Jaime F Modiano

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Negative regulators in homeostasis of naïve peripheral T cells
    Jaime F Modiano
    Integrated Department of Immunology, University of Colorado Denver, Denver, CO, USA
    Immunol Res 41:137-53. 2008
  2. pmc Gene expression profiles of sporadic canine hemangiosarcoma are uniquely associated with breed
    Beth A Tamburini
    Integrated Department of Immunology, University of Colorado Denver, Denver, Colorado, USA
    PLoS ONE 4:e5549. 2009
  3. pmc MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma
    Aaron L Sarver
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Orphanet J Rare Dis 8:7. 2013
  4. doi request reprint Molecular profiling reveals prognostically significant subtypes of canine lymphoma
    A M Frantz
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota, USA
    Vet Pathol 50:693-703. 2013
  5. pmc Inflammation, apoptosis, and necrosis induced by neoadjuvant fas ligand gene therapy improves survival of dogs with spontaneous bone cancer
    Jaime F Modiano
    ApopLogic Pharmaceuticals, Aurora, CO, USA
    Mol Ther 20:2234-43. 2012
  6. pmc CD40 ligand is necessary and sufficient to support primary diffuse large B-cell lymphoma cells in culture: a tool for in vitro preclinical studies with primary B-cell malignancies
    Daisuke Ito
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 5455, USA
    Leuk Lymphoma 53:1390-8. 2012
  7. pmc Combinatorial treatment of DNA and chromatin-modifying drugs cause cell death in human and canine osteosarcoma cell lines
    Venugopal Thayanithy
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 7:e43720. 2012
  8. pmc Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma
    Beth A Tamburini
    Integrated Department of Immunology, University of Colorado, Denver, School of Medicine, Denver, CO, USA
    BMC Cancer 10:619. 2010
  9. pmc Nicotine-mediated signals modulate cell death and survival of T lymphocytes
    Silvia C S Oloris
    Integrated Department of Immunology, School of Medicine, University of Colorado, Denver, Denver, CO, USA
    Toxicol Appl Pharmacol 242:299-309. 2010
  10. pmc Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach
    Milcah C Scott
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 5545, USA
    Bone 49:356-67. 2011

