Katrina Miranda

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. pmc Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate (NONOate) class
    Daniela Andrei
    Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, United States
    J Am Chem Soc 132:16526-32. 2010
  2. ncbi request reprint Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH
    Katrina M Miranda
    Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
    J Am Chem Soc 127:722-31. 2005
  3. ncbi request reprint Donors of HNO
    Katrina M Miranda
    Department of Chemistry, University of Arizona, Tucson, 85721, USA
    Curr Top Med Chem 5:649-64. 2005
  4. ncbi request reprint Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in Vivo
    Katrina M Miranda
    Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
    J Med Chem 48:8220-8. 2005
  5. pmc A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system
    Katrina M Miranda
    Radiation Biology Branch, Building 10, Room B3 B69, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:9196-201. 2003
  6. ncbi request reprint Ingress and reactive chemistry of nitroxyl-derived species within human cells
    Michael Graham Espey
    Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD20892, USA
    Free Radic Biol Med 33:827-34. 2002
  7. pmc Protein nitration is mediated by heme and free metals through Fenton-type chemistry: an alternative to the NO/O2- reaction
    Douglas D Thomas
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:12691-6. 2002
  8. ncbi request reprint The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signaling
    Sonia Donzelli
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Antioxid Redox Signal 8:1363-71. 2006
  9. ncbi request reprint Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm
    David A Wink
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bldg 10, Rm B3 B69, Bethesda, MD 20892, USA
    Am J Physiol Heart Circ Physiol 285:H2264-76. 2003
  10. ncbi request reprint Discriminating formation of HNO from other reactive nitrogen oxide species
    Sonia Donzelli
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 40:1056-66. 2006

