Research Topics
Species | A E MitchellSummaryAffiliation: University of California Country: USA Publications
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Publications
Three-year comparison of the content of antioxidant microconstituents and several quality characteristics in organic and conventionally managed tomatoes and bell peppersAlexander W Chassy
Department of Food Science and Technology, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA
J Agric Food Chem 54:8244-52. 2006..Burbank tomatoes generally had higher levels of quercetin, kaempferol, total phenolics, and ascorbic acid as compared to Ropreco tomatoes. Bell peppers were influenced less by environment and did not display cropping system differences...
Isozyme- and gender-specific induction of glutathione S-transferases by flavonoidsAlyson E Mitchell
Department of Food Science and Technology, University of California, One Shields Avenue, Davis, CA 95616, USA
Arch Toxicol 81:777-84. 2007..In this case, dietary flavone resulted in similar fourfold increases in total GST activity in inact and castrated animals. Isozyme specific studies indicate that increases could be attributed to an induction of mGSTM and mGSTP...
Ten-year comparison of the influence of organic and conventional crop management practices on the content of flavonoids in tomatoesAlyson E Mitchell
Department of Food Science and Technology and Department of Plant Sciences, One Shields Avenue, University of California Davis, Davis, California 95616, USA
J Agric Food Chem 55:6154-9. 2007..Well-quantified changes in tomato nutrients over years in organic farming systems have not been reported previously...
Quantification of individual glutathione S-transferase isozymes in hepatic and pulmonary tissues of naphthalene-tolerant miceA E Mitchell
Facility for Advanced Instrumentation, University of California, Davis 95616 8597, USA
Arch Toxicol 74:215-21. 2000..These results indicate that induction of hepatic GSTs is substantial and may be an important factor in the development of tolerance to naphthalene...
Animal models and analytical approaches for understanding the relationships between wine and cancerS E Ebeler
Department of Viticulture and Enology, University of California, Davis, CA 95616, USA
Drugs Exp Clin Res 31:19-27. 2005..These studies demonstrate the feasibility of these approaches for studying the chemopreventive potential of dietary components at physiologic levels in..
Copper, lysyl oxidase, and extracellular matrix protein cross-linkingR B Rucker
Department of Nutrition, University of California, Davis 95616, USA
Am J Clin Nutr 67:996S-1002S. 1998..For lysyl oxidase, recent evidence (Science 1996;273:1078-84) indicates that as an additional step, a lysyl group at the active center of lysyl oxidase reacts with TOPA or its precursor to form lysyl tyrosylquinone...
The influence of diet composition on phase I and II biotransformation enzyme inductionJaime L Rudolf
Department of Food Science and Technology, University of California, Cruess Hall, One Shields Avenue, UC Davis, Davis, CA 95616, USA
Arch Toxicol 82:893-901. 2008..respectively), when the SC diet fed group with or without flavone was compared...
Purification, mass spectrometric characterization, and covalent modification of murine glutathione S-transferasesA E Mitchell
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis 95616 8597, USA
Chem Res Toxicol 8:1054-62. 1995..Reactivities of these GSTs toward HNE differed and is related to the number of cysteine residues (alpha < mu < pi) within the amino acid sequence...
Comparison of the total phenolic and ascorbic acid content of freeze-dried and air-dried marionberry, strawberry, and corn grown using conventional, organic, and sustainable agricultural practicesDanny K Asami
Department of Food Science and Technology, University of California-Davis, 95616, USA
J Agric Food Chem 51:1237-41. 2003..In all samples, freeze-drying preserved higher levels of TPs in comparison with air-drying...
Lysyl oxidase and P-ATPase-7A expression during embryonic development in the ratE H Tchaparian
Department of Nutrition, Department of Food Science and Technology, University of California, One Shields Avenue, Davis, California 95616 8669, USA
Arch Biochem Biophys 379:71-7. 2000..The pattern of temporal expression for ATP7A was consistent with its possible role in copper delivery to lysyl oxidase...
The flavonoid glycosides and procyanidin composition of Deglet Noor dates (Phoenix dactylifera)Yun Jeong Hong
Department of Food Science and Technology, University of California Davis, One Shields Avenue, Davis, California 95616, USA
J Agric Food Chem 54:2405-11. 2006..LC-ESI/MS/MS spectra indicate that quercetin and luteolin formed primarily O-glycosidic linkages whereas apigenin is present as the C-glycoside...
Direct liquid chromatography-mass spectrometry method for the detection of glutathione S-transferase isozymes and investigation of their expression in response to dietary flavoneStephanie A Burns
Department of Food Science and Technology, Cruess Hall, University of California, One Shields Ave, Davis, CA 95616, USA
J Chromatogr B Analyt Technol Biomed Life Sci 809:331-7. 2004..Results obtained using direct LC/MS compare favorably to the specific activity of individual isozymes (P = 0.19), and are comparable to GST levels determined using affinity chromatography followed by LC/MS (P = 0.79)...
Regulation of phase II enzymes by genistein and daidzein in male and female Swiss Webster miceErik B Froyen
Department of Nutrition, University of California, Davis, Davis, California 95616, USA
J Med Food 12:1227-37. 2009..In conclusion, individual soy isoflavones modulate phase II enzymes in mice under short-term feeding and basal conditions. This study provides insights into the actions of isolated isoflavones in mice...
Characterization of glutathione S-transferases in juvenile white sturgeonRachel T Donham
Department of Environmental Toxicology, College of Agricultural and Environmental Sciences, University of California, 1 Shields Avenue, Davis, CA 95616-8588, USA
Aquat Toxicol 71:203-14. 2005..Activity of the cytosolic GSTs was evaluated using the substrate 1-chloro-2,4-dinitrobenzene (CDNB) and found to be 2.4 +/- 0.6 U/mg cytosolic protein, and 0.41 +/- 0.05 U/mg cytosolic protein using ethacrynic acid (ETHA)...
Identification of glutathione-related quercetin metabolites in humansYun-Jeong Hong
Department of Food Science and Technology, University of California Davis, Davis, California 95616, USA
Chem Res Toxicol 19:1525-32. 2006..Our results suggest that glutathionylation of quercetin occurs in both murine hepatic suspensions and humans and indicate that under certain conditions, quercetin intermediates require inactivation through conjugation with glutathione...
An exploratory study of the nutritional composition of Tanoak (Lithocarpus densiflorus) acorns after potassium phosphonate treatmentKatherine J Meyers
Department of Food Science and Technology, University of California Davis, Davis, California 95616, USA
J Agric Food Chem 55:6186-90. 2007....
Effect of dietary constituents with chemopreventive potential on adduct formation of a low dose of the heterocyclic amines PhIP and IQ and phase II hepatic enzymesKaren H Dingley
Biology and Biotechnology Research Program and Center for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA
Nutr Cancer 46:212-21. 2003..We conclude that PEITC and chlorophyllin are protective of PhIP-induced genotoxicity after a low exposure dose of carcinogen, possibly through modification of HCA metabolism...
