Braxton Mitchell

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Living the good life? Mortality and hospital utilization patterns in the Old Order Amish
    Braxton D Mitchell
    Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    PLoS ONE 7:e51560. 2012
  2. pmc Modeled nitrate levels in well water supplies and prevalence of abnormal thyroid conditions among the Old Order Amish in Pennsylvania
    Briseis Aschebrook-Kilfoy
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Environ Health 11:6. 2012
  3. pmc Association between bilirubin and cardiovascular disease risk factors: using Mendelian randomization to assess causal inference
    Patrick F McArdle
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, 660 West Redwood Street, RM, 492, Baltimore, MD 21201, USA
    BMC Cardiovasc Disord 12:16. 2012
  4. pmc Evaluation of self-reported ethnicity in a case-control population: the stroke prevention in young women study
    Jesse B Mez
    Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Res Notes 2:260. 2009
  5. pmc Neuroserpin polymorphisms and stroke risk in a biracial population: the stroke prevention in young women study
    John W Cole
    Veterans Affairs Medical Center, Baltimore, Maryland, USA
    BMC Neurol 7:37. 2007
  6. pmc Thrombomodulin Ala455Val Polymorphism and the risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study
    John W Cole
    Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    BMC Neurol 4:21. 2004
  7. pmc Nicotinic acetylcholine receptor subunit variants are associated with blood pressure; findings in the Old Order Amish and replication in the Framingham Heart Study
    Patrick F McArdle
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Med Genet 9:67. 2008
  8. pmc Homozygosity by descent mapping of blood pressure in the Old Order Amish: evidence for sex specific genetic architecture
    Patrick F McArdle
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Genet 8:66. 2007
  9. ncbi request reprint Insulin sensitivity, body fat distribution, and family diabetes history: the IRAS Family Study
    Braxton D Mitchell
    University of Maryland School of Medicine, Division of Endocrinology, Diabetes, and Nutrition, 660 W Redwood Street, Room 492, Baltimore, MD 21201, USA
    Obes Res 12:831-9. 2004
  10. pmc Genomic imprinting in diabetes
    Braxton D Mitchell
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland, 6601 West Redwood Street, Baltimore, MD 21201, USA
    Genome Med 2:55. 2010

Research Grants

  1. GENETICS OF BONE DENSITY IN MEXICAN AMERICANS
    Braxton Mitchell; Fiscal Year: 2001
  2. Genetic Influences on Coronary Artery Calcification
    Braxton Mitchell; Fiscal Year: 2009
  3. Genetic Influences on Coronary Artery Calcification
    Braxton Mitchell; Fiscal Year: 2007
  4. GENETICS OF BONE DENSITY IN MEXICAN AMERICANS
    Braxton Mitchell; Fiscal Year: 2007
  5. Joint Determinants of Bone Density and CVD Calcification
    Braxton Mitchell; Fiscal Year: 2004
  6. Genetic Influences on Coronary Artery Calcification
    Braxton D Mitchell; Fiscal Year: 2010

Detail Information

Publications88

  1. pmc Living the good life? Mortality and hospital utilization patterns in the Old Order Amish
    Braxton D Mitchell
    Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    PLoS ONE 7:e51560. 2012
    ....
  2. pmc Modeled nitrate levels in well water supplies and prevalence of abnormal thyroid conditions among the Old Order Amish in Pennsylvania
    Briseis Aschebrook-Kilfoy
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Environ Health 11:6. 2012
    ..Nitrate intake from drinking water and dietary sources can interfere with the uptake of iodide by the thyroid, thus potentially impacting thyroid function...
  3. pmc Association between bilirubin and cardiovascular disease risk factors: using Mendelian randomization to assess causal inference
    Patrick F McArdle
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, 660 West Redwood Street, RM, 492, Baltimore, MD 21201, USA
    BMC Cardiovasc Disord 12:16. 2012
    ..In this report, we demonstrate its use in assessing direct causal relations between serum bilirubin levels and CVD risk factors, including obesity, cholesterol, measures of vascular function and blood pressure...
  4. pmc Evaluation of self-reported ethnicity in a case-control population: the stroke prevention in young women study
    Jesse B Mez
    Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Res Notes 2:260. 2009
    ..Here we apply a model-based clustering approach to our case-control study of stroke among young women to examine if self-reported ethnicity can serve as a proxy for genetic ancestry...
