GORDON STEWART MITCHELL

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Intermittent hypoxia and stem cell implants preserve breathing capacity in a rodent model of amyotrophic lateral sclerosis
    Nicole L Nichols
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA
    Am J Respir Crit Care Med 187:535-42. 2013
  2. ncbi request reprint Layers of exercise hyperpnea: modulation and plasticity
    Gordon S Mitchell
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    Respir Physiol Neurobiol 151:251-66. 2006
  3. ncbi request reprint Time domains of the hypoxic ventilatory response in awake ducks: episodic and continuous hypoxia
    G S Mitchell
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53706, USA
    Respir Physiol 124:117-28. 2001
  4. ncbi request reprint Is there a link between intermittent hypoxia-induced respiratory plasticity and obstructive sleep apnoea?
    Safraaz Mahamed
    Department of Comparative Biosciences, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
    Exp Physiol 92:27-37. 2007
  5. ncbi request reprint Neuroplasticity in respiratory motor control
    Gordon S Mitchell
    Department of Comparative Biosciences, University of Wisconsin, Madison 53706, USA
    J Appl Physiol 94:358-74. 2003
  6. pmc Spinal serotonin receptor activation modulates the exercise ventilatory response with increased dead space in goats
    G S Mitchell
    Department of Comparative Biosciences and Center for Neuroscience, University of Wisconsin, Madison, WI 53706, USA
    Respir Physiol Neurobiol 161:230-8. 2008
  7. ncbi request reprint Chronic intermittent hypoxia elicits serotonin-dependent plasticity in the central neural control of breathing
    L Ling
    Departments of Comparative Biosciences and Preventive Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurosci 21:5381-8. 2001
  8. pmc Conversion from testosterone to oestradiol is required to modulate respiratory long-term facilitation in male rats
    A G Zabka
    Department of Comparative Biosciences, School of Veterinary Medicine, 2015 Linden Drive, Madison, WI 53706, USA
    J Physiol 576:903-12. 2006
  9. ncbi request reprint Serotonin-induced in vitro long-term facilitation exhibits differential pattern sensitivity in cervical and thoracic inspiratory motor output
    M R Lovett-Barr
    Department of Comparative Biosciences, School of Veterinary Medicine and Center for Neuroscience, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    Neuroscience 142:885-92. 2006
  10. pmc Developmental plasticity of the hypoxic ventilatory response in rats induced by neonatal hypoxia
    R W Bavis
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA
    J Physiol 557:645-60. 2004

Research Grants

  1. Respiratory plasticity and spinal cord Injury
    Gordon Mitchell; Fiscal Year: 2007
  2. Respiratory Neurobiology
    Gordon Mitchell; Fiscal Year: 2007
  3. Mechanisms of respiratory long-term facilitation
    Gordon Mitchell; Fiscal Year: 2007
  4. PLASTICITY IN RESPIRATORY MOTOR CONTROL
    Gordon Mitchell; Fiscal Year: 2004
  5. DEVELOPMENTAL PLASTICITY IN VENTILATORY CONTROL
    Gordon Mitchell; Fiscal Year: 2001
  6. Mechanisms of respiratory long-term facilitation
    GORDON STEWART MITCHELL; Fiscal Year: 2010

Detail Information

Publications87

  1. pmc Intermittent hypoxia and stem cell implants preserve breathing capacity in a rodent model of amyotrophic lateral sclerosis
    Nicole L Nichols
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA
    Am J Respir Crit Care Med 187:535-42. 2013
    ..hNPC transplants improved ipsilateral phrenic motor neuron survival. Conclusions: AIH-induced respiratory plasticity and stem cell therapy have complementary translational potential to treat breathing deficits in patients with ALS...
  2. ncbi request reprint Layers of exercise hyperpnea: modulation and plasticity
    Gordon S Mitchell
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    Respir Physiol Neurobiol 151:251-66. 2006
    ..g. development, aging, onset of disease) or exogenous (e.g. altitude, wearing a breathing apparatus during physical exertion) physiological conditions...
  3. ncbi request reprint Time domains of the hypoxic ventilatory response in awake ducks: episodic and continuous hypoxia
    G S Mitchell
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53706, USA
    Respir Physiol 124:117-28. 2001
    ..Although several time-dependent ventilatory responses to episodic hypoxia are observed in awake ducks, they are relatively small and biased towards facilitation versus inhibitory mechanisms...
  4. ncbi request reprint Is there a link between intermittent hypoxia-induced respiratory plasticity and obstructive sleep apnoea?
