Research Topics
| O W MoeSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Publications
Hypercalciuria from acid load: renal mechanismsO W Moe
Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA
J Nephrol 19:S53-61. 2006..At least one component of the acid effect is due to renal leak of calcium. This article summarizes the effect of acid on renal handling of calcium in the proximal tubule, thick ascending limb, and distal convoluted tubule...- Iron metabolism in end stage renal failure: rationale for re-evaluation of parenteral iron therapyOrson W Moe
Department of Internal Medicine, University of Texas Southwestern Medical Center and Medical Service, Dallas 75390, USA
Curr Opin Nephrol Hypertens 12:145-51. 2003..In this article we will examine the basis for using chronic high dose parenteral iron therapy in dialysis patients... - Pathophysiology of uric acid nephrolithiasisOrson W Moe
Department of Internal Medicine, Center for Mineral Metabolism and Clinical Research, Center of Human Nutrition, University of Texas Southwestern Medical Center, Department of Veteran Affairs Medical Center, Dallas, TX, USA
Endocrinol Metab Clin North Am 31:895-914. 2002..A novel renal manifestation of insulin resistance is a mild defect in ammonium excretion, which is not severe enough to disturb acid-base homeostasis, but is sufficient to set up the chemical milieu for uric acid nephrolithiasis... - Uric acid nephrolithiasis: proton titration of an essential molecule?Orson W Moe
Charles and Jane Pak Center of Mineral Metabolism and Clinical Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8855, USA
Curr Opin Nephrol Hypertens 15:366-73. 2006..This commentary examines the rationales behind the existence of uric acid in urine and body fluids in vertebrate evolution... - Posing the question again: does chronic uric acid nephropathy exist?Orson W Moe
Department of Internal Medicine, Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, Dallas, TX 75390 8855, USA
J Am Soc Nephrol 21:395-7. 2010..Human epidemiologic data are quite varied, but positive studies do exist. Pathophysiologic models of biology for this entity are sparse in animals and nonexistent in humans... - Clinical acid-base pathophysiology: disorders of plasma anion gapOrson W Moe
Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, 75390 8856, USA
Best Pract Res Clin Endocrinol Metab 17:559-74. 2003.... - Pharmacotherapy of urolithiasis: evidence from clinical trialsOrson W Moe
University of Texas Southwestern Medical Center, Dallas, Texas 75380, USA
Kidney Int 79:385-92. 2011.... - Genetic hypercalciuriaOrson W Moe
Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8855, USA
J Am Soc Nephrol 16:729-45. 2005..Finally, the problem is set in perspective of the current database, technologic advances and limitations are highlighted, and prospects of further advances in the field are speculated upon... - Kidney stones: pathophysiology and medical managementOrson W Moe
Charles and Jane Pak Center of Mineral Metabolism and Clinical Research and Department of Internal Medicine University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Lancet 367:333-44. 2006..Manipulation of inhibitors and epithelial factors is important and needs further investigation. Advances in the management of nephrolithiasis depend on combined efforts of clinicians and scientists to understand the pathophysiology... - ET(B) receptor activation causes exocytic insertion of NHE3 in OKP cellsY Peng
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235, USA
Am J Physiol Renal Physiol 280:F34-42. 2001..These studies demonstrate that ET-1 induces net trafficking of NHE3 to the apical membrane that is mediated by enhanced exocytic insertion and is required for increased NHE3 activity... - Renal cortical mitochondrial aconitase is regulated in hypo- and hypercitraturiaJ Z Melnick
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
Kidney Int 54:160-5. 1998..The present studies examined the regulation of mitochondrial aconitase (m-aconitase), the first step in mitochondrial citrate metabolism, in these conditions... - Effect of renal lipid accumulation on proximal tubule Na+/H+ exchange and ammonium secretionI Alexandru Bobulescu
