S S Mirvish

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi request reprint Nitrate and nitrite concentrations in human saliva for men and women at different ages and times of the day and their consistency over time
    S S Mirvish
    Eppley Institute for Research in Cancer, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha 68198 6805, USA
    Eur J Cancer Prev 9:335-42. 2000
  2. doi request reprint Effect of feeding nitrite, ascorbate, hemin, and omeprazole on excretion of fecal total apparent N-nitroso compounds in mice
    Sidney S Mirvish
    Eppley Institute for Research in Cancer, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Chem Res Toxicol 21:2344-51. 2008
  3. ncbi request reprint N-nitroso compounds in the gastrointestinal tract of rats and in the feces of mice with induced colitis or fed hot dogs or beef
    Sidney S Mirvish
    Eppley Institute for Research in Cancer and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Carcinogenesis 24:595-603. 2003
  4. ncbi request reprint Total N-nitroso compounds and their precursors in hot dogs and in the gastrointestinal tract and feces of rats and mice: possible etiologic agents for colon cancer
    Sidney S Mirvish
    Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    J Nutr 132:3526S-3529S. 2002
  5. ncbi request reprint Determination of total N-nitroso compounds and their precursors in frankfurters, fresh meat, dried salted fish, sauces, tobacco, and tobacco smoke particulates
    J Haorah
    Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Agric Food Chem 49:6068-78. 2001
  6. ncbi request reprint Depentylation of the rat esophageal carcinogen, methyl-n-pentylnitrosamine, by microsomes from various human and rat tissues and by cytochrome P450 2A3
    S C Chen
    Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198-6805, USA
    Drug Metab Dispos 29:1221-8. 2001
  7. ncbi request reprint Partial purification from hot dogs of N-nitroso compound precursors and their mutagenicity after nitrosation
    Lin Zhou
    Eppley Institute for Research in Cancer and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Agric Food Chem 54:5679-87. 2006
  8. ncbi request reprint Inhibition by allyl sulfides and crushed garlic of O6-methylguanine formation in liver DNA of dimethylnitrosamine-treated rats
    Lin Zhou
    Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Nutr Cancer 51:68-77. 2005
  9. ncbi request reprint Comparative analysis of tobacco-specific nitrosamines and total N-nitroso compounds in moldovan cigarette tobacco
    Irina Stepanov
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, Minnesota 55455, USA
    J Agric Food Chem 53:8082-6. 2005
  10. ncbi request reprint Nitrosation of glycine ethyl ester and ethyl diazoacetate to give the alkylating agent and mutagen ethyl chloro(hydroximino)acetate
    Lin Zhou
    Eppley Institute for Research in Cancer, 6805 University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Chem Res Toxicol 17:416-23. 2004