  5. pmc Neuroserpin polymorphisms and stroke risk in a biracial population: the stroke prevention in young women study
    John W Cole
    Veterans Affairs Medical Center, Baltimore, Maryland, USA
    BMC Neurol 7:37. 2007
    ..We sought to evaluate the association of neuroserpin polymorphisms with risk for ischemic stroke among young women...
  6. pmc Thrombomodulin Ala455Val Polymorphism and the risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study
    John W Cole
    Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    BMC Neurol 4:21. 2004
    ..Using data from the Stroke Prevention in Young Women Study, we sought to determine the association between the Ala455Val thrombomodulin polymorphism and the occurrence of ischemic stroke in young women...
  7. pmc Nicotinic acetylcholine receptor subunit variants are associated with blood pressure; findings in the Old Order Amish and replication in the Framingham Heart Study
    Patrick F McArdle
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Med Genet 9:67. 2008
    ..We assessed the role of genetic variation in three subunits of the neuromuscular nicotinic acetylcholine receptor positioned on chromosome 2q, a region showing replicated evidence of linkage to blood pressure...
  8. pmc Homozygosity by descent mapping of blood pressure in the Old Order Amish: evidence for sex specific genetic architecture
    Patrick F McArdle
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Genet 8:66. 2007
    ..Each individual in the study has a non zero probability of consanguinity. Systolic and diastolic blood pressures are shown to have appreciable dominance variance components...
  9. ncbi request reprint Insulin sensitivity, body fat distribution, and family diabetes history: the IRAS Family Study
    Braxton D Mitchell
    University of Maryland School of Medicine, Division of Endocrinology, Diabetes, and Nutrition, 660 W Redwood Street, Room 492, Baltimore, MD 21201, USA
    Obes Res 12:831-9. 2004
    ..Whether diabetes family history (FH) also predicts visceral fat accumulation and, if so, whether the increased insulin resistance in relatives of diabetic subjects occurs independently of visceral fat accumulation are not known...
  10. pmc Genomic imprinting in diabetes
    Braxton D Mitchell
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland, 6601 West Redwood Street, Baltimore, MD 21201, USA
    Genome Med 2:55. 2010
    ..We summarize current views on the role of imprinting in diabetes and in particular chromosome 6q24-related transient neonatal diabetes mellitus, the best known example of an imprinted genetic disorder that leads to diabetes...
  11. pmc The genetics of bone loss: challenges and prospects
    Braxton D Mitchell
    Department of Medicine, Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 96:1258-68. 2011
    ..However, much less is known about the genetics of age-related bone loss. Identifying bone loss-related genes may provide new routes for therapeutic intervention and osteoporosis prevention...
  12. ncbi request reprint Genetic and environmental determinants of bone mineral density in Mexican Americans: results from the San Antonio Family Osteoporosis Study
    Braxton D Mitchell
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Bone 33:839-46. 2003
    ..Identifying the individual genes involved will shed insights into the processes that govern bone remodeling and may suggest strategies for the prevention of osteoporosis...
  13. ncbi request reprint Familial aggregation of nutrient intake and physical activity: results from the San Antonio Family Heart Study
    Braxton D Mitchell
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Ann Epidemiol 13:128-35. 2003
    ..To evaluate the extent to which levels of physical activity and nutrient intake aggregate in families, and secondarily, to assess the repeatability of these behavioral measures over a 5-year period...
  14. pmc The genetic response to short-term interventions affecting cardiovascular function: rationale and design of the Heredity and Phenotype Intervention (HAPI) Heart Study
    Braxton D Mitchell
    Division of Endocrinology, Department of Medicine, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am Heart J 155:823-8. 2008
    ..Efforts to identify genes influencing CVD risk have met with limited success to date, likely because of the small effect sizes of common CVD risk alleles and the presence of gene by gene and gene by environment interactions...
  15. ncbi request reprint Genetic determinants of diabetes and atherosclerosis
    Braxton D Mitchell
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, 660 W Redwood Street, Room 492, Baltimore 21201, USA
    Curr Atheroscler Rep 4:193-8. 2002
    ....
  16. ncbi request reprint Heritability of life span in the Old Order Amish
    B D Mitchell
    Department of Medicine, Division of Endocrinology, University of Maryland School of Medicine, 660 W Redwood St, Baltimore, MD 21201, USA
    Am J Med Genet 102:346-52. 2001
    ..We conclude that longevity is moderately heritable in the OOA, that the genetic effects are additive, and that genetic influences on longevity are likely to be expressed across a broad range of ages. Published 2001 Wiley-Liss, Inc...