Dept of Internal Medicine, Univ of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
Am J Physiol Renal Physiol 294:F1315-22. 2008..These findings suggest that renal steatosis decreases ammonium secretion in the proximal tubule, in part by reducing NHE3 activity and by impairing the regulation of NHE3 by specific agonists... - Characterization of acute inhibition of Na/H exchanger NHE-3 by dopamine in opossum kidney cellsM R Wiederkehr
Medical Service, Department of Veteran Affairs Medical Center and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235-8856, USA
Kidney Int 59:197-209. 2001..2) DA1 is sufficient to inhibit NHE-3, while DA2 is insufficient but plays a synergistic role by altering NHE-3 phosphorylation... - Characterization of the regulation of renal Na+/H+ exchanger NHE3 by insulinDaniel G Fuster
Department of Internal Medicine, University of Texas Southwestern Medical Ctr, Dallas, TX 75390 8856, USA
Am J Physiol Renal Physiol 292:F577-85. 2007..In summary, insulin stimulates NHE3 acutely via yet undefined pathways and mechanisms. The chronic effect of insulin is mediated by the classic PI3K-SGK1 route... - Biochemical and stone-risk profiles with topiramate treatmentBrian J Welch
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Am J Kidney Dis 48:555-63. 2006..001). CONCLUSION: Treatment with topiramate causes systemic metabolic acidosis, markedly lower urinary citrate excretion, and increased urinary pH. These changes increase the propensity to form calcium phosphate stones... - Effect of high protein diet on stone-forming propensity and bone loss in ratsJamshid Amanzadeh
Center for Mineral Metabolism and Clinical Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8885, USA
Kidney Int 64:2142-9. 2003..Hypocitraturia is probably renal in origin. This rat model will be useful in elucidating the mechanisms by which high protein intake increases the risk of nephrolithiasis and bone loss in human beings... - OKP cells express the Na-dicarboxylate cotransporter NaDC-1Seiji Aruga
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8856, USA
Am J Physiol Cell Physiol 287:C64-72. 2004..In OKP cells transfected with a green fluorescent protein-oNaDC-1 construct, however, media acidification increases Na-dependent citrate uptake, demonstrating posttranscriptional acid regulation of NaDC-1 activity... - Effects of thyroid hormone on the neonatal renal cortical Na+/H+ antiporterM Baum
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA
Kidney Int 53:1254-8. 1998..001). These data are consistent with a potential role of thyroid hormone in the postnatal increase in Na+/H+ antiporter activity... - A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC)Dan Wang
Cecil H and Ida Green Center for Reproductive Biology Sciences, Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390 9051, USA
Proc Natl Acad Sci U S A 104:9325-30. 2007..We propose that the formation of this complex efficiently modulates intracellular pH and bicarbonate levels through the rapid and effective control of sAC and sNHE activities to facilitate sperm motility regulation... - When EGF is offside, magnesium is wastedShmuel Muallem
Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Clin Invest 117:2086-9. 2007..This work is another seminal example of the power of the study of monogenic disorders in the quest to understand human physiology... - Phosphatonin washout in Hyp mice proximal tubules: evidence for posttranscriptional regulationMichel Baum
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 9063, USA
Am J Physiol Renal Physiol 288:F363-70. 2005..These data are consistent with a rapidly reversible posttranscriptional defect in Hyp mice causing a reduction in phosphate transport... - Nephrolithiasis in childrenMary Ann Cameron
Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8885, USA
Pediatr Nephrol 20:1587-92. 2005..Environmental and hereditary factors are summarized to provide a guide in the evaluation of pediatric stone formers... - Circadian variation in urine pH and uric acid nephrolithiasis riskMary Ann Cameron
Department of Internal Medicine, Children's Medical Center, TX, USA
