Soumya Mitra

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Confocal fluorescence imaging enables noninvasive quantitative assessment of host cell populations in vivo following photodynamic therapy
    Soumya Mitra
    Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA
    Theranostics 2:840-9. 2012
  2. pmc Enzyme-activatable imaging probe reveals enhanced neutrophil elastase activity in tumors following photodynamic therapy
    Soumya Mitra
    University of Rochester Medical Center, Department of Imaging Sciences, Rochester, New York 14642, USA
    J Biomed Opt 18:101314. 2013
  3. pmc Tumor response to mTHPC-mediated photodynamic therapy exhibits strong correlation with extracellular release of HSP70
    Soumya Mitra
    Department of Imaging Sciences, University of Rochester Medical Center, Rochester, New York 14642, USA
    Lasers Surg Med 43:632-43. 2011
  4. doi request reprint Respiratory deficiency enhances the sensitivity of the pathogenic fungus Candida to photodynamic treatment
    Yeissa Chabrier-Roselló
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA
    Photochem Photobiol 84:1141-8. 2008
  5. pmc Inhibition of electron transport chain assembly and function promotes photodynamic killing of Candida
    Yeissa Chabrier-Roselló
    Department of Microbiology and Immunology, University of Rochester Medical Center, Box 672, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Photochem Photobiol B 99:117-25. 2010
  6. pmc Migration of skin dendritic cells in response to ionizing radiation exposure
    Ryan J Cummings
    Department of Microbiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Radiat Res 171:687-97. 2009
  7. pmc Simulations of measured photobleaching kinetics in human basal cell carcinomas suggest blood flow reductions during ALA-PDT
    Ken Kang Hsin Wang
    Department of Physics and Astronomy, University of Rochester, Rochester, New York 14627, USA
    Lasers Surg Med 41:686-96. 2009
  8. ncbi request reprint Photodynamic therapy mediates the oxygen-independent activation of hypoxia-inducible factor 1alpha
    Soumya Mitra
    Department of Imaging Sciences, University of Rochester, 601 Elmwood Avenue, Box 648, Rochester, NY 14642, USA
    Mol Cancer Ther 5:3268-74. 2006
  9. pmc Photodynamic dose does not correlate with long-term tumor response to mTHPC-PDT performed at several drug-light intervals
    Ken Kang Hsin Wang
    Department of Physics and Astronomy, University of Rochester, Rochester, New York 14627, USA
    Med Phys 35:3518-26. 2008
  10. pmc Sensitivity of Candida albicans germ tubes and biofilms to photofrin-mediated phototoxicity
    Yeissa Chabrier-Roselló
    Department of Microbiology and Immunology, Center for Oral Biology, University of Rochester Medical Center, New York 14642, USA
    Antimicrob Agents Chemother 49:4288-95. 2005

