Research Topics
| Katrina MirandaSummaryAffiliation: University of Arizona Country: USA Publications
Research Grants
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Detail Information
Publications
Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in VivoKatrina M Miranda
Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
J Med Chem 48:8220-8. 2005..These data suggest that primary amine NONOates may be useful as HNO donors in complement to the existing series of secondary amine NONOates, which are well-characterized NO donors...- Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pHKatrina M Miranda
Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
J Am Chem Soc 127:722-31. 2005..The mechanism of product autoxidation is also considered... - Donors of HNOKatrina M Miranda
Department of Chemistry, University of Arizona, Tucson, 85721, USA
Curr Top Med Chem 5:649-64. 2005..This review provides a detailed discussion of the most commonly utilized donors of HNO as well as a guideline for the characterization of novel donors... 
A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular systemKatrina M Miranda
Radiation Biology Branch, Building 10, Room B3 B69, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 100:9196-201. 2003..The orthogonality of HNO and NO may be due to differential reactivity toward metals and thiols and in the cardiovascular system, may ultimately be driven by respective alteration of cAMP and cGMP levels...- The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signalingSonia Donzelli
Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Antioxid Redox Signal 8:1363-71. 2006..In this review, we discuss the biochemistry of such reactions in the context of their pharmacologic and biologic implications... - Protein nitration is mediated by heme and free metals through Fenton-type chemistry: an alternative to the NO/O2- reactionDouglas D Thomas
Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:12691-6. 2002..Metal catalyzed nitration may account for the observed specificity of protein nitration seen under pathological conditions, suggesting a major role for translocated metals and the labilization of heme in NT formation... - Ingress and reactive chemistry of nitroxyl-derived species within human cellsMichael Graham Espey
Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD20892, USA
Free Radic Biol Med 33:827-34. 2002..The substantial facilitation of oxygen-dependent nitroxyl chemistry by intact lipid bilayers supports a focusing role for the membrane in modulation of cellular constituents proteins by this unique species... - Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitriteKatrina M Miranda
Radiation Biology Branch, National Cancer Institute NIH, Building 10, Room B3 B69, Bethesda, MD 20892, USA
Arch Biochem Biophys 401:134-44. 2002..This study emphasizes the importance of buffer composition on chemical outcome and thus on interpretation and provides further evidence that ONOO(-) is not an intermediate formed between the reaction of O(2) and HNO produced by AS... - Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigmDavid A Wink
Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bldg 10, Rm B3 B69, Bethesda, MD 20892, USA
Am J Physiol Heart Circ Physiol 285:H2264-76. 2003..This article discusses the emerging aspects of HNO chemistry and attempts to provide a framework for the distinct effects of NO and HNO in vivo... - Discriminating formation of HNO from other reactive nitrogen oxide speciesSonia Donzelli
Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Free Radic Biol Med 40:1056-66. 2006..These data indicate that free HNO can be biosynthesized and thus may function as an endogenous signaling agent that is regulated by GSH content... - Heme proteins and nitric oxide (NO): the neglected, eloquent chemistry in NO redox signaling and regulationDouglas D Thomas
Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Antioxid Redox Signal 5:307-17. 2003..Here the basic chemistry of nitrosylation and the interactions of NO and other nitrogen oxides with metal-oxo species such as found in peroxidases and monoxygenases are discussed... - Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOSKatrina M Miranda
Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room B3-B69, Bethesda, MD 20892, USA
J Inorg Biochem 93:52-60. 2003.... - Direct real-time evaluation of nitration with green fluorescent protein in solution and within human cells reveals the impact of nitrogen dioxide vs. peroxynitrite mechanismsMichael Graham Espey
Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:3481-6. 2002..Taken together, these findings exemplified that heme-peroxidase-catalyzed formation of NO(2) may play a pivotal role in inflammatory and chronic disease settings while calling into question the significance of nitration by peroxynitrite... - Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systemsDouglas D Thomas
Tumor Biology Section, Radiation Biology Branch, National Institutes of Health/National Cancer Institute, Bethesda, Maryland 20892, USA
Methods Enzymol 359:84-105. 2002 - Focusing of nitric oxide mediated nitrosation and oxidative nitrosylation as a consequence of reaction with superoxideMichael G Espey
Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:11127-32. 2002..These modifications may be favored in microenvironments where the rate of O2- production is temporally and spatially contemporaneous with nitric oxide synthase activity, but not in excess of NO generation... - The chemical dynamics of NO and reactive nitrogen oxides: a practical guideDaniele Mancardi
Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Curr Mol Med 4:723-40. 2004..From this discussion, a picture can be formed concerning the possible chemical dynamics, which can be plausible in different biological mechanisms... - Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginineSonia Donzelli
Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Free Radic Biol Med 45:578-84. 2008..That peroxidation of NH2OH by horseradish peroxidase produced free HNO, which was able to affect intracellular targets, was verified by conversion of 4,5-diaminofluorescein to the corresponding fluorophore within intact cells... - The emergence of nitroxyl (HNO) as a pharmacological agentChristopher H Switzer
Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room B3 B35, Bethesda, MD 20892, USA
Biochim Biophys Acta 1787:835-40. 2009..This also gives insight into the potential molecular motifs that may be reactive towards HNO and opens up a novel field of pharmacological development... - A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide speciesMichael G Espey
Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Ann N Y Acad Sci 962:195-206. 2002..From this perspective of NO chemistry, the type, magnitude, location, and duration of either ROS or RNOS reactions may be predicted... 
