Shigeki Miyamoto

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Bone marrow stromal cells from multiple myeloma patients uniquely induce bortezomib resistant NF-kappaB activity in myeloma cells
    Stephanie Markovina
    Program in Cellular and Molecular Biology and Medical Science Training Program, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
    Mol Cancer 9:176. 2010
  2. ncbi request reprint Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli
    Zhao Hui Wu
    Department of Pharmacology, University of Wisconsin Madison, 301 SMI, 1300 University Avenue, Madison, WI 53706, USA
    Science 311:1141-6. 2006
  3. pmc Bortezomib-resistant nuclear factor-kappaB activity in multiple myeloma cells
    Stephanie Markovina
    Department of Pharmacology, University of Wisconsin, Madison, WI 53706, USA
    Mol Cancer Res 6:1356-64. 2008
  4. pmc Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress
    Zhao Hui Wu
    Department of Pharmacology, University of Wisconsin, Madison, WI 53706, USA
    EMBO J 27:1963-73. 2008
  5. pmc Calcium-dependent regulation of NEMO nuclear export in response to genotoxic stimuli
    Craig M Berchtold
    Department of Pharmacology, 301 SMI, 1300 University Avenue, University of Wisconsin, Madison, WI 53706, USA
    Mol Cell Biol 27:497-509. 2007
  6. ncbi request reprint Inhibition of IkappaBalpha nuclear export as an approach to abrogate nuclear factor-kappaB-dependent cancer cell survival
    Shelby O'Connor
    Program in Cellular and Molecular Biology, Department of Pharmacology, University of Wisconsin Madison, 3795 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Mol Cancer Res 3:42-9. 2005
  7. ncbi request reprint PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress
    Angela M Mabb
    Program in Molecular and Cellular Pharmacology, Department of Pharmacology, University of Wisconsin, Madison, WI 53706, USA
    Nat Cell Biol 8:986-93. 2006
  8. ncbi request reprint Nuclear factor-kappaB dimer exchange promotes a p21(waf1/cip1) superinduction response in human T leukemic cells
    Pei Yun Chang
    Program in Molecular and Cellular Pharmacology, Department of Pharmacology, University of Wisconsin Madison, 301 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Mol Cancer Res 4:101-12. 2006
  9. pmc NF-κB induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress
    Moon Hee Lee
    McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin Madison, 6159 Wisconsin Institute for Medical Research, 1111 Highland Avenue, Madison, WI 53705, USA
    Mol Cell 43:180-91. 2011
  10. doi request reprint A PAR-SUMOnious mechanism of NEMO activation
    Kevin McCool
    Molecular and Cellular Pharmacology Program, Medical Scientist Training Program, Department of Pharmacology, University of Wisconsin, Madison, 6159 Wisconsin Institute for Medical Research, Madison, WI 53705, USA
    Mol Cell 36:349-50. 2009

Collaborators

  • Zhao Hui Wu
  • Peiman Hematti
  • David T Yang
  • Fotis Asimakopoulos
  • P Leif Bergsagel
  • Alexander Hoffmann
  • Renren Wen
  • Yufang Shi
  • Colleen E Hayes
  • GRACE B GILL
  • Bing Yang
  • Neehar Bhatia
  • Shelly M Wuerzberger-Davis
  • Stephanie Markovina
  • Shelby O'Connor
  • Tony T Huang
  • Pei Yun Chang
  • Chelsea Hope
  • Ellen Hebron
  • Jaehyup Kim
  • Angela M Mabb
  • Ioanna Maroulakou
  • Jeffrey L Jensen
  • Natalie Callander
  • Shawn S Jackson
  • Kevin W McCool
  • Moon Hee Lee
  • Stuart D Shumway
  • Kyungmann Kim
  • Catherine P Leith
  • Kevin McCool
  • Natalie S Callander
  • Shelby L O'Connor
  • Sara J S Simonson
  • Craig M Berchtold
  • Catherine Leith
  • Marta Chesi
  • Erika Heninger
  • Samuel J Ollar
  • Joshua J Coon
  • Emma E Coughlin
  • Constantine Mitsiades
  • Claire Flanagan
  • Nicholas C Ladell
  • Jeffrey D Kearns
  • Demin Wang
  • Mei Yu
  • Hu Zeng
  • Andrew Podd
  • Yuhong Chen
  • Edward T H Yeh
  • Candace Lynch
  • Paul W Bates
  • Guangwu Xu
  • Parul Trivedi
  • Martha Raschko
  • Brad S Kahl
  • Jihoon Kim
  • Jae E Werndli
  • Michelle A Kelliher
  • Kyle Draheim
  • Craig Berchtold
  • Stuart Shumway
  • Ian J Amanna
  • Shelby L Feinberg
  • Sainath Suryanarayanan

Detail Information

Publications29

  1. pmc Bone marrow stromal cells from multiple myeloma patients uniquely induce bortezomib resistant NF-kappaB activity in myeloma cells
    Stephanie Markovina
    Program in Cellular and Molecular Biology and Medical Science Training Program, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
    Mol Cancer 9:176. 2010
    ..The mediating factor(s) of this bortezomib-resistant NF-kappaB activity is induced by BMSCs is not currently understood...