Research Grants

Collaborators

Detail Information

Publications23

  1. pmc Negative regulators in homeostasis of naïve peripheral T cells
    Jaime F Modiano
    Integrated Department of Immunology, University of Colorado Denver, Denver, CO, USA
    Immunol Res 41:137-53. 2008
    ....
  2. pmc Gene expression profiles of sporadic canine hemangiosarcoma are uniquely associated with breed
    Beth A Tamburini
    Integrated Department of Immunology, University of Colorado Denver, Denver, Colorado, USA
    PLoS ONE 4:e5549. 2009
    ..Our results suggest heritable factors mold gene expression phenotypes, and consequently biological behavior in sporadic, naturally occurring tumors...
  3. pmc MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma
    Aaron L Sarver
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Orphanet J Rare Dis 8:7. 2013
    ..We showed previously that clusters of miRNAs at the 14q32 locus are downregulated in human osteosarcoma...
  4. doi request reprint Molecular profiling reveals prognostically significant subtypes of canine lymphoma
    A M Frantz
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota, USA
    Vet Pathol 50:693-703. 2013
    ..Finally, we developed a benchtop diagnostic test based on expression of 4 genes that can robustly classify canine lymphomas into one of these 3 subgroups, enabling a direct clinical application for our results...
  5. pmc Inflammation, apoptosis, and necrosis induced by neoadjuvant fas ligand gene therapy improves survival of dogs with spontaneous bone cancer
    Jaime F Modiano
    ApopLogic Pharmaceuticals, Aurora, CO, USA
    Mol Ther 20:2234-43. 2012
    ....
  6. pmc CD40 ligand is necessary and sufficient to support primary diffuse large B-cell lymphoma cells in culture: a tool for in vitro preclinical studies with primary B-cell malignancies
    Daisuke Ito
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 5455, USA
    Leuk Lymphoma 53:1390-8. 2012
    ..We conclude that this system has broad applications for in vitro preclinical development for B-cell malignancies...
  7. pmc Combinatorial treatment of DNA and chromatin-modifying drugs cause cell death in human and canine osteosarcoma cell lines
    Venugopal Thayanithy
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 7:e43720. 2012
    ..These results suggested that the combination of these chromatin-modifying drugs may be a useful adjuvant in the treatment of rapidly progressive OS...
  8. pmc Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma
    Beth A Tamburini
    Integrated Department of Immunology, University of Colorado, Denver, School of Medicine, Denver, CO, USA
    BMC Cancer 10:619. 2010
    ..The hypothesis for this study was that characteristic molecular features distinguish hemangiosarcoma from non-malignant endothelial cells, and that such features are informative for the etiology of this disease...
  9. pmc Nicotine-mediated signals modulate cell death and survival of T lymphocytes
    Silvia C S Oloris
    Integrated Department of Immunology, School of Medicine, University of Colorado, Denver, Denver, CO, USA
    Toxicol Appl Pharmacol 242:299-309. 2010
    ..The sum of our data suggests that selective modulation of nAChRs might be useful to regulate lymphocyte activation and survival in health and disease...
  10. pmc Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach
    Milcah C Scott
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 5545, USA
    Bone 49:356-67. 2011
    ..This in turn may enhance prognosis and prediction, and identify relevant therapeutic targets...
  11. ncbi request reprint Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium
    Susan P Fosmire
    AMC Cancer Research Center and Integrated Department of Immunology, University of Colorado Health Sciences Center, Denver, 80214, USA
    Lab Invest 84:562-72. 2004
    ..In summary, these cell lines represent a unique and novel resource to improve our understanding of endothelial cell biology in general and canine HSA in particular...
  12. pmc Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma
    Venugopal Thayanithy
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, USA
    Bone 50:171-81. 2012
    ..Together, our data support a model where the deregulation of a network involving 14q32 miRNAs, cMYC and miR-17-92 miRNAs could contribute to osteosarcoma pathogenesis...
  13. pmc MHC-dependent desensitization of intrinsic anti-self reactivity
    Cristan M Jubala
    University of Colorado Cancer Center, Aurora, CO, USA
    Cancer Immunol Immunother 58:171-85. 2009
    ..Our data suggest that self-peptide/MHC interactions have dual roles to facilitate survival and restrain autoreactivity, thus acting as integral components of an intrinsic network of negative regulation that maintains tolerance...
  14. ncbi request reprint Gene expression profiles of sporadic canine hemangiosarcoma are uniquely associated with breed
    Beth A Tamburini
    Integrated Department of Immunology, University of Colorado Denver, Denver, Colorado, United States of America
    PLoS ONE 4:e5549. 2009
    ..Our results suggest heritable factors mold gene expression phenotypes, and consequently biological behavior in sporadic, naturally occurring tumors...
  15. ncbi request reprint Nicotine activates nuclear factor of activated T cells c2 (NFATc2) and prevents cell cycle entry in T cells
    Ashley A Frazer-Abel
    Integrated Department of Immunology, University of Colorado Health Sciences Center, AMC Cancer Center, 2 Diamond Building, 1600 Pierce Street, Denver, CO 80214, USA
    J Pharmacol Exp Ther 311:758-69. 2004
    ..This offers insight into possible reasons that underlie the unique effects of nicotine on distinct cell types and identifies new targets that may be useful control tobacco-related diseases...
  16. ncbi request reprint Initial evaluation of safety of wide-field irradiation in the treatment of hematopoietic neoplasia in the cat
    Brian D Husbands
    Veterinary Medical Center, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    Vet Radiol Ultrasound 51:688-96. 2010
    ..In summary, wide-field external beam radiation therapy can be administered safely to, and may provide therapeutic benefit for, cats with disseminated hematopoietic neoplasia...
  17. ncbi request reprint Distinct B-cell and T-cell lymphoproliferative disease prevalence among dog breeds indicates heritable risk
    Jaime F Modiano
    Department of Immunology, AMC Cancer Center, Denver, Colorado 80214, USA
    Cancer Res 65:5654-61. 2005
    ..The data show that domestic dogs provide a unique and valuable resource to define factors that mediate risk as well as genes involved in the initiation of B-cell and T-cell LPD...
  18. ncbi request reprint Fas ligand-dependent suppression of autoimmunity via recruitment and subsequent termination of activated T cells
    Jaime F Modiano
    Integrated Department of Immunology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Clin Immunol 112:54-65. 2004
    ..These data show that gene delivery of membrane-bound FasL can effectively recruit and eliminate autoreactive T cells...
  19. pmc Exclusion of cytoplasmic fragments in flow cytometric analysis of lymph node samples from dogs with lymphoma using membrane-permeable violet laser-excitable DNA-binding fluorescent dye (DyeCycle Violet)
    Daisuke Ito
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
    Vet Clin Pathol 39:494-8. 2010
    ..These cytoplasmic fragments interfere with accurate gating of target cells and quantification protocols used for flow cytometry because of their variable size and expression of lymphoid cell surface antigens on their membranes...
  20. pmc Parenchymal signal intensity in 3-T body MRI of dogs with hematopoietic neoplasia
    Daniel A Feeney
    Department of Veterinary Clinical Sciences, University of Minnesota, St Paul, Minnesota, USA
    Comp Med 63:174-82. 2013
    ....
  21. pmc Chronic nicotine consumption does not influence 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis
    Sharon E Murphy
    Department of Biochemistry Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
    Cancer Prev Res (Phila) 4:1752-60. 2011
    ..These negative findings in a commonly used model of human lung carcinogenesis should lead us to question the interpretation of the many in vitro studies that find that nicotine stimulates cancer cell growth...
  22. ncbi request reprint Enhancing antimelanoma immune responses through apoptosis
    Stacie R Bianco
    Center for Cancer Causation and Prevention, AMC Cancer Research Center and Donald Monk Cancer Research Foundation, Denver, Colorado 80214, USA
    Cancer Gene Ther 10:726-36. 2003
    ..The results also suggest that intratumoral administration of FasL offers a safe route for therapeutic gene delivery...
  23. ncbi request reprint Hydroquinone and catechol interfere with T cell cycle entry and progression through the G1 phase
    Jesica M McCue
    Division of Allergy and Clinical Immunology, University of Colorado Health Sciences Center, 4200 E 9th Ave, B 164, Denver, CO 80262, USA
    Mol Immunol 39:995-1001. 2003
    ..These studies provide further indication of the regulatory pathways by which cigarette smoke inhibits T cell responses in the lungs of smokers...

Research Grants1

  1. Role of Negative Regulation in Development of Diabetes
    Jaime Modiano; Fiscal Year: 2003
    ..abstract_text> ..