    Safraaz Mahamed
    Department of Comparative Biosciences, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
    Exp Physiol 92:27-37. 2007
    ....
  5. ncbi request reprint Neuroplasticity in respiratory motor control
    Gordon S Mitchell
    Department of Comparative Biosciences, University of Wisconsin, Madison 53706, USA
    J Appl Physiol 94:358-74. 2003
    ....
  6. pmc Spinal serotonin receptor activation modulates the exercise ventilatory response with increased dead space in goats
    G S Mitchell
    Department of Comparative Biosciences and Center for Neuroscience, University of Wisconsin, Madison, WI 53706, USA
    Respir Physiol Neurobiol 161:230-8. 2008
    ..We conclude that spinal 5-HT2 receptors modulate the exercise ventilatory response with increased VD in goats...
  7. ncbi request reprint Chronic intermittent hypoxia elicits serotonin-dependent plasticity in the central neural control of breathing
    L Ling
    Departments of Comparative Biosciences and Preventive Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurosci 21:5381-8. 2001
    ..The results suggest that CIH elicits unique forms of serotonin-dependent plasticity in the central neural control of breathing. Enhanced LTF after CIH may involve an upregulation of a non-5-HT(2) serotonin receptor subtype or subtypes...
  8. pmc Conversion from testosterone to oestradiol is required to modulate respiratory long-term facilitation in male rats
    A G Zabka
    Department of Comparative Biosciences, School of Veterinary Medicine, 2015 Linden Drive, Madison, WI 53706, USA
    J Physiol 576:903-12. 2006
    ..In contrast, LTF was not restored in T + ADT or DHT-treated gonadectomized rats. We conclude that the conversion of testosterone to oestradiol modulates phrenic and XII LTF in male F344 rats...
  9. ncbi request reprint Serotonin-induced in vitro long-term facilitation exhibits differential pattern sensitivity in cervical and thoracic inspiratory motor output
    M R Lovett-Barr
    Department of Comparative Biosciences, School of Veterinary Medicine and Center for Neuroscience, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    Neuroscience 142:885-92. 2006
    ..Thus, 5-HT is sufficient to induce spinal LTF in neonatal rats and differences in pattern sensitivity suggest heterogeneity in underlying mechanisms...
  10. pmc Developmental plasticity of the hypoxic ventilatory response in rats induced by neonatal hypoxia
    R W Bavis
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA
    J Physiol 557:645-60. 2004
    ..The basis of sex differences in this developmental plasticity is unknown...
  11. ncbi request reprint Short-term modulation of the exercise ventilatory response in goats: effects of 8-OH-DPAT and MPPI
    D R Henderson
    Department of Comparative Biosciences, Division of Science and Math, University of Wisconsin, Madison, Wisconsin 53706, USA
    Am J Physiol Regul Integr Comp Physiol 279:R1880-8. 2000
    ..Although nonspecific effects of 8-OH-DPAT cannot be ruled out, impaired STM is consistent with the hypothesis that STM requires active raphe serotonergic neurons and 5-HT release...
  12. pmc Long term facilitation of respiratory motor output decreases with age in male rats
    A G Zabka
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    J Physiol 531:509-14. 2001
    ..05). Decreased phrenic and XII LTF suggests that serotonergic modulation of respiratory motor output decreases in ageing male rats. We speculate that decreased serotonergic modulation may contribute to age-related breathing disorders...
  13. pmc NADPH oxidase activity is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation
    P M MacFarlane
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA
    J Physiol 587:1931-42. 2009
    ....
  14. ncbi request reprint Time-dependent hypoxic ventilatory responses in rats: effects of ketanserin and 5-carboxamidotryptamine
    R Kinkead
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    Am J Physiol 277:R658-66. 1999
    ....
  15. pmc Episodic spinal serotonin receptor activation elicits long-lasting phrenic motor facilitation by an NADPH oxidase-dependent mechanism
    P M MacFarlane
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA
    J Physiol 587:5469-81. 2009
    ....
  16. ncbi request reprint Age and gender effects on serotonin-dependent plasticity in respiratory motor control
    M Behan
    Department of Comparative Biosciences, School of Veterinary Medicine, 2015 Linden Drive, University of Wisconsin, Madison, WI 53706, USA
    Respir Physiol Neurobiol 131:65-77. 2002
    ..We speculate about a possible relationship between age and gender effects on serotonin-dependent plasticity in upper airway motoneuron pools and the prevalence of obstructive sleep apnea...