  2. ncbi request reprint Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli
    Zhao Hui Wu
    Department of Pharmacology, University of Wisconsin Madison, 301 SMI, 1300 University Avenue, Madison, WI 53706, USA
    Science 311:1141-6. 2006
    ..Thus, regulated nuclear shuttling of NEMO links two signaling kinases, ATM and IKK, to activate NF-kappaB by genotoxic signals...
  3. pmc Bortezomib-resistant nuclear factor-kappaB activity in multiple myeloma cells
    Stephanie Markovina
    Department of Pharmacology, University of Wisconsin, Madison, WI 53706, USA
    Mol Cancer Res 6:1356-64. 2008
    ..Further elucidation of the mechanism of PIR NF-kappaB regulation could lead to the identification of novel diagnostic biomarkers and/or therapeutic targets for MM treatment...
  4. pmc Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress
    Zhao Hui Wu
    Department of Pharmacology, University of Wisconsin, Madison, WI 53706, USA
    EMBO J 27:1963-73. 2008
    ..Thus, replication stress and DSB inducers activate NF-kappaB through a conserved pathway with opposite biologic outcomes, and ATR antagonizes ATM function at least in part by competing for NEMO association...
  5. pmc Calcium-dependent regulation of NEMO nuclear export in response to genotoxic stimuli
    Craig M Berchtold
    Department of Pharmacology, 301 SMI, 1300 University Avenue, University of Wisconsin, Madison, WI 53706, USA
    Mol Cell Biol 27:497-509. 2007
    ....
  6. ncbi request reprint Inhibition of IkappaBalpha nuclear export as an approach to abrogate nuclear factor-kappaB-dependent cancer cell survival
    Shelby O'Connor
    Program in Cellular and Molecular Biology, Department of Pharmacology, University of Wisconsin Madison, 3795 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Mol Cancer Res 3:42-9. 2005
    ....
  7. ncbi request reprint PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress
    Angela M Mabb
    Program in Molecular and Cellular Pharmacology, Department of Pharmacology, University of Wisconsin, Madison, WI 53706, USA
    Nat Cell Biol 8:986-93. 2006
    ..Our findings demonstrate that PIASy is the first SUMO ligase for NEMO whose substrate specificity seems to be controlled by IKK interaction, subcellular targeting and oxidative stress conditions...
  8. ncbi request reprint Nuclear factor-kappaB dimer exchange promotes a p21(waf1/cip1) superinduction response in human T leukemic cells
    Pei Yun Chang
    Program in Molecular and Cellular Pharmacology, Department of Pharmacology, University of Wisconsin Madison, 301 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Mol Cancer Res 4:101-12. 2006
    ..Thus, we propose that low basal NFKB1 expression coupled with sequential NF-kappaB activation events can promote increased chemoresistance in certain T leukemic cells...
  9. pmc NF-κB induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress
    Moon Hee Lee
    McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin Madison, 6159 Wisconsin Institute for Medical Research, 1111 Highland Avenue, Madison, WI 53705, USA
    Mol Cell 43:180-91. 2011
    ..Our study establishes a self-attenuating feedback mechanism selective to DNA damage-induced signaling to limit NF-κB-dependent cell survival responses...
  10. doi request reprint A PAR-SUMOnious mechanism of NEMO activation
    Kevin McCool
    Molecular and Cellular Pharmacology Program, Medical Scientist Training Program, Department of Pharmacology, University of Wisconsin, Madison, 6159 Wisconsin Institute for Medical Research, Madison, WI 53705, USA
    Mol Cell 36:349-50. 2009
    ..In this issue of Molecular Cell, Stilmann et al. (2009) demonstrate a new mode of prosurvival NF-kappaB activation through the formation of a PARP-1-poly(ADP-ribose) signaling scaffold in response to DNA damage...
