Paul Moberg

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Meta-analysis of olfactory function in schizophrenia, first-degree family members, and youths at-risk for psychosis
    Paul J Moberg
    To whom correspondence should be addressed 10 Gates, HUP, 3400 Spruce Street, Philadelphia, PA 19104, US tel 215 615 3608, fax 215 662 7903, E mail
    Schizophr Bull 40:50-9. 2014
  2. doi Association of schizophrenia with the phenylthiocarbamide taste receptor haplotype on chromosome 7q
    Paul J Moberg
    Neuropsychiatry Section, Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    Psychiatr Genet 22:286-9. 2012
  3. ncbi Decision-making capacity and competency in the elderly: a clinical and neuropsychological perspective
    Paul J Moberg
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    NeuroRehabilitation 23:403-13. 2008
  4. ncbi Physiologic impairment of olfactory stimulus processing in schizophrenia
    Bruce I Turetsky
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 53:403-11. 2003
  5. ncbi Unirhinal olfactory function in schizophrenia patients and first-degree relatives
    David R Roalf
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Neuropsychiatry Clin Neurosci 18:389-96. 2006
  6. pmc Mild cognitive impairment is common in Parkinson's disease patients with normal Mini-Mental State Examination (MMSE) scores
    Eugenia Mamikonyan
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Parkinsonism Relat Disord 15:226-31. 2009
  7. ncbi Assessing the executive function deficits of patients with Parkinson's disease: utility of the Tower of London-Drexel
    William C Culbertson
    Drexel University, Neuropsychology Program, Philadelphia, PA 19104, USA
    Assessment 11:27-39. 2004
  8. pmc Montreal cognitive assessment performance in patients with Parkinson's disease with "normal" global cognition according to mini-mental state examination score
    Sarra Nazem
    Department of Psychiatry, University of Pennsyvania, Philadelphia, USA
    J Am Geriatr Soc 57:304-8. 2009
  9. ncbi Association between facial emotion recognition and odor identification in schizophrenia
    Christian G Kohler
    Schizophrenia Research Center, University of Pennsylvania, Department of Psychiatry, 10th Floor, Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Neuropsychiatry Clin Neurosci 19:128-31. 2007
  10. pmc Phenylthiocarbamide (PTC) perception in patients with schizophrenia and first-degree family members: relationship to clinical symptomatology and psychophysical olfactory performance
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Schizophr Res 90:221-8. 2007

Detail Information

Publications44

  1. pmc Meta-analysis of olfactory function in schizophrenia, first-degree family members, and youths at-risk for psychosis
    Paul J Moberg
    To whom correspondence should be addressed 10 Gates, HUP, 3400 Spruce Street, Philadelphia, PA 19104, US tel 215 615 3608, fax 215 662 7903, E mail
    Schizophr Bull 40:50-9. 2014
    ..Thus, the current meta-analysis was undertaken to incorporate additional studies, risk cohorts, olfactory test domains, and moderator variable analyses...
  2. doi Association of schizophrenia with the phenylthiocarbamide taste receptor haplotype on chromosome 7q
    Paul J Moberg
    Neuropsychiatry Section, Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    Psychiatr Genet 22:286-9. 2012
    ..The PTC nontaster haplotype is a genetic marker that may be used to identify subsets of schizophrenia patients who potentially harbor vulnerability genes in this region of chromosome 7q...
  3. ncbi Decision-making capacity and competency in the elderly: a clinical and neuropsychological perspective
    Paul J Moberg
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    NeuroRehabilitation 23:403-13. 2008
    ..The importance of assessing decision-making capacity in the context of specific functions and of respecting the values and interests of older adults are emphasized...
  4. ncbi Physiologic impairment of olfactory stimulus processing in schizophrenia
    Bruce I Turetsky
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 53:403-11. 2003
    ..Only limited efforts have been made to investigate the neurophysiologic substrate of these olfactory abnormalities. This article reports the first examination of olfactory electrophysiologic responses in patients with schizophrenia...
  5. ncbi Unirhinal olfactory function in schizophrenia patients and first-degree relatives
    David R Roalf
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Neuropsychiatry Clin Neurosci 18:389-96. 2006
    ....
  6. pmc Mild cognitive impairment is common in Parkinson's disease patients with normal Mini-Mental State Examination (MMSE) scores
    Eugenia Mamikonyan
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Parkinsonism Relat Disord 15:226-31. 2009
    ..We report on the frequency and characteristics of cognitive deficits in PD patients with intact global cognition based on Mini-Mental State Examination (MMSE) performance...
