Robert Modlin

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc "Dermal dendritic cells" comprise two distinct populations: CD1+ dendritic cells and CD209+ macrophages
    Maria Teresa Ochoa
    Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Invest Dermatol 128:2225-31. 2008
  2. pmc Innate immunity: ignored for decades, but not forgotten
    Robert L Modlin
    Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Invest Dermatol 132:882-6. 2012
  3. ncbi request reprint Human keratinocyte Toll-like receptors promote distinct immune responses
    Lloyd S Miller
    Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Invest Dermatol 127:262-3. 2007
  4. ncbi request reprint Learning from leprosy: insights into contemporary immunology from an ancient disease
    Robert L Modlin
    Division of Dermatology and Department of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Skin Pharmacol Appl Skin Physiol 15:1-6. 2002
  5. pmc The innate immune response in leprosy
    Robert L Modlin
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, CA 90095, USA
    Curr Opin Immunol 22:48-54. 2010
  6. ncbi request reprint Immunology. Now presenting: gammadelta T cells
    Robert L Modlin
    Division of Dermatology and Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Science 309:252-3. 2005
  7. ncbi request reprint Mammalian toll-like receptors
    Robert L Modlin
    Department of Medicine, Molecular Biology Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
    Ann Allergy Asthma Immunol 88:543-7; quiz 548-50, 583. 2002
  8. ncbi request reprint Use of genetic profiling in leprosy to discriminate clinical forms of the disease
    Joshua R Bleharski
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California Los Angeles UCLA, Los Angeles, CA 90095, USA
    Science 301:1527-30. 2003
  9. ncbi request reprint A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response
    Joshua R Bleharski
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 170:3812-8. 2003
  10. ncbi request reprint Toll-like receptors: mammalian "taste receptors" for a smorgasbord of microbial invaders
    Peter A Sieling
    Division of Dermatology, Department of Medicine, Molecular Biology Institute, University of California Los Angeles School of Medicine, Los Angeles, CA 90095, USA
    Curr Opin Microbiol 5:70-5. 2002

Detail Information

Publications77

  1. pmc "Dermal dendritic cells" comprise two distinct populations: CD1+ dendritic cells and CD209+ macrophages
    Maria Teresa Ochoa
    Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Invest Dermatol 128:2225-31. 2008
    ..These data suggest that dermal dendritic-appearing macrophages comprise a novel part of the innate immune response in the resident skin immune system...
  2. pmc Innate immunity: ignored for decades, but not forgotten
    Robert L Modlin
    Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Invest Dermatol 132:882-6. 2012
    ....
  3. ncbi request reprint Human keratinocyte Toll-like receptors promote distinct immune responses
    Lloyd S Miller
    Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Invest Dermatol 127:262-3. 2007
    ..However, it appears that keratinocytes, via differential activation of TLRs, may play a key role in determining the type of subsequent cutaneous immune response generated against a particular pathogen...
  4. ncbi request reprint Learning from leprosy: insights into contemporary immunology from an ancient disease
    Robert L Modlin
    Division of Dermatology and Department of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Skin Pharmacol Appl Skin Physiol 15:1-6. 2002
    ..Together, these findings provide a rationale for developing new strategies to treat and prevent infectious disease...
  5. pmc The innate immune response in leprosy
    Robert L Modlin
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, CA 90095, USA
    Curr Opin Immunol 22:48-54. 2010
    ..These insights provide targets for therapeutic intervention in modulating the course of leprosy and other chronic infectious diseases...
  6. ncbi request reprint Immunology. Now presenting: gammadelta T cells
    Robert L Modlin
    Division of Dermatology and Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Science 309:252-3. 2005
  7. ncbi request reprint Mammalian toll-like receptors
    Robert L Modlin
    Department of Medicine, Molecular Biology Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
    Ann Allergy Asthma Immunol 88:543-7; quiz 548-50, 583. 2002
    ..To review the role of mammalian Toll-like receptors (TLRs) in host defense...