Nephrol Dial Transplant 22:2375-8. 2007 - Physicochemical metabolic characteristics for calcium oxalate stone formation in patients with gouty diathesisCharles Y C Pak
Center for Mineral Metabolism and Clinical Research, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
J Urol 173:1606-9. 2005..We determined why calcium oxalate stones instead of uric acid stones form in some patients with gouty diathesis... - Urine composition in type 2 diabetes: predisposition to uric acid nephrolithiasisMary Ann Cameron
Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
J Am Soc Nephrol 17:1422-8. 2006..Higher body mass and increased acid intake can contribute to but cannot entirely account for the lower urine pH in patients with type 2 diabetes... - Glucocorticoids acutely increase cell surface Na+/H+ exchanger-3 (NHE3) by activation of NHE3 exocytosisI Alexandru Bobulescu
Univ. of Texas Southwestern Medical Ctr, 5323 Harry Hines Blvd, Dallas, TX 75390-8856, USA
Am J Physiol Renal Physiol 289:F685-91. 2005.... - Novel insights into the pathogenesis of uric acid nephrolithiasisNaim M Maalouf
Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8885, USA
Curr Opin Nephrol Hypertens 13:181-9. 2004.... - The dopamine precursor L-dihydroxyphenylalanine is transported by the amino acid transporters rBAT and LAT2 in renal cortexHENRY QUINONES
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8856, USA
Am J Physiol Renal Physiol 287:F74-80. 2004..We conclude that rBAT and LAT2 can mediate apical and basolateral l-DOPA uptake into the proximal tubule, respectively. Additional l-DOPA transport mechanisms exist in the renal cortex that remain to be identified... - Klotho deficiency causes vascular calcification in chronic kidney diseaseMing Chang Hu
Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
J Am Soc Nephrol 22:124-36. 2011..Klotho ameliorates vascular calcification by enhancing phosphaturia, preserving glomerular filtration, and directly inhibiting phosphate uptake by vascular smooth muscle. Replacement of Klotho may have therapeutic potential for CKD... - Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protectiveMing Chang Hu
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Kidney Int 78:1240-51. 2010..Thus, endogenous Klotho not only serves as an early biomarker for AKI but also functions as a renoprotective factor with therapeutic potential... - Biochemical and histological assessment of alkali therapy during high animal protein intake in the ratJoseph E Zerwekh
Department of Internal Medicine, Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8885, USA
Bone 45:1004-9. 2009..In this animal model of high dietary animal protein intake, the major skeletal effect of alkali therapy is to reduce bone resorption, with little or no effect on bone formation... - Metabolic basis for low urine pH in type 2 diabetesNaim M Maalouf
Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
Clin J Am Soc Nephrol 5:1277-81. 2010..This study was conducted to assess the metabolic basis responsible for the excessive urinary acidity of individuals with type 2 diabetes... - Reduction of renal triglyceride accumulation: effects on proximal tubule Na+/H+ exchange and urinary acidificationI Alexandru Bobulescu
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8856, USA
Am J Physiol Renal Physiol 297:F1419-26. 2009.... - The calcineurin homologous protein-1 increases Na(+)/H(+) -exchanger 3 trafficking via ezrin phosphorylationFrancesca Di Sole
Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8885, USA
J Am Soc Nephrol 20:1776-86. 2009..Taken together, these results demonstrate that CHP1 increases NHE3 abundance and constitutive function in a manner dependent on ezrin phosphorylation... - Long-term combined treatment with thiazide and potassium citrate in nephrolithiasis does not lead to hypokalemia or hypochloremic metabolic alkalosisClarita V Odvina
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, and Department of Veterans Affairs Medical Center, Dallas, Texas 75390 8885, USA
Kidney Int 63:240-7. 2003..This retrospective analysis was conducted to determine if these two potential complications are encountered in patients on long-term potassium citrate and thiazide therapy... - Mechanism of urinary calcium regulation by urinary magnesium and pHOlivier Bonny