  17. ncbi request reprint Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish
    Coleen M Damcott
    Division of Endocrinology, Diabetesand Nutrition, University of Maryland School of Medicine, 660 West Redwood St, Room 494, Baltimore, MD 21201, USA
    Diabetes 54:2245-50. 2005
    ..001; OR 1.64-1.71). To our knowledge, these data provide the first evidence for association between variation in the adiponectin receptors and type 2 diabetes...
  18. pmc Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish
    Patrick F McArdle
    University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Arthritis Rheum 58:2874-81. 2008
    ..This study was undertaken to investigate associations between uric acid levels and single-nucleotide polymorphisms (SNPs)...
  19. ncbi request reprint Polymorphism in the calsequestrin 1 (CASQ1) gene on chromosome 1q21 is associated with type 2 diabetes in the old order Amish
    Mao Fu
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Diabetes 53:3292-9. 2004
    ..These findings, coupled with similar findings in Utah Caucasians, suggest that sequence variation in CASQ1 may influence risk of type 2 diabetes...
  20. pmc Variants in scavenger receptor class B type I gene are associated with HDL cholesterol levels in younger women
    Caroline G P Roberts
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hum Hered 64:107-13. 2007
    ....
  21. ncbi request reprint Eating behavior in the Old Order Amish: heritability analysis and a genome-wide linkage analysis
    Nanette I Steinle
    University of Maryland School of Medicine, Baltimore 21201, USA
    Am J Clin Nutr 75:1098-106. 2002
    ..Eating behavior and thus dietary intake affect the development of obesity-related diseases such as diabetes, hypertension, and hyperlipidemia...
  22. pmc Relation of candidate genes that encode for endothelial function to migraine and stroke: the Stroke Prevention in Young Women study
    Leah R MacClellan
    Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD 21201 1559, USA
    Stroke 40:e550-7. 2009
    ..Genes encoding for endothelial function are promising candidate genes for migraine and stroke susceptibility because of the importance of endothelial function in regulating vascular tone and cerebral blood flow...
  23. ncbi request reprint Vesicle-associated membrane protein 4, a positional candidate gene on 1q24-q25, is not associated with type 2 diabetes in the Old Order Amish
    Mona M Sabra
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, United States
    Mol Genet Metab 85:133-9. 2005
    ..VAMP4 is expressed in liver and skeletal muscle and participates in intracellular trafficking of secreted and membrane-associated proteins...
  24. ncbi request reprint Type 2 diabetes is associated with increased bone mineral density in Mexican-American women
    W H Linda Kao
    Department of Epidemiology, The Johns Hopkins University, Baltimore, MD, USA
    Arch Med Res 34:399-406. 2003
    ..Our purpose was to determine whether type 2 diabetes is associated with altered bone mineral density (BMD) and whether fasting serum insulin levels are correlated with BMD...
  25. pmc Sequence variation in IGF1R is associated with differences in insulin levels in nondiabetic Old Order Amish
    Adam C Naj
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Diabetes Metab Res Rev 25:773-9. 2009
    ..3, in a region of linkage (LOD = 2.53, P = 0.00032) to Insulin30 on an OGTT in the Old Order Amish. Mouse models with beta-cell-specific deficiency of IGF1R demonstrate defects in glucose-stimulated insulin secretion...
  26. pmc Approaches for unraveling the joint genetic determinants of schizophrenia and bipolar disorder
    Ping I Lin
    Division of Endocrinology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Schizophr Bull 34:791-7. 2008
    ..We have put a particular emphasis on incorporating the concept of endophenotypes in research of shared genetic liability for these 2 disorders...
  27. ncbi request reprint Exploring the genetics of longevity in the Old Order Amish
    John Sorkin
    Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Mech Ageing Dev 126:347-50. 2005
    ..In this article, we describe our strategy for identifying variants in genes that influence longevity in the Amish and present the results of our studies to date...
  28. ncbi request reprint A genome-wide scan of serum lipid levels in the Old Order Amish
    Toni I Pollin
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, 660 W Redwood Street, Room 492, Baltimore, MD 21201, USA
    Atherosclerosis 173:89-96. 2004
    ....
  29. pmc Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification
    Haiqing Shen
    Division of Endocrinology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Arterioscler Thromb Vasc Biol 30:2648-54. 2010
    ..We hypothesized that DNA sequence variation in genes regulating vitamin D metabolism and signaling pathways might influence variation in coronary artery calcification (CAC)...
