Research Topics
| Soumya MitraSummaryAffiliation: University of Rochester Country: USA Publications
| Collaborators
|
Detail Information
Publications
Tumor response to mTHPC-mediated photodynamic therapy exhibits strong correlation with extracellular release of HSP70Soumya Mitra
Department of Imaging Sciences, University of Rochester Medical Center, Rochester, New York 14642, USA
Lasers Surg Med 43:632-43. 2011....
Respiratory deficiency enhances the sensitivity of the pathogenic fungus Candida to photodynamic treatmentYeissa Chabrier-Roselló
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA
Photochem Photobiol 84:1141-8. 2008....- Inhibition of electron transport chain assembly and function promotes photodynamic killing of CandidaYeissa Chabrier-Roselló
Department of Microbiology and Immunology, University of Rochester Medical Center, Box 672, 601 Elmwood Ave, Rochester, NY 14642, USA
J Photochem Photobiol B 99:117-25. 2010..The data demonstrate that selective inhibition of ETC Complexes III and IV significantly increases the sensitivity of C. albicans, C. glabrata and S. cerevisiae to PDT sensitized with TMP-1363... - Migration of skin dendritic cells in response to ionizing radiation exposureRyan J Cummings
Department of Microbiology, University of Rochester Medical Center, Rochester, New York 14642, USA
Radiat Res 171:687-97. 2009.... 
Photodynamic therapy mediates the oxygen-independent activation of hypoxia-inducible factor 1alphaSoumya Mitra
Department of Imaging Sciences, University of Rochester, 601 Elmwood Avenue, Box 648, Rochester, NY 14642, USA
Mol Cancer Ther 5:3268-74. 2006....- Photodynamic dose does not correlate with long-term tumor response to mTHPC-PDT performed at several drug-light intervalsKen Kang Hsin Wang
Department of Physics and Astronomy, University of Rochester, Rochester, New York 14627, USA
Med Phys 35:3518-26. 2008..In situations like this one, other reporters of biological response to therapy would be necessary... - Sensitivity of Candida albicans germ tubes and biofilms to photofrin-mediated phototoxicityYeissa Chabrier-Roselló
Department of Microbiology and Immunology, Center for Oral Biology, University of Rochester Medical Center, New York 14642, USA
Antimicrob Agents Chemother 49:4288-95. 2005..albicans. These observations provide support and rationale for the continued investigation of PDT as an adjunctive, or possibly alternative, mode of therapy against cutaneous and mucocutaneous candidiasis... - Simulations of measured photobleaching kinetics in human basal cell carcinomas suggest blood flow reductions during ALA-PDTKen Kang Hsin Wang
Department of Physics and Astronomy, University of Rochester, Rochester, New York 14627, USA
Lasers Surg Med 41:686-96. 2009..We have performed a detailed analysis of this hypothesis... - Irradiation-induced enhancement of Pc 4 fluorescence and changes in light scattering are potential dosimeters for Pc 4-PDTKen Kang Hsin Wang
Department of Physics and Astronomy, University of Rochester, Rochester, NY, USA
Photochem Photobiol 83:1056-62. 2007..Taken together, these data suggest that Pc 4 is initially aggregated at high local concentration in mitochondria and that irradiation relaxes the quenching of Pc 4 fluorescence through a mechanism that may involve mitochondrial swelling... - Antibody-labeled fluorescence imaging of dendritic cell populations in vivoRyan J Cummings
University of Rochester Medical Center, Department of Microbiology and Immunology, Rochester, New York 14642, USA
J Biomed Opt 13:044041. 2008..The method achieves micron-scale spatial resolution to depths greater than 100 mum. We illustrate the capabilities of this approach by imaging two dendritic cell populations in the skin and normal and tumor vasculature in vivo... - Effective photosensitization and selectivity in vivo of Candida Albicans by meso-tetra (N-methyl-4-pyridyl) porphine tetra tosylateSoumya Mitra
Department of Imaging Sciences, University of Rochester Medical Center, Rochester, New York 14642, USA
Lasers Surg Med 43:324-32. 2011..We investigated the effectiveness of the photosensitizer meso-tetra (N-methyl-4-pyridyl) porphine tetra tosylate (TMP-1363) in the photodynamic treatment (PDT) of C. albicans infection in vitro and its selectivity in an animal model... - In vivo confocal fluorescence imaging of the intratumor distribution of the photosensitizer mono-L-aspartylchlorin-e6Soumya Mitra
Department of Imaging Sciences, University of Rochester, Rochester, NY 14642, USA
