Makoto Miyazaki

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 279:25164-71. 2004
  2. ncbi [Role of stearoyl-CoA desaturase in regulation of energy metabolism]
    Makoto Miyazaki
    Tanpakushitsu Kakusan Koso 53:1375-82. 2008
  3. ncbi Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    J Biol Chem 279:35017-24. 2004
  4. pmc Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver
    Pawel Dobrzyn
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 101:6409-14. 2004
  5. ncbi Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver
    Agnieszka Dobrzyn
    Department of Biochemistry, University of Wisconsin Madison, 53706, USA
    J Biol Chem 280:23356-62. 2005
  6. pmc Site and mechanism of leptin action in a rodent form of congenital lipodystrophy
    Esra Asilmaz
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    J Clin Invest 113:414-24. 2004
  7. ncbi Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    J Lipid Res 47:2668-80. 2006
  8. ncbi Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat
    Harini Sampath
    Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 282:2483-93. 2007
  9. ncbi Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome
    Sudha B Biddinger
    Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Diabetes 54:1314-23. 2005
  10. ncbi Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 278:33904-11. 2003

Collaborators

Detail Information

Publications38

  1. ncbi Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 279:25164-71. 2004
    ....
  2. ncbi [Role of stearoyl-CoA desaturase in regulation of energy metabolism]
    Makoto Miyazaki
    Tanpakushitsu Kakusan Koso 53:1375-82. 2008
  3. ncbi Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    J Biol Chem 279:35017-24. 2004
    ....
  4. pmc Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver
    Pawel Dobrzyn
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 101:6409-14. 2004
    ..001) thereby stimulating the oxidation of mitochondrial palmitoyl-CoA. Our results identify AMPK as a mediator of increased fatty acid oxidation in liver of SCD1-deficient mice...
  5. ncbi Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver
    Agnieszka Dobrzyn
    Department of Biochemistry, University of Wisconsin Madison, 53706, USA
    J Biol Chem 280:23356-62. 2005
    ..Our study revealed that SCD1 deficiency specifically increases CCT activity by promoting its translocation into membrane and enhances PC biosynthesis in liver...
  6. pmc Site and mechanism of leptin action in a rodent form of congenital lipodystrophy
    Esra Asilmaz
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    J Clin Invest 113:414-24. 2004
    ..Intracerebroventricular leptin improves glucose homeostasis by improving insulin signal transduction in liver, but in this case the effect appears to be independent of SCD-1...
  7. ncbi Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    J Lipid Res 47:2668-80. 2006
    ..Therefore, endogenous MUFA synthesis is essential during dietary unsaturated fat insufficiency and influences the dietary requirement of PUFA...
  8. ncbi Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat
    Harini Sampath
    Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 282:2483-93. 2007
    ..SCD1 thus serves as a molecular switch in the promotion or prevention of lipid-induced disorders brought on by consumption of excess saturated fat...
  9. ncbi Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome
    Sudha B Biddinger
    Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Diabetes 54:1314-23. 2005
    ..Thus, dietary fat and genetic background act through SREBP-1c and SCD1 to affect hepatic lipid metabolism contributing to the development of the metabolic syndrome...
  10. ncbi Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 278:33904-11. 2003
    ..The current studies identify a novel heart-specific SCD isoform that demonstrates tissue-specific regulation by leptin and dietary factors...
  11. ncbi Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    Cell Metab 6:484-96. 2007
    ....
  12. pmc Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis
    Chi Chen
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 7:135-47. 2008
    ....
  13. ncbi Polyunsaturated fatty acids do not activate AMP-activated protein kinase in mouse tissues
    Agnieszka Dobrzyn
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Biochem Biophys Res Commun 332:892-6. 2005
    ..The data suggest that PUFA are not involved in AMPK activation in mouse tissues and that the increased activity of AMPK in SCD1-/- mice is probably PUFA-independent...
  14. ncbi Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanism
    Hyoun ju Kim
    Departments of Biochemistry, University of Wisconsin, Madison, Wisconsin, 53706, USA
    J Lipid Res 43:1750-7. 2002
    ..This study demonstrates that cholesterol overrides the PUFA-mediated repression of the SCD1 gene and regulates SCD1 gene expression through a mechanism independent of SREBP-1 maturation...
  15. pmc Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
    James M Ntambi
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 99:11482-6. 2002
    ..These observations suggest that a consequence of SCD1 deficiency is an activation of lipid oxidation in addition to reduced triglyceride synthesis and storage...
  16. ncbi Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss
    Paul Cohen
    Laboratory of Molecular Genetics, Center for Studies in Physics and Biology, Rogosin Institute, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 297:240-3. 2002
    ..These findings suggest that down-regulation of SCD-1 is an important component of leptin's metabolic actions...
  17. pmc Probing the role of stearoyl-CoA desaturase-1 in hepatic insulin resistance
    Matthew T Flowers
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Clin Invest 116:1478-81. 2006
    ....
  18. ncbi Identification of mouse palmitoyl-coenzyme A Delta9-desaturase
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    J Lipid Res 47:700-4. 2006
    ..We identify SCD3 as a mammalian palmitotyl-CoA Delta9-desaturase, and its existence in mouse helps explain distinct physiological roles for each SCD isoform...
  19. ncbi Colocalization of SCD1 and DGAT2: implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis
    Weng Chi Man
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    J Lipid Res 47:1928-39. 2006
