesicles: dependence on protein kinase A-mediated NHE3 phosphorylation
    M C Hu
    Medical Service, Department of Veterans Affairs Medical Center, Dallas, Texas 75216, USA
    J Biol Chem 276:26906-15. 2001
    ..We conclude that one mechanism by which DA induces natriuresis is via protein kinase A-mediated phosphorylation of proximal tubule NHE3 leading to endocytosis of NHE3 via clathrin-coated vesicles...
  62. pmc Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule
    Ming Chang Hu
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 8885, USA
    FASEB J 24:3438-50. 2010
    ....
  63. pmc Inhibition of osteoclast formation and function by bicarbonate: role of soluble adenylyl cyclase
    Weidong Geng
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75390 8885, USA
    J Cell Physiol 220:332-40. 2009
    ..This HCO(3)(-) effect on BV/TV was blocked by 2-hydroxyestradiol. In summary, sAC mediates the inhibition of osteoclast function by HCO(3)(-), by acting as a HCO(3)(-) sensor...
  64. pmc Effect of claudins 6 and 9 on paracellular permeability in MDCK II cells
    David Sas
    Dept of Pediatrics, U T Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1713-9. 2008
    ....
  65. pmc Comparison of insulin action on glucose versus potassium uptake in humans
    Trang Q Nguyen
    The Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Clin J Am Soc Nephrol 6:1533-9. 2011
    ..This study examines whether the cellular uptake of these molecules is regulated in concert or independently...
  66. pmc Synergistic upregulation of erythropoietin receptor (EPO-R) expression by sense and antisense EPO-R transcripts in the canine lung
    Quiyang Zhang
    Departments of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9034, USA
    Proc Natl Acad Sci U S A 105:7612-7. 2008
    ..This demonstrates synergism between sense-antisense EPO-R transcripts in response to physiological stimulation in a robust model of induced lung growth...
  67. ncbi request reprint Minimal change disease with acute renal failure: a case against the nephrosarca hypothesis
    Mary Ann Cameron
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8885, USA
    Nephrol Dial Transplant 19:2642-6. 2004
    ..The time profile of the clinical events is not compatible with the nephrosarca hypothesis and suggests an alternative pathophysiological model for the diminished glomerular filtration rate seen in some cases of minimal change disease...
  68. ncbi request reprint Upregulation of erythropoietin receptor during postnatal and postpneumonectomy lung growth
    David J Foster
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9034, USA
    Am J Physiol Lung Cell Mol Physiol 287:L1107-15. 2004
    ..We conclude that both developmental and compensatory lung growth involve paracrine EPO signaling with parallel upregulation but differential processing of EPOR...
  69. pmc Comparison of semi-empirical and computer derived methods for estimating urinary saturation of brushite
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Urol 181:1423-8. 2009
    ..To attempt resolution the supersaturation index according to the Joint Expert Speciation System and the relative saturation ratio according to Equil 2 were compared with the semi-empirically derived concentration-to-product ratio...
  70. ncbi request reprint Bicarbonate reabsorption and NHE-3 expression: abundance and activity are increased in Henle's loop of remnant rats
    Giovambattista Capasso
    Nephrology and Research Centre for Cardiovascular Diseases, Second University of Naples, Naples, Italy
    Kidney Int 62:2126-35. 2002
    ..We investigated whether the reduction of renal mass is associated with alterations in LOH bicarbonate transport coupled to changes in NHE-3 gene expression and in vivo activity...
  71. pmc Monitoring protein-protein interactions between the mammalian integral membrane transporters and PDZ-interacting partners using a modified split-ubiquitin membrane yeast two-hybrid system
    Serge M Gisler
    Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Mol Cell Proteomics 7:1362-77. 2008
    ..In summary, our study establishes the MYTH 2.0 system as a novel tool for interactive proteomics studies of membrane protein complexes...
  72. ncbi request reprint Dopamine acutely decreases apical membrane Na/H exchanger NHE3 protein in mouse renal proximal tubule
    Desa Bacic
    Institute of Anatomy, University of Zurich, Zurich, Switzerland
    Kidney Int 64:2133-41. 2003
    ..Dopamine acutely alters glomerular filtration rate (GFR) and decreases Na+ absorption in both the proximal and distal nephron. Proximal tubule natriuresis is effected through inhibition of the apical membrane Na/H exchanger NHE3...
  73. ncbi request reprint Insulin activates Na(+)/H(+) exchanger 3: biphasic response and glucocorticoid dependence
    Jelena Klisic
    Department of Physiology, University of Zurich Irchel, CH 8057 Zurich, Switzerland
    Am J Physiol Renal Physiol 283:F532-9. 2002
    ....
  74. pmc Molecular aspects of acute inhibition of Na(+)-H(+) exchanger NHE3 by A(2)-adenosine receptor agonists
    Francesca Di Sole
    Department of Physiology and Pathophysiology, Division of Vegetative Physiology and Pathophysiology, Georg August University of Gottingen, D 37073 Gottingen, Germany
    J Physiol 541:529-43. 2002
    ..In conclusion, two highly conserved target serine sites on NHE3 determine NHE3 modulation upon A(2)-receptor activation and NHE3 inactivation by adenosine proceeds via two phases with distinct mechanisms...