  30. pmc A common variant in fibroblast growth factor binding protein 1 (FGFBP1) is associated with bone mineral density and influences gene expression in vitro
    Nicole Hoppman
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Bone 47:272-80. 2010
    ..Collectively, these findings suggest that sequence variation in FGFBP1 may contribute to variation in BMD, possibly influencing osteoporosis risk...
  31. pmc From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene
    Ying Wang
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 106:226-31. 2009
    ..Thus, variants in STK39 may influence BP by increasing STK39 expression and consequently altering renal Na(+) excretion, thus unifying rare and common BP-regulating alleles in the same physiological pathway...
  32. pmc Bitter taste receptors influence glucose homeostasis
    Cedrick D Dotson
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA
    PLoS ONE 3:e3974. 2008
    ..Together, these findings suggest that a functionally compromised TAS2R receptor negatively impacts glucose homeostasis, providing an important link between alimentary chemosensation and metabolic disease...
  33. ncbi request reprint A genome-wide linkage scan of insulin level derived traits: the Amish Family Diabetes Study
    Wen Chi Hsueh
    Department of Medicine, School of Medicine, University of California, San Francisco, California, USA
    Diabetes 56:2643-8. 2007
    ..The goal of our study was to identify chromosomal regions that are likely to harbor genetic determinants of these traits...
  34. pmc Physical activity and the association of common FTO gene variants with body mass index and obesity
    Evadnie Rampersaud
    Department of Medicine, University of Maryland, Baltimore, USA
    Arch Intern Med 168:1791-7. 2008
    ..The role of lifestyle factors (such as physical activity) in those with an underlying FTO genetic predisposition is unknown...
  35. ncbi request reprint Polymorphisms in both promoters of hepatocyte nuclear factor 4-alpha are associated with type 2 diabetes in the Amish
    Coleen M Damcott
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Diabetes 53:3337-41. 2004
    ..022; dominant model, P = 0.010). The results of this study provide evidence that variants in both the P1 and P2 promoters of HNF4A increase risk for typical type 2 diabetes...
  36. pmc The association of coronary artery calcification and carotid artery intima-media thickness with distinct, traditional coronary artery disease risk factors in asymptomatic adults
    Evadnie Rampersaud
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Am J Epidemiol 168:1016-23. 2008
    ..Results suggest that some of the same genes influence variation in CAC and low density lipoprotein cholesterol, whereas a different set of genes influences variation in CIMT and waist circumference...
  37. ncbi request reprint Family history of type 2 diabetes is associated with increased carotid artery intimal-medial thickness in Mexican Americans
    W H Linda Kao
    Department of Epidemiology, Bloomberg School of Public Health, John s Hopkins University, Baltimore, Maryland, USA
    Diabetes Care 28:1882-9. 2005
    ..To evaluate whether the joint risk of diabetes and atherosclerosis tracked within families, we assessed the correlation between a family history of diabetes and intimal-medial thickness (IMT) of the common carotid artery (CCA)...
  38. pmc Aspirin Resistance in healthy drug-naive men versus women (from the Heredity and Phenotype Intervention Heart Study)
    Haiqing Shen
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 104:606-12. 2009
    ....
  39. ncbi request reprint Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations
    Evadnie Rampersaud
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, 660 West Redwood St, Room 494, Baltimore, MD 21201, USA
    Diabetes 56:3053-62. 2007
    ..We sought to identify type 2 diabetes susceptibility genes through a genome-wide association scan (GWAS) in the Amish...
  40. pmc Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women
    Cedrick D Dotson
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Appetite 54:93-9. 2010
    ..Therefore, our results indicate that a polymorphism in TAS2R38 is associated with differences in ingestive behavior...
  41. ncbi request reprint Association between Val108/158 Met polymorphism of the COMT gene and schizophrenia
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    Am J Med Genet B Neuropsychiatr Genet 120:47-50. 2003
    ..These results provide support for a role of this variant in the etiopathophysiology of schizophrenia...
  42. pmc Genome-wide association scan identifies variants near Matrix Metalloproteinase (MMP) genes on chromosome 11q21-22 strongly associated with serum MMP-1 levels
    Yu Ching Cheng
    Division of Endocrinology, Diabetes and Nutrition, School of Medicine, University of Maryland, Baltimore, MD, USA
    Circ Cardiovasc Genet 2:329-37. 2009
    ..Matrix metalloproteinase (MMP)-1 may play a role in cardiovascular disease susceptibility by influencing plaque rupture via its ability to degrade extracellular collagens...
