SAMIR S MITRAGOTRI

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint A theoretical analysis of permeation of small hydrophobic solutes across the stratum corneum based on Scaled Particle Theory
    Samir Mitragotri
    Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    J Pharm Sci 91:744-52. 2002
  2. ncbi request reprint Modeling skin permeability to hydrophilic and hydrophobic solutes based on four permeation pathways
    Samir Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    J Control Release 86:69-92. 2003
  3. pmc Induction of cancer-specific cytotoxicity towards human prostate and skin cells using quercetin and ultrasound
    S Paliwal
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106 5080, USA
    Br J Cancer 92:499-502. 2005
  4. pmc Permeation of insulin, calcitonin and exenatide across Caco-2 monolayers: measurement using a rapid, 3-day system
    Vivek Gupta
    Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, California, USA
    PLoS ONE 8:e57136. 2013
  5. pmc Macrophages recognize size and shape of their targets
    Nishit Doshi
    Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, California, United States of America
    PLoS ONE 5:e10051. 2010
  6. doi request reprint Engineering approaches to transdermal drug delivery: a tribute to contributions of prof. Robert Langer
    S Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    Skin Pharmacol Physiol 26:263-76. 2013
  7. doi request reprint Devices for overcoming biological barriers: the use of physical forces to disrupt the barriers
    Samir Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara, 93106, USA
    Adv Drug Deliv Rev 65:100-3. 2013
  8. pmc Rapid sampling of molecules via skin for diagnostic and forensic applications
    Sumit Paliwal
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    Pharm Res 27:1255-63. 2010
  9. pmc Novel topical microbicides through combinatorial strategies
    Anubhav Arora
    Department of Chemical Engineering, Biomolecular Science and Engineering, University of California, Santa Barbara, California 93106, USA
    Pharm Res 27:1264-72. 2010
  10. pmc Ultrasound-enhanced drug transport and distribution in the brain
    Ying Liu
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 0100, USA
    AAPS PharmSciTech 11:1005-17. 2010

Research Grants

  1. A Novel and Non-Invasive Method of Dermal Sampling
    Samir Mitragotri; Fiscal Year: 2003
  2. Cutaneous Gene Therapy with Ultrasound: DNA Vaccination
    Samir Mitragotri; Fiscal Year: 2006

Collaborators

Detail Information

Publications74

  1. ncbi request reprint A theoretical analysis of permeation of small hydrophobic solutes across the stratum corneum based on Scaled Particle Theory
    Samir Mitragotri
    Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    J Pharm Sci 91:744-52. 2002
    ..6 x 10(-6)K(0.7)(o/w)exp(-0.46r(2)(A1)--where r is solute molecular radius in Angstroms (A) and P is in cm/s. The predicted skin permeabilities compare well with the experimental data...
  2. ncbi request reprint Modeling skin permeability to hydrophilic and hydrophobic solutes based on four permeation pathways
    Samir Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    J Control Release 86:69-92. 2003
    ..The model yielded a series of equations to predict skin permeability based on solute radius and octanol-water partition coefficient. Predictions of the model compare well with the experimental data...
  3. pmc Induction of cancer-specific cytotoxicity towards human prostate and skin cells using quercetin and ultrasound
    S Paliwal
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106 5080, USA
    Br J Cancer 92:499-502. 2005
    ..Ultrasound reduced the LC50 of quercetin for skin cancer cells by almost 80-fold, while showing no effect on LC50 for nonmalignant skin cells...
  4. pmc Permeation of insulin, calcitonin and exenatide across Caco-2 monolayers: measurement using a rapid, 3-day system
    Vivek Gupta
    Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, California, USA
    PLoS ONE 8:e57136. 2013
    ..Here, we report on the use of 3-day Caco-2 monolayers for assessing permeability of polypeptide drugs...