  8. ncbi request reprint Use of genetic profiling in leprosy to discriminate clinical forms of the disease
    Joshua R Bleharski
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California Los Angeles UCLA, Los Angeles, CA 90095, USA
    Science 301:1527-30. 2003
    ..Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens...
  9. ncbi request reprint A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response
    Joshua R Bleharski
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 170:3812-8. 2003
    ..Our data suggest that activation of TREM-1 on monocytes participates during the early-induced and adaptive immune responses involved in host defense against microbial challenges...
  10. ncbi request reprint Toll-like receptors: mammalian "taste receptors" for a smorgasbord of microbial invaders
    Peter A Sieling
    Division of Dermatology, Department of Medicine, Molecular Biology Institute, University of California Los Angeles School of Medicine, Los Angeles, CA 90095, USA
    Curr Opin Microbiol 5:70-5. 2002
    ..These findings have also provided a framework for determining how TLRs may by used to therapeutically modulate immune responses to infection...
  11. pmc TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells
    Stephan R Krutzik
    Division of Dermatology, University of California at Los Angeles, 611 Charles Young Drive East, 536 Boyer Hall, Los Angeles, CA 90095, USA
    Nat Med 11:653-60. 2005
    ..Thus, TLR-induced differentiation of monocytes into either macrophages or dendritic cells seems to crucially influence effective host defenses in human infectious disease...
  12. ncbi request reprint Human NKT cells express granulysin and exhibit antimycobacterial activity
    Jennifer L Gansert
    Division of Hematology and Oncology and Department of Microbiology and Immunology, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 170:3154-61. 2003
    ..These studies provide evidence that alpha Gal Cer-activated CD1d-restricted T cells can participate in human host defense against M. tuberculosis infection...
  13. ncbi request reprint Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
    Philip T Liu
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Science 311:1770-3. 2006
    ..These data support a link between TLRs and vitamin D-mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection...
  14. pmc Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells
    Robert E Hunger
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles UCLA, Los Angeles, California 90095, USA
    J Clin Invest 113:701-8. 2004
    ..LCs in leprosy lesions coexpress CD1a and langerin, placing LCs in position to efficiently present a subset of antigens to T cells as part of the host response to human infectious disease...
  15. ncbi request reprint Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses
    Jenny Kim
    Division of Dermatology, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 169:1535-41. 2002
    ..These data suggest that P. acnes triggers inflammatory cytokine responses in acne by activation of TLR2. As such, TLR2 may provide a novel target for treatment of this common skin disease...
  16. ncbi request reprint IRF3 mediates a TLR3/TLR4-specific antiviral gene program
    Sean Doyle
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Immunity 17:251-63. 2002
    ..These results suggest that TLR3 and TLR4 have evolutionarily diverged from other TLRs to activate IRF3, which mediates a specific gene program responsible for innate antiviral responses...
  17. ncbi request reprint Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin
    Philip T Liu
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 179:2060-3. 2007
    ..These data demonstrate that cathelicidin is required for the 1,25D(3)-triggered antimicrobial activity against intracellular M. tuberculosis...
  18. pmc LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells
    Delphine J Lee
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles 90095, USA
    J Immunol 179:8128-36. 2007
    ....
  19. ncbi request reprint Activation and regulation of Toll-like receptors 2 and 1 in human leprosy
    Stephan R Krutzik
    Division of Dermatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA
    Nat Med 9:525-32. 2003
    ..These data provide evidence that regulated expression and activation of TLRs at the site of disease contribute to the host defense against microbial pathogens...
  20. pmc Activation of Fc gamma RI on monocytes triggers differentiation into immature dendritic cells that induce autoreactive T cell responses
    Motoyuki Tanaka
    Division of Dermatology, University of California, Los Angeles, CA 90095, USA
    J Immunol 183:2349-55. 2009
    ..Therefore, activation of FcgammaRI on monocytes triggers differentiation into specialized iDC with the capacity to expand autoreactive T cells that may contribute to the pathogenesis of immune complex-mediated tissue injury...