  43. pmc Investigations of the Y chromosome, male founder structure and YSTR mutation rates in the Old Order Amish
    Toni I Pollin
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Hum Hered 65:91-104. 2008
    ..Using Y chromosome short tandem repeat (YSTR) genotypes, (1) evaluate the accuracy and completeness of the Lancaster County Old Order Amish (OOA) genealogical records and (2) estimate YSTR mutation rates...
  44. pmc A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection
    Toni I Pollin
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Science 322:1702-5. 2008
    ..Subclinical atherosclerosis, as measured by coronary artery calcification, was less common in carriers than noncarriers, which suggests that lifelong deficiency of apoC-III has a cardioprotective effect...
  45. pmc Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy
    Alan R Shuldiner
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, 660 W Redwood St, Room 494, Baltimore, MD 21201, USA
    JAMA 302:849-57. 2009
    ..However, nonresponsiveness is widely recognized and is related to recurrent ischemic events...
  46. pmc Genetic effects on postprandial variations of inflammatory markers in healthy individuals
    Yu Ching Cheng
    Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Obesity (Silver Spring) 18:1417-22. 2010
    ..Genetic factors appear to play a significant role influencing basal inflammatory levels but to have minimal influence on post-fat intake inflammatory changes...
  47. pmc Dopamine transporter polymorphism modulates oculomotor function and DAT1 mRNA expression in schizophrenia
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, 21228, USA
    Am J Med Genet B Neuropsychiatr Genet 150:282-9. 2009
    ..05), but higher expression in schizophrenia donors. Findings suggest regulatory effects of another gene(s) or etiological factor in schizophrenia, which modulate DAT1 gene function...
  48. pmc Ischemic stroke risk, smoking, and the genetics of inflammation in a biracial population: the stroke prevention in young women study
    John W Cole
    Veterans Affairs Medical Center, Baltimore, Maryland, USA
    Thromb J 6:11. 2008
    ..Here we evaluate the association of several inflammatory gene single nucleotide polymorphisms (SNPs) with ischemic stroke risk among young women, further stratified by current cigarette smoking status...
  49. pmc Glucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention study
    Haiqing Shen
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, 660 West Redwood Street, Rm 494, Baltimore, MD 21201, USA
    Hum Genet 126:567-74. 2009
    ..03). Our data indicate that the rs1260326 T allele of GCKR is associated with both higher fasting levels of TG as well as the postprandial TG response, which may result in higher atherogenic risk...
  50. pmc Sensory gating endophenotype based on its neural oscillatory pattern and heritability estimate
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Arch Gen Psychiatry 65:1008-16. 2008
    ..Frequency-specific sensory gating may be less complex than the P50 response, and therefore closer to the direct genetic effects, and thus a more valid endophenotype...
  51. pmc Evidence of missense mutations on the neuregulin 1 gene affecting function of prepulse inhibition
    L Elliot Hong
    Department of Psychiatry, Maryland Psychiatric Research Center, Baltimore, Maryland 21228, USA
    Biol Psychiatry 63:17-23. 2008
    ..A widely used surrogate measure of psychosis in animal models, PPI is considered a schizophrenia endophenotype. We hypothesized that if NRG1 influences PPI in rodents, then it should have a similar effect on PPI in humans...
  52. ncbi request reprint Dihydropyrimidinase-related protein 2 (DRP-2) gene and association to deficit and nondeficit schizophrenia
    L Elliot Hong
    Department of Psychiatry, Maryland Psychiatric Research Center, School of Medicine, University of Maryland, Baltimore, 21228, USA
    Am J Med Genet B Neuropsychiatr Genet 136:8-11. 2005
    ..2%, P =0.050) forms of schizophrenia compared to controls (allele frequency 25.0%). We conclude that the DRP-2 *2236 C allele may mark another polymorphism in DRP-2, or in a nearby gene, that may influence susceptibility to schizophrenia...
  53. ncbi request reprint Familial aggregation of ischemic stroke in young women: the Stroke Prevention in Young Women Study
    Leah R MacClellan
    Department of Epidemiology and Preventive Medicine, School of Medicine, University of Maryland, Baltimore, MD, USA
    Genet Epidemiol 30:602-8. 2006
    ..To address this issue, we compared the frequency of stroke in relatives of stroke cases to that in relatives of controls across different ages and by stroke subtype...
  54. ncbi request reprint Linkage of plasma adiponectin levels to 3q27 explained by association with variation in the APM1 gene
    Toni I Pollin
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, 660 W Redwood St, Rm 478, Baltimore, MD 21201, USA
    Diabetes 54:268-74. 2005
    ..51 LOD units (to 0.71). These findings, combined with a two-point LOD score of 2.35 for SNP +2019, provide evidence that variation in APM1 is responsible for linkage of adiponectin levels to 3q27 in the Old Order Amish...