  5. pmc Macrophages recognize size and shape of their targets
    Nishit Doshi
    Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, California, United States of America
    PLoS ONE 5:e10051. 2010
    ..These findings have significant implications in understanding the pathogenicity of bacteria and in designing drug delivery carriers...
  6. doi request reprint Engineering approaches to transdermal drug delivery: a tribute to contributions of prof. Robert Langer
    S Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    Skin Pharmacol Physiol 26:263-76. 2013
    ..At the same time, he has inspired several generations of engineers by collaborations and mentorship. His scientific insights, innovative technologies, translational efforts and dedicated mentorship have transformed the field...
  7. doi request reprint Devices for overcoming biological barriers: the use of physical forces to disrupt the barriers
    Samir Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara, 93106, USA
    Adv Drug Deliv Rev 65:100-3. 2013
    ..A summary of the working principles of these devices and their ability to enhance drug delivery is presented...
  8. pmc Rapid sampling of molecules via skin for diagnostic and forensic applications
    Sumit Paliwal
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    Pharm Res 27:1255-63. 2010
    ..This study describes the use of low-frequency ultrasound as a one-step methodology for rapid sampling of molecules from the skin...
  9. pmc Novel topical microbicides through combinatorial strategies
    Anubhav Arora
    Department of Chemical Engineering, Biomolecular Science and Engineering, University of California, Santa Barbara, California 93106, USA
    Pharm Res 27:1264-72. 2010
    ..Here, we report on the discovery of unique surfactant formulations with improved safety and efficacy profile for epithelial applications, via a combination of high throughput screening techniques...
  10. pmc Ultrasound-enhanced drug transport and distribution in the brain
    Ying Liu
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 0100, USA
    AAPS PharmSciTech 11:1005-17. 2010
    ..Altogether, these studies demonstrate that ultrasound can increase drug permeation in the brain in vitro and in vivo under conditions that did not cause detectable damage...
  11. ncbi request reprint Temperature dependence of skin permeability to hydrophilic and hydrophobic solutes
    Samir Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, California 93106, USA
    J Pharm Sci 96:1832-9. 2007
    ..Theoretical equations are also presented to facilitate interpretation of the dependence of activation energy on molecular properties of the solute...
  12. ncbi request reprint Immunization without needles
    Samir Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    Nat Rev Immunol 5:905-16. 2005
    ..This article focuses on contemporary developments in needle-free methods of immunization, such as liquid-jet injectors, topical application to the skin, oral pills and nasal sprays...
  13. ncbi request reprint Low-frequency sonophoresis: a review
    Samir Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    Adv Drug Deliv Rev 56:589-601. 2004
    ..Mechanistic insights gained through a number of investigations are also reviewed. Finally, reports on the synergistic effect of low-frequency ultrasound with other enhancers including chemicals and iontophoresis are summarized...
  14. pmc Physical approaches to biomaterial design
    Samir Mitragotri
    Department of Chemical Engineering, University of California Santa Barbara, California 93106, USA
    Nat Mater 8:15-23. 2009
    ..In each case, we present examples demonstrating the significance of these properties in biology. We also discuss synthesis methods and biological applications for designer biomaterials, which offer unique physical properties...
  15. ncbi request reprint Healing sound: the use of ultrasound in drug delivery and other therapeutic applications
    Samir Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    Nat Rev Drug Discov 4:255-60. 2005
    ..In addition, ultrasound has also been shown to facilitate the healing of wounds and bone fractures. This article reviews the principles and current status of ultrasound-based treatments...
  16. ncbi request reprint Current status and future prospects of needle-free liquid jet injectors
    Samir Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    Nat Rev Drug Discov 5:543-8. 2006
    ..This article reviews jet injectors with respect to their current clinical applications, emerging applications, mechanistic understanding and future prospects...
  17. doi request reprint Mathematical models of skin permeability: an overview
    Samir Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, United States
    Int J Pharm 418:115-29. 2011
    ..This article provides an overview of various modeling approaches with respect to their advantages, limitations and future prospects...