  21. ncbi request reprint TGF-alpha regulates TLR expression and function on epidermal keratinocytes
    Lloyd S Miller
    Division of Dermatology, Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 174:6137-43. 2005
    ..These findings provide evidence that TGF-alpha up-regulates TLR expression and function, augmenting host defense mechanisms at epithelial surfaces...
  22. pmc Expression of Toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy
    Rosane B Oliveira
    Division of Dermatology, Department of Microbiology and Immunology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    Infect Immun 71:1427-33. 2003
    ..The ability of M. leprae ligands to induce the apoptosis of Schwann cells through TLR2 provides a mechanism by which activation of the innate immune response contributes to nerve injury in leprosy...
  23. ncbi request reprint Granulysin crystal structure and a structure-derived lytic mechanism
    Daniel H Anderson
    Howard Hughes Medical Institute, 5 748 MacDonald, Box 951662, Los Angeles, CA 90095 1662, USA
    J Mol Biol 325:355-65. 2003
    ..The loosely packed core facilitates a hinge or scissors motion towards exposure of hydrophobic surface that we propose tunnels the granulysin into the fracturing target membrane...
  24. ncbi request reprint The role of toll-like receptors in the pathogenesis and treatment of dermatological disease
    Jamie E McInturff
    Division of Dermatology, CHS David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Invest Dermatol 125:1-8. 2005
    ..In the future, it seems possible there may also be drugs capable of blocking TLR activation and thus TLR-dependent inflammatory responses, providing new treatment options for inflammatory diseases...
  25. pmc Integrated pathways for neutrophil recruitment and inflammation in leprosy
    Delphine J Lee
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles 90095, USA
    J Infect Dis 201:558-69. 2010
    ....
  26. ncbi request reprint Vitamin D in defense of the human immune response
    John S Adams
    Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Room B 131, Los Angeles, CA 90048, USA
    Ann N Y Acad Sci 1117:94-105. 2007
    ....
  27. pmc Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy
    Daniel Cruz
    Division of Cardiology, Molecular Biology Institute, Department of Microbiology, Immunology, and Molecular Genetics, UCLA David Geffen School of Medicine, Howard Hughes Medical Institute, Los Angeles, California 90095, USA
    J Clin Invest 118:2917-28. 2008
    ....
  28. pmc The vitamin D connection to pediatric infections and immune function
    Valencia P Walker
    Department of Pediatrics, David Geffen School of Medicine at UCLA Los Angeles, California 90095, USA
    Pediatr Res 65:106R-113R. 2009
    ..The connection among vitamin D, infections, and immune function in the pediatric population indicates a possible role for vitamin D supplementation in potential interventions and adjuvant therapies...
  29. pmc Regulation of human T-cell homing receptor expression in cutaneous bacterial infection
    Peter A Sieling
    Division of Dermatology, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Immunology 120:518-25. 2007
    ..6-3.4, n = 3). Our data indicate that CLA expression is regulated during the course of leprosy infection and suggest that T-cell responsiveness to a microbial antigen directs antigen-specific T cells to the site of infection...
  30. pmc Divergence of macrophage phagocytic and antimicrobial programs in leprosy
    Dennis Montoya
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Host Microbe 6:343-53. 2009
    ..These data indicate that macrophage programs for phagocytosis and antimicrobial responses are distinct and differentially regulated in innate immunity to bacterial infections...
  31. ncbi request reprint The human CD1-restricted T cell repertoire is limited to cross-reactive antigens: implications for host responses against immunologically related pathogens
    Peter A Sieling
    Division of Dermatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 174:2637-44. 2005
    ..In comparison with the MHC class II-restricted T cell repertoire, the CD1-restricted T cell repertoire is limited to recognition of cross-reactive Ags, imparting a distinct role in the host response to immunologically related pathogens...
  32. ncbi request reprint Toll-like receptor 2 ligands as adjuvants for human Th1 responses
    Peter A Sieling
    Department of Medicine, Division of Dermatology, David Gefffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 170:194-200. 2003
    ..Our data suggest that bLPs adjuvant adaptive Th1 responses by enhancing Ag presentation of endogenous peptides...