  7. ncbi Assessing the executive function deficits of patients with Parkinson's disease: utility of the Tower of London-Drexel
    William C Culbertson
    Drexel University, Neuropsychology Program, Philadelphia, PA 19104, USA
    Assessment 11:27-39. 2004
    ..Support was found for the convergent and divergent validity of the TOLDX. The clinical and theoretical implications of the findings are discussed...
  8. pmc Montreal cognitive assessment performance in patients with Parkinson's disease with "normal" global cognition according to mini-mental state examination score
    Sarra Nazem
    Department of Psychiatry, University of Pennsyvania, Philadelphia, USA
    J Am Geriatr Soc 57:304-8. 2009
    ..To examine Montreal Cognitive Assessment (MoCA) performance in patients with Parkinson's disease (PD) with "normal" global cognition according to Mini-Mental State Examination (MMSE) score...
  9. ncbi Association between facial emotion recognition and odor identification in schizophrenia
    Christian G Kohler
    Schizophrenia Research Center, University of Pennsylvania, Department of Psychiatry, 10th Floor, Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Neuropsychiatry Clin Neurosci 19:128-31. 2007
    ..Olfactory and emotion recognition abilities appear significantly linked in schizophrenia...
  10. pmc Phenylthiocarbamide (PTC) perception in patients with schizophrenia and first-degree family members: relationship to clinical symptomatology and psychophysical olfactory performance
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Schizophr Res 90:221-8. 2007
    ..Phenotypic variation in PTC sensitivity is thought to be genetic in origin and suggests greater illness risk for those subjects with recessive taster alleles...
  11. ncbi Olfactory functioning in schizophrenia: relationship to clinical, neuropsychological, and volumetric MRI measures
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Exp Neuropsychol 28:1444-61. 2006
    ....
  12. pmc Reduced posterior nasal cavity volume: a gender-specific neurodevelopmental abnormality in schizophrenia
    Bruce I Turetsky
    Schizophrenia Research Center, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, Pennsylvania, 19104, USA
    Schizophr Res 93:237-44. 2007
    ....
  13. ncbi Evaluation of competency: ethical considerations for neuropsychologists
    Paul J Moberg
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Appl Neuropsychol 13:101-14. 2006
    ..The purpose of this article is to examine these issues in the context of neuropsychological practice...
  14. ncbi Phenylthiocarbamide (PTC) perception in Parkinson disease
    Paul J Moberg
    Parkinson s Disease Research, Education, and Clinical Center, Philadelphia Veterans Affairs Medical Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cogn Behav Neurol 20:145-8. 2007
    ..To examine phenylthiocarbamide (PTC) sensitivity in Parkinson disease (PD) patients and healthy volunteers to determine whether taster status represented a simple vulnerability marker for PD...
  15. pmc Olfactory physiological impairment in first-degree relatives of schizophrenia patients
    Bruce I Turetsky
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Schizophr Res 102:220-9. 2008
    ..It is unclear, however, whether these behavioral abnormalities reflect basic olfactory sensory processing deficits or nonspecific disruptions of attention and cognition...
  16. pmc Olfactory receptor neuron dysfunction in schizophrenia
    Bruce I Turetsky
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 34:767-74. 2009
    ..It unambiguously demonstrates that neurophysiological disturbances in schizophrenia are not limited to cortical and subcortical structures, but rather include even the most peripheral sensory neurons...
  17. pmc An odor-specific threshold deficit implicates abnormal intracellular cyclic AMP signaling in schizophrenia
    Bruce I Turetsky
    Department of Psychiatry, University of Pennsylvania, 10th Floor, Gates Building, 3400 Spruce St, Philadelphia, PA 19104, USA
    Am J Psychiatry 166:226-33. 2009
    ..This study was designed to test this hypothesis by determining odor detection threshold sensitivities to two odorants that differ in their relative activations of this intracellular cAMP signaling cascade...
  18. pmc Facial emotion perception in schizophrenia: a meta-analytic review
    Christian G Kohler
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Schizophr Bull 36:1009-19. 2010
    ..0 (Borenstein M, Hedges L, Higgins J and Rothstein H. Comprehensive Meta-analysis. 2. Englewood, NJ: Biostat; 2005)...
  19. pmc Depth of the olfactory sulcus: a marker of early embryonic disruption in schizophrenia?
    Bruce I Turetsky
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA
    Schizophr Res 115:8-11. 2009
    ..Olfactory and orbital sulcal depths were correlated in controls, but not in patients. Olfactory sulcal depth may therefore be a biomarker denoting an early embryonic disruption in individuals at risk for schizophrenia...
  20. pmc Scents and nonsense: olfactory dysfunction in schizophrenia
    Bruce I Turetsky
    Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Schizophr Bull 35:1117-31. 2009
    ..This could help to clarify underlying brain mechanisms and facilitate identification of clinically relevant biomarkers...