  18. ncbi request reprint Synergistic effect of enhancers for transdermal drug delivery
    S Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara 93106, USA
    Pharm Res 17:1354-9. 2000
    ..This paper summarizes literature studies on these combinations with respect to their efficacy and mechanisms...
  19. ncbi request reprint Effect of therapeutic ultrasound on partition and diffusion coefficients in human stratum corneum
    S Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    J Control Release 71:23-9. 2001
    ..However, it did not significantly enhance partition coefficients. The method described in this paper is quite general and can be used to measure the effect of various enhancers on partition and diffusion coefficients...
  20. ncbi request reprint Transdermal extraction of analytes using low-frequency ultrasound
    S Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara 93106, USA
    Pharm Res 17:466-70. 2000
    ..In this paper, we report a potential method for non-invasive diagnostics based on ultrasonic skin permeabilization and subsequent extraction of interstitial fluid (ISF) across the skin...
  21. ncbi request reprint Effect of bilayer distruption on transdermal transport of low-molecular weight hydrophobic solutes
    S Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara 93106, USA
    Pharm Res 18:1018-23. 2001
    ..The objective of this study was to develop a mathematical model to describe the effect of bilayer disrupting agents on skin permeability to low molecular weight hydrophobic drugs...
  22. ncbi request reprint Transdermal delivery of heparin and low-molecular weight heparin using low-frequency ultrasound
    S Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara 93106, USA
    Pharm Res 18:1151-6. 2001
    ..We hypothesized that transdermal delivery of heparin may provide an attractive alternative to injections. However, the dose of transdermally delivered heparin is limited by low skin permeability...
  23. ncbi request reprint Analysis of ultrasonically extracted interstitial fluid as a predictor of blood glucose levels
    S Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    J Appl Physiol (1985) 89:961-6. 2000
    ..The model accounts for convective, as well as diffusive, transport processes across blood capillaries, epidermis, and the stratum corneum. The overall predictions of the model compare favorably with the experimental observations...
  24. ncbi request reprint Synergistic effect of low-frequency ultrasound and sodium lauryl sulfate on transdermal transport
    S Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara 93016, USA
    J Pharm Sci 89:892-900. 2000
    ..Possible mechanisms for the synergistic effect of ultrasound and SLS are also discussed...
  25. ncbi request reprint Low-frequency sonophoresis: a noninvasive method of drug delivery and diagnostics
    S Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara, California 93016, USA
    Biotechnol Prog 16:488-92. 2000
    ..Studies on diagnostics are performed using glucose as a model analyte. Applications of this technology to drug delivery and diagnostics are discussed...
  26. ncbi request reprint High throughput screening of transdermal formulations
    Pankaj Karande
    Department of Chemical Engineering, University of California, Santa Barbara 93106, USA
    Pharm Res 19:655-60. 2002
    ....
  27. pmc Micro-scale devices for transdermal drug delivery
    Anubhav Arora
    Biomolecular Science and Engineering, University of California, Santa Barbara, CA 93106, USA
    Int J Pharm 364:227-36. 2008
    ..These include liquid jet injectors, powder injectors, microneedles and thermal microablation. The historical perspective, mechanisms of action, important design parameters, applications and challenges are discussed for each method...
  28. pmc Interactions of inertial cavitation bubbles with stratum corneum lipid bilayers during low-frequency sonophoresis
    Ahmet Tezel
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    Biophys J 85:3502-12. 2003
    ..Theoretical predictions were compared to experimentally measured parameters of cavitation events...
  29. ncbi request reprint Description of transdermal transport of hydrophilic solutes during low-frequency sonophoresis based on a modified porous pathway model
    Ahmet Tezel
    Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, California 93106, USA
    J Pharm Sci 92:381-93. 2003
    ..The results of this study show that low-frequency sonophoresis creates pathways for permeant delivery with a wide range of pore sizes. The optimum pore size utilized by solutes is related to their molecular radii...