  33. ncbi request reprint The role of Toll-like receptors in combating mycobacteria
    Stephan R Krutzik
    Department of Microbiology and Immunology, Division of Dermatology, 52 121 CHS, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Semin Immunol 16:35-41. 2004
    ..However, the activation of TLRs by mycobacteria may also provide a means of immune evasion. Therefore, the modulation of TLR activation can influence the ability to properly destroy invading pathogens such as mycobacteria...
  34. pmc Distribution of Toll-like receptor 1 and Toll-like receptor 2 in human lymphoid tissue
    Maria Teresa Ochoa
    Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Immunology 108:10-5. 2003
    ..The co-expression of TLR1 and TLR2 on myeloid cells in lymphoid tissue provides the host with the ability to respond to a variety of microbial ligands at sites conducive to the generation of an immune response...
  35. ncbi request reprint Role of toll-like receptors in response to bacterial infection
    Cheryl J Hertz
    Division of Dermatology, UCLA School of Medicine, Los Angeles, Calif, USA
    Contrib Microbiol 10:149-63. 2003
  36. doi request reprint Human macrophage host defense against Mycobacterium tuberculosis
    Philip T Liu
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, United States
    Curr Opin Immunol 20:371-6. 2008
    ..Further understanding these defense mechanisms in human tuberculosis will help the development of new interventional strategies to prevent and treat disease...
  37. pmc Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosy
    Rosane M B Teles
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA
    Infect Immun 78:4634-43. 2010
    ..Therefore, the regulated expression of CD209 represents a common mechanism by which Schwann cells and macrophages bind and take up M. leprae, contributing to the pathogenesis of leprosy...
  38. pmc Toll-like receptors induce a phagocytic gene program through p38
    Sean E Doyle
    Dept of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, 8 240 Factor Building, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Exp Med 199:81-90. 2004
    ..Taken together, our data describe an evolutionarily conserved mechanism by which TLRs can specifically promote phagocytic clearance of bacteria during infection...
  39. ncbi request reprint Specific phospholipid oxidation products inhibit ligand activation of toll-like receptors 4 and 2
    Kimberly A Walton
    Department of Medicine, University of California, Los Angeles, CA 90095 1732, USA
    Arterioscler Thromb Vasc Biol 23:1197-203. 2003
    ..The current studies identify specific phospholipids that inhibit chemokine induction by Toll-like receptor-4 (TLR4) and -2 (TLR2) ligands inECs and macrophages...
  40. ncbi request reprint TLR activation of Langerhans cell-like dendritic cells triggers an antiviral immune response
    Claudia N Renn
    Division of Dermatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 177:298-305. 2006
    ..Finally, CXCL9 colocalized with LCs in skin biopsy specimens from viral infections. Together, our data suggest that LCs exhibit a direct antiviral activity that is dependent on type I IFN as part of the innate immune system...
  41. ncbi request reprint Cutting edge: all-trans retinoic acid down-regulates TLR2 expression and function
    Philip T Liu
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at University of California, Los Angeles, USA
    J Immunol 174:2467-70. 2005
    ..Agents that target TLR expression and function represent a novel strategy to treat inflammation in humans...
  42. ncbi request reprint Substrate and enzyme trafficking as a means of regulating 1,25-dihydroxyvitamin D synthesis and action: the human innate immune response
    John S Adams
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Bone Miner Res 22:V20-4. 2007
    ..In this review, we use vitamin D-directed events in the human innate immune response to Mycobacterium tuberculosis as a physiologically relevant model system in which to highlight the importance of these intracellular traffic patterns...
  43. pmc Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism
    Jürgen Schauber
    Division of Dermatology, University of California, San Diego, and VA San Diego Healthcare System, San Diego, California, USA
    J Clin Invest 117:803-11. 2007
    ..Thus, we demonstrate what we believe to be a previously unexpected role for vitamin D3 in innate immunity, enabling keratinocytes to recognize and respond to microbes and to protect wounds against infection...