  21. pmc Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease
    Steven E Arnold
    Alzheimer s Disease Core Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Neurol 67:462-9. 2010
    ..However, their frequency, abundance, and disease specificity, and the relationships of OE pathology to brain pathology have not been established...
  22. pmc Frequency and correlates of co-morbid psychosis and depression in Parkinson's disease
    Daniel Weintraub
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Parkinsonism Relat Disord 12:427-31. 2006
    ..02), depression with mild-cognitive impairment (P=.03), and their co-occurrence with higher daily levodopa dosages (P<.01). These results suggest that psychosis and depression in PD are distinct neurobehavioral disorders...
  23. ncbi Apolipoprotein E genotype and odor identification in schizophrenia
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Neuropsychiatry Clin Neurosci 18:231-3. 2006
    ..No significant associations between ApoE status and olfaction were observed in either diagnostic group. The authors concluded that olfactory deficits in schizophrenia do not appear to be mediated by the ApoE allele...
  24. ncbi Patient attitudes towards surgically implantable, long-term delivery of psychiatric medicine
    Farzin Irani
    Division of Neuropsychiatry, Department of Psychiatry, Stanley Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 29:960-8. 2004
    ..Thus, the study provides impetus for future work in this area...
  25. ncbi Decrements in volume of anterior ventromedial temporal lobe and olfactory dysfunction in schizophrenia
    Bruce I Turetsky
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Arch Gen Psychiatry 60:1193-200. 2003
    ..Patients with schizophrenia exhibit olfactory deficits, but it is unclear whether these represent a specific abnormality. The link between olfactory impairments and regional brain abnormalities has yet to be established...
  26. ncbi Relationship between clock-drawing and neuropsychological and functional status in elderly institutionalized patients with schizophrenia
    Natasha Lowery
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Geriatr Psychiatry 11:621-8. 2003
    ..The authors sought to examine the usefulness of the clock-drawing test (CDT) as a measure of general cognitive and adaptive functioning in elderly patients with schizophrenia...
  27. ncbi Impairment of odor hedonics in men with schizophrenia
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, the Smell and Taste Center, PA 1914, USA
    Am J Psychiatry 160:1784-9. 2003
    ..This study examined intensity and hedonic judgments in patients with schizophrenia to determine whether these functions were differentially impaired...
  28. ncbi Recognition and treatment of depression in Parkinson's disease
    Daniel Weintraub
    Parkinson s Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, USA
    J Geriatr Psychiatry Neurol 16:178-83. 2003
    ..Most depressed patients are untreated, and half of antidepressant users remain depressed, suggesting that even when delivered, treatment is often inadequate or ineffective...
  29. ncbi Scent of a disorder: olfactory functioning in schizophrenia
    Paul J Moberg
    Department of Psychiatry, Brain Behavior Laboratory, University of Pennsylvania School of Medicine, 10th Floor Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Curr Psychiatry Rep 5:311-9. 2003
    ..Because the olfactory system continuously regenerates throughout life, it allows for a unique view of an ongoing neurodevelopmental process...
  30. ncbi Low olfactory bulb volume in first-degree relatives of patients with schizophrenia
    Bruce I Turetsky
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, USA
    Am J Psychiatry 160:703-8. 2003
    ..This study examined olfactory bulbs in patients' relatives to determine whether low bulb volume represents an endophenotypic marker of genetic vulnerability...
  31. ncbi Memory-delineated subtypes of schizophrenia: relationship to clinical, neuroanatomical, and neurophysiological measures
    Bruce I Turetsky
    Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Neuropsychology 16:481-90. 2002
    ..Unimpaired patients had fewer negative symptoms and dorsal medial prefrontal hypermetabolism. The authors conclude that categorizing patients on the basis of memory deficits may yield neurobiologically meaningful disease subtypes...
  32. ncbi The Penn Conditional Exclusion Test: a new measure of executive-function with alternate forms of repeat administration
    Matthew M Kurtz
    Department of Psychiatry, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Arch Clin Neuropsychol 19:191-201. 2004
    ..Divergent validity was established through low, nonsignificant correlations between the PCET and measures of facial emotion recognition, word and face memory, visuospatial function, and verbal reasoning...
  33. ncbi Effect of psychiatric and other nonmotor symptoms on disability in Parkinson's disease
    Daniel Weintraub
    Parkinson s Disease Research, Education and Clinical Center, Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
    J Am Geriatr Soc 52:784-8. 2004
    ..To examine the effect of depression and other nonmotor symptoms on functional ability in Parkinson's disease (PD)...