  30. ncbi request reprint Low-frequency sonophoresis: current status and future prospects
    Makoto Ogura
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    Adv Drug Deliv Rev 60:1218-23. 2008
    ..Novel theoretical and experimental approaches have provided insights into the mechanisms of low-frequency sonophoresis. Current understanding of these mechanisms is presented...
  31. pmc A model for intracellular trafficking of adenoviral vectors
    Anh Tuan Dinh
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    Biophys J 89:1574-88. 2005
    ..Model predictions agree well with experimental data available in literature. The paper serves as a guide for future theoretical and experimental efforts to understand viral gene delivery...
  32. ncbi request reprint Evaluation of chemical enhancers in the transdermal delivery of lidocaine
    Philip J Lee
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, USA
    Int J Pharm 308:33-9. 2006
    ..These findings allow a more rational approach for designing oil-based formulations for the transdermal delivery of lidocaine free base and similar drugs...
  33. ncbi request reprint Synergistic effects of chemical enhancers on skin permeability: a case study of sodium lauroylsarcosinate and sorbitan monolaurate
    Pankaj Karande
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    Eur J Pharm Sci 31:1-7. 2007
    ..However, mixtures of NLS and S20 resulted in micelle-like aggregates at certain specific compositions. Interestingly, compositions with increased aggregation showed resemblance to those that exhibited highest skin permeabilization...
  34. ncbi request reprint Breaking the skin barrier
    Samir Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    Adv Drug Deliv Rev 56:555-6. 2004
  35. ncbi request reprint Ultrasound-induced cavitation: applications in drug and gene delivery
    Sumit Paliwal
    University of California, Department of Chemical Engineering, Santa Barbara, CA 93106, USA
    Expert Opin Drug Deliv 3:713-26. 2006
    ..This review provides a detailed account of mechanisms, current status and future prospects of ultrasonic cavitation in drug and gene delivery applications...
  36. ncbi request reprint Discovery of transdermal penetration enhancers by high-throughput screening
    Pankaj Karande
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    Nat Biotechnol 22:192-7. 2004
    ..These studies show the feasibility of using penetration enhancers for systemic delivery of macromolecules from a transdermal patch...
  37. ncbi request reprint Synergistic effect of low-frequency ultrasound and surfactants on skin permeability
    Ahmet Tezel
    Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, California 93106, USA
    J Pharm Sci 91:91-100. 2002
    ..We performed imaging experiments to assess the effect of ultrasound on delivery of a model permeant, sulforhodamine B, into the skin. These experiments show that ultrasound enhances surfactant delivery and dispersion in the skin...
  38. ncbi request reprint Dependence of skin permeability on contact area
    Pankaj Karande
    Department of Chemical Engineering University of California, Santa Barbara, California 93106, USA
    Pharm Res 20:257-63. 2003
    ..Our results suggest that an array of smaller reservoirs should thus be more effective in increasing transdermal drug delivery compared to a large single reservoir of the same total area...
  39. pmc Needle-free delivery of macromolecules across the skin by nanoliter-volume pulsed microjets
    Anubhav Arora
    Biomolecular Science and Engineering, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 104:4255-60. 2007
    ..Pulsed microjet injectors could be used to deliver drugs for local as well as systemic applications without using needles...
  40. ncbi request reprint Low-frequency sonophoresis: ultrastructural basis for stratum corneum permeability assessed using quantum dots
    Sumit Paliwal
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    J Invest Dermatol 126:1095-101. 2006
    ..This contention is consistent with previously conceived theoretical mechanistic understanding of LFS-induced enhanced transport across the skin...
  41. pmc Design principles of chemical penetration enhancers for transdermal drug delivery
    Pankaj Karande
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 102:4688-93. 2005
    ..These molecules significantly broaden the repertoire of CPEs that can aid the design of optimized transdermal, dermatological, and cosmetic formulations in the future...