  17. ncbi request reprint Selected contribution: chronic intermittent hypoxia enhances respiratory long-term facilitation in geriatric female rats
    A G Zabka
    Department of Comparative Biosciences, School of Veterinary Medicine, Madison, WI 53706, USA
    J Appl Physiol 95:2614-23; discussion 2604. 2003
    ..05). The magnitude of phrenic and XII LTF in all groups was inversely related to the ratio of progesterone to estradiol serum levels (P < 0.05). Thus CIH and sex hormones influence the magnitude of LTF in geriatric female rats...
  18. ncbi request reprint Critical developmental period for hyperoxia-induced blunting of hypoxic phrenic responses in rats
    R W Bavis
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Appl Physiol 92:1013-8. 2002
    ..005). Adult hypoxic phrenic responses are impaired by 1 wk of hyperoxia during the first and second postnatal weeks in rats, indicating a developmental window coincident with carotid chemoreceptor maturation...
  19. ncbi request reprint Adult carotid chemoafferent responses to hypoxia after 1, 2, and 4 wk of postnatal hyperoxia
    G E Bisgard
    Department of Comparative Biosciences, University of Wisconsin Madison, Madison, WI 53706, USA
    J Appl Physiol 95:946-52. 2003
    ..These studies illustrate the importance of normoxia during the first 2 wk of life in development of carotid chemoreceptor afferent function...
  20. pmc Reactive oxygen species and respiratory plasticity following intermittent hypoxia
    P M MacFarlane
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    Respir Physiol Neurobiol 164:263-71. 2008
    ..Here, we review possible sources of ROS, and the impact of ROS on phosphorylation events relevant to respiratory plasticity...
  21. ncbi request reprint Time-dependent changes in spontaneous respiratory activity in turtle brainstems in vitro
    J E R Wilkerson
    Center for Neuroscience, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    Respir Physiol Neurobiol 138:253-63. 2003
    ..Certain bath solutions may minimize time-dependent frequency reductions but may also cause breathing pattern changes...
  22. pmc Ageing and gonadectomy have similar effects on hypoglossal long-term facilitation in male Fischer rats
    A G Zabka
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    J Physiol 563:557-68. 2005
    ..Furthermore, LTF is similarly impaired in middle-aged and gonadectomized male rats, suggesting that gonadal hormones play an important role in modulating the capacity for neuroplasticity in upper airway motor control...
  23. pmc Ventilatory impairment in the dysmyelinated Long Evans shaker rat
    R A Johnson
    Department of Surgical Sciences, University of Wisconsin, Madison, WI 53706, USA
    Neuroscience 169:1105-14. 2010
    ..This study is the first reporting age-related breathing abnormalities in a rodent dysmyelination model, and provides the foundation for mechanistic studies of respiratory insufficiency and therapeutic interventions...
  24. ncbi request reprint Sustained hypoxia-induced proliferation of carotid body type I cells in rats
    Z Y Wang
    Dept of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
    J Appl Physiol 104:803-8. 2008
    ..Taken together, our results suggest that SH stimulates CB type I cell proliferation, which may produce long-lasting changes in CB morphology and function...
  25. pmc Respiratory long-term facilitation following intermittent hypoxia requires reactive oxygen species formation
    P M MacFarlane
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    Neuroscience 152:189-97. 2008
    ..Phrenic LTF is a novel form of ROS-dependent neuroplasticity since its ROS-dependence resides in the spinal cord...
  26. pmc Spinal adenosine A2(A) receptor inhibition enhances phrenic long term facilitation following acute intermittent hypoxia
    M S Hoffman
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706 1102, USA
    J Physiol 588:255-66. 2010
    ..A(2A) receptor antagonists (such as caffeine) may exert beneficial therapeutic effects by enhancing the capacity for AIH-induced respiratory plasticity...
  27. pmc Differential expression of respiratory long-term facilitation among inbred rat strains
    T L Baker-Herman
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    Respir Physiol Neurobiol 170:260-7. 2010
    ..BN had higher 5-HT(7) and TrkB mRNA versus F344; BN and Lewis had higher BDNF mRNA levels versus F344. Genetic variations in serotonergic function may underlie strain differences in AIH-induced pLTF...
  28. pmc Life-long impairment of hypoxic phrenic responses in rats following 1 month of developmental hyperoxia
    D D Fuller
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53076, USA
    J Physiol 538:947-55. 2002
    ..4 (+/- 1.6) x 10(6) microm3; P <0.01). We conclude that exposure to hyperoxia for the first month of life causes life-long impairment of carotid chemoreceptor function and, consequently, blunted phrenic responses to hypoxia...
