Research Topics
| Michael J MinzenbergSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Social-emotion recognition in borderline personality disorderMichael J Minzenberg
University of California, Davis Medical Center, Sacramento, CA 95817, USA
Compr Psychiatry 47:468-74. 2006..These results suggest that patients with BPD have deficits in higher order integration of social information, which may be related to some of the more serious symptoms of the disorder...
Diminished orientation-specific surround suppression of visual processing in schizophreniaJong H Yoon
Department of Psychiatry and Imaging Research Center, University of California Davis, 4701 X Street, Sacramento, CA 95817, USA
Schizophr Bull 35:1078-84. 2009..In conjunction with physiological and anatomical evidence from basic and postmortem studies, our results suggest a deficit of inhibition in primary visual cortex in schizophrenia...
Prefrontal cortical deficits and impaired cognition-emotion interactions in schizophreniaStefan Ursu
Department of Psychiatry and Behavioral Sciences, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
Am J Psychiatry 168:276-85. 2011....
Modafinil modulation of the default mode networkMichael J Minzenberg
Department of Psychiatry, University of California, Davis School of Medicine, Sacramento, CA, USA
Psychopharmacology (Berl) 215:23-31. 2011..How this network is modulated by neurochemical systems during functional brain activity is not yet understood...
Multivariate pattern analysis of functional magnetic resonance imaging data reveals deficits in distributed representations in schizophreniaJong H Yoon
Department of Psychiatry and Imaging Research Center, University of California Davis, Sacramento, California 95817, USA
Biol Psychiatry 64:1035-41. 2008..We applied this method to test the hypothesis of the impairment in distributed representations in schizophrenia. We also compared the results of this method with traditional general linear model (GLM)-based univariate analysis...
A neurocognitive model of borderline personality disorder: effects of childhood sexual abuse and relationship to adult social attachment disturbanceMichael J Minzenberg
University of California, Sacramento, CA 95817, USA
Dev Psychopathol 20:341-68. 2008....
Gamma oscillatory power is impaired during cognitive control independent of medication status in first-episode schizophreniaMichael J Minzenberg
Department of Psychiatry, University of California, Davis School of Medicine, Sacramento, CA 95817, USA
Neuropsychopharmacology 35:2590-9. 2010..This suggests that altered local circuit function supporting high-frequency oscillatory activity in prefrontal cortex ensembles may serve as the pathophysiological substrate of cognitive control deficits in schizophrenia...
Excessive contralateral motor overflow in schizophrenia measured by fMRIMichael J Minzenberg
Department of Psychiatry, University of California, Davis School of Medicine, Sacramento, CA, USA
Psychiatry Res 202:38-45. 2012..This pathological motor overflow may be partly due to altered modulation of intended movement within the basal ganglia and premotor cortex...
Developing treatments for impaired cognition in schizophreniaMichael J Minzenberg
Department of Psychiatry and Center for Neuroscience, University of California Davis School of Medicine, Sacramento, CA 95817, USA
Trends Cogn Sci 16:35-42. 2012..Each of these approaches shows promise and their integration may optimize benefits for patients in the future...
Reduced Self-Referential Source Memory Performance is Associated with Interpersonal Dysfunction in Borderline Personality DisorderMichael J Minzenberg
University of California, Davis Medical Center, Sacramento, CA 95817, USA
J Pers Disord 20:42-54. 2006..Heterogeneity in source memory function may be specifically related to some of the hallmark interpersonal disturbances of BPD, independent of the effects of general negative affect or general memory impairment...
GABA concentration is reduced in visual cortex in schizophrenia and correlates with orientation-specific surround suppressionJong H Yoon
Department of Psychiatry and Imaging Research Center, University of California, Davis, Davis, California 95817, USA
J Neurosci 30:3777-81. 2010..10). These results suggest that a neocortical GABA deficit in subjects with schizophrenia leads to impaired cortical inhibition and that GABAergic synaptic transmission in visual cortex plays a critical role in OSSS...
Cognitive control deficits in schizophrenia: mechanisms and meaningTyler A Lesh
Department of Psychiatry, UC Davis Imaging Research Center, Davis School of Medicine, University of California, Sacramento, CA 95817, USA
Neuropsychopharmacology 36:316-38. 2011..Finally, we discuss recent advances in the neuropharmacology of cognition and how they can inform a targeted approach to the development of effective therapies for this disabling aspect of schizophrenia...
Modafinil shifts human locus coeruleus to low-tonic, high-phasic activity during functional MRIMichael J Minzenberg
Department of Psychiatry, University of California, Davis School of Medicine, Sacramento, CA, USA
Science 322:1700-2. 2008..These results confirm in humans the role of the LC-NE system in PFC function and cognitive control and suggest a mechanism for therapeutic action of procognitive noradrenergic agents...