  42. ncbi request reprint Transdermal drug delivery by jet injectors: energetics of jet formation and penetration
    Joy Schramm
    Department of Chemical Engineering, University of California, Santa Barbara 93106, USA
    Pharm Res 19:1673-9. 2002
    ..These studies were performed using two experimental models, porcine skin and human skin. Our rationale for using two models was to explore the possibility of using porcine skin as a model for human skin...
  43. ncbi request reprint Mechanistic analysis of chemical permeation enhancers for oral drug delivery
    Kathryn Whitehead
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106 5080, USA
    Pharm Res 25:1412-9. 2008
    ..Although certain permeation enhancers have been proposed for use in oral delivery, potential for application is often unclear when the route of enhancer action is unknown...
  44. ncbi request reprint Investigations of the role of cavitation in low-frequency sonophoresis using acoustic spectroscopy
    Ahmet Tezel
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    J Pharm Sci 91:444-53. 2002
    ..No correlation was found between the subharmonic pressure amplitude and conductivity enhancement...
  45. doi request reprint Dynamic control of needle-free jet injection
    Jeanne C Stachowiak
    University of California, Berkeley, Department of Mechanical Engineering, Berkeley, CA 94720, USA
    J Control Release 135:104-12. 2009
    ..This dynamic control of jet velocity creates the potential for better control of needle-free injections, as demonstrated through injection studies on whole ex vivo human skin samples...
  46. pmc Polymer particles that switch shape in response to a stimulus
    Jin Wook Yoo
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 107:11205-10. 2010
    ..Elliptical disk-shaped particles that are not phagocytosed by macrophages were made to internalize through shape switch, demonstrating the ability of shape-switchable particles in modulating interaction with cells...
  47. ncbi request reprint Topical delivery of anti-sense oligonucleotides using low-frequency sonophoresis
    Ahmet Tezel
    Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, California 93106, USA
    Pharm Res 21:2219-25. 2004
    ..Herein, we assessed the potential of low-frequency ultrasound (20 kHz, 2.4 W/cm2) in delivering therapeutically significant quantities of anti-sense oligonucleotides into skin...
  48. ncbi request reprint Low-frequency ultrasound as a transcutaneous immunization adjuvant
    Ahmet Tezel
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    Vaccine 23:3800-7. 2005
    ..These studies demonstrate generation of a potent systemic immune response through TCI without using toxin adjuvants or skin abrasion. Ultrasonic TCI offers a needle-free and painless mode of immunization...
  49. ncbi request reprint Jet injection into polyacrylamide gels: investigation of jet injection mechanics
    Joy Schramm-Baxter
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    J Biomech 37:1181-8. 2004
    ..The penetration depth of the jets as well as the rate of erosion decreased with increasing Young's modulus. The mechanics of jet penetration into polyacrylamide gels provides an important tool for understanding jet injection into skin...
  50. ncbi request reprint Needle-free jet injections: dependence of jet penetration and dispersion in the skin on jet power
    Joy Schramm-Baxter
    Department of Chemical Engineering, University of California, Engineering II Building, Santa Barbara, CA 93106, USA
    J Control Release 97:527-35. 2004
    ..These experiments demonstrated that jet power also effectively describes gel erosion due to liquid impingement...
  51. ncbi request reprint Oral delivery of macromolecules using intestinal patches: applications for insulin delivery
    Kathryn Whitehead
    Department of Chemical Engineering, University of California, Engineering II Building, Santa Barbara 93106, USA
    J Control Release 98:37-45. 2004
    ..These studies demonstrate that reduction in blood glucose levels comparable to that induced by subcutaneous injections can be achieved via enteral insulin absorption with doses only 2-10-fold higher than subcutaneous doses...
  52. ncbi request reprint A reversibly switching surface
    Joerg Lahann
    Department of Chemical Engineering, Massachusetts Institute of Technology MIT, 45 Carleton Street, Cambridge, MA 02139, USA
    Science 299:371-4. 2003
    ..Such reversibly switching surfaces may open previously unknown opportunities in interfacial engineering...