  29. ncbi request reprint p-Chlorophenylalanine eliminates long-term modulation of the exercise ventilatory response in goats
    R A Johnson
    University of Wisconsin, Department of Comparative Biosciences, 2015 Linden Drive, Madison, WI 53706, USA
    Respir Physiol 128:161-9. 2001
    ..4+/-1mmHg; post-training 1: 1.4+/-3mmHg; post-training 2: 1.1+/-5mmHg; P>0.05). Thus, PCPA abolishes long-term modulation, implicating serotonin in its underlying mechanism...
  30. ncbi request reprint N-methyl-D-aspartate-mediated bulbospinal respiratory drive is pH/P(CO2)-insensitive in turtle brainstem-spinal cord
    S M Johnson
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA
    Respir Physiol 113:201-12. 1998
    ..The pH/P(CO2)-insensitivity of NMDA-dependent bulbospinal respiratory synaptic transmission may represent an important adaptation in turtles...
  31. ncbi request reprint Post-hypoxia frequency decline in rats: sensitivity to repeated hypoxia and alpha2-adrenoreceptor antagonism
    K B Bach
    Department of Comparative Biosciences and Center for Neuroscience, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive West, Madison, WI, 53706
    Brain Res 817:25-33. 1999
    ..05). We conclude that the magnitude of PHFD is dependent on the prior history of hypoxia and that alpha2 adrenoreceptor activation plays a role in its underlying mechanism...
  32. ncbi request reprint Effects of serotonin re-uptake inhibition on ventilatory control in goats
    D R Henderson
    Department of Comparative Biosciences, University of Wisconsin, Madison 53706, USA
    Respir Physiol 115:1-10. 1999
    ..We conclude that chronic fluoxetine slightly depresses respiratory control at rest, but, has minimal effects during exercise or with mild hypercapnia during rest or exercise in goats...
  33. ncbi request reprint Methysergide augments the acute, but not the sustained, hypoxic ventilatory response in goats
    J K Herman
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, 53706, USA
    Respir Physiol 118:25-37. 1999
    ..v.). Ketanserin had no effect on the acute hypoxic ventilatory response, or on VAH. We conclude that while 5-HT modulates the acute hypoxic ventilatory response in goats, it does not appear to act through the 5-HT2A/2C receptor subtypes...
  34. ncbi request reprint Phrenic long-term facilitation requires 5-HT receptor activation during but not following episodic hypoxia
    D D Fuller
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA
    J Appl Physiol 90:2001-6; discussion 2000. 2001
    ..Conversely, ketanserin pretreatment abolished phrenic LTF. We conclude that 5-HT receptor activation is necessary to initiate (during hypoxia) but not maintain (following hypoxia) phrenic LTF...
  35. ncbi request reprint Serotonin reuptake inhibition does not enhance short term modulation of the exercise ventilatory response
    D R Henderson
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Dr West Madison, WI 53706, USA
    Respir Physiol 121:45-52. 2000
    ..Fenfluramine had no detectable effects on STM. The data suggest that: (1) chronic fluoxetine diminishes STM, possibly via down-regulation of relevant 5-HT receptors, and (2) drugs that release 5-HT acutely do not enhance STM...
  36. pmc Responses of single-unit carotid body chemoreceptors in adult rats
    E H Vidruk
    John Rankin Laboratory of Pulmonary Medicine and Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53705, USA
    J Physiol 531:165-70. 2001
    ..089 spikes s-1 (mmHg Pa,CO2)-1 (r2 = 0.7). 4. We conclude that carotid body chemoreceptors in adult rats have responses to changes in Pa,O2 and Pa,CO2 similar to those of other species...
  37. pmc Episodic but not continuous hypoxia elicits long-term facilitation of phrenic motor output in rats
    T L Baker
    Center for Neuroscience and Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53706, USA
    J Physiol 529:215-9. 2000
    ..1 +/- 2 bursts min-1 60 min post-hypoxia, respectively; P > 0.05). 4. The results indicate that hypoxia-induced long-term facilitation of phrenic motor output is sensitive to the pattern of hypoxic exposure in anaesthetized rats...
  38. ncbi request reprint Expression of hypoglossal long-term facilitation differs between substrains of Sprague-Dawley rat
    D D Fuller
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Physiol Genomics 4:175-81. 2001
    ..We conclude that the expression of hypoglossal LTF differs between SD rat substrains, indicating a difference in their genetic predisposition to neural plasticity...