  44. pmc Conserved mycobacterial lipoglycoproteins activate TLR2 but also require glycosylation for MHC class II-restricted T cell activation
    Peter A Sieling
    Division of Dermatology, David Geffen School of Medicine at UCLA, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Immunol 180:5833-42. 2008
    ..This study demonstrates that the universe of bacterial T cell Ags includes lipoglycoproteins, which act as TLR2 ligands but also require glycosylation for MHC class II-restricted T cell activation in vivo...
  45. doi request reprint Learning from leprosy: insight into the human innate immune response
    Dennis Montoya
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California, USA
    Adv Immunol 105:1-24. 2010
    ..These insights provide targets for therapeutic intervention to modulate innate immune responses against microbial infection in humans...
  46. ncbi request reprint Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2
    Cheryl J Hertz
    Division of Dermatology, University of California, Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 171:6820-6. 2003
    ..Together, these data suggest that TLRs monitor epithelial surfaces to enhance host defense by inducing the production of an antimicrobial peptide...
  47. ncbi request reprint PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4
    Taruna Arora
    Division of Hematology Oncology, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1678, USA
    J Biol Chem 278:21327-30. 2003
    ..Finally the inhibitory activity of PIASx on Stat4-mediated gene activation is abolished by the histone deacetylase inhibitor trichostatin A. Our results suggest that PIASx may function as a co-repressor of Stat4...
  48. ncbi request reprint MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus
    Lloyd S Miller
    Division of Dermatology, David Geffen School of Medicine at UCLA, 52 121 CHS, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
    Immunity 24:79-91. 2006
    ..This neutrophil recruitment was not dependent upon IL-1R/MyD88 signaling by recruited bone marrow-derived cells, suggesting that resident skin cells utilize IL-1R/MyD88 signaling to promote neutrophil recruitment...
  49. pmc Vitamin D-binding protein directs monocyte responses to 25-hydroxy- and 1,25-dihydroxyvitamin D
    Rene F Chun
    Orthopaedic Hospital Research Center, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Clin Endocrinol Metab 95:3368-76. 2010
    ..Both vitamin D metabolites circulate bound to vitamin D-binding protein (DBP), but the effect of this on induction of monocyte cathelicidin remains unclear...
  50. pmc Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses
    Philip T Liu
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 4:e5810. 2009
    ..Therefore, these data identify a novel mechanism of host defense requiring the induction of IL-1beta in synergy with vitamin D activation, for the TLR-induced antimicrobial pathway against an intracellular pathogen...
  51. ncbi request reprint Therapeutic implications of the TLR and VDR partnership
    Philip T Liu
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
    Trends Mol Med 13:117-24. 2007
    ..Owing to their capability to combat a wide array of pathogens, TLRs are attractive therapeutic targets. However, additional knowledge about their antimicrobial mechanisms is needed...
  52. ncbi request reprint Cathelicidin antimicrobial peptides block dendritic cell TLR4 activation and allergic contact sensitization
    Anna Di Nardo
    Division of Dermatology, Department of Medicine, University of California, San Diego, CA 92161, USA
    J Immunol 178:1829-34. 2007
    ..These observations provide evidence that cathelicidin antimicrobial peptides mediate an anti-inflammatory response in part by their activity at the membrane...
  53. pmc Diversity through phosphine catalysis identifies octahydro-1,6-naphthyridin-4-ones as activators of endothelium-driven immunity
    Daniel Cruz
    Department of Medicine, Division of Cardiology, A2 237 Center for Health Sciences, University of California, Los Angeles, CA 90095 1679, USA
    Proc Natl Acad Sci U S A 108:6769-74. 2011
    ....
  54. pmc IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway
    Stephan R Krutzik
    Division of Dermatology, David Geffen School of Medicine at University of California Los Angeles, CA 90095, USA
    J Immunol 181:7115-20. 2008
    ..Therefore, IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway...
  55. pmc IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice
    John S Cho
    Division of Dermatology, UCLA, Los Angeles, California 90095, USA
    J Clin Invest 120:1762-73. 2010
    ..Our study defines what we believe to be a novel role for IL-17-producing epidermal gammadelta T cells in innate immunity against S. aureus cutaneous infection...