  53. ncbi request reprint A theoretical analysis of low-frequency sonophoresis: dependence of transdermal transport pathways on frequency and energy density
    Ahmet Tezel
    Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, California 93106, USA
    Pharm Res 19:1841-6. 2002
    ..In this study, we seek to determine the dependence of transport pathways during low-frequency sonophoresis on ultrasound parameters...
  54. ncbi request reprint Incorporation of lipophilic pathways into the porous pathway model for describing skin permeabilization during low-frequency sonophoresis
    Ahmet Tezel
    Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    J Control Release 83:183-8. 2002
    ..The aim of this note is to incorporate the lipophilic pathway into the porous pathway model to describe transdermal drug transport in the absence and presence of ultrasound...
  55. ncbi request reprint Relationships between skin's electrical impedance and permeability in the presence of chemical enhancers
    Pankaj Karande
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, United States
    J Control Release 110:307-13. 2006
    ..9 for both mannitol and estradiol). These studies demonstrate the feasibility of using skin's electrical impedance to screen potent chemical enhancers...
  56. ncbi request reprint Porous resins as a cavitation enhancer for low-frequency sonophoresis
    Takaaki Terahara
    Department of Chemical Engineering, Massachusetts Institute of Technology E25 342, 45 Carlton Street, Cambridge, MA 02139, USA
    J Pharm Sci 91:753-9. 2002
    ..2MG was also effective in enhancing transdermal mannitol transport. These results confirm that the addition of cavitation nuclei such as porous resins further increases the effect of low-frequency ultrasound on skin permeability...
  57. ncbi request reprint Insights into synergistic interactions in binary mixtures of chemical permeation enhancers for transdermal drug delivery
    Pankaj Karande
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    J Control Release 115:85-93. 2006
    ..Simple but invaluable rules like these will provide guiding principles for designing libraries to further speed up the formulation discovery process...
  58. ncbi request reprint On the origin of size-dependent tortuosity for permeation of hydrophilic solutes across the stratum corneum
    Ahmet Tezel
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    J Control Release 86:183-6. 2003
    ..The proposed theoretical model describing the dependence of solute tortuosity on solute size and SC porosity is in agreement with prior experimentally derived tortuosity values...
  59. pmc An experimental and theoretical analysis of ultrasound-induced permeabilization of cell membranes
    Jagannathan Sundaram
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    Biophys J 84:3087-101. 2003
    ..For each mechanism, the volume around the bubble within which bubbles induce reversible and irreversible membrane permeabilization was determined. Predictions of the model are consistent with experimental data...
  60. ncbi request reprint Multicomponent chemical enhancer formulations for transdermal drug delivery: more is not always better
    Anubhav Arora
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, United States
    J Control Release 144:175-80. 2010
    ..Ternary formulations exhibited the best cost to benefit ratio as judged by the fraction of total formulations that provide high potency...
  61. ncbi request reprint Prolonged circulation of large polymeric nanoparticles by non-covalent adsorption on erythrocytes
    Elizabeth Chambers
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    J Control Release 100:111-9. 2004
    ..Although particles were eventually eliminated from circulation, RBCs were not cleared. RBC-anchored nanoparticles offer a novel approach for intravascular drug delivery and blood pool imaging...
  62. pmc Understanding intracellular transport processes pertinent to synthetic gene delivery via stochastic simulations and sensitivity analyses
    Anh Tuan Dinh
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    Biophys J 92:831-46. 2007
    ..Based on comparison with gene delivery by viruses, the model suggests possible strategies to significantly improve transfection efficiencies of synthetic gene vectors...
  63. pmc Particle shape: a new design parameter for micro- and nanoscale drug delivery carriers
    Julie A Champion
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, United States
    J Control Release 121:3-9. 2007
    ..This article provides a review of this field with respect to methods of particle preparation and the role of particle shape in drug delivery...