  39. ncbi request reprint Differential sensitivity to acute administration of cocaine, GBR 12909, and fluoxetine in mice selectively bred for hyperactive wheel-running behavior
    J S Rhodes
    Department of Zoology, University of Wisconsin, 430 Lincoln Drive, Madison, WI 53706, USA
    Psychopharmacology (Berl) 158:120-31. 2001
    ..To study the neural basis of genetic hyperactivity, we measured acute drug responses of mice (Mus domesticus) from four replicate lines that had been selectively bred (23-24 generations) for increased running-wheel activity...
  40. pmc Integrated phrenic responses to carotid afferent stimulation in adult rats following perinatal hyperoxia
    L Ling
    Department of Comparative Biosciences, University of Wisconsin, Madison 53706, USA
    J Physiol 500:787-96. 1997
    ..It is speculated that carotid chemoreceptors per se are impaired in perinatal treated rats...
  41. pmc Slow recovery of impaired phrenic responses to hypoxia following perinatal hyperoxia in rats
    L Ling
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA
    J Physiol 511:599-603. 1998
    ..5. These data suggest that partial spontaneous recovery may occur in 6-month-old perinatal treated rats and that full recovery occurs by 15 months of age...
  42. ncbi request reprint Respiratory plasticity: differential actions of continuous and episodic hypoxia and hypercapnia
    T L Baker
    Center for Neuroscience, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53706, USA
    Respir Physiol 129:25-35. 2001
    ..We hypothesize that the response of respiratory motoneurons to serotonergic and noradrenergic modulation may contribute to pattern sensitivity to hypoxia and hypercapnia...
  43. ncbi request reprint Selected contribution: Time-dependent hypoxic respiratory responses in female rats are influenced by age and by the estrus cycle
    A G Zabka
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Dr West, Madison, WI 53706, USA
    J Appl Physiol 91:2831-8. 2001
    ..05), whereas XII LTF increased in middle-aged female rats during diestrus only. Age and gender influence time-dependent hypoxic phrenic and XII responses in a complex manner...
  44. pmc Attenuation of the hypoxic ventilatory response in adult rats following one month of perinatal hyperoxia
    L Ling
    Department of Comparative Biosciences, University of Wisconsin, Madison 53706, USA
    J Physiol 495:561-71. 1996
    ....
  45. pmc Long-term facilitation of ventilation following repeated hypoxic episodes in awake goats
    D L Turner
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706 1102, USA
    J Physiol 499:543-50. 1997
    ..The persistent increase in VI strongly suggests that episodic hypoxia elicits LTF in respiratory neurons in the awake goat. Complex changes in respiratory pattern underpin the ventilatory manifestation of LTF...
  46. ncbi request reprint Phrenic responses to isocapnic hypoxia in adult rats following perinatal hyperoxia
    L Ling
    Department of Comparative Biosciences, University of Wisconsin, Madison 53706, USA
    Respir Physiol 109:107-16. 1997
    ..These effects cannot be accounted for by differences in blood gases (O2 or CO2) or pulmonary mechanics...
  47. pmc Induced recovery of hypoxic phrenic responses in adult rats exposed to hyperoxia for the first month of life
    D D Fuller
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53076, USA
    J Physiol 536:917-26. 2001
    ....
  48. ncbi request reprint Serotonin elicits long-lasting enhancement of rhythmic respiratory activity in turtle brain stems in vitro
    S M Johnson
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Dr West, Madison, WI 53706, USA
    J Appl Physiol 91:2703-12. 2001
    ..05), but neither spinal-expiratory nor -inspiratory burst amplitude were altered. The 5-HT(3) receptor-dependent persistent frequency increase represents a unique model of plasticity in vertebrate rhythm generation...
  49. ncbi request reprint Developmental plasticity of the hypoxic ventilatory response
    L Ling
    Department of Comparative Biosciences, University of Wisconsin, Madison 53706, USA
    Respir Physiol 110:261-8. 1997
    ..These findings may have important clinical implications for patients subjected to excessive O2 therapy during neonatal intensive care...
  50. pmc Serotonin 2A and 2B receptor-induced phrenic motor facilitation: differential requirement for spinal NADPH oxidase activity
    P M MacFarlane
    Department of Comparative Biosciences, University of Wisconsin, Madison School of Veterinary Medicine, 2015 Linden Drive, Madison, WI 53706, USA
    Neuroscience 178:45-55. 2011
    ..Thus, multiple spinal type 2 serotonin receptors elicit pMF, but they act via distinct mechanisms that differ in their requirement for NADPH oxidase activity...
