J R Mitchell

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint A telomerase component is defective in the human disease dyskeratosis congenita
    J R Mitchell
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3204, USA
    Nature 402:551-5. 1999
  2. ncbi request reprint Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase
    J R Mitchell
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Mol Cell 6:361-71. 2000
  3. pmc RNA binding domain of telomerase reverse transcriptase
    C K Lai
    Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3204, USA
    Mol Cell Biol 21:990-1000. 2001

Collaborators

Detail Information

Publications3

  1. ncbi request reprint A telomerase component is defective in the human disease dyskeratosis congenita
    J R Mitchell
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3204, USA
    Nature 402:551-5. 1999
    ..The pathology of DKC is consistent with compromised telomerase function leading to a defect in telomere maintenance, which may limit the proliferative capacity of human somatic cells in epithelia and blood...
  2. ncbi request reprint Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase
    J R Mitchell
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Mol Cell 6:361-71. 2000
    ..Our results establish fundamental differences between vertebrate and ciliate telomerase ribonucleoprotein architectures and also suggest strategies for the pharmaceutical development of telomerase-based anticancer therapies...
  3. pmc RNA binding domain of telomerase reverse transcriptase
    C K Lai
    Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3204, USA
    Mol Cell Biol 21:990-1000. 2001
    ..Our results reveal at least one evolutionarily conserved molecular mechanism by which the telomerase reverse transcriptase is functionally specialized for obligate use of an internal RNA template...