Jaime F Modiano

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi Negative regulators in homeostasis of naïve peripheral T cells
    Jaime F Modiano
    Integrated Department of Immunology, University of Colorado Denver, Denver, CO, USA
    Immunol Res 41:137-53. 2008
  2. ncbi Inflammation, apoptosis, and necrosis induced by neoadjuvant fas ligand gene therapy improves survival of dogs with spontaneous bone cancer
    Jaime F Modiano
    ApopLogic Pharmaceuticals, Aurora, CO, USA
    Mol Ther 20:2234-43. 2012
  3. ncbi Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma
    Beth A Tamburini
    Integrated Department of Immunology, University of Colorado, Denver, School of Medicine, Denver, CO, USA
    BMC Cancer 10:619. 2010
  4. ncbi Nicotine-mediated signals modulate cell death and survival of T lymphocytes
    Silvia C S Oloris
    Integrated Department of Immunology, School of Medicine, University of Colorado, Denver, Denver, CO, USA
    Toxicol Appl Pharmacol 242:299-309. 2010
  5. ncbi MHC-dependent desensitization of intrinsic anti-self reactivity
    Cristan M Jubala
    University of Colorado Cancer Center, Aurora, CO, USA
    Cancer Immunol Immunother 58:171-85. 2009
  6. ncbi Gene expression profiles of sporadic canine hemangiosarcoma are uniquely associated with breed
    Beth A Tamburini
    Integrated Department of Immunology, University of Colorado Denver, Denver, Colorado, United States of America
    PLoS ONE 4:e5549. 2009
  7. ncbi Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium
    Susan P Fosmire
    AMC Cancer Research Center and Integrated Department of Immunology, University of Colorado Health Sciences Center, Denver, 80214, USA
    Lab Invest 84:562-72. 2004
  8. ncbi Exclusion of cytoplasmic fragments in flow cytometric analysis of lymph node samples from dogs with lymphoma using membrane-permeable violet laser-excitable DNA-binding fluorescent dye (DyeCycle Violet)
    Daisuke Ito
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
    Vet Clin Pathol 39:494-8. 2010
  9. ncbi Initial evaluation of safety of wide-field irradiation in the treatment of hematopoietic neoplasia in the cat
    Brian D Husbands
    Veterinary Medical Center, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    Vet Radiol Ultrasound 51:688-96. 2010
  10. ncbi Distinct B-cell and T-cell lymphoproliferative disease prevalence among dog breeds indicates heritable risk
    Jaime F Modiano
    Department of Immunology, AMC Cancer Center, Denver, Colorado 80214, USA
    Cancer Res 65:5654-61. 2005

Research Grants

  1. Role of Negative Regulation in Development of Diabetes
    Jaime Modiano; Fiscal Year: 2003

Collaborators

  • Jerome Schaack
  • Julie Lang
  • Shairaz Baksh
  • Susan E Lana
  • Cathy S Carlson
  • Heidi G Parker
  • Juan Sun
  • Matthew Breen
  • Kerstin Lindblad-Toh
  • Stephen J Withrow
  • Daniel Chan
  • Elaine A Ostrander
  • Paul R Avery
  • Jill E Slansky
  • Rachael Thomas
  • Beth A Tamburini
  • Susan P Fosmire
  • Donald Bellgrau
  • Ashley A Frazer-Abel
  • LAWRENCE E HUNTER
  • Cristan M Jubala
  • Gary R Cutter
  • Megan M Duckett
  • Sally R Robinson
  • Silvia C S Oloris
  • Stacie R Bianco
  • Daisuke Ito
  • Brian D Husbands
  • Karen M Helm
  • Susan Trapp
  • Jill T Schappa
  • Tzu Lip Phang
  • Heather Meylemans
  • David M Getzy
  • Stuart C Helfand
  • Jesica M McCue
  • Elizabeth A McNiel
  • Leslie C Sharkey
  • Derek M Korpela
  • Milcah C Scott
  • Susan C Trapp
  • TIMOTHY D O'BRIEN
  • John W Wojcieszyn
  • Tzu L Phang
  • Robert M Gemmill
  • Monika Baier
  • Angela R Lamerato-Kozicki
  • Lori A Gardner
  • Michelle Borakove
  • David Coffey
  • Steven J Burakoff
  • Marcia Padilla
  • Marilyn J Pettengill
  • Darwin S Linthicum
  • Allyson M Scott
  • Nasim Akhtar
  • Angela M Pierce
  • Erin B Dickerson
  • Teresa Coons
  • John Wojcieszyn
  • Derall Willis
  • David T Matthiesen
  • Richard C Duke
  • Michelle G Ritt
  • Kenneth Hance
  • Steven W Dow
  • Marcia L Padilla
  • Brian M Freed
  • Sabine Lazis
  • J John Cohen

