Jennifer M Mitchell

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Alcohol self-administration, anxiety, and cortisol levels predict changes in delta opioid receptor function in the ventral tegmental area
    Jennifer M Mitchell
    Ernest Gallo Clinic and Research Center, University of California, San Francisco 94608, USA
    Behav Neurosci 126:515-22. 2012
  2. pmc Varenicline decreases alcohol consumption in heavy-drinking smokers
    Jennifer M Mitchell
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
    Psychopharmacology (Berl) 223:299-306. 2012
  3. doi request reprint The anticonvulsant levetiracetam potentiates alcohol consumption in non-treatment seeking alcohol abusers
    Jennifer M Mitchell
    Ernest Gallo Clinic and Research Center, Emeryville, CA 94608, USA
    J Clin Psychopharmacol 32:269-72. 2012
  4. ncbi request reprint Endogenous opioid blockade and impulsive responding in alcoholics and healthy controls
    Jennifer M Mitchell
    Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA 94608, USA
    Neuropsychopharmacology 32:439-49. 2007
  5. doi request reprint Delta-opioid receptor expression in the ventral tegmental area protects against elevated alcohol consumption
    Elyssa B Margolis
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 28:12672-81. 2008
  6. doi request reprint Dopamine, corticostriatal connectivity, and intertemporal choice
    Andrew S Kayser
    Department of Neurology, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 32:9402-9. 2012
  7. ncbi request reprint Immediate reward bias in humans: fronto-parietal networks and a role for the catechol-O-methyltransferase 158(Val/Val) genotype
    Charlotte A Boettiger
    Ernest Gallo Clinic and Research Center, Emeryville, California 94608, USA
    J Neurosci 27:14383-91. 2007
  8. doi request reprint Alcohol consumption induces endogenous opioid release in the human orbitofrontal cortex and nucleus accumbens
    Jennifer M Mitchell
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, CA 94608, USA
    Sci Transl Med 4:116ra6. 2012
  9. doi request reprint Naltrexone aversion and treatment efficacy are greatest in humans and rats that actively consume high levels of alcohol
    Jennifer M Mitchell
    Department of Neurology, University of California at San Francisco, San Francisco, CA 94143, USA
    Neurobiol Dis 33:72-80. 2009
  10. doi request reprint Midbrain dopamine neurons: projection target determines action potential duration and dopamine D(2) receptor inhibition
    Elyssa B Margolis
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 28:8908-13. 2008

