John Minna

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Distinct transcriptome profiles identified in normal human bronchial epithelial cells after exposure to γ-rays and different elemental particles of high Z and energy
    Liang Hao Ding
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390, USA
    BMC Genomics 14:372. 2013
  2. pmc Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations
    Mitsuo Sato
    Hamon Center for Therapeutic Oncology Research, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas 75390, USA
    Mol Cancer Res 11:638-50. 2013
  3. pmc MFSD2A is a novel lung tumor suppressor gene modulating cell cycle and matrix attachment
    Monica Spinola
    Department of Predictive and for Prevention Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Mol Cancer 9:62. 2010
  4. pmc Identification of 5 novel genes methylated in breast and other epithelial cancers
    Victoria K Hill
    Department of Medical and Molecular Genetics, University of Birmingham, UK
    Mol Cancer 9:51. 2010
  5. pmc MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs
    Liqin Du
    Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, Texas, USA
    J Exp Clin Cancer Res 29:75. 2010
  6. pmc sIR: siRNA Information Resource, a web-based tool for siRNA sequence design and analysis and an open access siRNA database
    Jyoti K Shah
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    BMC Bioinformatics 8:178. 2007
  7. pmc How do we safely get people to stop smoking?
    David C L Lam
    Department of Medicine, University of Hong Kong, Hong Kong SAR, China
    Cancer Prev Res (Phila) 4:1724-7. 2011
  8. pmc Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer
    John D Minna
    Hamon Center for Therapeutic Oncology Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Invest 111:31-3. 2003
  9. ncbi request reprint A big step in the study of small cell lung cancer
    John D Minna
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cancer Cell 4:163-6. 2003
  10. ncbi request reprint Cancer. A bull's eye for targeted lung cancer therapy
    John D Minna
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 304:1458-61. 2004

Research Grants

  1. Molecular Pathology of Lung Cancer
    John Minna; Fiscal Year: 2005
  2. Characterization of Human 3p Recessive Oncogenes
    John Minna; Fiscal Year: 2004
  3. HUMAN 3P RECESSIVE ONCOGENES
    John Minna; Fiscal Year: 1999

Detail Information

Publications107 found, 100 shown here

  1. pmc Distinct transcriptome profiles identified in normal human bronchial epithelial cells after exposure to γ-rays and different elemental particles of high Z and energy
    Liang Hao Ding
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390, USA
    BMC Genomics 14:372. 2013
    ....
  2. pmc Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations
    Mitsuo Sato
    Hamon Center for Therapeutic Oncology Research, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas 75390, USA
    Mol Cancer Res 11:638-50. 2013
    ....
  3. pmc MFSD2A is a novel lung tumor suppressor gene modulating cell cycle and matrix attachment
    Monica Spinola
    Department of Predictive and for Prevention Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Mol Cancer 9:62. 2010
    ..MFSD2A (major facilitator superfamily domain containing 2) gene maps on chromosome 1p34 within a linkage disequilibrium block containing genetic elements associated with progression of lung cancer...
  4. pmc Identification of 5 novel genes methylated in breast and other epithelial cancers
    Victoria K Hill
    Department of Medical and Molecular Genetics, University of Birmingham, UK
    Mol Cancer 9:51. 2010
    ..We utilized one such recently developed approach, MIRA (methylated-CpG island recovery assay) combined with CpG island arrays to identify novel genes that are epigenetically inactivated in breast cancer...
  5. pmc MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs
    Liqin Du
    Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, Texas, USA
    J Exp Clin Cancer Res 29:75. 2010
    ..However, the role of miRNAs in the pathogenesis and diagnosis of small cell carcinoma (SCLC), the majority of which represent the most aggressive lung tumors, has not been investigated...
  6. pmc sIR: siRNA Information Resource, a web-based tool for siRNA sequence design and analysis and an open access siRNA database
    Jyoti K Shah
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    BMC Bioinformatics 8:178. 2007
    ....
  7. pmc How do we safely get people to stop smoking?
    David C L Lam
    Department of Medicine, University of Hong Kong, Hong Kong SAR, China
    Cancer Prev Res (Phila) 4:1724-7. 2011
    ..However, the normal and pathophysiologic role of nicotine, nAChRs, and the signaling pathways they activate in lung epithelial cells and lung cancer still requires elucidation...