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Am Soc Nephrol 19:1530-7. 2008..In summary, these data are compatible with the hypothesis that urinary magnesium directly inhibits renal calcium absorption, which can be negated by high luminal pH, and that this regulation likely takes place in the distal tubule... - Acute regulation of Na/H exchanger NHE3 by adenosine A(1) receptors is mediated by calcineurin homologous proteinFrancesca Di Sole
Department of Internal Medicine, University of Texas Southwestern, Dallas, Texas 75390 8856, USA
J Biol Chem 279:2962-74. 2004..We conclude that CHPNHE3 interaction is regulated by A(1)R activation and this interaction is a necessary and integral part of the signaling pathway between adenosine and NHE3... - Klotho and kidney diseaseMing Chang Hu
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 7390 8855, USA
J Nephrol 23:S136-44. 2010..In summary, Klotho is a critical molecule in a wide variety of renal diseases and bears great potential as a diagnostic and prognostic biomarker as well as for therapeutic replacement therapy... - Low urine pH: a novel feature of the metabolic syndromeNaim M Maalouf
The Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, Dallas, Texas, USA
Clin J Am Soc Nephrol 2:883-8. 2007..This study examined the association between the metabolic syndrome and urine pH in individuals without a history of nephrolithiasis... - The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistanceNicola Abate
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9169, USA
Kidney Int 65:386-92. 2004.... - Pathophysiologic basis for normouricosuric uric acid nephrolithiasisKhashayar Sakhaee
Center of Mineral Metabolism and Clinical Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8891, USA
Kidney Int 62:971-9. 2002..Although net acid excretion is maintained at the expense of increased titratable acidity and to some degree hypocitraturia, the compromise is acid urine pH and may result in uric acid nephrolithiasis... - Nephrolithiasis-associated bone disease: pathogenesis and treatment optionsKhashayar Sakhaee
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
Kidney Int 79:393-403. 2011..This manuscript reviews the epidemiology, pathophysiology, and potential treatments of bone disease in patients with nephrolithiasis... - Sodium-hydrogen exchange in renal epithelia: mechanisms of acute regulationO W Moe
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8856, USA
Curr Opin Nephrol Hypertens 6:440-6. 1997..This review updates understanding of the renal distribution and highlights some of the recent advances in understanding the mechanisms of acute regulation of sodium-hydrogen exchangers in the kidney... - Etiological role of estrogen status in renal stone formationHoward J Heller
Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Center for Mineral Metabolism and Clinical Research, USA
J Urol 168:1923-7. 2002..Estrogen treatment may decrease the risk of stone recurrence in postmenopausal women by lowering urinary calcium and calcium oxalate saturation... - Lipid- and mechanosensitivities of sodium/hydrogen exchangers analyzed by electrical methodsDaniel Fuster
Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA
Proc Natl Acad Sci U S A 101:10482-7. 2004..Expressed in AP-1 cells, however, NHE1 is insensitive to these agents but remains sensitive to volume changes. Thus, changes of hydrophobic mismatch can modulate NHE1 but do not underlie its volume sensitivity... - Role of c-SRC and ERK in acid-induced activation of NHE3Hirohiko Tsuganezawa
Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9003, USA
Kidney Int 62:41-50. 2002..Incubation of cultured renal epithelial cells in acid media activates c-Src... - Luminal Na(+)/H (+) exchange in the proximal tubuleI Alexandru Bobulescu
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 75390 8856, USA
Pflugers Arch 458:5-21. 2009..This article discusses the physiology of proximal Na(+)/H(+) exchange, the multiple mechanisms of NHE3 regulation, and the reciprocal relationship between NHE3 and NHE8 at the lumen of the proximal tubule... - Ontogeny of NHE8 in the rat proximal tubuleAmy M Becker