Detail Information

Publications15

  1. pmc Alcohol self-administration, anxiety, and cortisol levels predict changes in delta opioid receptor function in the ventral tegmental area
    Jennifer M Mitchell
    Ernest Gallo Clinic and Research Center, University of California, San Francisco 94608, USA
    Behav Neurosci 126:515-22. 2012
    ..These data also extend our understanding of the possible therapeutic value of the DOR for treatment of alcoholism by showing that its relevant synaptic action persists during abstinence...
  2. pmc Varenicline decreases alcohol consumption in heavy-drinking smokers
    Jennifer M Mitchell
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
    Psychopharmacology (Berl) 223:299-306. 2012
    ..Proc Natl Acad Sci U S A 104:12518-12523, 2007) and in human laboratory and open-label studies (Fucito et al., Psychopharmacology (Berl) 215:655-663, 2011; McKee et al., Biol Psychiatry 66:185-190 2009)...
  3. doi request reprint The anticonvulsant levetiracetam potentiates alcohol consumption in non-treatment seeking alcohol abusers
    Jennifer M Mitchell
    Ernest Gallo Clinic and Research Center, Emeryville, CA 94608, USA
    J Clin Psychopharmacol 32:269-72. 2012
    ..Levetiracetam (Keppra) is a commonly prescribed anticonvulsant that has been shown to attenuate alcohol consumption in an open-label study of treatment-seeking, alcohol-dependent subjects...
  4. ncbi request reprint Endogenous opioid blockade and impulsive responding in alcoholics and healthy controls
    Jennifer M Mitchell
    Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA 94608, USA
    Neuropsychopharmacology 32:439-49. 2007
    ..Determining the biological basis of this dependence could have important implications for effective alcoholism treatment...
  5. doi request reprint Delta-opioid receptor expression in the ventral tegmental area protects against elevated alcohol consumption
    Elyssa B Margolis
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 28:12672-81. 2008
    ..Together, our findings demonstrate the protective nature of VTA DORs and identify an important new target for therapeutic intervention for alcoholism...
  6. doi request reprint Dopamine, corticostriatal connectivity, and intertemporal choice
    Andrew S Kayser
    Department of Neurology, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 32:9402-9. 2012
    ..These results indicate that raising cortical dopamine levels attenuates impulsive choice by changing corticostriatal function...
  7. ncbi request reprint Immediate reward bias in humans: fronto-parietal networks and a role for the catechol-O-methyltransferase 158(Val/Val) genotype
    Charlotte A Boettiger
    Ernest Gallo Clinic and Research Center, Emeryville, California 94608, USA
    J Neurosci 27:14383-91. 2007
    ..These results shed new light on the neurobiological underpinnings of temporal discounting behavior and identify novel behavioral and neural consequences of genetic variation in dopamine metabolism...
  8. doi request reprint Alcohol consumption induces endogenous opioid release in the human orbitofrontal cortex and nucleus accumbens
    Jennifer M Mitchell
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, CA 94608, USA
    Sci Transl Med 4:116ra6. 2012
    ..These results also suggest a possible mechanism by which opioid antagonists such as naltrexone act to treat alcohol abuse...
  9. doi request reprint Naltrexone aversion and treatment efficacy are greatest in humans and rats that actively consume high levels of alcohol
    Jennifer M Mitchell
    Department of Neurology, University of California at San Francisco, San Francisco, CA 94143, USA
    Neurobiol Dis 33:72-80. 2009
    ..We conclude that naltrexone treatment efficacy is greater during active ethanol consumption and may be partly due to aversive side effects...
  10. doi request reprint Midbrain dopamine neurons: projection target determines action potential duration and dopamine D(2) receptor inhibition
    Elyssa B Margolis
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 28:8908-13. 2008
    ..Therefore, in the VTA, AP duration and inhibition by D(2)R agonists may be valid markers of DA content in neurons of known projection target...
  11. pmc A novel opioid receptor-mediated enhancement of GABAA receptor function induced by stress in ventral tegmental area neurons
    Elyssa B Margolis
    Ernest Gallo Clinic and Research Centre, 5858 Horton Street, Suite no 200, Emeryville, CA, USA
    J Physiol 589:4229-42. 2011
    ....
  12. ncbi request reprint Impulsive responding in alcoholics
    Jennifer M Mitchell
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, CA 94608, USA
    Alcohol Clin Exp Res 29:2158-69. 2005
    ..In DD paradigms subjects choose between a small, immediate reward and a larger, delayed reward...
  13. ncbi request reprint Cholecystokinin is necessary for the expression of morphine conditioned place preference
    Jennifer M Mitchell
    Department of Neurology, Box 0114, University of California at San Francisco, San Francisco, CA 94143, USA
    Pharmacol Biochem Behav 85:787-95. 2006
    ..These results indicate that endogenous CCK modulates the incentive-salience of morphine-associated cues and suggest that CCK antagonists may be useful in the treatment of drug craving...
  14. ncbi request reprint A single injection of the kappa opioid antagonist norbinaltorphimine increases ethanol consumption in rats
    Jennifer M Mitchell
    Department of Neurology, University of California at San Francisco, P O Box 0114, San Francisco, CA 94143, USA
    Psychopharmacology (Berl) 182:384-92. 2005
    ..If KOR antagonists increase drug self-administration then it is likely that endogenous KOR agonists directly modulate drug intake...
  15. ncbi request reprint Locomotor activity predicts acquisition of self-administration behavior but not cocaine intake
    Jennifer M Mitchell
    Department of Neurology, University of California, San Francisco, CA 94143, USA
    Behav Neurosci 119:464-72. 2005
    ....