Collaborators

Detail Information

Publications27

  1. pmc Confocal fluorescence imaging enables noninvasive quantitative assessment of host cell populations in vivo following photodynamic therapy
    Soumya Mitra
    Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA
    Theranostics 2:840-9. 2012
    ..Co-localization analysis reveals an increase in the fraction of Gr1(+) cells expressing MHC-II, suggesting that HPPH-PDT is stimulating neutrophils to express an antigen-presenting phenotype...
  2. pmc Enzyme-activatable imaging probe reveals enhanced neutrophil elastase activity in tumors following photodynamic therapy
    Soumya Mitra
    University of Rochester Medical Center, Department of Imaging Sciences, Rochester, New York 14642, USA
    J Biomed Opt 18:101314. 2013
    ....
  3. pmc Tumor response to mTHPC-mediated photodynamic therapy exhibits strong correlation with extracellular release of HSP70
    Soumya Mitra
    Department of Imaging Sciences, University of Rochester Medical Center, Rochester, New York 14642, USA
    Lasers Surg Med 43:632-43. 2011
    ....
  4. doi request reprint Respiratory deficiency enhances the sensitivity of the pathogenic fungus Candida to photodynamic treatment
    Yeissa Chabrier-Roselló
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA
    Photochem Photobiol 84:1141-8. 2008
    ....
  5. pmc Inhibition of electron transport chain assembly and function promotes photodynamic killing of Candida
    Yeissa Chabrier-Roselló
    Department of Microbiology and Immunology, University of Rochester Medical Center, Box 672, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Photochem Photobiol B 99:117-25. 2010
    ..The data demonstrate that selective inhibition of ETC Complexes III and IV significantly increases the sensitivity of C. albicans, C. glabrata and S. cerevisiae to PDT sensitized with TMP-1363...
  6. pmc Migration of skin dendritic cells in response to ionizing radiation exposure
    Ryan J Cummings
    Department of Microbiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Radiat Res 171:687-97. 2009
    ....
  7. pmc Simulations of measured photobleaching kinetics in human basal cell carcinomas suggest blood flow reductions during ALA-PDT
    Ken Kang Hsin Wang
    Department of Physics and Astronomy, University of Rochester, Rochester, New York 14627, USA
    Lasers Surg Med 41:686-96. 2009
    ..We have performed a detailed analysis of this hypothesis...
  8. ncbi request reprint Photodynamic therapy mediates the oxygen-independent activation of hypoxia-inducible factor 1alpha
    Soumya Mitra
    Department of Imaging Sciences, University of Rochester, 601 Elmwood Avenue, Box 648, Rochester, NY 14642, USA
    Mol Cancer Ther 5:3268-74. 2006
    ....
  9. pmc Photodynamic dose does not correlate with long-term tumor response to mTHPC-PDT performed at several drug-light intervals
    Ken Kang Hsin Wang
    Department of Physics and Astronomy, University of Rochester, Rochester, New York 14627, USA
    Med Phys 35:3518-26. 2008
    ..In situations like this one, other reporters of biological response to therapy would be necessary...
  10. pmc Sensitivity of Candida albicans germ tubes and biofilms to photofrin-mediated phototoxicity
    Yeissa Chabrier-Roselló
    Department of Microbiology and Immunology, Center for Oral Biology, University of Rochester Medical Center, New York 14642, USA
    Antimicrob Agents Chemother 49:4288-95. 2005
    ..albicans. These observations provide support and rationale for the continued investigation of PDT as an adjunctive, or possibly alternative, mode of therapy against cutaneous and mucocutaneous candidiasis...
  11. pmc Antibody-labeled fluorescence imaging of dendritic cell populations in vivo
    Ryan J Cummings
    University of Rochester Medical Center, Department of Microbiology and Immunology, Rochester, New York 14642, USA
    J Biomed Opt 13:044041. 2008
    ..The method achieves micron-scale spatial resolution to depths greater than 100 mum. We illustrate the capabilities of this approach by imaging two dendritic cell populations in the skin and normal and tumor vasculature in vivo...
  12. pmc Effective photosensitization and selectivity in vivo of Candida Albicans by meso-tetra (N-methyl-4-pyridyl) porphine tetra tosylate
    Soumya Mitra
    Department of Imaging Sciences, University of Rochester Medical Center, Rochester, New York 14642, USA
    Lasers Surg Med 43:324-32. 2011
    ..We investigated the effectiveness of the photosensitizer meso-tetra (N-methyl-4-pyridyl) porphine tetra tosylate (TMP-1363) in the photodynamic treatment (PDT) of C. albicans infection in vitro and its selectivity in an animal model...
  13. ncbi request reprint Irradiation-induced enhancement of Pc 4 fluorescence and changes in light scattering are potential dosimeters for Pc 4-PDT
    Ken Kang Hsin Wang
    Department of Physics and Astronomy, University of Rochester, Rochester, NY, USA
    Photochem Photobiol 83:1056-62. 2007
    ..Taken together, these data suggest that Pc 4 is initially aggregated at high local concentration in mitochondria and that irradiation relaxes the quenching of Pc 4 fluorescence through a mechanism that may involve mitochondrial swelling...
  14. pmc In vivo confocal fluorescence imaging of the intratumor distribution of the photosensitizer mono-L-aspartylchlorin-e6
    Soumya Mitra
    Department of Imaging Sciences, University of Rochester, Rochester, NY 14642, USA
    Neoplasia 10:429-38. 2008