Research Grants

Collaborators

Detail Information

Publications32

  1. pmc Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate (NONOate) class
    Daniela Andrei
    Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, United States
    J Am Chem Soc 132:16526-32. 2010
    ....
  2. ncbi request reprint Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH
    Katrina M Miranda
    Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
    J Am Chem Soc 127:722-31. 2005
    ..The mechanism of product autoxidation is also considered...
  3. ncbi request reprint Donors of HNO
    Katrina M Miranda
    Department of Chemistry, University of Arizona, Tucson, 85721, USA
    Curr Top Med Chem 5:649-64. 2005
    ..This review provides a detailed discussion of the most commonly utilized donors of HNO as well as a guideline for the characterization of novel donors...
  4. ncbi request reprint Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in Vivo
    Katrina M Miranda
    Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
    J Med Chem 48:8220-8. 2005
    ..These data suggest that primary amine NONOates may be useful as HNO donors in complement to the existing series of secondary amine NONOates, which are well-characterized NO donors...
  5. pmc A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system
    Katrina M Miranda
    Radiation Biology Branch, Building 10, Room B3 B69, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:9196-201. 2003
    ..The orthogonality of HNO and NO may be due to differential reactivity toward metals and thiols and in the cardiovascular system, may ultimately be driven by respective alteration of cAMP and cGMP levels...
  6. ncbi request reprint Ingress and reactive chemistry of nitroxyl-derived species within human cells
    Michael Graham Espey
    Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD20892, USA
    Free Radic Biol Med 33:827-34. 2002
    ..The substantial facilitation of oxygen-dependent nitroxyl chemistry by intact lipid bilayers supports a focusing role for the membrane in modulation of cellular constituents proteins by this unique species...
  7. pmc Protein nitration is mediated by heme and free metals through Fenton-type chemistry: an alternative to the NO/O2- reaction
    Douglas D Thomas
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:12691-6. 2002
    ..Metal catalyzed nitration may account for the observed specificity of protein nitration seen under pathological conditions, suggesting a major role for translocated metals and the labilization of heme in NT formation...
  8. ncbi request reprint The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signaling
    Sonia Donzelli
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Antioxid Redox Signal 8:1363-71. 2006
    ..In this review, we discuss the biochemistry of such reactions in the context of their pharmacologic and biologic implications...
  9. ncbi request reprint Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm
    David A Wink
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bldg 10, Rm B3 B69, Bethesda, MD 20892, USA
    Am J Physiol Heart Circ Physiol 285:H2264-76. 2003
    ..This article discusses the emerging aspects of HNO chemistry and attempts to provide a framework for the distinct effects of NO and HNO in vivo...
  10. ncbi request reprint Discriminating formation of HNO from other reactive nitrogen oxide species
    Sonia Donzelli
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 40:1056-66. 2006
    ..These data indicate that free HNO can be biosynthesized and thus may function as an endogenous signaling agent that is regulated by GSH content...
  11. ncbi request reprint Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite
    Katrina M Miranda
    Radiation Biology Branch, National Cancer Institute NIH, Building 10, Room B3 B69, Bethesda, MD 20892, USA
    Arch Biochem Biophys 401:134-44. 2002
    ..This study emphasizes the importance of buffer composition on chemical outcome and thus on interpretation and provides further evidence that ONOO(-) is not an intermediate formed between the reaction of O(2) and HNO produced by AS...
  12. pmc Direct real-time evaluation of nitration with green fluorescent protein in solution and within human cells reveals the impact of nitrogen dioxide vs. peroxynitrite mechanisms
    Michael Graham Espey
    Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:3481-6. 2002
    ..Taken together, these findings exemplified that heme-peroxidase-catalyzed formation of NO(2) may play a pivotal role in inflammatory and chronic disease settings while calling into question the significance of nitration by peroxynitrite...
  13. ncbi request reprint Heme proteins and nitric oxide (NO): the neglected, eloquent chemistry in NO redox signaling and regulation
    Douglas D Thomas
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Antioxid Redox Signal 5:307-17. 2003
    ..Here the basic chemistry of nitrosylation and the interactions of NO and other nitrogen oxides with metal-oxo species such as found in peroxidases and monoxygenases are discussed...
  14. ncbi request reprint The chemical dynamics of NO and reactive nitrogen oxides: a practical guide
    Daniele Mancardi
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Curr Mol Med 4:723-40. 2004
    ..From this discussion, a picture can be formed concerning the possible chemical dynamics, which can be plausible in different biological mechanisms...
  15. pmc Focusing of nitric oxide mediated nitrosation and oxidative nitrosylation as a consequence of reaction with superoxide
    Michael G Espey
    Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:11127-32. 2002
    ..These modifications may be favored in microenvironments where the rate of O2- production is temporally and spatially contemporaneous with nitric oxide synthase activity, but not in excess of NO generation...
  16. ncbi request reprint Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS
    Katrina M Miranda
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room B3 B69, Bethesda, MD 20892, USA
    J Inorg Biochem 93:52-60. 2003
    ....
  17. ncbi request reprint Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems
    Douglas D Thomas
    Tumor Biology Section, Radiation Biology Branch, National Institutes of Health National Cancer Institute, Bethesda, Maryland 20892, USA
    Methods Enzymol 359:84-105. 2002
  18. doi request reprint Comparing the chemical biology of NO and HNO
    Wilmarie Flores-Santana
    Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Pharm Res 32:1139-53. 2009
    ..In this review, we summarize some of the most important findings regarding NO and HNO chemistry, revealing some of the possible mechanisms of their beneficial actions...
  19. pmc The emergence of nitroxyl (HNO) as a pharmacological agent
    Christopher H Switzer
    Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room B3 B35, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1787:835-40. 2009
    ..This also gives insight into the potential molecular motifs that may be reactive towards HNO and opens up a novel field of pharmacological development...
  20. pmc Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine
    Sonia Donzelli
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Free Radic Biol Med 45:578-84. 2008
    ..That peroxidation of NH2OH by horseradish peroxidase produced free HNO, which was able to affect intracellular targets, was verified by conversion of 4,5-diaminofluorescein to the corresponding fluorophore within intact cells...
  21. ncbi request reprint A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species
    Michael G Espey
    Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 962:195-206. 2002
    ..From this perspective of NO chemistry, the type, magnitude, location, and duration of either ROS or RNOS reactions may be predicted...
  22. pmc Bordetella bronchiseptica responses to physiological reactive nitrogen and oxygen stresses
    Anders Omsland
    Department of Cell Biology and Anatomy, Arizona Health Sciences Center, University of Arizona, AZ 85724 5030, USA
    FEMS Microbiol Lett 284:92-101. 2008
    ....
  23. ncbi request reprint The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations
    Lisa A Ridnour
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Biol Chem 385:1-10. 2004
    ....
  24. pmc Nitric oxide-induced cellular stress and p53 activation in chronic inflammation
    Lorne J Hofseth
    Laboratories of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:143-8. 2003
    ..Our study highlights a pivotal role of NO in the induction of cellular stress and the activation of a p53 response pathway during chronic inflammation...
  25. pmc Mechanism of pH-dependent decomposition of monoalkylamine diazeniumdiolates to form HNO and NO, deduced from the model compound methylamine diazeniumdiolate, density functional theory, and CBS-QB3 calculations
    Andrew S Dutton
    Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA
    Inorg Chem 45:2448-56. 2006
    ..The production of NO at lower pH is predicted to result from fragmentation of the amide/NO adduct upon protonation of the amine nitrogen...
  26. pmc The reduction potential of nitric oxide (NO) and its importance to NO biochemistry
    Michael D Bartberger
    Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 99:10958-63. 2002
    ..The singlet state of nitroxyl anion, 1NO-, is physiologically inaccessible. The significance of these potentials to physiological and pathophysiological processes involving NO and O2 under reductive conditions is discussed...
  27. doi request reprint Persistent susceptibility of cathepsin B to irreversible inhibition by nitroxyl (HNO) in the presence of endogenous nitric oxide
    Antti J Väänänen
    Department of Pharmacology, Institute of Biomedicine, Biomedicum Helsinki, P O Box 63, FIN 00014 University of Helsinki, Finland
    Free Radic Biol Med 45:749-55. 2008
    ..Our results provide first evidence on a cellular level for the remarkably high sensitivity of active-site cysteines in cysteine proteases for modification by HNO...
  28. pmc Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: independence from beta-adrenergic signaling
    Nazareno Paolocci
    Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 100:5537-42. 2003
    ..This suggests potential of HNO/NO(-) donors for the treatment of heart failure...
  29. ncbi request reprint Peroxynitrite and myocardial contractility: in vivo versus in vitro effects
    Tatsuo Katori
    935 Ross, Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Free Radic Biol Med 41:1606-18. 2006
    ..These data demonstrate that the site of generation within the cardiovascular system largely dictates the ability of ONOO- to directly or indirectly modulate cardiac pump function...
  30. ncbi request reprint Nitroxyl (HNO): chemistry, biochemistry, and pharmacology
    Jon M Fukuto
    Interdepartmental Program in Molecular Toxicology, UCLA School of Public Health, Los Angeles, California 90095 1772, USA
    Annu Rev Pharmacol Toxicol 45:335-55. 2005
    ..Moreover, many of the previously accepted chemical properties of HNO have been recently revised, thus requiring reevaluation of possible mechanisms of biological action. Herein, we review these developments in HNO chemistry and biology...
  31. ncbi request reprint Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning
    Pasquale Pagliaro
    Dipartimento di Scienze Cliniche e Biologiche, Universita degli Studi di Torino, Orbassano, Italy
    Free Radic Biol Med 34:33-43. 2003
    ....
  32. ncbi request reprint Inhibition of poly(ADP-RIBOSE) polymerase (PARP) by nitric oxide and reactive nitrogen oxide species
    Olga Sidorkina
    Groupe Reparation de l ADN UMR 8113, LBPA ENS Cachan, Intitut Gustave Roussy, Villejuif Cedex, France
    Free Radic Biol Med 35:1431-8. 2003
    ....

Research Grants5

  1. Assessment of the Chemical Biology of HNO via New Donors
    Katrina M Miranda; Fiscal Year: 2010
    ..Additionally, new biological targets, such as zinc fingers and non-heme iron centers, are likely to be revealed, which may suggest other therapeutic interventions. ..
  2. Assessment of the Chemical Biology of HNO via New Donors
    Katrina Miranda; Fiscal Year: 2006
    ..Additionally, new biological targets, such as zinc fingers and non-heme iron centers, are likely to be revealed, which may suggest other therapeutic interventions. ..
  3. Assessment of the Chemical Biology of HNO via New Donors
    Katrina Miranda; Fiscal Year: 2007
    ..Additionally, new biological targets, such as zinc fingers and non-heme iron centers, are likely to be revealed, which may suggest other therapeutic interventions. ..
  4. Assessment of the Chemical Biology of HNO via New Donors
    Katrina Miranda; Fiscal Year: 2009
    ..Additionally, new biological targets, such as zinc fingers and non-heme iron centers, are likely to be revealed, which may suggest other therapeutic interventions. ..