  55. ncbi request reprint Association of a polymorphism in the betacellulin gene with type 1 diabetes mellitus in two populations
    Kristi D Silver
    Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, 21201, USA
    J Mol Med (Berl) 84:616-23. 2006
    ..We conclude that the intron 4 T-4 allele in the betacellulin gene is associated with lower risk of T1DM and may interact with HLA. Further studies will be necessary to establish the significance of this association...
  56. ncbi request reprint Familial aggregation of eye-tracking endophenotypes in families of schizophrenic patients
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA
    Arch Gen Psychiatry 63:259-64. 2006
    ..Recent studies have suggested that deficit in predictive pursuit, a specific component of the SPEMs, marks schizophrenia susceptibility...
  57. ncbi request reprint Variants in the ghrelin gene are associated with metabolic syndrome in the Old Order Amish
    Nanette I Steinle
    Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 90:6672-7. 2005
    ..Its gene, GHRL, is located on chromosome 3 in a region where we have shown linkage to eating behavior, percentage body fat, and total and low-density lipoprotein cholesterol levels in subjects of the Amish Family Diabetes Study...
  58. ncbi request reprint The exon 1 Cys7Gly polymorphism within the betacellulin gene is associated with type 2 diabetes in African Americans
    Kristi Silver
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Diabetes 54:1179-84. 2005
    ..Further studies will be needed to understand the different roles that betacellulin polymorphisms play in susceptibility to type 2 diabetes in Caucasians and African Americans...
  59. ncbi request reprint The relationship between parity and bone mineral density in women characterized by a homogeneous lifestyle and high parity
    Elizabeth A Streeten
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Room N3W130, 22 South Greene Street, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 90:4536-41. 2005
    ..We reported previously that Old Order Amish (OOA) women have fewer hip fractures and higher bone mineral density (BMD) than non-Amish Caucasian women...
  60. ncbi request reprint Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance
    Coleen M Damcott
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Diabetes 55:2654-9. 2006
    ..04 and P = 0.007, respectively). These data provide replicating evidence that variants in TCF7L2 increase the risk for type 2 diabetes and novel evidence that the variants likely influence both insulin secretion and insulin sensitivity...
  61. ncbi request reprint Quantitative trait loci for BMD identified by autosome-wide linkage scan to chromosomes 7q and 21q in men from the Amish Family Osteoporosis Study
    Elizabeth A Streeten
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Bone Miner Res 21:1433-42. 2006
    ..Using autosome-wide linkage analysis in 964 Amish, strong evidence was found for the presence of genes affecting hip and spine BMD in men on chromosomes 7q31 and 21q22 (LOD = 4.15 and 3.36, respectively)...
  62. ncbi request reprint Variation in the lamin A/C gene: associations with metabolic syndrome
    Nanette I Steinle
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Arterioscler Thromb Vasc Biol 24:1708-13. 2004
    ..To determine whether polymorphisms in LMNA influence susceptibility to metabolic syndrome and its constituent components...
  63. pmc Associations between genetic variants in the NOS1AP (CAPON) gene and cardiac repolarization in the old order Amish
    Wendy Post
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Hum Hered 64:214-9. 2007
    ..The purpose of the current study was to replicate this association in the Old Order Amish...
  64. ncbi request reprint Reduced incidence of hip fracture in the Old Order Amish
    Elizabeth A Streeten
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Bone Miner Res 19:308-13. 2004
    ..The incidence of hip fracture was estimated in a community of Old Order Amish and compared with available data from non-Amish whites. Hip fracture rates were 40% lower in the Amish, and the Amish also experienced higher BMD...
  65. ncbi request reprint Evidence that Rho guanine nucleotide exchange factor 11 (ARHGEF11) on 1q21 is a type 2 diabetes susceptibility gene in the Old Order Amish
    Mao Fu
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Diabetes 56:1363-8. 2007
    ..These results, coupled with similar findings in Pima Indians, suggest that sequence variation in ARHGEF11 may influence risk of type 2 diabetes...
  66. pmc Persistent Staphylococcus aureus colonization is not a strongly heritable trait in Amish families
    Mary Claire Roghmann
    University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e17368. 2011
    ..aureus colonization in this community...