  75. ncbi request reprint Scaffolds: Orchestrating proteins to achieve concerted function
    Orson W Moe
    Kidney Int 64:1916-7. 2003
  76. ncbi request reprint Shank2 associates with and regulates Na+/H+ exchanger 3
    Wonsun Han
    Department of Pharmacology, Brain Korea 21 Project for Medical Science, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 120 752, Korea
    J Biol Chem 281:1461-9. 2006
    ..These results indicate that Shank2 is a novel NHE3 interacting protein that is involved in the fine regulation of transepithelial salt and water transport through affecting NHE3 expression and activity...
  77. ncbi request reprint Dual role of citrate in mammalian urine
    Orson W Moe
    Curr Opin Nephrol Hypertens 15:419-24. 2006
  78. ncbi request reprint Hypothesizing on the evolutionary origins of salt-induced hypercalciuria
    Orson W Moe
    Curr Opin Nephrol Hypertens 14:368-72. 2005
  79. ncbi request reprint Phosphatonins: a new class of phosphate-regulating proteins
    Susan C Schiavi
    Applied Genomics, Genzyme Corporation, One Mountain Road, Framingham, Massachusetts 01701, USA
    Curr Opin Nephrol Hypertens 11:423-30. 2002
    ..The molecular characterization of these substances will prove to be critical for understanding phosphate physiology and clinical disorders of phosphate metabolism...
  80. ncbi request reprint Activation of dopamine D1-like receptors induces acute internalization of the renal Na+/phosphate cotransporter NaPi-IIa in mouse kidney and OK cells
    Desa Bacic
    Institute of Physiology, Univ of Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    Am J Physiol Renal Physiol 288:F740-7. 2005
    ..In summary, dopamine induces internalization of NaPi-IIa by activation of luminal D(1)-like receptors, an effect that is mediated by PKA...
  81. ncbi request reprint Albumin regulates the Na+/H+ exchanger 3 in OKP cells
    Jelena Klisic
    Department of Physiology, University of Zurich Irchel, Zurich, Switzerland
    J Am Soc Nephrol 14:3008-16. 2003
    ..The effects of albumin on NHE3 protein abundance were modified by hydrocortisone in a complicated pattern. These results indicate that albumin directly regulates proximal tubular NHE3 at multiple levels...
  82. pmc Characterization of the sodium/hydrogen exchanger NHA2
    Daniel G Fuster
    Division of Nephrology and Hypertension and Institute for Biochemistry and Molecular Medicine, University of Bern, Buhlstrasse 28, CH 3012 Bern, Switzerland
    J Am Soc Nephrol 19:1547-56. 2008
    ..In summary, NHA2 is a ubiquitous mammalian sodium proton/exchanger that is restricted to the distal convoluted tubule in the kidney...

Research Grants13

  1. Acute Regulation of the Renal Na/H Exchanger NHE-3
    Orson Moe; Fiscal Year: 2003
    ..These studies will uncover highly fundamental mechanisms of regulation of an important epithelial Na transporter and further our understanding 01 disturbance in acid-base balance, Na retention and hypertension. ..
  2. ENDOGENOUS AND EXOGENOUS IL 10 AND RENAL INJURY
    Orson Moe; Fiscal Year: 1999
    ....
  3. ENDOGENOUS AND EXOGENOUS IL 10 AND RENAL INJURY
    Orson Moe; Fiscal Year: 2001
    ....
  4. H+-ATPase B-subunit Dysfunction and Calcium Nephrolithiasis
    Orson Moe; Fiscal Year: 2009
    ....
  5. Acute Regulation of the Renal Na/H Exchanger NHE-3
    Orson Moe; Fiscal Year: 2005
    ..These studies will uncover highly fundamental mechanisms of regulation of an important epithelial Na transporter and further our understanding 01 disturbance in acid-base balance, Na retention and hypertension. ..
  6. Acute Regulation of the Renal Na/H Exchanger NHE-3
    Orson Moe; Fiscal Year: 2004
    ..These studies will uncover highly fundamental mechanisms of regulation of an important epithelial Na transporter and further our understanding 01 disturbance in acid-base balance, Na retention and hypertension. ..
  7. H+-ATPase B-subunit Dysfunction and Calcium Nephrolithiasis
    Orson W Moe; Fiscal Year: 2010
    ....
  8. Acute Regulation of the Renal Na/H Exchanger NHE-3
    Orson Moe; Fiscal Year: 2002
    ..These studies will uncover highly fundamental mechanisms of regulation of an important epithelial Na transporter and further our understanding 01 disturbance in acid-base balance, Na retention and hypertension. ..
  9. Acute Regulation of the Renal Na/H Exchanger NHE-3
    Orson Moe; Fiscal Year: 2001
    ..These studies will uncover highly fundamental mechanisms of regulation of an important epithelial Na transporter and further our understanding 01 disturbance in acid-base balance, Na retention and hypertension. ..
  10. ENDOGENOUS AND EXOGENOUS IL 10 AND RENAL INJURY
    Orson Moe; Fiscal Year: 2000
    ....
  11. FORMULATION OF RATIONAL THERAPY OF NEPHROLITHIASIS
    Orson Moe; Fiscal Year: 2007
    ..This proposal will address the nature of calcium-oxalate interaction and how it impacts on dsk of developing kidney stones. ..