    ..By performing subcellular fractionation using mouse livers, we also show, for the first time, that SCD is present in the mitochondria-associated membrane...
  20. ncbi Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c
    Sudha B Biddinger
    Research Division, Joslin Diabetes Center, One Joslin Pl, Boston, MA 02215, USA
    Diabetes 55:2032-41. 2006
    ..Thus, the effect of leptin on SCD1 in liver is independent of insulin and SREBP-1c, and leptin, rather than insulin, is the major regulator of hepatic MUFA synthesis in obesity-linked diabetes...
  21. pmc Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation
    Kiki Chu
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    Mol Cell Biol 26:6786-98. 2006
    ..In addition, SCD1 deficiency also increased plasma high-density lipoprotein cholesterol levels induced by LXR activation...
  22. ncbi Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart
    Pawel Dobrzyn
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    Am J Physiol Endocrinol Metab 294:E357-64. 2008
    ..This increase in cardiac insulin sensitivity and glucose utilization due to SCD1 deficiency could prove therapeutic in pathological conditions such as obesity that are characterized by skewed cardiac substrate utilization...
  23. pmc Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia
    Rebecca Mar-Heyming
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Arterioscler Thromb Vasc Biol 28:1193-9. 2008
    ..We used the fatty acid desaturation index (the plasma ratio of 18:1/18:0) as a marker of SCD1 activity to investigate the relationship of SCD1 to familial combined hyperlipidemia (FCHL)...
  24. ncbi Membrane topology of mouse stearoyl-CoA desaturase 1
    Weng Chi Man
    Biochemistry andNutritional Sciences, University of Wisconsin Madison, 53706, USA
    J Biol Chem 281:1251-60. 2006
    ....
  25. ncbi Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans
    Matthew W Hulver
    Pennington Biomedical Research, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    Cell Metab 2:251-61. 2005
    ..These results suggest that elevated expression of SCD1 in skeletal muscle contributes to abnormal lipid metabolism and progression of obesity...
  26. pmc Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 102:12501-6. 2005
    ....
  27. ncbi Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    J Lipid Res 43:1899-907. 2002
    ..We propose that many of the factors that influence plasma triglyceride levels do so by converging upon the regulation of SCD activity...
  28. ncbi Lack of stearoyl-CoA desaturase-1 function induces a palmitoyl-CoA Delta6 desaturase and represses the stearoyl-CoA desaturase-3 gene in the preputial glands of the mouse
    Makoto Miyazaki
    Departments of Biochemistry, University of Wisconsin, Madison, Wisconsin Nutritional Sciences, University of Wisconsin, Madison, Wisconsin, USA
    J Lipid Res 43:2146-54. 2002
    ..These observations demonstrate that loss of SCD1 function alters the expression of SCD3 and reveal for the first time the presence and regulation of a palmitoyl-CoA Delta6 desaturase enzyme in mammals...
  29. ncbi Role of stearoyl-coenzyme A desaturase in lipid metabolism
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, WI 53706, USA
    Prostaglandins Leukot Essent Fatty Acids 68:113-21. 2003
    ..In this review we discuss our current understanding of the physiological role of SCD in lipid synthesis and metabolism...
  30. ncbi Recent insights into stearoyl-CoA desaturase-1
    James M Ntambi
    Departments of Biochemistry and Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Curr Opin Lipidol 14:255-61. 2003
    ..Why, then, is stearoyl-CoA desaturase a highly regulated enzyme? This review summarizes the recent and timely advances concerning the important role of stearoyl-CoA desaturase in metabolism...
  31. pmc Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle
    Shaikh Mizanoor Rahman
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 100:11110-5. 2003
    ..We hypothesize that loss of SCD1 function induces increased insulin signaling at least in part by a reduction in the expression of protein-tyrosine phosphatase 1B. SCD1 could be a therapeutic target in the treatment of diabetes...
  32. ncbi Regulation of stearoyl-CoA desaturases and role in metabolism
    James M Ntambi
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    Prog Lipid Res 43:91-104. 2004
    ....
  33. ncbi Evidence that the anti-obesity effect of conjugated linoleic acid is independent of effects on stearoyl-CoA desaturase1 expression and enzyme activity
    Kihwa Kang
    Department of Food Microbiology and Toxicology, Food Research Institute, University of Wisconsin Madison, Madison, WI 53706, USA
    Biochem Biophys Res Commun 315:532-7. 2004
    ....
  34. ncbi Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment
    Seong Ho Lee
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    J Lipid Res 45:1674-82. 2004
    ..The hypothermia and hypoglycemia in cold-exposed SCD1-/- mice and the compensatory recovery by oleate indicate an important role of SCD1 gene expression in thermoregulation...
  35. ncbi Stearoyl-CoA desaturase 1 deficiency increases insulin signaling and glycogen accumulation in brown adipose tissue
    Shaikh Mizanoor Rahman
    Dept of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    Am J Physiol Endocrinol Metab 288:E381-7. 2005
    ..Taken together, these studies illustrate increased insulin signaling and increased glycogen metabolism in BAT of SCD1(-/-) mice...
  36. ncbi Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle
    Agnieszka Dobrzyn
    Dept of Biochemistry, Univ of Wisconsin, 433 Babcock Dr, Madison, WI 53706, USA
    Am J Physiol Endocrinol Metab 288:E599-607. 2005
    ..Taken together, these results indicate that SCD1 deficiency reduces ceramide synthesis by decreasing SPT expression and increasing the rate of beta-oxidation in oxidative muscles...
  37. ncbi Regulation of stearoyl-CoA desaturase expression
    James M Ntambi
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    Lipids 39:1061-5. 2004
    ..By using SCD1-/- mice, which are deficient in tissue oleate, we begin to learn more about the physiological role of SCD gene expression and oleate in normal and disease states...
  38. ncbi Molecular differences caused by differentiation of 3T3-L1 preadipocytes in the presence of either dehydroepiandrosterone (DHEA) or 7-oxo-DHEA
    F Enrique Gomez
    Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Biochemistry 41:5473-82. 2002
    ....