  8. pmc Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer
    John D Minna
    Hamon Center for Therapeutic Oncology Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Invest 111:31-3. 2003
  9. ncbi request reprint A big step in the study of small cell lung cancer
    John D Minna
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cancer Cell 4:163-6. 2003
    ....
  10. ncbi request reprint Cancer. A bull's eye for targeted lung cancer therapy
    John D Minna
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 304:1458-61. 2004
  11. ncbi request reprint Erlotinib hydrochloride
    John D Minna
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, 75390 8593, USA
    Nat Rev Drug Discov . 2005
    ..It is the first such drug to demonstrate an increase in survival in Phase III trials in patients with advanced non-small-cell lung cancer...
  12. ncbi request reprint Differential expression of FEZ1/LZTS1 gene in lung cancers and their cell cultures
    Shinichi Toyooka
    Hamon Center for Therapeutic Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    Clin Cancer Res 8:2292-7. 2002
    ..Because loss of heterozygosity at 8p21-22 is a frequent event in lung cancers, we studied FEZ1 alteration in short-term cultures of resected lung cancer tumors and cell lines...
  13. ncbi request reprint Aberrant promoter methylation and silencing of the RASSF1A gene in pediatric tumors and cell lines
    Kenichi Harada
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, TX 75390, USA
    Oncogene 21:4345-9. 2002
    ..In five of six cell lines, restoration of RASSF1A mRNA was confirmed by RT-PCR. Our findings indicate that aberrant promoter methylation of RASSF1A may contribute to the pathogenesis of many different forms of pediatric tumors...
  14. ncbi request reprint Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells
    Mitsuo Sato
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas 75390 8593, USA
    Cancer Res 66:2116-28. 2006
    ....
  15. ncbi request reprint Aberrant methylation of TMS1 in small cell, non small cell lung cancer and breast cancer
    Arvind Virmani
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Int J Cancer 106:198-204. 2003
    ..Our results suggest that methylation of TMS1 may play a role in the pathogenesis of small cell and non small lung and breast cancers...
  16. ncbi request reprint Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer
    Noriaki Sunaga
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    Cancer Res 64:4277-85. 2004
    ..These results suggest different roles for CAV1 in SCLC, where CAV1 acts like a tumor suppressor gene, and NSCLC, where it appears required for survival and growth...
  17. pmc A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies
    David S Shames
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS Med 3:e486. 2006
    ....
  18. ncbi request reprint Epigenetic inactivation of laminin-5-encoding genes in lung cancers
    Ubaradka G Sathyanarayana
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    Clin Cancer Res 9:2665-72. 2003
    ..We further studied the methylation patterns of primary non-small cell lung cancer [NSCLC (n = 36)], small cell lung cancer [SCLC (n = 26)], and carcinoids (n = 24) tumors...
  19. ncbi request reprint Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins
    Ruben D Ramirez
    Hamon Center for Therapeutic Oncology Research and Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer Res 64:9027-34. 2004
    ..These HBEC lines are a valuable new tool for studying of the pathogenesis of lung cancer...
  20. ncbi request reprint RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells
    Makoto Suzuki
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    Cancer Res 64:3137-43. 2004
    ..These results provide direct evidence that loss of DNMT1 expression abrogates tumor-associated promoter methylation and the resultant silencing of multiple genes implicated in the pathogenesis of human lung and breast cancer...
  21. ncbi request reprint Non-small-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation
    Amit K Das
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, 2201 Inwood Road, NC 7 208, Mail Code 9187, Dallas, TX 75390, USA
    Cancer Res 66:9601-8. 2006
    ....
  22. ncbi request reprint Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer
    Shinichi Toyooka
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas TX 75390 8593, USA
    Int J Cancer 103:153-60. 2003
    ..Our findings demonstrate important smoke exposure, histologic type and geography-related differences in the methylation profiles of NSCLC tumors...