  67. doi request reprint Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study
    Hua Ling
    Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, Maryland, USA
    Obesity (Silver Spring) 17:737-44. 2009
    ..We additionally identified a second gene (CDH13) possibly influencing variation in adiponectin levels. The impact of these SNPs on health and disease has yet to be determined...
  68. pmc Investigating parent of origin effects in studies of type 2 diabetes and obesity
    Evadnie Rampersaud
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland, Baltimore, MD, USA
    Curr Diabetes Rev 4:329-39. 2008
    ..Through this paper, we hope emphasizes the potentially significant importance of POE in the etiology of T2DM and obesity...
  69. ncbi request reprint Genetic epidemiology of insulin resistance and visceral adiposity. The IRAS Family Study design and methods
    Leora Henkin
    Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Ann Epidemiol 13:211-7. 2003
    ..In this report, we describe the methods of the IRAS Family Study, which was designed to identify the genetic and environmental risk factors for insulin resistance and visceral adiposity...
  70. ncbi request reprint The genetics of obesity in Mexican Americans: the evidence from genome scanning efforts in the San Antonio family heart study
    Anthony G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    Hum Biol 75:635-46. 2003
    ..Here, we summarize the latest results from our ongoing efforts to identify obesity genes in the San Antonio Family Heart Study...
  71. ncbi request reprint Pleiotropy and heterogeneity in the expression of atherogenic lipoproteins: the IRAS Family Study
    John E Hokanson
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colo 80262, USA
    Hum Hered 55:46-50. 2003
    ..Dyslipidemia is an important determinant of coronary disease. Phenotypic correlations between atherogenic lipids are well established, but the contribution of common genetic influences is less clear...
  72. ncbi request reprint A genome scan for fasting insulin and fasting glucose identifies a quantitative trait locus on chromosome 17p: the insulin resistance atherosclerosis study (IRAS) family study
    Stephen S Rich
    Department of Public Health Sciences, Wake Forest University School of Medicine, 3rd Floor MRI Center, Winston Salem, NC 27157, USA
    Diabetes 54:290-5. 2005
    ..Identifying genes in these regions should provide insight into the nature of genetic factors regulating plasma glucose and insulin concentrations...
  73. ncbi request reprint Quantitative trait loci on chromosomes 2p, 4p, and 13q influence bone mineral density of the forearm and hip in Mexican Americans
    Candace M Kammerer
    Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 18:2245-52. 2003
    ..We obtained evidence for QTL on chromosome 4p, affecting forearm BMD overall, and on chromosomes 2p and 13q, affecting hip BMD in men...
  74. ncbi request reprint Linkage of the metabolic syndrome to 1q23-q31 in Hispanic families: the Insulin Resistance Atherosclerosis Study Family Study
    Carl D Langefeld
    Department of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157 1063, USA
    Diabetes 53:1170-4. 2004
    ..These results contribute to the growing evidence that chromosome 1q harbors at least one locus related to the metabolic precursors of diabetes...
  75. ncbi request reprint Identification of quantitative trait loci for glucose homeostasis: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study
    Stephen S Rich
    Department of Public Health Sciences, Wake Forest University School of Medicine, 3rd Floor, MRI Center, Winston Salem, NC 27157, USA
    Diabetes 53:1866-75. 2004
    ....
  76. ncbi request reprint Genetic and environmental influences on bone mineral density in pre- and post-menopausal women
    Lillian B Brown
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA
    Osteoporos Int 16:1849-56. 2005
    ..Overall, these analyses suggest that many, but not all, of the genetic factors influencing variation in BMD are common to both pre- and post-menopausal women...
  77. ncbi request reprint Decreased bone mineral density is correlated with increased subclinical atherosclerosis in older, but not younger, Mexican American women and men: the San Antonio Family Osteoporosis Study
    John R Shaffer
    Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Calcif Tissue Int 81:430-41. 2007
    ..In summary, our results demonstrate that decreased BMD is correlated with increased IMT in older (but not younger) Mexican American men and women, independent of serum CVD risk factors...
  78. pmc Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis Consortium
    Weihua Guan
    Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Hum Hered 66:35-49. 2008
    ..The International Type 2 Diabetes Linkage Analysis Consortium was formed to localize type 2 diabetes predisposing variants based on 23 autosomal linkage scans...
  79. pmc Genetic influences on blood pressure response to the cold pressor test: results from the Heredity and Phenotype Intervention Heart Study
    Marie Hélène Roy-Gagnon
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA
    J Hypertens 26:729-36. 2008
    ..Additionally, to our knowledge, no study has examined the genetics of BP recovery from the CPT, including whether shared genetic factors influence both reactivity and recovery...