    ..Our findings are of immediate clinical relevance and demonstrate the importance of an in vivo imaging approach to examine the dynamic process of intratumor drug distribution...
  15. ncbi request reprint Photobleaching kinetics of Photofrin in vivo and in multicell tumour spheroids indicate two simultaneous bleaching mechanisms
    Jarod C Finlay
    Department of Physics and Astronomy, University of Rochester, Rochester, NY 14642, USA
    Phys Med Biol 49:4837-60. 2004
    ..At all concentrations, photoproduct accumulation was greater under conditions of abundant oxygen...
  16. ncbi request reprint Fluorescence anisotropy imaging reveals localization of meso-tetrahydroxyphenyl chlorin in the nuclear envelope
    Thomas H Foster
    Department of Imaging Sciences, University of Rochester, Rochester, NY 14642, USA
    Photochem Photobiol 81:1544-7. 2005
    ..12. The change from a positive intrinsic anisotropy in homogeneous solution to a negative value in cells suggests an environmentally induced change in the relative orientations of the absorption and emission dipole moments...
  17. ncbi request reprint Photophysical parameters, photosensitizer retention and tissue optical properties completely account for the higher photodynamic efficacy of meso-tetra-hydroxyphenyl-chlorin vs Photofrin
    Soumya Mitra
    Department of Radiology, University of Rochester, 601 Elmwood Avenue, Box 648, Rochester, NY 14642, USA
    Photochem Photobiol 81:849-59. 2005
    ....
  18. ncbi request reprint Activation of heat shock protein 70 promoter with meso-tetrahydroxyphenyl chlorin photodynamic therapy reported by green fluorescent protein in vitro and in vivo
    Soumya Mitra
    Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY 14642, USA
    Photochem Photobiol 78:615-22. 2003
    ....
  19. ncbi request reprint Carbogen breathing significantly enhances the penetration of red light in murine tumours in vivo
    Soumya Mitra
    Department of Biochemistry and Biophysics, University of Rochester, 601 Elmwood Avenue, Box 648, Rochester, NY 14642, USA
    Phys Med Biol 49:1891-904. 2004
    ....
  20. pmc Optical property measurements establish the feasibility of photodynamic therapy as a minimally invasive intervention for tumors of the kidney
    Timothy M Baran
    University of Rochester, Institute of Optics, Rochester, New York, USA
    J Biomed Opt 17:98002-1. 2012
    ..Our results support the feasibility of PDT in selected renal cancer patients, especially with photosensitizers activated at longer wavelengths...
  21. ncbi request reprint Temporally and spatially heterogeneous distribution of mTHPC in a murine tumor observed by two-color confocal fluorescence imaging and spectroscopy in a whole-mount model
    Soumya Mitra
    Department of Radiology, University of Rochester, Rochester, NY, USA
    Photochem Photobiol 81:1123-30. 2005
    ..This imaging technique can be applied to screen the dynamic intratumor distribution of other fluorescent photosensitizers and anticancer drugs...
  22. ncbi request reprint A comprehensive mathematical model of microscopic dose deposition in photodynamic therapy
    Ken Kang Hsin Wang
    Department of Physics and Astronomy, University of Rochester, Rochester, New York 14642, USA
    Med Phys 34:282-93. 2007
    ..We anticipate that this model will make useful dosimetry predictions that should inform optimal treatment conditions and improve current clinical protocols...
  23. ncbi request reprint Lysosome-damage-induced scattering changes coincide with release of cytochrome c
    Jeremy D Wilson
    Department of Physics and Astronomy, University of Rochester, Rochester, New York 14627, USA
    Opt Lett 32:2517-9. 2007
    ....
  24. pmc Intratumor administration of the photosensitizer pc 4 affords photodynamic therapy efficacy and selectivity at short drug-light intervals
    Thomas H Foster
    Department of Imaging Sciences, University of Rochester, Rochester, NY, USA
    Transl Oncol 3:135-41. 2010
    ..In this model, IT-Pc 4 administration provides improved tumor control, greater selectivity, and opportunity for a short drug-light interval...
  25. ncbi request reprint In vivo mTHPC photobleaching in normal rat skin exhibits unique irradiance-dependent features
    Jarod C Finlay
    Department of Physics and Astronomy, University of Rochester, NY 14642, USA
    Photochem Photobiol 75:282-8. 2002
    ..The fluorescence from the in vivo bleaching experiments thus reports a phenomenon that is not reported by measurements of the photochemical oxygen consumption in the spheroids...
  26. ncbi request reprint Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors
    Kathlyn Santos
    Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    Hum Gene Ther 18:93-105. 2007
    ..From this and previous work, we conclude that amplicons may engender a potent immune response by directly transducing dendritic cells as well as by cross-priming of antigen produced by other transduced host cells...
  27. pmc Imaging morphogenesis of Candida albicans during infection in a live animal
    Soumya Mitra
    University of Rochester Medical Center, Department of Imaging Sciences, 601 Elmwood Avenue, Box 648, Rochester, New York 1462University of Rochester Medical Center, Department of Pediatrics, 601 Elmwood Avenue, Box 690, Rochester, New York 14642
    J Biomed Opt 15:010504. 2010
    ..This model system will allow us to gain significant new information about C. albicans pathogenesis through studies of host-C. albicans interactions in the native environment...