  56. ncbi request reprint The CD1b structure: antigen presentation adapts to a high-fat diet
    Kayvan R Niazi
    Department of Microbiology, Immunology, and Molecular Genetics, University of California School of Medicine, Los Angeles, CA 90095, USA
    Nat Immunol 3:703-4. 2002
  57. doi request reprint A vitamin for autophagy
    Mario Fabri
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 3075, USA
    Cell Host Microbe 6:201-3. 2009
    ..Now, Yuk et al. (2009) show how vitamin D induces autophagy and mediates colocalization of Mycobacterium tuberculosis and antimicrobial peptides within an autophagolysosome, leading to killing of the bacterium...
  58. pmc Functional characterization of a T-cell receptor BV6+ T-cell clone derived from a leprosy lesion
    Shereen Sabet
    Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Immunology 120:354-61. 2007
    ..leprae-pulsed antigen-presenting cells by the granule exocytosis pathway, and expressed the antimicrobial protein granulysin. BV6(+) T cells may therefore functionally contribute to the cell-mediated immune response against M. leprae...
  59. ncbi request reprint Granulysin-derived peptides demonstrate antimicrobial and anti-inflammatory effects against Propionibacterium acnes
    Jamie E McInturff
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    J Invest Dermatol 125:256-63. 2005
    ..acnes-stimulated cytokine release. Taken together, these data suggest that granulysin peptides may be useful as topical therapeutic agents, providing alternatives to current acne therapies...
  60. ncbi request reprint Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo
    Lloyd S Miller
    Division of Dermatology, University of California, Los Angeles, CA 90095, USA
    J Immunol 179:6933-42. 2007
    ..aureus in vivo...
  61. ncbi request reprint Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens
    Belinda H Tan
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 177:1864-71. 2006
    ....
  62. ncbi request reprint Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease
    Martin Hewison
    Burns and Allen Research Institute, Division of Endocrinology, Cedars Sinai Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA 90048, USA
    J Steroid Biochem Mol Biol 103:316-21. 2007
    ..Data suggest that local synthesis of 1,25(OH)(2)D(3) may be a preferred mode of response to antigenic challenge in many tissues...
  63. ncbi request reprint Toll-like receptors in the skin
    Lloyd S Miller
    Division of Dermatology and Department of Microbiology, Immunology and Molecular Genetics, Center for Health Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Semin Immunopathol 29:15-26. 2007
    ..In addition, TLRs have also been implicated in the pathophysiology of various inflammatory skin diseases...
  64. ncbi request reprint Breaking tolerance--another piece added to the vitiligo puzzle
    Delphine J Lee
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California Los Angeles UCLA, Los Angeles, California 90095, USA
    J Invest Dermatol 124:xiii-xv. 2005
  65. doi request reprint TLR2 looks at lipoproteins
    Mirjam Schenk
    Division of Dermatology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Immunity 31:847-9. 2009
    ..In this issue of Immunity, Kang et al. (2009) provide insight into the mechanisms by which TLR2-TLR6 heterodimers recognize diacylated liporoteins, whereas TLR2-TLR1 heterodimers recognize triacylated lipopeptides...
  66. ncbi request reprint From plankton to pathogen recognition
    Robert L Modlin
    Nat Med 10:1173-4. 2004
  67. ncbi request reprint Truncated structural variants of lipoarabinomannan in Mycobacterium leprae and an ethambutol-resistant strain of Mycobacterium tuberculosis
    Jordi B Torrelles
    Department of Microbiology, Colorado Stae University, Fort Collins 80523, USA
    J Biol Chem 279:41227-39. 2004
    ....
  68. ncbi request reprint Coordinate expression of CC chemokine ligand 5, granulysin, and perforin in CD8+ T cells provides a host defense mechanism against Mycobacterium tuberculosis
    Frank Stegelmann
    Institut fur Klinische Mikrobiologie, Immunologie und Hygiene der Friedrich Alexander Universitaet Erlangen Nuernberg, Erlangen, Germany
    J Immunol 175:7474-83. 2005
    ..tuberculosis-infected macrophages and kill the intracellular pathogen...