  23. ncbi request reprint A translational view of the molecular pathogenesis of lung cancer
    Mitsuo Sato
    Hamon Center for Therapeutic Oncology Research Simmons Cancer Center, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Thorac Oncol 2:327-43. 2007
    ..These advances highlight the translation of molecular discoveries on lung cancer pathogenesis from the laboratory to the clinic...
  24. ncbi request reprint Progressive aberrant methylation of the RASSF1A gene in simian virus 40 infected human mesothelial cells
    Shinichi Toyooka
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, TX 75390, USA
    Oncogene 21:4340-4. 2002
    ..These data, together with our previous findings, support a causal relationship between SV40 infection, progressive RASSF1A methylation and its silencing, and the pathogenesis of mesothelioma...
  25. pmc The RASSF1A tumor suppressor restrains anaphase-promoting complex/cyclosome activity during the G1/S phase transition to promote cell cycle progression in human epithelial cells
    Angelique W Whitehurst
    Department Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75220 9039, USA
    Mol Cell Biol 28:3190-7. 2008
    ..Progression to tumorigenicity upon RASSF1A gene inactivation should therefore require collaborating genetic aberrations that bypass the consequences of impaired APC/C regulation at the G(1)/S phase cell cycle transition...
  26. ncbi request reprint Aberrant methylation of multiple genes in the upper aerodigestive tract epithelium of heavy smokers
    Sabine Zochbauer-Muller
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Int J Cancer 107:612-6. 2003
    ..Our findings suggest that detection of methylation should be investigated as an intermediate marker for lung cancer risk assessment and response to chemopreventive regimens...
  27. ncbi request reprint Differential inactivation of caspase-8 in lung cancers
    Narayan Shivapurkar
    Hamon Center for Therapeutic Oncology Research, Departments of Pathology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390 8593, USA
    Cancer Biol Ther 1:65-9. 2002
    ..CASP8 may function as a tumor suppressor gene in neuroendocrine lung tumors...
  28. ncbi request reprint Molecular pathogenesis of lung cancer and potential translational applications
    John D Minna
    Hamon Center for Therapeutic Oncology Research, Department of Internal Medicine, Unversity of Texas, Dallas 75390 8593, USA
    Cancer J 8:S41-6. 2002
    ..Finally, correcting even single genetic abnormalities can reverse the malignant phenotype...
  29. ncbi request reprint Promoter hypermethylation profile of ovarian epithelial neoplasms
    Prakash B Makarla
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Clin Cancer Res 11:5365-9. 2005
    ..The aim of this study was to compare the promoter hypermethylation profiles of ovarian epithelial neoplasms to better understand the role of epigenetic silencing in carcinogenesis...
  30. ncbi request reprint Imatinib mesylate efficiently achieves therapeutic intratumor concentrations in vivo but has limited activity in a xenograft model of small cell lung cancer
    Nicholas C Wolff
    Division of Hematology Oncology, Department of Medicine, Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Clin Cancer Res 10:3528-34. 2004
    ....
  31. ncbi request reprint Understanding the mechanisms of FHIT inactivation in cervical cancer for biomarker development
    Jayanthi S Lea
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9032, USA
    J Soc Gynecol Investig 11:329-37. 2004
    ..The goal of this study was to confirm the utility of homozygous deletions, aberrant methylation, and immunohistochemical evaluations of FHIT as functionally relevant determinants of FHIT expression...
  32. pmc Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers
    Masaharu Nomura
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS Med 4:e125. 2007
    ..The objective of this study was to examine distributions of these three polymorphisms and their relationships to each other and to EGFR gene mutations and allelic imbalance (AI) in non-small cell lung cancers...
  33. pmc Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells
    Emely Castro-Rivera
    Departments of Internal Medicine, Hamon Center for Therapeutic Oncology Research Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    Cancer Res 68:8295-303. 2008
    ..We conclude that SEMA3B is a potential tumor suppressor that induces apoptosis in SEMA3B-inactivated tumor cells through the Np-1 receptor by inactivating the Akt signaling pathway. CA118384..
  34. ncbi request reprint Somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) abrogate EGFR-mediated radioprotection in non-small cell lung carcinoma
    Amit K Das
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cancer Res 67:5267-74. 2007
    ....
