Affiliation: University of Michigan
Yang J, Mishina Y. Generation and Identification of Genetically Modified Mice for BMP Receptors. Methods Mol Biol. 2019;1891:165-177 pubmed publisher
..These methods include regular PCR and genomic real-time PCR using specific primers based on different constructs in different mice strains. ..
Yang J, Mishina Y. Phenotypic Analyses of Genetically Modified Mice for BMP Receptors. Methods Mol Biol. 2019;1891:179-189 pubmed publisher
Hayano S, Komatsu Y, Pan H, Mishina Y. Augmented BMP signaling in the neural crest inhibits nasal cartilage morphogenesis by inducing p53-mediated apoptosis. Development. 2015;142:1357-67 pubmed publisher
..Thus, an appropriate level of BMP signaling is required for proper craniofacial morphogenesis. ..
Graf D, Malik Z, Hayano S, Mishina Y. Common mechanisms in development and disease: BMP signaling in craniofacial development. Cytokine Growth Factor Rev. 2016;27:129-39 pubmed publisher
..A more detailed understanding of BMP function in growth, homeostasis, and repair of postnatal craniofacial tissues will contribute to our ability to rationally manipulate this signaling network in the context of tissue engineering. ..
Zhang Y, McNerny E, Terajima M, Raghavan M, Romanowicz G, Zhang Z, et al
. Loss of BMP signaling through BMPR1A in osteoblasts leads to greater collagen cross-link maturation and material-level mechanical properties in mouse femoral trabecular compartments. Bone. 2016;88:74-84 pubmed publisher
..These studies emphasize the pivotal role of BMPR1A in the determination of bone quality and mechanical integrity under physiological conditions, with different impact on femoral cortical and trabecular compartments. ..
Agarwal S, Loder S, Brownley C, Eboda O, Peterson J, Hayano S, et al
. BMP signaling mediated by constitutively active Activin type 1 receptor (ACVR1) results in ectopic bone formation localized to distal extremity joints. Dev Biol. 2015;400:202-9 pubmed publisher
..These findings demonstrate that this model may allow for further studies of heterotopic ossification, which does not require the use of stem cells, direct trauma or activation with exogenous Cre gene administration. ..
Pan H, Zhang H, Abraham P, Komatsu Y, Lyons K, Kaartinen V, et al
. BmpR1A is a major type 1 BMP receptor for BMP-Smad signaling during skull development. Dev Biol. 2017;429:260-270 pubmed publisher
..These results also suggest differential involvement of each type 1 receptor in pathogenesis of syndromic craniosynostoses. ..
Shi C, Mandair G, Zhang H, Vanrenterghem G, Ridella R, Takahashi A, et al
. Bone morphogenetic protein signaling through ACVR1 and BMPR1A negatively regulates bone mass along with alterations in bone composition. J Struct Biol. 2018;201:237-246 pubmed publisher
..Our study suggested that BMP signaling in osteoblast mediated by BMP receptors, namely ACVR1 and BMPR1A, is critical in regulating bone quantity and bone quality. ..