  11. ncbi request reprint Enhanced G2-M arrest by nuclear factor-{kappa}B-dependent p21waf1/cip1 induction
    Shelly M Wuerzberger-Davis
    Department of Pharmacology, University of Wisconsin, 301 Service Memorial Institute, 1300 University Avenue, Madison, WI 53706, USA
    Mol Cancer Res 3:345-53. 2005
    ..Thus, cell cycle-coupled induction of p21waf1/cip1 by NF-kappaB represents a resistance mechanism in certain cancer cells...
  12. pmc Regulation of constitutive p50/c-Rel activity via proteasome inhibitor-resistant IkappaBalpha degradation in B cells
    Shelby O'Connor
    Department of Pharmacology, University of Wisconsin, 301 SMI, 1300 University Ave, Madison, WI 53706, USA
    Mol Cell Biol 24:4895-908. 2004
    ..Thus, our findings suggest that nonconventional PIR degradation of IkappaBalpha may play a physiological role in the development of B cells in vivo...
  13. ncbi request reprint RelA life and death decisions
    Shigeki Miyamoto
    Department of Pharmacology, University of Wisconsin Madison, 1300 University Avenue, Madison, WI 53706, USA
    Mol Cell 13:763-4. 2004
    ..However, in this issue of Molecular Cell, demonstrate that anticancer drugs turn RelA into an accomplice of apoptosis by instructing it to dominantly repress survival gene transcription...
  14. pmc Prevalence of bortezomib-resistant constitutive NF-kappaB activity in mantle cell lymphoma
    David T Yang
    Department of Pharmacology, University of Wisconsin School of Medicine and Public Health, Madison, USA
    Mol Cancer 7:40. 2008
    ..While MCL cells have been shown to harbor constitutive NF-kappaB activity, what fraction of this activity in primary MCL samples is sensitive or resistant to inhibition by bortezomib remains unclear...
  15. ncbi request reprint Evidence for a phosphorylation-independent role for Ser 32 and 36 in proteasome inhibitor-resistant (PIR) IkappaBalpha degradation in B cells
    Shelby O'Connor
    Program in Cellular and Molecular Biology, Department of Pharmacology, University of Wisconsin, 3795 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Exp Cell Res 307:15-25. 2005
    ..These results suggest that B lineage cells can differentiate between PIR and canonical IkappaBalpha degradation through the absence or presence of dually phosphorylated IkappaBalpha...
  16. ncbi request reprint NFKB1 is a direct target of the TAL1 oncoprotein in human T leukemia cells
    Pei Yun Chang
    Program in Molecular and Cellular Pharmacology, Department of Pharmacology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Cancer Res 66:6008-13. 2006
    ..Thus, TAL1 modulates NFKB1 expression and an NF-kappaB-dependent transcriptional program in a subset of human T-cell leukemia cells...
  17. ncbi request reprint PIDD: a switch hitter
    Zhao Hui Wu
    Department of Pharmacology, University of Wisconsin Madison, 1300 University Avenue, Madison, WI 53706, USA
    Cell 123:980-2. 2005
    ..2005) demonstrate that, in response to such stress, PIDD forms a nuclear complex that enhances sumoylation of NEMO. This modification is important for the activation of the antiapoptotic transcription factor NF-kappaB...
  18. pmc TPL2 kinase regulates the inflammatory milieu of the myeloma niche
    Chelsea Hope
    Department of Medicine, Division of Hematology Oncology, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI University of Wisconsin Carbone Cancer Center, Madison, WI
    Blood 123:3305-15. 2014
    ..Our results highlight a TLR2/6-dependent TPL2 pathway as novel therapeutic target acting nonautonomously through macrophages to control myeloma progression. ..
  19. pmc DNA damage-dependent NF-κB activation: NEMO turns nuclear signaling inside out
    Kevin W McCool
    Medical Scientist Training Program, University of Wisconsin Madison, Madison, WI 53705, USA
    Immunol Rev 246:311-26. 2012
    ..Accumulating evidence suggests that DNA damage-dependent NF-κB activation may play significant biological roles, particularly during lymphocyte differentiation and progression of human malignancies...
  20. ncbi request reprint Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress
    Tony T Huang
    Department of Pharmacology, University of Wisconsin Madison, 301 SMI, 1300 University Avenue, Madison, WI 53706, USA
    Cell 115:565-76. 2003
    ..These SUMO and ubiquitin modification pathways may serve as anticancer drug targets...