Research Grants

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Nitrate and nitrite concentrations in human saliva for men and women at different ages and times of the day and their consistency over time
    S S Mirvish
    Eppley Institute for Research in Cancer, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha 68198 6805, USA
    Eur J Cancer Prev 9:335-42. 2000
    ..10 and 0.28 for day 2, respectively. Hence, saliva nitrite levels rose at night and were higher in older people, especially older men, and saliva nitrate and nitrite levels varied little from day to day, but varied more after 4-6 years...
  2. doi request reprint Effect of feeding nitrite, ascorbate, hemin, and omeprazole on excretion of fecal total apparent N-nitroso compounds in mice
    Sidney S Mirvish
    Eppley Institute for Research in Cancer, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Chem Res Toxicol 21:2344-51. 2008
    ..The observed effect of NaNO2 is thus far not consistent with the proposed hypothesis. The enhancement by hemin may help explain why red meat is a cause of colon cancer...
  3. ncbi request reprint N-nitroso compounds in the gastrointestinal tract of rats and in the feces of mice with induced colitis or fed hot dogs or beef
    Sidney S Mirvish
    Eppley Institute for Research in Cancer and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Carcinogenesis 24:595-603. 2003
    ..Results should help evaluate the view that colonic NOC causes colon cancer associated with colitis and ingestion of red and nitrite-preserved meat...
  4. ncbi request reprint Total N-nitroso compounds and their precursors in hot dogs and in the gastrointestinal tract and feces of rats and mice: possible etiologic agents for colon cancer
    Sidney S Mirvish
    Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    J Nutr 132:3526S-3529S. 2002
    ..Feeding a similar hot dog mixture to mice did not affect normal 7-methyldeoxyguanosine level in colonic mucosal DNA. Overall, results support the hypothesis that colonic NOCs are a cause of colon cancer...
  5. ncbi request reprint Determination of total N-nitroso compounds and their precursors in frankfurters, fresh meat, dried salted fish, sauces, tobacco, and tobacco smoke particulates
    J Haorah
    Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Agric Food Chem 49:6068-78. 2001
    ..5 and 660 for fresh meat, 5.8 and 5800 for salted, dried fish, and 660 and 2900 for chewing tobacco (all for aqueous extracts) and 220 and 20000 nmol/cigarette for MeCN extracts of cigarette smoke filter pads...
  6. ncbi request reprint Depentylation of the rat esophageal carcinogen, methyl-n-pentylnitrosamine, by microsomes from various human and rat tissues and by cytochrome P450 2A3
    S C Chen
    Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198-6805, USA
    Drug Metab Dispos 29:1221-8. 2001
    ..Nevertheless, the relatively high activity of four human esophagi might indicate increased susceptibility of some individuals to carcinogenesis by unsymmetrical dialkylnitrosamines...
  7. ncbi request reprint Partial purification from hot dogs of N-nitroso compound precursors and their mutagenicity after nitrosation
    Lin Zhou
    Eppley Institute for Research in Cancer and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Agric Food Chem 54:5679-87. 2006
    ..Hot dog patties prepared with or without sucrose or glucose showed similar ANC and ANCP levels. We discuss possible implications of these findings for the etiology of colon cancer...
  8. ncbi request reprint Inhibition by allyl sulfides and crushed garlic of O6-methylguanine formation in liver DNA of dimethylnitrosamine-treated rats
    Lin Zhou
    Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Nutr Cancer 51:68-77. 2005
    ..Hence, dosing with DAS or feeding garlic may be useful chemopreventive strategies against nitrosamine-induced cancers...
  9. ncbi request reprint Comparative analysis of tobacco-specific nitrosamines and total N-nitroso compounds in moldovan cigarette tobacco
    Irina Stepanov
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, Minnesota 55455, USA
    J Agric Food Chem 53:8082-6. 2005
    ..66; P < 0.0001). These findings demonstrate that current technologies involved in the manufacture of some blended cigarettes create conditions that favor N-nitrosation of alkaloids and other tobacco constituents...
  10. ncbi request reprint Nitrosation of glycine ethyl ester and ethyl diazoacetate to give the alkylating agent and mutagen ethyl chloro(hydroximino)acetate
    Lin Zhou
    Eppley Institute for Research in Cancer, 6805 University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Chem Res Toxicol 17:416-23. 2004
    ..In conclusion, gastric nitrosation of glycine derivatives such as peptides with a N-terminal glycine might produce ECHA analogues that alkylate bases of gastric mucosal DNA and thereby initiate gastric cancer...

Research Grants3

  1. Chemoprevention of Colonic NOC Formation and Action
    SIDNEY MIRVISH; Fiscal Year: 2006
    ..Overall results will indicate how fecal NOC levels are controlled and can be reduced, and whether fecal NOC can induce colon cancer. ..
  2. NOC in processed meat as a likely cause of colon cancer
    Sidney S Mirvish; Fiscal Year: 2010
    ..We will test whether sodium nitrite which, like hot dog ANC, increased fecal ANC levels in mice, behaves like hot dog ANC in inducing aberrant crypts (a precancer lesion for colon cancer) in the mouse colon. ..
  3. NOC in processed meat as a likely cause of colon cancer
    Sidney S Mirvish; Fiscal Year: 2011
    ..We will test whether sodium nitrite which, like hot dog ANC, increased fecal ANC levels in mice, behaves like hot dog ANC in inducing aberrant crypts (a precancer lesion for colon cancer) in the mouse colon. ..