  51. ncbi request reprint Long term facilitation of phrenic motor output
    D D Fuller
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53706, USA
    Respir Physiol 121:135-46. 2000
    ....
  52. ncbi request reprint Respiratory plasticity following intermittent hypoxia: roles of protein phosphatases and reactive oxygen species
    J E R Wilkerson
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, U S A
    Biochem Soc Trans 35:1269-72. 2007
    ....
  53. ncbi request reprint Invited review: Intermittent hypoxia and respiratory plasticity
    G S Mitchell
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Appl Physiol 90:2466-75. 2001
    ....
  54. ncbi request reprint Hippocampal brain-derived neurotrophic factor but not neurotrophin-3 increases more in mice selected for increased voluntary wheel running
    R A Johnson
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    Neuroscience 121:1-7. 2003
    ..This is the first study to demonstrate that mice which choose to run more have greater elevations in hippocampal BDNF, suggesting enhanced potential for exercise-induced hippocampal neuroplasticity...
  55. pmc Atypical protein kinase C expression in phrenic motor neurons of the rat
    C H Guenther
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53706, USA
    Neuroscience 169:787-93. 2010
    ..Documenting the expression of atypical PKCs in phrenic motor neurons provides a framework within which to assess their role in respiratory motor control, including novel forms of respiratory plasticity known to occur in this region...
  56. pmc Diaphragm long-term facilitation following acute intermittent hypoxia during wakefulness and sleep
    J Terada
    Department of Comparative Biosciences, University of Wisconsin Madison, Madison, WI 53706, USA
    J Appl Physiol 110:1299-310. 2011
    ..The capacity for plasticity in spinal pump muscles during sleep and wakefulness suggests an important role in the neural control of breathing...
  57. pmc Spinal 5-HT7 receptor activation induces long-lasting phrenic motor facilitation
    M S Hoffman
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive, Madison, WI, 53706, USA
    J Physiol 589:1397-407. 2011
    ....
  58. ncbi request reprint Synaptic pathways to phrenic motoneurons are enhanced by chronic intermittent hypoxia after cervical spinal cord injury
    David D Fuller
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurosci 23:2993-3000. 2003
    ..05). We conclude that CIH induced spinal cord plasticity-enhanced phrenic motor output. This plasticity required preconditions established by chronic spinal injury...
  59. doi request reprint Okadaic acid-sensitive protein phosphatases constrain phrenic long-term facilitation after sustained hypoxia
    Julia E R Wilkerson
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurosci 28:2949-58. 2008
    ..The specific okadaic acid-sensitive phosphatase(s) constraining pLTF and their spatiotemporal dynamics during and/or after IH and SH remain to be determined...
  60. ncbi request reprint Carotid chemoafferent plasticity in adult rats following developmental hyperoxia
    Gerald E Bisgard
    Department of Comparative Biosciences, University of Wisconsin, School of Veterinary Medicine, 2015 Linden Drive, Madison, WI 53706, USA
    Respir Physiol Neurobiol 145:3-11. 2005
    ....
  61. ncbi request reprint Sex steroid hormones and the neural control of breathing
    Mary Behan
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    Respir Physiol Neurobiol 136:249-63. 2003
    ....
  62. pmc Simulated apnoeas induce serotonin-dependent respiratory long-term facilitation in rats
    Safraaz Mahamed
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive, Madison, WI 3706 1102, USA
    J Physiol 586:2171-81. 2008
    ..Apnoea-induced LTF may have implications for the maintenance of breathing stability, particularly during sleep...
  63. pmc Determinants of frequency long-term facilitation following acute intermittent hypoxia in vagotomized rats
    Tracy L Baker-Herman
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA
    Respir Physiol Neurobiol 162:8-17. 2008
    ..Variations in baseline burst frequency may contribute to variation in frequency LTF and may underlie the apparent effects of some drug treatments...
  64. ncbi request reprint Phrenic long-term facilitation requires spinal serotonin receptor activation and protein synthesis
    Tracy L Baker-Herman
    Department of Comparative Biosciences and Center for Neuroscience, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurosci 22:6239-46. 2002
    ..We conclude that phrenic LTF requires spinal serotonin receptor activation and protein synthesis. Serotonin receptors on phrenic motoneuron dendrites may induce new protein synthesis, thereby giving rise to phrenic LTF...
  65. pmc Breathing: rhythmicity, plasticity, chemosensitivity
    Jack L Feldman
    Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1763, USA
    Annu Rev Neurosci 26:239-66. 2003
    ..Neurons with appropriate chemosensitivity are spread throughout the brainstem; their individual properties and collective role are just beginning to be understood...
