K Mirnics

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex
    K Mirnics
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Neuron 28:53-67. 2000
  2. ncbi Critical appraisal of DNA microarrays in psychiatric genomics
    Karoly Mirnics
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Biol Psychiatry 60:163-76. 2006
  3. ncbi Presenilin-1-dependent transcriptome changes
    Karoly Mirnics
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 25:1571-8. 2005
  4. ncbi Heat shock protein 12A shows reduced expression in the prefrontal cortex of subjects with schizophrenia
    Julie L Pongrac
    Department of Psychiatry, E1655 BST, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Biol Psychiatry 56:943-50. 2004
  5. ncbi Progress in the use of microarray technology to study the neurobiology of disease
    Karoly Mirnics
    Department of Psychiatry, University of Pittsburgh, School of Medicine, E1453 Biomedical Science, Pittsburgh, Pennsylvania 15261, USA
    Nat Neurosci 7:434-9. 2004
  6. ncbi Microarrays in brain research: the good, the bad and the ugly
    K Mirnics
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Nat Rev Neurosci 2:444-7. 2001
  7. ncbi Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia
    K Mirnics
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Mol Psychiatry 6:293-301. 2001
  8. ncbi Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia
    T Hashimoto
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 13:147-61. 2008
  9. ncbi Specificity and timing of neocortical transcriptome changes in response to BDNF gene ablation during embryogenesis or adulthood
    C Glorioso
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15261, USA
    Mol Psychiatry 11:633-48. 2006
  10. ncbi Transcriptome differences between the frontal cortex and hippocampus of wild-type and humanized presenilin-1 transgenic mice
    Travis Unger
    Department of Psychiatry, University of Pittsburgh School of Medicine, E1453 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Am J Geriatr Psychiatry 13:1041-51. 2005

Detail Information

Publications21

  1. ncbi Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex
    K Mirnics
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Neuron 28:53-67. 2000
    ..The combined data suggest that subjects with schizophrenia share a common abnormality in presynaptic function. We set forth a predictive, testable model...
  2. ncbi Critical appraisal of DNA microarrays in psychiatric genomics
    Karoly Mirnics
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Biol Psychiatry 60:163-76. 2006
    ..Microarray gene expression studies are ideally suited to reveal these putative disease-associated molecular hubs and to identify promising candidates for genetic association studies...
  3. ncbi Presenilin-1-dependent transcriptome changes
    Karoly Mirnics
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 25:1571-8. 2005
    ..The opposite directionality of these changes in transcript levels must be a function of APP and/or APP derivatives...
  4. ncbi Heat shock protein 12A shows reduced expression in the prefrontal cortex of subjects with schizophrenia
    Julie L Pongrac
    Department of Psychiatry, E1655 BST, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Biol Psychiatry 56:943-50. 2004
    ..001; mean log2 signal difference = -.58) in transcript expression for a gene clone KIAA0417. This database entry has been recently annotated as two highly homologous members of a heat-shock protein family (HSPA12A and HSPA12B)...
  5. ncbi Progress in the use of microarray technology to study the neurobiology of disease
    Karoly Mirnics
    Department of Psychiatry, University of Pittsburgh, School of Medicine, E1453 Biomedical Science, Pittsburgh, Pennsylvania 15261, USA
    Nat Neurosci 7:434-9. 2004
    ..Nevertheless, recent microarray-based studies have implicated both individual dysregulated genes and abnormal patterns of gene expression in brain disorders...
  6. ncbi Microarrays in brain research: the good, the bad and the ugly
    K Mirnics
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Nat Rev Neurosci 2:444-7. 2001
    ..To ensure rapid and meaningful data exchange, we need to create some order out of the existing chaos. In these ground-breaking microarray standardization and data sharing efforts, NIH agencies should take a leading role..
  7. ncbi Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia
    K Mirnics
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Mol Psychiatry 6:293-301. 2001
    ....
  8. ncbi Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia
    T Hashimoto
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 13:147-61. 2008
    ..In concert with previous findings, these data suggest that working memory dysfunction in schizophrenia is mediated by altered GABA neurotransmission in certain DLPFC microcircuits...
  9. ncbi Specificity and timing of neocortical transcriptome changes in response to BDNF gene ablation during embryogenesis or adulthood
    C Glorioso
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15261, USA
    Mol Psychiatry 11:633-48. 2006
    ..These BDNF-dependent gene expression changes may illuminate the biological basis for transcriptome changes observed in certain human brain disorders...
  10. ncbi Transcriptome differences between the frontal cortex and hippocampus of wild-type and humanized presenilin-1 transgenic mice
    Travis Unger
    Department of Psychiatry, University of Pittsburgh School of Medicine, E1453 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Am J Geriatr Psychiatry 13:1041-51. 2005
    ..CONCLUSIONS: Data suggest that disturbed gene-expression ratios between cortical regions may be an important event in altered brain physiology...
  11. ncbi Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse
    K Mirnics
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Trends Neurosci 24:479-86. 2001
    ....
  12. ncbi Novel animal models for studying complex brain disorders: BAC-driven miRNA-mediated in vivo silencing of gene expression
    K A Garbett
    Department of Psychiatry, Vanderbilt University, Nashville, TN 37232, USA
    Mol Psychiatry 15:987-95. 2010
    ....
  13. ncbi Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice
    Orly Lazarov
    Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, IL 60637, USA
    Cell 120:701-13. 2005
    ....
  14. ncbi DNA pooling: a comprehensive, multi-stage association analysis of ACSL6 and SIRT5 polymorphisms in schizophrenia
    K V Chowdari
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Genes Brain Behav 6:229-39. 2007
    ..This strategy may be particularly useful for research groups lacking access to high throughput genotyping facilities. Our analyses did not yield convincing evidence for associations of schizophrenia with ACSL6 or SIRT5...
  15. ncbi DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changes
    Z K Mirnics
    Department of Pediatrics and Neurology, University of Pittsburgh, School of Medicine, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 8:863-78. 2003
    ....
  16. ncbi True and false discovery in DNA microarray experiments: transcriptome changes in the hippocampus of presenilin 1 mutant mice
    Travis Unger
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Methods 37:261-73. 2005
    ..Finally, we provide an in-depth analysis of the hippocampal transcriptome of DeltaE9 hPS1 transgenic mice and mice with a conditional ablation of the PS1 gene...
  17. ncbi Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression
    R C Shelton
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Mol Psychiatry 16:751-62. 2011
    ..The results of this study indicate that post-mortem brain tissue samples from BA10, a region that is involved in reward-related behavior, show evidence of local inflammatory, apoptotic, and oxidative stress in MDD...
  18. ncbi Expression of a familial Alzheimer's disease-linked presenilin-1 variant enhances perforant pathway lesion-induced neuronal loss in the entorhinal cortex
    Orly Lazarov
    Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 26:429-34. 2006
    ..We conclude that expression of FAD-linked mutant PS1 variants enhances the vulnerability of neurons in the entorhinal cortex to PP lesion-induced cytotoxicity...
  19. ncbi Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited
    Orly Lazarov
    Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 25:2386-95. 2005
    ....
  20. ncbi Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice
    Orly Lazarov
    Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 22:9785-93. 2002
    ....
  21. ncbi Effects of maternal immune activation on gene expression patterns in the fetal brain
    K A Garbett
    Department of Psychiatry, Vanderbilt University, Nashville, TN 37203, USA
    Transl Psychiatry 2:e98. 2012
    ..We propose that this cascade of events might parallel the mechanisms by which environmental insults contribute to the risk of neurodevelopmental disorders such as schizophrenia and autism...