Comparing the chemical biology of NO and HNOWilmarie Flores-Santana
Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Arch Pharm Res 32:1139-53. 2009..In this review, we summarize some of the most important findings regarding NO and HNO chemistry, revealing some of the possible mechanisms of their beneficial actions...- The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situationsLisa A Ridnour
Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Biol Chem 385:1-10. 2004.... - Nitric oxide-induced cellular stress and p53 activation in chronic inflammationLorne J Hofseth
Laboratories of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 100:143-8. 2003..Our study highlights a pivotal role of NO in the induction of cellular stress and the activation of a p53 response pathway during chronic inflammation... - Bordetella bronchiseptica responses to physiological reactive nitrogen and oxygen stressesAnders Omsland
Department of Cell Biology and Anatomy, Arizona Health Sciences Center, University of Arizona, AZ 85724 5030, USA
FEMS Microbiol Lett 284:92-101. 2008.... - Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: independence from beta-adrenergic signalingNazareno Paolocci
Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Proc Natl Acad Sci U S A 100:5537-42. 2003..This suggests potential of HNO/NO(-) donors for the treatment of heart failure... - Mechanism of pH-dependent decomposition of monoalkylamine diazeniumdiolates to form HNO and NO, deduced from the model compound methylamine diazeniumdiolate, density functional theory, and CBS-QB3 calculationsAndrew S Dutton
Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA
Inorg Chem 45:2448-56. 2006..The production of NO at lower pH is predicted to result from fragmentation of the amide/NO adduct upon protonation of the amine nitrogen... - Persistent susceptibility of cathepsin B to irreversible inhibition by nitroxyl (HNO) in the presence of endogenous nitric oxideAntti J Väänänen
Department of Pharmacology, Institute of Biomedicine, Biomedicum Helsinki, P O Box 63, FIN 00014 University of Helsinki, Finland
Free Radic Biol Med 45:749-55. 2008..Our results provide first evidence on a cellular level for the remarkably high sensitivity of active-site cysteines in cysteine proteases for modification by HNO... - The reduction potential of nitric oxide (NO) and its importance to NO biochemistryMichael D Bartberger
Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 99:10958-63. 2002..The singlet state of nitroxyl anion, 1NO-, is physiologically inaccessible. The significance of these potentials to physiological and pathophysiological processes involving NO and O2 under reductive conditions is discussed... - Peroxynitrite and myocardial contractility: in vivo versus in vitro effectsTatsuo Katori
935 Ross, Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205, USA
Free Radic Biol Med 41:1606-18. 2006..These data demonstrate that the site of generation within the cardiovascular system largely dictates the ability of ONOO- to directly or indirectly modulate cardiac pump function... - Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioningPasquale Pagliaro
Dipartimento di Scienze Cliniche e Biologiche, Universita degli Studi di Torino, Orbassano, Italy
Free Radic Biol Med 34:33-43. 2003.... - Nitroxyl (HNO): chemistry, biochemistry, and pharmacologyJon M Fukuto
Interdepartmental Program in Molecular Toxicology, UCLA School of Public Health, Los Angeles, California 90095 1772, USA
Annu Rev Pharmacol Toxicol 45:335-55. 2005..Moreover, many of the previously accepted chemical properties of HNO have been recently revised, thus requiring reevaluation of possible mechanisms of biological action. Herein, we review these developments in HNO chemistry and biology... - Inhibition of poly(ADP-RIBOSE) polymerase (PARP) by nitric oxide and reactive nitrogen oxide speciesOlga Sidorkina
Groupe Reparation de l ADN UMR 8113, LBPA ENS Cachan, Intitut Gustave Roussy, Villejuif Cedex, France
Free Radic Biol Med 35:1431-8. 2003....
Research Grants
- Assessment of the Chemical Biology of HNO via New DonorsKatrina M Miranda; Fiscal Year: 2010..Additionally, new biological targets, such as zinc fingers and non-heme iron centers, are likely to be revealed, which may suggest other therapeutic interventions. ..
- Assessment of the Chemical Biology of HNO via New DonorsKatrina Miranda; Fiscal Year: 2007..Additionally, new biological targets, such as zinc fingers and non-heme iron centers, are likely to be revealed, which may suggest other therapeutic interventions. ..
- Assessment of the Chemical Biology of HNO via New DonorsKatrina Miranda; Fiscal Year: 2009..Additionally, new biological targets, such as zinc fingers and non-heme iron centers, are likely to be revealed, which may suggest other therapeutic interventions. ..