  66. pmc Role of synaptic inhibition in turtle respiratory rhythm generation
    Stephen M Johnson
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA
    J Physiol 544:253-65. 2002
    ..Thus, these data indicate that the adult turtle respiratory rhythm generator has the potential to operate in a pacemaker-driven manner...
  67. doi request reprint Spinal adenosine A2a receptor activation elicits long-lasting phrenic motor facilitation
    Francis J Golder
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurosci 28:2033-42. 2008
    ....
  68. ncbi request reprint Activity-dependent plasticity in descending synaptic inputs to respiratory spinal motoneurons
    Stephen M Johnson
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    Respir Physiol Neurobiol 131:79-90. 2002
    ..g. serotonin-dependent long-term facilitation) may predominate in these pathways. In contrast, expiratory descending pathways appear biased towards activity-dependent depression possibly to conserve resources during passive expiration...
  69. ncbi request reprint Chronic cervical spinal sensory denervation reveals ineffective spinal pathways to phrenic motoneurons in the rat
    David D Fuller
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53706, USA
    Neurosci Lett 323:25-8. 2002
    ..v.) had no effect on the crossed phrenic potential amplitude (91+/-17% of control at 800 microA; P>0.05). Thus, CDR enhances crossed phrenic pathways but serotonin receptor activation is not necessary to maintain this effect...
  70. ncbi request reprint Exercise-induced changes in hippocampal brain-derived neurotrophic factor and neurotrophin-3: effects of rat strain
    Rebecca A Johnson
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    Brain Res 983:108-14. 2003
    ..Although exercise decreases hippocampal NT-3, strain does not alter NT-3 levels. In contrast, BDNF levels increase with exercise and basal levels differ between strains, possibly due to strain differences in spontaneous activity...
  71. doi request reprint Long-term effects of the perinatal environment on respiratory control
    Ryan W Bavis
    Department of Biology, Bates College, Lewiston, ME 04240, USA
    J Appl Physiol 104:1220-9. 2008
    ..Future directions for studies concerning the mechanisms and functional implications of developmental plasticity in respiratory motor control are discussed...
  72. ncbi request reprint Cervical spinal cord injury upregulates ventral spinal 5-HT2A receptors
    David D Fuller
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA
    J Neurotrauma 22:203-13. 2005
    ..05). Our data are consistent with the hypothesis that spontaneous increase in 5-HT2A receptor expression on or near phrenic motoneurons contributes to strengthened crossed-spinal synaptic pathways to phrenic motoneurons following C2HS...
  73. ncbi request reprint Spinal synaptic enhancement with acute intermittent hypoxia improves respiratory function after chronic cervical spinal cord injury
    Francis J Golder
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurosci 25:2925-32. 2005
    ....
  74. ncbi request reprint Carotid sinus nerve responses and ventilatory acclimatization to hypoxia in adult rats following 2 weeks of postnatal hyperoxia
    Julie M Wenninger
    Department of Comparative Biosciences, University of Wisconsin Madison, School of Veterinary Medicine, 2015 Linden Dr, Madison, WI 53706, USA
    Respir Physiol Neurobiol 150:155-64. 2006
    ....
  75. ncbi request reprint Recovery of phrenic activity and ventilation after cervical spinal hemisection in rats
    David D Fuller
    Dept of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, USA
    J Appl Physiol 100:800-6. 2006
    ..Enhanced crossed phrenic activity post-C2HS may reflect plasticity associated with spinal axons not activated by our ventrolateral spinal stimulation...
  76. ncbi request reprint Early postnatal chronic intermittent hypoxia modifies hypoxic respiratory responses and long-term phrenic facilitation in adult rats
    Stephen R Reeves
    Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, Suite 204, 570 South Preston St, Louisville, KY 40202, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1664-71. 2006
    ..e., metaplasticity) and markedly differ from previously reported increased neural plasticity changes induced by CIH in adult rats...
  77. ncbi request reprint Breathing in thin air: acclimatization to altitude in ducks
    Frank L Powell
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0623, USA
    Respir Physiol Neurobiol 144:225-35. 2004
    ..Increased VP tends to restore PaO2 toward normoxic levels and decreases adverse effects of gas exchange limitation, which apparently increased during acclimatization in ducks...
  78. ncbi request reprint Differences in time-dependent hypoxic phrenic responses among inbred rat strains
    Francis J Golder
    Department of Comparative Bioscience, University of Wisconsin, Madison, Wisconsin, USA
    J Appl Physiol 98:838-44. 2005
    ..Furthermore, genetic diversity observed in hypoxic ventilatory responses in unanesthetized rats may arise from multiple neural mechanisms...