Detail Information

Publications15

  1. ncbi Negative regulators in homeostasis of naïve peripheral T cells
    Jaime F Modiano
    Integrated Department of Immunology, University of Colorado Denver, Denver, CO, USA
    Immunol Res 41:137-53. 2008
    ....
  2. ncbi Inflammation, apoptosis, and necrosis induced by neoadjuvant fas ligand gene therapy improves survival of dogs with spontaneous bone cancer
    Jaime F Modiano
    ApopLogic Pharmaceuticals, Aurora, CO, USA
    Mol Ther 20:2234-43. 2012
    ....
  3. ncbi Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma
    Beth A Tamburini
    Integrated Department of Immunology, University of Colorado, Denver, School of Medicine, Denver, CO, USA
    BMC Cancer 10:619. 2010
    ..The hypothesis for this study was that characteristic molecular features distinguish hemangiosarcoma from non-malignant endothelial cells, and that such features are informative for the etiology of this disease...
  4. ncbi Nicotine-mediated signals modulate cell death and survival of T lymphocytes
    Silvia C S Oloris
    Integrated Department of Immunology, School of Medicine, University of Colorado, Denver, Denver, CO, USA
    Toxicol Appl Pharmacol 242:299-309. 2010
    ..The sum of our data suggests that selective modulation of nAChRs might be useful to regulate lymphocyte activation and survival in health and disease...
  5. ncbi MHC-dependent desensitization of intrinsic anti-self reactivity
    Cristan M Jubala
    University of Colorado Cancer Center, Aurora, CO, USA
    Cancer Immunol Immunother 58:171-85. 2009
    ..Our data suggest that self-peptide/MHC interactions have dual roles to facilitate survival and restrain autoreactivity, thus acting as integral components of an intrinsic network of negative regulation that maintains tolerance...
  6. ncbi Gene expression profiles of sporadic canine hemangiosarcoma are uniquely associated with breed
    Beth A Tamburini
    Integrated Department of Immunology, University of Colorado Denver, Denver, Colorado, United States of America
    PLoS ONE 4:e5549. 2009
    ..Our results suggest heritable factors mold gene expression phenotypes, and consequently biological behavior in sporadic, naturally occurring tumors...
  7. ncbi Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium
    Susan P Fosmire
    AMC Cancer Research Center and Integrated Department of Immunology, University of Colorado Health Sciences Center, Denver, 80214, USA
    Lab Invest 84:562-72. 2004
    ..In summary, these cell lines represent a unique and novel resource to improve our understanding of endothelial cell biology in general and canine HSA in particular...
  8. ncbi Exclusion of cytoplasmic fragments in flow cytometric analysis of lymph node samples from dogs with lymphoma using membrane-permeable violet laser-excitable DNA-binding fluorescent dye (DyeCycle Violet)
    Daisuke Ito
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
    Vet Clin Pathol 39:494-8. 2010
    ..These cytoplasmic fragments interfere with accurate gating of target cells and quantification protocols used for flow cytometry because of their variable size and expression of lymphoid cell surface antigens on their membranes...
  9. ncbi Initial evaluation of safety of wide-field irradiation in the treatment of hematopoietic neoplasia in the cat
    Brian D Husbands
    Veterinary Medical Center, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    Vet Radiol Ultrasound 51:688-96. 2010
    ..In summary, wide-field external beam radiation therapy can be administered safely to, and may provide therapeutic benefit for, cats with disseminated hematopoietic neoplasia...
  10. ncbi Distinct B-cell and T-cell lymphoproliferative disease prevalence among dog breeds indicates heritable risk
    Jaime F Modiano
    Department of Immunology, AMC Cancer Center, Denver, Colorado 80214, USA
    Cancer Res 65:5654-61. 2005
    ..The data show that domestic dogs provide a unique and valuable resource to define factors that mediate risk as well as genes involved in the initiation of B-cell and T-cell LPD...
  11. ncbi Gene expression profiles of sporadic canine hemangiosarcoma are uniquely associated with breed
    Beth A Tamburini
    Integrated Department of Immunology, University of Colorado Denver, Denver, Colorado, USA
    PLoS ONE 4:e5549. 2009
    ..Our results suggest heritable factors mold gene expression phenotypes, and consequently biological behavior in sporadic, naturally occurring tumors...
  12. ncbi Fas ligand-dependent suppression of autoimmunity via recruitment and subsequent termination of activated T cells
    Jaime F Modiano
    Integrated Department of Immunology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Clin Immunol 112:54-65. 2004
    ..These data show that gene delivery of membrane-bound FasL can effectively recruit and eliminate autoreactive T cells...
  13. ncbi Nicotine activates nuclear factor of activated T cells c2 (NFATc2) and prevents cell cycle entry in T cells
    Ashley A Frazer-Abel
    Integrated Department of Immunology, University of Colorado Health Sciences Center, AMC Cancer Center, 2-Diamond Building, 1600 Pierce Street, Denver, CO 80214, USA
    J Pharmacol Exp Ther 311:758-69. 2004
    ..This offers insight into possible reasons that underlie the unique effects of nicotine on distinct cell types and identifies new targets that may be useful control tobacco-related diseases...
  14. ncbi Enhancing antimelanoma immune responses through apoptosis
    Stacie R Bianco
    Center for Cancer Causation and Prevention, AMC Cancer Research Center and Donald Monk Cancer Research Foundation, Denver, Colorado 80214, USA
    Cancer Gene Ther 10:726-36. 2003
    ..The results also suggest that intratumoral administration of FasL offers a safe route for therapeutic gene delivery...
  15. ncbi Hydroquinone and catechol interfere with T cell cycle entry and progression through the G1 phase
    Jesica M McCue
    Division of Allergy and Clinical Immunology, University of Colorado Health Sciences Center, 4200 E. 9th Ave, B-164, Denver, CO 80262, USA
    Mol Immunol 39:995-1001. 2003
    ..These studies provide further indication of the regulatory pathways by which cigarette smoke inhibits T cell responses in the lungs of smokers...

Research Grants1

  1. Role of Negative Regulation in Development of Diabetes
    Jaime Modiano; Fiscal Year: 2003
    ..abstract_text> ..