Adult social attachment disturbance is related to childhood maltreatment and current symptoms in borderline personality disorderMichael J Minzenberg
University of California, Davis Medical Center, Sacramento, California 95817, USA
J Nerv Ment Dis 194:341-8. 2006....
Meta-analysis of 41 functional neuroimaging studies of executive function in schizophreniaMichael J Minzenberg
Department of Psychiatry, University of California Davis School of Medicine, Sacramento, CA 95817, USA
Arch Gen Psychiatry 66:811-22. 2009..Whether these impairments are properly considered reflective of hypofrontality vs hyperfrontality remains unresolved...
Fronto-limbic dysfunction in response to facial emotion in borderline personality disorder: an event-related fMRI studyMichael J Minzenberg
Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
Psychiatry Res 155:231-43. 2007..The neural substrates underlying processing of anger may also be altered. These changes may represent an expression of the volumetric and serotonergic deficits observed in these brain areas in BPD...
The cognitive neuroscience of memory function and dysfunction in schizophreniaCharan Ranganath
Center for Neuroscience and Department of Psychology, University of California at Davis, Davis, CA 95618, USA
Biol Psychiatry 64:18-25. 2008..A brief summary of research on episodic memory in schizophrenia is presented to provide a context for investigating item-specific and relational memory processes. Candidate brain regions are also discussed...
Modafinil: a review of neurochemical actions and effects on cognitionMichael J Minzenberg
Imaging Research Center, Davis School of Medicine, UC Davis Health System, University of California, Sacramento, CA 95817, USA
Neuropsychopharmacology 33:1477-502. 2008..These effects are in general advantageous for cognitive processes. Overall, modafinil is an excellent candidate agent for remediation of cognitive dysfunction in neuropsychiatric disorders...
Frontolimbic structural changes in borderline personality disorderMichael J Minzenberg
Mount Sinai School of Medicine and Bronx VA Medical Center, Bronx, NY, USA
J Psychiatr Res 42:727-33. 2008..We tested the hypothesis that BPD patients exhibit gross structural changes that parallel the respective increases in amygdala activation and impairment of rostral/subgenual ACC activation...
An index of relative central α-adrenergic receptor antagonism by antipsychotic medicationsMichael J Minzenberg
Department of Psychiatry, University of California, Davis School of Medicine, Sacramento, CA 95817, USA
Exp Clin Psychopharmacol 19:31-9. 2011..This index of HALα equivalents should facilitate the determination of the effects of α-adrenergic antagonism by these medications on clinical efficacy, side effects, and biological and cognitive measures of illness and treatment...
Association of dorsolateral prefrontal cortex dysfunction with disrupted coordinated brain activity in schizophrenia: relationship with impaired cognition, behavioral disorganization, and global functionJong H Yoon
Department of Psychiatry and Imaging Research Center, University of California, Davis, Sacramento, Calif 95817, USA
Am J Psychiatry 165:1006-14. 2008....
Semantic priming in schizophrenia: a review and synthesisMichael J Minzenberg
Department of Psychiatry, University of California, San Francisco, USA
J Int Neuropsychol Soc 8:699-720. 2002..We also describe associations with other neurocognitive dysfunction, neurochemical and electrophysiological disturbances, and clinical manifestations (such as thought disorder)...
The effects of guanfacine on context processing abnormalities in schizotypal personality disorderMargaret M McClure
VA VISN3 Mental Illness Research, Education, and Clinical Center, Bronx, New York 10468, USA
Biol Psychiatry 61:1157-60. 2007..This study examined the potential of guanfacine for improving context processing, a feature of working memory, in SPD...
Association of anticholinergic load with impairment of complex attention and memory in schizophreniaMichael J Minzenberg
Department of Psychiatry, Mount Sinai School of Medicine and VA Medical Center, Bronx, NY, USA
Am J Psychiatry 161:116-24. 2004....
Exaggerated affect-modulated startle during unpleasant stimuli in borderline personality disorderErin A Hazlett
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
Biol Psychiatry 62:250-5. 2007..The affect-modulated startle response is a reliable indicator of emotional processing of stimuli. The aim of this study was to examine emotional processing in BPD patients (n = 27) and healthy control subjects (n = 21)...
Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groupsMichael J Minzenberg
Bronx Veterans Affairs Medical Center, Bronx, New York, 14068, USA
Psychiatr Genet 16:117-24. 2006..We evaluated the relationship of the COMT genotype with diagnostic status and cognitive performance in schizotypal personality disorder...