  21. ncbi request reprint CYLD: a DUB with many talents
    Sara J S Simonson
    Department of Pharmacology, University of Wisconsin Madison, 1300 University Avenue, Madison, WI 53706, USA
    Dev Cell 13:601-3. 2007
    ....
  22. pmc MAP3K8 kinase regulates myeloma growth by cell-autonomous and non-autonomous mechanisms involving myeloma-associated monocytes/macrophages
    Ellen Hebron
    Department of Medicine, Division of Hematology Oncology, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA
    Br J Haematol 160:779-84. 2013
    ..Pharmacological MAP3K8 inhibition results in dose-dependent, tumour cell-autonomous apoptosis despite contact with primary stroma. MAP3K8 blockade may disrupt crucial macrophage-tumour cell interactions within myeloma niches...
  23. ncbi request reprint TAK-ling IKK activation: "Ub" the judge
    Shelly M Wuerzberger-Davis
    Department of Pharmacology, University of Wisconsin Madison, 6159 Wisconsin Institute for Medical Research, 1111 Highland Avenue, Madison, WI 53705, USA
    Sci Signal 3:pe3. 2010
    ..This study introduces a paradigm shift in the still-evolving mechanism of regulation of NF-kappaB...
  24. pmc Nuclear initiated NF-κB signaling: NEMO and ATM take center stage
    Shigeki Miyamoto
    Department of Pharmacology, University of Wisconsin Madison, 6159 Wisconsin Institute for Medical Research, 1111 Highland Avenue, Madison, WI 53705, USA
    Cell Res 21:116-30. 2011
    ..This review will summarize these new developments, while identifying significant unanswered questions and providing new hypotheses that may be addressed in future studies...
  25. pmc Identifying post-translational modifications of NEMO by tandem mass spectrometry after high affinity purification
    Shawn S Jackson
    McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin Madison, 6159 Wisconsin Institute for Medical Research, 1111 Highland Avenue, Madison, WI 53705, USA Medical Scientist Training Program, University of Wisconsin Madison, 6159 Wisconsin Institute for Medical Research, 1111 Highland Avenue, Madison, WI 53705, USA Cellular and Molecular Biology Program, University of Wisconsin Madison, 6159 Wisconsin Institute for Medical Research, 1111 Highland Avenue, Madison, WI 53705, USA
    Protein Expr Purif 92:48-53. 2013
    ..Thus, S387 phosphorylation of NEMO is not a general requirement to mediate efficient NF-κB signalling and therefore may have cell type and/or stimulus-specific activity in vivo. ..
  26. pmc A Novel Pathway Links Oxidative Stress to Loss of Insulin Growth Factor-2 (IGF2) Imprinting through NF-κB Activation
    Bing Yang
    Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
    PLoS ONE 9:e88052. 2014
    ..This novel finding connects inflammation found in aging prostate tissues with the altered epigenetic landscape. ..
  27. pmc Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation
    Shelly M Wuerzberger-Davis
    McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin Carbone Cancer Center, University of Wisconsin Madison, 6159 Wisconsin Institute for Medical Research, 1111 Highland Avenue, Madison, WI 53705, USA
    Immunity 34:188-200. 2011
    ..Thus, IκBα nuclear export is essential to maintain constitutive, canonical, and noncanonical NF-κB activation potentials in mature B cells in vivo...
  28. pmc A mechanistic insight into a proteasome-independent constitutive inhibitor kappaBalpha (IkappaBalpha) degradation and nuclear factor kappaB (NF-kappaB) activation pathway in WEHI-231 B-cells
    Stuart D Shumway
    Program in Cellular and Molecular Biology, Department of Pharmacology, University of Wisconsin, 3795 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Biochem J 380:173-80. 2004
    ..These findings further support the notion that IkappaB instability governs the maintenance of constitutive p50-c-Rel activity in certain B-cells via a unique degradation pathway...
  29. pmc The zinc finger domain of NEMO is selectively required for NF-kappa B activation by UV radiation and topoisomerase inhibitors
    Tony T Huang
    Program in Molecular and Cellular Pharmacology, Department of Pharmacology, University of Wisconsin Madison, Madison, Wisconsin 53706 1532, USA
    Mol Cell Biol 22:5813-25. 2002
    ..Thus, we suggest that the zinc finger domain of NEMO likely represents a point of convergence for signaling pathways initiated by slow and weak NF-kappa B-activating conditions...