  34. ncbi Dimensions of executive function in Parkinson's disease
    Daniel Weintraub
    Parkinson s Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    Dement Geriatr Cogn Disord 20:140-4. 2005
    ..Executive impairment is common in Parkinson's disease (PD). However, it is unknown which dimensions of executive function are assessed by commonly used neuropsychological instruments and if clinical correlates of specific dimensions exist...
  35. pmc Antidepressant studies in Parkinson's disease: a review and meta-analysis
    Daniel Weintraub
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mov Disord 20:1161-9. 2005
    ..In addition, PD patients may benefit less from antidepressant treatment, particularly selective serotonin reuptake inhibitors, than do elderly patients without PD...
  36. ncbi Phenylthiocarbamide perception in patients with schizophrenia and first-degree family members
    Paul J Moberg
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104, USA
    Am J Psychiatry 162:788-90. 2005
    ..The authors examined PTC sensitivity in schizophrenia patients and their non-ill relatives to determine whether this represented a vulnerability marker...
  37. ncbi Striatal dopamine transporter imaging correlates with anxiety and depression symptoms in Parkinson's disease
    Daniel Weintraub
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Nucl Med 46:227-32. 2005
    ..We studied the correlation of striatal dopamine transporter (DAT) imaging with anxiety and depression symptoms in Parkinson's disease (PD)...
  38. ncbi Normative data for the symbol cancellation test in young healthy adults
    Natasha Lowery
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Appl Neuropsychol 11:218-21. 2004
    ..In addition, a relation likely exists between SCT performance and age and education, but a larger sample seems warranted to reliably model the pattern...
  39. ncbi Evidence for impaired encoding and retrieval memory profiles in Parkinson disease
    Daniel Weintraub
    Parkinson s Disease Research, Education and Clinical Center PADRECC, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
    Cogn Behav Neurol 17:195-200. 2004
    ..Specifically, we sought to ascertain whether the memory performance of PD patients can be categorized as fitting an unimpaired, an impaired retrieval, or an impaired encoding memory profile...
  40. ncbi Smaller nasal volumes as stigmata of aberrant neurodevelopment in schizophrenia
    Paul J Moberg
    Brain Behavior Laboratory, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104, USA
    Am J Psychiatry 161:2314-6. 2004
    ....
  41. ncbi Neuropsychological functioning in elderly patients with schizophrenia and Alzheimer's disease
    Thomas McBride
    Brain Behaviour Laboratory, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia 19104, USA
    Schizophr Res 55:217-27. 2002
    ..Though the specific histopathology of the two disorders differs, abnormalities in the common sites may underlie the common neuropsychological profile...
  42. ncbi Influences of age and sex on a microencapsulated odor memory test
    Eric S Choudhury
    Department of Otorhinolaryngology Head and Neck Surgery, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Chem Senses 28:799-805. 2003
    ..The findings are discussed in light of the complexities of the construct of odor memory...
  43. pmc Pathological 43-kDa transactivation response DNA-binding protein in older adults with and without severe mental illness
    Felix Geser
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Arch Neurol 67:1238-50. 2010
    ....
  44. pmc Association of dopamine agonist use with impulse control disorders in Parkinson disease
    Daniel Weintraub
    Department of Psychiatry, University of Pennsylvania, and Parkinson s Disease Research, Education, and Clinical Center, USA
    Arch Neurol 63:969-73. 2006
    ..To determine the frequency and correlates of impulse control disorders (ICDs) in Parkinson disease (PD)...

Research Grants9

  1. Olfactory Function in Schizophrenia: A Lifespan Analysis
    Paul Moberg; Fiscal Year: 2002
    ....
  2. Olfactory Function in Schizophrenia: A Lifespan Analysis
    Paul Moberg; Fiscal Year: 2003
    ....
  3. Olfactory Function in Schizophrenia: A Lifespan Analysis
    Paul Moberg; Fiscal Year: 2004
    ....
  4. Olfactory Function in Schizophrenia: A Lifespan Analysis
    Paul Moberg; Fiscal Year: 2005
    ....
  5. Olfactory Function in Schizophrenia: A Lifespan Analysis
    Paul Moberg; Fiscal Year: 2006
    ....
  6. Olfactory Function in Schizophrenia: A Lifespan Analysis
    Paul Moberg; Fiscal Year: 2009
    ....
  7. Olfactory Function in Schizophrenia: A Lifespan Analysis
    Paul J Moberg; Fiscal Year: 2010
    ....
  8. Olfactory Function in Schizophrenia: A Lifespan Analysis
    Paul Moberg; Fiscal Year: 2009
    ..4 billion in regional economic activity, with the area's highly trained workforce producing more than 24,600 applications for just 840 open Penn staff research positions. The current proposal will create or retain 2.5 jobs. ..