Dept of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
Am J Physiol Renal Physiol 293:F255-61. 2007..These data demonstrate that NHE8 does undergo maturational changes on the apical membrane of the rat proximal tubule and may account for the Na(+)-dependent proton flux in neonatal proximal tubules... - Expression of epidermal growth factor and surfactant proteins during postnatal and compensatory lung growthDavid J Foster
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9034, USA
Am J Physiol Lung Cell Mol Physiol 283:L981-90. 2002.... - Recurrent calcium nephrolithiasis associated with primary aldosteronismJason Shey
Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8885, USA
Am J Kidney Dis 44:e7-12. 2004..The patient had severe recurrent renal calcium calculi that corrected with adrenalectomy. The clinical physiology of renal calcium and citrate handling in hyperaldosteronism is reviewed... - Characterization of Na+/H+ exchanger NHE8 in cultured renal epithelial cellsJianning Zhang
Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
Am J Physiol Renal Physiol 293:F761-6. 2007..NHE8 activity is Na+ dependent, displaying a cooperative sigmoidal relationship, and is highly sensitive to 5-(N-ethyl-n-isopropyl)-amiloride (EIPA). NRK cells provide a useful system where NHE8 can be studied in its native environment... - Na+/H+ exchangers in renal regulation of acid-base balanceI Alexandru Bobulescu
Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Semin Nephrol 26:334-44. 2006..This article reviews some important aspects of NHEs in the kidney, with special emphasis on the role of renal NHE3 in the maintenance of acid-base balance... - Steady-state function of the ubiquitous mammalian Na/H exchanger (NHE1) in relation to dimer coupling models with 2Na/2H stoichiometryDaniel Fuster
Department of Physiology and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Gen Physiol 132:465-80. 2008..We conclude that a large fraction of mammalian Na/H activity may occur with a 2Na/2H stoichiometry... - Rapid Communication: relative effect of urinary calcium and oxalate on saturation of calcium oxalateCharles Y C Pak
Center for Mineral Metabolism and Clinical Research, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 8571, USA
Kidney Int 66:2032-7. 2004..The study compared the effect of urinary calcium with that of oxalate on urinary saturation [relative saturation ratio (RSR)] of calcium oxalate... - Cloning and characterization of the human soluble adenylyl cyclaseWeidong Geng
Center for Mineral Metabolism and Clinical Research, Department of Internal Medicine. University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390-8885, USA
Am J Physiol Cell Physiol 288:C1305-16. 2005..In summary, hsAC is a divalent cation and HCO(3)(-) sensor, and its HCO(3)(-) sensitivity is modulated by divalent cations... - Post-renal transplantation hypophosphatemia: a review and novel insightsHrishikesh Ghanekar
Department of Internal Medicine and Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Curr Opin Nephrol Hypertens 15:97-104. 2006..Further studies of the regulatory mechanism of fibroblast growth factor-23 and its metabolism may offer additional insights into phosphorus homeostasis and its clinical application in the post-renal transplantation population... - Na+/H+ exchangers: physiology and link to hypertension and organ ischemiaI Alexandru Bobulescu
Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 77530, USA
Curr Opin Nephrol Hypertens 14:485-94. 2005..SUMMARY: This paper provides the interested reader with a concise overview of NHE physiology, and aims to address the implication of NHEs in the pathophysiology of hypertension and organ ischemia in light of the most recent literature... - Endothelin-1/endothelin-B receptor-mediated increases in NHE3 activity in chronic metabolic acidosisK Laghmani
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9003, USA
J Clin Invest 107:1563-9. 2001..In conclusion, metabolic acidosis increases ET-1 expression, which increases NHE3 activity via the ET(B) receptor... - Dopamine acutely stimulates Na+/H+ exchanger (NHE3) endocytosis via clathrin-coated vesicles: dependence on protein kinase A-mediated NHE3 phosphorylationM C Hu