  80. pmc Differences in prevalence and severity of coronary artery calcification between two non-Hispanic white populations with diverse lifestyles
    Lawrence F Bielak
    Department of Epidemiology, University of Michigan, Ann Arbor, MI 48104 3028, USA
    Atherosclerosis 196:888-95. 2008
    ....
  81. pmc Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects
    Katharine R Owen
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, U K
    Diabetes 56:879-83. 2007
    ..However, in a meta-analysis including other available data, there is evidence that rs4641 has a modest effect on diabetes susceptibility (1.10 [1.04-1.16], P = 0.001)...
  82. pmc Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels
    Wei Min Chen
    Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
    J Clin Invest 118:2620-8. 2008
    ....
  83. ncbi request reprint Determinants of coronary artery and aortic calcification in the Old Order Amish
    Wendy Post
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Circulation 115:717-24. 2007
    ..Our goal was to characterize risk factors for CAC and AC and to estimate the genetic contribution to their variation...
  84. ncbi request reprint Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK
    Diabetes 55:2541-8. 2006
    ..These data exclude USF1 as a major contributor to type 2 diabetes susceptibility and the basis for the chromosome 1q linkage. They reveal only limited evidence for replication of USF1 effects on continuous metabolic traits...
  85. pmc Phosphodiesterase 4D polymorphisms and the risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study
    Qing Song
    Morehouse School of Medicine, Atlanta, GA 30314, USA
    Hum Mol Genet 15:2468-78. 2006
    ..9, P=0.75) or former smokers (OR=1.2, P=0.66), demonstrating a gene-environment interaction (P=0.03). A strong dose-response relationship was also seen among current smokers. No specific risk haplotypes were identified...
  86. ncbi request reprint Genome-wide linkage of plasma adiponectin reveals a major locus on chromosome 3q distinct from the adiponectin structural gene: the IRAS family study
    Xiuqing Guo
    Medical Genetics Institutes, Cedars Sinai Medical Center, 8700 Beverly Blvd, 665W, Los Angeles, CA 90048, USA
    Diabetes 55:1723-30. 2006
    ..Therefore, a quantitative trait locus at 3q27, likely distinct from the APM1 gene, contributes to the variation of plasma adiponectin levels in the Hispanic-American population...
  87. ncbi request reprint The Thr92Ala deiodinase type 2 (DIO2) variant is not associated with type 2 diabetes or indices of insulin resistance in the old order of Amish
    Daniela Mentuccia
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1613, USA
    Thyroid 15:1223-7. 2005
    ..These findings could be secondary to a different genetic background or to environmental factors specific for this population...
  88. ncbi request reprint Genome-wide and fine-mapping linkage studies of type 2 diabetes and glucose traits in the Old Order Amish: evidence for a new diabetes locus on chromosome 14q11 and confirmation of a locus on chromosome 1q21-q24
    Wen Chi Hsueh
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Diabetes 52:550-7. 2003
    ..07, P = 0.000085 for HbA(1c) and LOD = 1.50 for glucose 0). In conclusion, our findings provide evidence that type 2 diabetes susceptibility genes reside on chromosomes 1, 14, and 18...

Research Grants16

  1. GENETICS OF BONE DENSITY IN MEXICAN AMERICANS
    Braxton Mitchell; Fiscal Year: 2001
    ....
  2. Genetic Influences on Coronary Artery Calcification
    Braxton Mitchell; Fiscal Year: 2009
    ..This will impact substantially on mortality, quality of life, and health care costs for millions of middle-aged and elderly Americans. ..
  3. Genetic Influences on Coronary Artery Calcification
    Braxton Mitchell; Fiscal Year: 2007
    ..This will impact substantially on mortality, quality of life, and health care costs for millions of middle-aged and elderly Americans. ..
  4. GENETICS OF BONE DENSITY IN MEXICAN AMERICANS
    Braxton Mitchell; Fiscal Year: 2007
    ..abstract_text> ..
  5. Joint Determinants of Bone Density and CVD Calcification
    Braxton Mitchell; Fiscal Year: 2004
    ..Such insights could lead to elucidation of specific genetic pathways that can be exploited in the future for early identification of high-risk individuals, as well as development of new preventive and therapeutic approaches...
  6. Genetic Influences on Coronary Artery Calcification
    Braxton D Mitchell; Fiscal Year: 2010
    ..This will impact substantially on mortality, quality of life, and health care costs for millions of middle-aged and elderly Americans. ..