  69. ncbi request reprint Control of Mycobacterium tuberculosis through mammalian Toll-like receptors
    Steffen Stenger
    Institut fur Klinische Mikrobiologie, Immunologie und Hygiene, Universitat Erlangen Nurnberg, Wasserturmstrasse 3, Erlangen, Germany
    Curr Opin Immunol 14:452-7. 2002
    ..TLRs influence the adaptive immune response by upregulation of immunomodulatory molecules supporting the development of a Th1-biased T cell response. In this manner, activation of TLRs contributes to defense against microbial infection...
  70. ncbi request reprint Expression of CD1d molecules by human schwann cells and potential interactions with immunoregulatory invariant NK T cells
    Jin S Im
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 177:5226-35. 2006
    ....
  71. ncbi request reprint Angiogenesis in cutaneous lesions of leprosy: implications for treatment
    Sulochana S Bhandarkar
    Department of Dermatology, Emory University School of Medicine, WMB 5309, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Arch Dermatol 143:1527-9. 2007
    ..To examine the potential role of angiogenesis in leprosy...
  72. ncbi request reprint Saposin C is required for lipid presentation by human CD1b
    Florian Winau
    Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrasse 21 22, D 10117 Berlin, Germany
    Nat Immunol 5:169-74. 2004
    ..We propose a model in which SAP-C exposes lipid antigens from intralysosomal membranes for loading onto CD1b. Thus, SAP-C represents a missing link in antigen presentation of lipids through CD1b to human T cells...
  73. ncbi request reprint Ito cells are liver-resident antigen-presenting cells for activating T cell responses
    Florian Winau
    Department of Immunology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Immunity 26:117-29. 2007
    ....
  74. ncbi request reprint Human dendritic cell expression of HLA-DO is subset specific and regulated by maturation
    Tara M C Hornell
    Department of Pediatrics, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, USA
    J Immunol 176:3536-47. 2006
    ..The range of APC types shown to express DO suggests a broader role for DO in immune function than previously appreciated...
  75. pmc Activation of human CD4+ T cells by targeting MHC class II epitopes to endosomal compartments using human CD1 tail sequences
    Kayvan R Niazi
    Discovery Translation Unit, Buck Institute, Novato, CA, USA
    Immunology 122:522-31. 2007
    ..These findings may have implications in designing DNA vaccines, providing a greater variety of tools to generate T-cell responses against microbial pathogens or tumours...
  76. ncbi request reprint Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis
    Ulrich E Schaible
    Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrasse 21 22, D 10117 Berlin, Germany
    Nat Med 9:1039-46. 2003
    ....
  77. ncbi request reprint Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins
    Osamu Takeuchi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    J Immunol 169:10-4. 2002
    ..Taken together, TLR1 interacts with TLR2 to recognize the lipid configuration of the native mycobacterial lipoprotein as well as several triacylated lipopeptides...

Research Grants62

  1. GRANULYSIN: ANTIMICROBIAL/ANTI-INFLAMMATORY ROLE IN ACNE
    Robert Modlin; Fiscal Year: 2007
    ..These studies will have the potential to develop a new class of antibiotic compounds for use in the treatment of cutaneous infections ncluding acne vulgaris as well as other skin infections in which bacteria are involved. ..
  2. Molecular analysis of host immune responses in leprosy
    Robert Modlin; Fiscal Year: 2007
    ..These issues are timely, given the rise in emerging infections and the threat of bioterrorist attacks. ..
  3. ROLE OF TOLL-LIKE RECEPTORS IN SKIN
    Robert Modlin; Fiscal Year: 2007
    ....
  4. CD1-targeted Vaccination against Tuberculosis
    Robert Modlin; Fiscal Year: 2007
    ..Finally, the CD1-based vaccine technology should prove useful in the vaccination against microbial pathogens in which MHC class II-restricted presentation of antigen to CD4+ T cells is required for host defense. ..