Medical Service, Department of Veterans Affairs Medical Center, Dallas, Texas 75216, USA
J Biol Chem 276:26906-15. 2001..We conclude that one mechanism by which DA induces natriuresis is via protein kinase A-mediated phosphorylation of proximal tubule NHE3 leading to endocytosis of NHE3 via clathrin-coated vesicles... - Inhibition of osteoclast formation and function by bicarbonate: role of soluble adenylyl cyclaseWeidong Geng
Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75390 8885, USA
J Cell Physiol 220:332-40. 2009..This HCO(3)(-) effect on BV/TV was blocked by 2-hydroxyestradiol. In summary, sAC mediates the inhibition of osteoclast function by HCO(3)(-), by acting as a HCO(3)(-) sensor... - Effect of claudins 6 and 9 on paracellular permeability in MDCK II cellsDavid Sas
Dept of Pediatrics, U T Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235, USA
Am J Physiol Regul Integr Comp Physiol 295:R1713-9. 2008.... - Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubuleMing Chang Hu
Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 8885, USA
FASEB J 24:3438-50. 2010.... - Comparison of insulin action on glucose versus potassium uptake in humansTrang Q Nguyen
The Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Clin J Am Soc Nephrol 6:1533-9. 2011..This study examines whether the cellular uptake of these molecules is regulated in concert or independently... - Comparison of semi-empirical and computer derived methods for estimating urinary saturation of brushiteCharles Y C Pak
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Urol 181:1423-8. 2009..To attempt resolution the supersaturation index according to the Joint Expert Speciation System and the relative saturation ratio according to Equil 2 were compared with the semi-empirically derived concentration-to-product ratio... - Synergistic upregulation of erythropoietin receptor (EPO-R) expression by sense and antisense EPO-R transcripts in the canine lungQuiyang Zhang
Departments of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9034, USA
Proc Natl Acad Sci U S A 105:7612-7. 2008..This demonstrates synergism between sense-antisense EPO-R transcripts in response to physiological stimulation in a robust model of induced lung growth... - Upregulation of erythropoietin receptor during postnatal and postpneumonectomy lung growthDavid J Foster
Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9034, USA
Am J Physiol Lung Cell Mol Physiol 287:L1107-15. 2004..We conclude that both developmental and compensatory lung growth involve paracrine EPO signaling with parallel upregulation but differential processing of EPOR... - Minimal change disease with acute renal failure: a case against the nephrosarca hypothesisMary Ann Cameron
Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8885, USA
Nephrol Dial Transplant 19:2642-6. 2004..The time profile of the clinical events is not compatible with the nephrosarca hypothesis and suggests an alternative pathophysiological model for the diminished glomerular filtration rate seen in some cases of minimal change disease... - Insulin activates Na(+)/H(+) exchanger 3: biphasic response and glucocorticoid dependenceJelena Klisic
Department of Physiology, University of Zurich-Irchel, CH-8057 Zurich, Switzerland
Am J Physiol Renal Physiol 283:F532-9. 2002.... - Molecular aspects of acute inhibition of Na(+)-H(+) exchanger NHE3 by A(2)-adenosine receptor agonistsFrancesca Di Sole
Department of Physiology and Pathophysiology, Division of Vegetative Physiology and Pathophysiology, , , Germany
J Physiol 541:529-43. 2002..In conclusion, two highly conserved target serine sites on NHE3 determine NHE3 modulation upon A(2)-receptor activation and NHE3 inactivation by adenosine proceeds via two phases with distinct mechanisms... - Monitoring protein-protein interactions between the mammalian integral membrane transporters and PDZ-interacting partners using a modified split-ubiquitin membrane yeast two-hybrid systemSerge M Gisler
Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Mol Cell Proteomics 7:1362-77. 2008..In summary, our study establishes the MYTH 2.0 system as a novel tool for interactive proteomics studies of membrane protein complexes... - Bicarbonate reabsorption and NHE-3 expression: abundance and activity are increased in Henle's loop of remnant ratsGiovambattista Capasso
Nephrology and Research Centre for Cardiovascular Diseases, Second University of Naples, Naples, Italy
Kidney Int 62:2126-35. 2002..We investigated whether the reduction of renal mass is associated with alterations in LOH bicarbonate transport coupled to changes in NHE-3 gene expression and in vivo activity... - Dopamine acutely decreases apical membrane Na/H exchanger NHE3 protein in mouse renal proximal tubuleDesa Bacic
Institute of Anatomy, University of Zurich, Zurich, Switzerland
Kidney Int 64:2133-41. 2003..Dopamine acutely alters glomerular filtration rate (GFR) and decreases Na+ absorption in both the proximal and distal nephron. Proximal tubule natriuresis is effected through inhibition of the apical membrane Na/H exchanger NHE3... - Activation of dopamine D1-like receptors induces acute internalization of the renal Na+/phosphate cotransporter NaPi-IIa in mouse kidney and OK cellsDesa Bacic
Institute of Physiology, Univ of Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
Am J Physiol Renal Physiol 288:F740-7. 2005..In summary, dopamine induces internalization of NaPi-IIa by activation of luminal D(1)-like receptors, an effect that is mediated by PKA... - Hypothesizing on the evolutionary origins of salt-induced hypercalciuriaOrson W Moe
Curr Opin Nephrol Hypertens 14:368-72. 2005 - Dual role of citrate in mammalian urineOrson W Moe
Curr Opin Nephrol Hypertens 15:419-24. 2006 - Phosphatonins: a new class of phosphate-regulating proteinsSusan C Schiavi
Applied Genomics, Genzyme Corporation, One Mountain Road, Framingham, Massachusetts 01701, USA
Curr Opin Nephrol Hypertens 11:423-30. 2002..The molecular characterization of these substances will prove to be critical for understanding phosphate physiology and clinical disorders of phosphate metabolism... - Characterization of the sodium/hydrogen exchanger NHA2Daniel G Fuster
Division of Nephrology and Hypertension and Institute for Biochemistry and Molecular Medicine, University of Bern, Buhlstrasse 28, CH 3012 Bern, Switzerland
J Am Soc Nephrol 19:1547-56. 2008..In summary, NHA2 is a ubiquitous mammalian sodium proton/exchanger that is restricted to the distal convoluted tubule in the kidney... - Albumin regulates the Na+/H+ exchanger 3 in OKP cellsJelena Klisic
Department of Physiology, University of Zurich-Irchel, Zurich, Switzerland
J Am Soc Nephrol 14:3008-16. 2003..The effects of albumin on NHE3 protein abundance were modified by hydrocortisone in a complicated pattern. These results indicate that albumin directly regulates proximal tubular NHE3 at multiple levels... - Scaffolds: Orchestrating proteins to achieve concerted functionOrson W Moe
Kidney Int 64:1916-7. 2003 - Shank2 associates with and regulates Na+/H+ exchanger 3Wonsun Han
Department of Pharmacology, Brain Korea 21 Project for Medical Science, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 120 752, Korea
J Biol Chem 281:1461-9. 2006..These results indicate that Shank2 is a novel NHE3 interacting protein that is involved in the fine regulation of transepithelial salt and water transport through affecting NHE3 expression and activity...
Research Grants
- H+-ATPase B-subunit Dysfunction and Calcium NephrolithiasisOrson Moe; Fiscal Year: 2009....
- FORMULATION OF RATIONAL THERAPY OF NEPHROLITHIASISOrson Moe; Fiscal Year: 2007..This proposal will address the nature of calcium-oxalate interaction and how it impacts on dsk of developing kidney stones. ..
- Acute Regulation of the Renal Na/H Exchanger NHE-3Orson Moe; Fiscal Year: 2005..These studies will uncover highly fundamental mechanisms of regulation of an important epithelial Na transporter and further our understanding 01 disturbance in acid-base balance, Na retention and hypertension. ..
- ENDOGENOUS AND EXOGENOUS IL 10 AND RENAL INJURYOrson Moe; Fiscal Year: 2001....
- H+-ATPase B-subunit Dysfunction and Calcium NephrolithiasisOrson W Moe; Fiscal Year: 2010....