  79. ncbi request reprint BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia
    Tracy L Baker-Herman
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Nat Neurosci 7:48-55. 2004
    ..These experiments also illustrate the potential use of RNAi to investigate functional consequences of gene expression in the mammalian nervous system in vivo...
  80. ncbi request reprint Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running
    Justin S Rhodes
    Department of Zoology, University of Wisconsin at Madison, Madison, WI, USA
    Behav Neurosci 117:1006-16. 2003
    ..This is the first evidence that neurogenesis can occur without learning enhancement. The authors propose an alternative function of neurogenesis in the control of motor behavior...
  81. ncbi request reprint Episodic stimulation of alpha1-adrenoreceptors induces protein kinase C-dependent persistent changes in motoneuronal excitability
    Natalia V Neverova
    Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 27:4435-42. 2007
    ..Elucidating the mechanism underlying LTF can be of clinical importance to the patients suffering from sleep-disordered breathing...
  82. ncbi request reprint Respiratory plasticity after perinatal hypercapnia in rats
    Ryan W Bavis
    Department of Biology, Bates College, 44 Campus Ave, Carnegie Science Hall, Lewiston, ME 04240, USA
    Respir Physiol Neurobiol 153:78-91. 2006
    ..This plasticity appears similar to that observed after chronic hypercapnia in adult animals and, therefore, is not unique to development...
  83. ncbi request reprint Short-term modulation of the exercise ventilatory response in young men
    Helen E Wood
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, and University of Texas Southwestern Medical Center Dallas, Dallas, Texas 75231, USA
    J Appl Physiol 104:244-52. 2008
    ..We conclude that STM of the exercise ventilatory response is induced in young men when resting ventilatory drive is increased with external DS, confirming the existence of STM in humans...
  84. ncbi request reprint Respiratory long-term facilitation: too much or too little of a good thing?
    Safraaz Mahamed
    University of Wisconsin Madison, Department of Comparative Biosciences, USA
    Adv Exp Med Biol 605:224-7. 2008
    ..Based on these considerations alone, the impact of respiratory LTF on respiratory stability remains unclear...
  85. ncbi request reprint Intermittent hypoxia induces phrenic long-term facilitation in carotid-denervated rats
    Ryan W Bavis
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, 53706, USA
    J Appl Physiol 94:399-409. 2003
    ..05), but episodic hyperoxia had no detectable effect. These data suggest that hypoxia per se initiates LTF independently from carotid chemoafferent neuron activation, perhaps through direct central nervous system effects...
  86. pmc Respiratory plasticity after perinatal hyperoxia is not prevented by antioxidant supplementation
    Ryan W Bavis
    Department of Biology, Bates College, Carnegie Science Hall, Lewiston, ME 04240, USA
    Respir Physiol Neurobiol 160:301-12. 2008
    ..Collectively, these data do not support the hypothesis that perinatal hyperoxia impairs peripheral chemoreceptor development through ROS-mediated oxygen toxicity...
  87. ncbi request reprint Back to the future: carbon dioxide chemoreceptors in the mammalian brain
    Gordon S Mitchell
    Nat Neurosci 7:1288-90. 2004

Research Grants21

  1. Respiratory plasticity and spinal cord Injury
    Gordon Mitchell; Fiscal Year: 2007
    ..Further, the conceptual advances promised from these studies may be applicable to other disorders of respiratory control, including neurodegenerative diseases such as ALS. ..
  2. Respiratory Neurobiology
    Gordon Mitchell; Fiscal Year: 2007
    ..Thus, we propose to continue a training program that meets important goals of the NIH research-training mission. ..
  3. Mechanisms of respiratory long-term facilitation
    Gordon Mitchell; Fiscal Year: 2007
    ....
  4. PLASTICITY IN RESPIRATORY MOTOR CONTROL
    Gordon Mitchell; Fiscal Year: 2004
    ..A multidisciplinary approach will be used to test key elements of the model. ..
  5. DEVELOPMENTAL PLASTICITY IN VENTILATORY CONTROL
    Gordon Mitchell; Fiscal Year: 2001
    ..Further understanding of mechanism(s) that underlie developmental plasticity with its associated functional impairments may provide the rationale for therapeutic intervention, thereby enhancing functional recovery. ..
  6. Mechanisms of respiratory long-term facilitation
    GORDON STEWART MITCHELL; Fiscal Year: 2010
    ....