J R Mitchell
Affiliation: University of California
- A telomerase component is defective in the human disease dyskeratosis congenitaJ R Mitchell
Department of Molecular and Cell Biology, University of California, Berkeley 94720 3204, USA
Nature 402:551-5. 1999..The pathology of DKC is consistent with compromised telomerase function leading to a defect in telomere maintenance, which may limit the proliferative capacity of human somatic cells in epithelia and blood...
- Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptaseJ R Mitchell
Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
Mol Cell 6:361-71. 2000..Our results establish fundamental differences between vertebrate and ciliate telomerase ribonucleoprotein architectures and also suggest strategies for the pharmaceutical development of telomerase-based anticancer therapies...
- RNA binding domain of telomerase reverse transcriptaseC K Lai
Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3204, USA
Mol Cell Biol 21:990-1000. 2001..Our results reveal at least one evolutionarily conserved molecular mechanism by which the telomerase reverse transcriptase is functionally specialized for obligate use of an internal RNA template...