  64. ncbi request reprint Safe and effective permeation enhancers for oral drug delivery
    Kathryn Whitehead
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106 5080, USA
    Pharm Res 25:1782-8. 2008
    ..This study attempts to gain insight into the principles governing the potency and toxicity behavior of enhancers...
  65. ncbi request reprint Therapeutic opportunities in biological responses of ultrasound
    Sumit Paliwal
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    Ultrasonics 48:271-8. 2008
    ..Overall, this review presents the increasing importance of ultrasound's role as a biological sensitizer enabling novel therapeutic strategies...
  66. pmc Role of particle size in phagocytosis of polymeric microspheres
    Julie A Champion
    Department of Chemical Engineering, University of California, Santa Barbara, California, 93106, USA
    Pharm Res 25:1815-21. 2008
    ..Here, we investigate the previously unexplained dependence of phagocytosis on particle size...
  67. ncbi request reprint Jet-induced skin puncture and its impact on needle-free jet injections: experimental studies and a predictive model
    Joy Baxter
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    J Control Release 106:361-73. 2005
    ..Prediction of the hole depth in the skin is a first step in quantitatively predicting drug delivery by jet injection...
  68. pmc Shape induced inhibition of phagocytosis of polymer particles
    Julie A Champion
    Department of Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Pharm Res 26:244-9. 2009
    ..To determine if particle shape can be engineered to inhibit phagocytosis of drug delivery particles by macrophages, which can be a significant barrier to successful therapeutic delivery...
  69. doi request reprint Discovery of synergistic permeation enhancers for oral drug delivery
    Kathryn Whitehead
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106 5080, United States
    J Control Release 128:128-33. 2008
    ..These results encourage further exploration of several leading formulations for in vivo applications in oral drug delivery...
  70. pmc One-step acquisition of functional biomolecules from tissues
    Sumit Paliwal
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 107:14627-32. 2010
    ..Applications of this sampling methodology to rapid molecular diagnostics of cutaneous allergies and infectious diseases are also presented...
  71. ncbi request reprint Long circulating nanoparticles via adhesion on red blood cells: mechanism and extended circulation
    Elizabeth Chambers
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    Exp Biol Med (Maywood) 232:958-66. 2007
    ..This manuscript reports an in depth analysis of the behavior of nanoparticles bound to red blood cells, especially their circulation characteristics, biodistribution, and mechanisms of clearance...
  72. pmc Red blood cell-mimicking synthetic biomaterial particles
    Nishit Doshi
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 106:21495-9. 2009
    ..These particles provide a paradigm for the design of drug delivery and imaging carriers, because they combine the functionality of natural RBCs with the broad applicability and versatility of synthetic drug delivery particles...
  73. pmc Role of target geometry in phagocytosis
    Julie A Champion
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 103:4930-4. 2006
    ..Failure to create the required actin structure results in simple spreading and not internalization. Particle size primarily impacts the completion of phagocytosis in cases where particle volume exceeds the cell volume...
  74. ncbi request reprint Dynamics and spatial organization of endosomes in mammalian cells
    Chinmay Pangarkar
    Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, California 93106, USA
    Phys Rev Lett 95:158101. 2005
    ..Facilitated diffusion results in rapid equilibration of vesicles on microtubules. The asterlike organization of microtubules causes perinuclear accumulation of vesicles despite symmetric transport...

Research Grants2

  1. A Novel and Non-Invasive Method of Dermal Sampling
    Samir Mitragotri; Fiscal Year: 2003
    ..abstract_text> ..
  2. Cutaneous Gene Therapy with Ultrasound: DNA Vaccination
    Samir Mitragotri; Fiscal Year: 2006
    ..3. Using an in vitro model, Epiderm, and in vivo mouse model, assess safety of skin exposure to low-frequency ultrasound. ..