  5. Role of Vitamin D Prohormone 25-OHD in the Innate Immune Response to Tuberculosis
    Robert L Modlin; Fiscal Year: 2010
    ....
  6. Molecular Analysis of the Host Immune Response in Leprosy
    Robert L Modlin; Fiscal Year: 2011
    ..The investigation of these aspects of host defense mechanisms will yield new insights into the human immune system as well as provide novel targets for therapeutic intervention against a wide range of infectious diseases. ..
  7. Divergence of Phagocytic and Antimicrobial Programs in Leprosy
    Robert L Modlin; Fiscal Year: 2010
    ..Insights into the host response to infection will provide new avenues for therapeutic intervention in infectious disease. ..
  8. Application of Novel Antigens and Integrated Microfluidics for Leprosy Diagnosis
    Robert L Modlin; Fiscal Year: 2010
    ....
  9. CD1-RESTRICTED T CELL RESPONSES IN SKIN
    Robert L Modlin; Fiscal Year: 2010
    ..We propose to study leprosy as a model to gain insight into the mechanism by which Langerhans cells indirectly contribute to host defense against infection by the activation of T cells and directly mediate antimicrobial responses. ..
  10. Role of Vitamin D Prohormone 25-OHD in the Innate Immune Response to Tuberculosis
    Robert L Modlin; Fiscal Year: 2010
    ....
  11. Molecular Analysis of the Host Immune Response in Leprosy
    Robert L Modlin; Fiscal Year: 2010
    ..The investigation of these aspects of host defense mechanisms will yield new insights into the human immune system as well as provide novel targets for therapeutic intervention against a wide range of infectious diseases. ..
  12. Application of Novel Antigens and Integrated Microfluidics for Leprosy Diagnosis
    Robert Modlin; Fiscal Year: 2009
    ....
  13. CD-1 Restricted T-cell Responses in Skin
    Robert Modlin; Fiscal Year: 2009
    ..The studies we propose are intended to provide a comprehensive analysis of CD-1 restricted T-cell function in relation to a model of human skin disease, with particular emphasis on their role in immunity. ..
  14. GRANULYSIN: ANTIMICROBIAL/ANTI-INFLAMMATORY ROLE IN ACNE
    Robert Modlin; Fiscal Year: 2009
    ..These studies will have the potential to develop a new class of antibiotic compounds for use in the treatment of cutaneous infections ncluding acne vulgaris as well as other skin infections in which bacteria are involved. ..
  15. Molecular Analysis of the Host Immune Response in Leprosy
    Robert Modlin; Fiscal Year: 2009
    ..The investigation of these aspects of host defense mechanisms will yield new insights into the human immune system as well as provide novel targets for therapeutic intervention against a wide range of infectious diseases. ..
  16. CD1-RESTRICTED T-CELL RESPONSES IN SKIN
    Robert Modlin; Fiscal Year: 2004
    ..Such insights would provide new avenues for development of new treatments for a variety of human skin and infectious diseases. ..
  17. DETERMINANTS OF TH1 CYTOKINE RESPONSES IN LEPROSY
    Robert Modlin; Fiscal Year: 2003
    ..Such insights, they would hope, would provide new avenues for development of immunomodulatory treatments for a variety of human infectious diseases. ..
  18. CD 1--RESTRICTED T CELL RESPONSES IN SKIN
    Robert Modlin; Fiscal Year: 1999
    ..We believe that these studies will provide insight into the immunoregulatory role of CD1- restricted T-cell responses. ..
  19. TCR GAMMA/DELTA LYMPHOCYTES IN HUMAN SKIN LESIONS
    Robert Modlin; Fiscal Year: 1993
  20. IMMUNOREGULATORY T-LYMPHOCYTES IN LEPROSY SKIN LESIONS
    Robert Modlin; Fiscal Year: 1992
    ..leprae and the identification of the precise epitopes that contribute to protective immunity. This will lead to more exacting immunodiagnostic reagents and more logical intervention strategies...