Neoplasia 10:429-38. 2008..Our findings are of immediate clinical relevance and demonstrate the importance of an in vivo imaging approach to examine the dynamic process of intratumor drug distribution... - Fluorescence anisotropy imaging reveals localization of meso-tetrahydroxyphenyl chlorin in the nuclear envelopeThomas H Foster
Department of Imaging Sciences, University of Rochester, Rochester, NY 14642, USA
Photochem Photobiol 81:1544-7. 2005..12. The change from a positive intrinsic anisotropy in homogeneous solution to a negative value in cells suggests an environmentally induced change in the relative orientations of the absorption and emission dipole moments... - Photophysical parameters, photosensitizer retention and tissue optical properties completely account for the higher photodynamic efficacy of meso-tetra-hydroxyphenyl-chlorin vs PhotofrinSoumya Mitra
Department of Radiology, University of Rochester, 601 Elmwood Avenue, Box 648, Rochester, NY 14642, USA
Photochem Photobiol 81:849-59. 2005.... - A comprehensive mathematical model of microscopic dose deposition in photodynamic therapyKen Kang Hsin Wang
Department of Physics and Astronomy, University of Rochester, Rochester, New York 14642, USA
Med Phys 34:282-93. 2007..We anticipate that this model will make useful dosimetry predictions that should inform optimal treatment conditions and improve current clinical protocols... - Temporally and spatially heterogeneous distribution of mTHPC in a murine tumor observed by two-color confocal fluorescence imaging and spectroscopy in a whole-mount modelSoumya Mitra
Department of Radiology, University of Rochester, Rochester, NY, USA
Photochem Photobiol 81:1123-30. 2005..This imaging technique can be applied to screen the dynamic intratumor distribution of other fluorescent photosensitizers and anticancer drugs... - Lysosome-damage-induced scattering changes coincide with release of cytochrome cJeremy D Wilson
Department of Physics and Astronomy, University of Rochester, Rochester, New York 14627, USA
Opt Lett 32:2517-9. 2007.... - Intratumor administration of the photosensitizer pc 4 affords photodynamic therapy efficacy and selectivity at short drug-light intervalsThomas H Foster
Department of Imaging Sciences, University of Rochester, Rochester, NY, USA
Transl Oncol 3:135-41. 2010..In this model, IT-Pc 4 administration provides improved tumor control, greater selectivity, and opportunity for a short drug-light interval... - Activation of heat shock protein 70 promoter with meso-tetrahydroxyphenyl chlorin photodynamic therapy reported by green fluorescent protein in vitro and in vivoSoumya Mitra
Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY 14642, USA
Photochem Photobiol 78:615-22. 2003.... - Photobleaching kinetics of Photofrin in vivo and in multicell tumour spheroids indicate two simultaneous bleaching mechanismsJarod C Finlay
Department of Physics and Astronomy, University of Rochester, Rochester, NY 14642, USA
Phys Med Biol 49:4837-60. 2004..At all concentrations, photoproduct accumulation was greater under conditions of abundant oxygen... - Carbogen breathing significantly enhances the penetration of red light in murine tumours in vivoSoumya Mitra
Department of Biochemistry and Biophysics, University of Rochester, 601 Elmwood Avenue, Box 648, Rochester, NY 14642, USA
Phys Med Biol 49:1891-904. 2004.... - Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectorsKathlyn Santos
Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
Hum Gene Ther 18:93-105. 2007..From this and previous work, we conclude that amplicons may engender a potent immune response by directly transducing dendritic cells as well as by cross-priming of antigen produced by other transduced host cells... - Confocal fluorescence imaging enables noninvasive quantitative assessment of host cell populations in vivo following photodynamic therapySoumya Mitra
Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA
Theranostics 2:840-9. 2012..Co-localization analysis reveals an increase in the fraction of Gr1(+) cells expressing MHC-II, suggesting that HPPH-PDT is stimulating neutrophils to express an antigen-presenting phenotype... - Imaging morphogenesis of Candida albicans during infection in a live animalSoumya Mitra
University of Rochester Medical Center, Department of Imaging Sciences, 601 Elmwood Avenue, Box 648, Rochester, New York 1462University of Rochester Medical Center, Department of Pediatrics, 601 Elmwood Avenue, Box 690, Rochester, New York 14642
J Biomed Opt 15:010504. 2010..This model system will allow us to gain significant new information about C. albicans pathogenesis through studies of host-C. albicans interactions in the native environment...