  35. ncbi request reprint The 3p21 candidate tumor suppressor gene BAF180 is normally expressed in human lung cancer
    Ikuo Sekine
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75390 8593, USA
    Oncogene 24:2735-8. 2005
    ..We conclude that abnormalities of BAF180 are not frequently involved in the pathogenesis of lung cancer...
  36. pmc Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized
    David Padron
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Cancer Res 67:7695-702. 2007
    ..Thus, the mutations that altered signaling also decreased the interaction of EGFRs with the mechanisms responsible for endosomal sorting...
  37. ncbi request reprint EGFR mutations and molecularly targeted therapy: a new era in the treatment of lung cancer
    Jonathan E Dowell
    University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Nat Clin Pract Oncol 3:170-1. 2006
  38. pmc Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation
    Di Cai
    Division of Translational Research, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cancer Res 70:6477-85. 2010
    ..Taken together, these data suggest that SRC-3 may be an important oncogene and therapeutic target for lung cancer...
  39. ncbi request reprint Increased expression and no mutation of the Flap endonuclease (FEN1) gene in human lung cancer
    Mitsuo Sato
    Department of Internal Medicine, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Oncogene 22:7243-6. 2003
    ..Our results suggest that alterations of FEN1 are not likely to contribute to development of lung cancer...
  40. pmc Histone deacetylase inhibitor romidepsin enhances anti-tumor effect of erlotinib in non-small cell lung cancer (NSCLC) cell lines
    Wei Zhang
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    J Thorac Oncol 4:161-6. 2009
    ..In this study, we examined the effects of the histone deacetylase inhibitor, romidepsin, in combination with erlotinib, in NSCLC cell lines and xenografts...
  41. pmc Global survey of chromatin accessibility using DNA microarrays
    M Ryan Weil
    Program in Molecular Biophysics, Division of Cell and Molecular Biology, Southwestern Graduate School of Biomedical Science, UT Southwestern Medical Center, Dallas, Texas 75390, USA
    Genome Res 14:1374-81. 2004
    ..Using functional annotation and comparative genomic hybridization data, we have begun to decipher the possible biological implications of the relationship between chromatin accessibility and expression...
  42. ncbi request reprint Methods for detecting DNA methylation in tumors: from bench to bedside
    David S Shames
    The Hamon Center of Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX, USA
    Cancer Lett 251:187-98. 2007
    ..In this article, we review genome-wide and quantitative, high- resolution methods for methylation analysis that are used in the laboratory and clinic, and discuss their potential for use in a clinical setting...
  43. pmc Parallel assessment of CpG methylation by two-color hybridization with oligonucleotide arrays
    Robert P Balog
    Center for Biomedical Inventions, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8573, USA
    Anal Biochem 309:301-10. 2002
    ..This method provides advantages in parallelism over existing methods of methylation analysis. We have demonstrated this technique with a region from the promoter of the tumor suppressor gene p16, which is hypermethylated in many cancers...
  44. ncbi request reprint Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    Hisayuki Shigematsu
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    J Natl Cancer Inst 97:339-46. 2005
    ..However, the role of such mutations in the pathogenesis of lung cancers is unclear...
  45. pmc Cells lacking IKKα show nuclear cyclin D1 overexpression and a neoplastic phenotype: role of IKKα as a tumor suppressor
    Youn Tae Kwak
    Department of Medicine, Division of Hematology Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Mol Cancer Res 9:341-9. 2011
    ..These results suggest that IKKα may function as a tumor suppressor gene. Absence of IKKα may induce tumorigenicity by nuclear localization of cyclin D1 and modulating the expression of genes involved in neoplastic transformation...
  46. ncbi request reprint Sun exposure related methylation in malignant and non-malignant skin lesions
    Ubaradka G Sathyanarayana
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas 75390 8593, USA
    Cancer Lett 245:112-20. 2007
    ..These differences were highly significant (P<0.0001). These findings suggest that methylation commences in UV exposed skin at a relatively early age and occurs in skin prior to the onset of recognizable preneoplastic changes...
  47. pmc RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers
    Boning Gao
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390 8593, USA
    Cancer Res 68:22-5. 2008
    ..Our results warrant a large-scale study to examine the effect of the A133S polymorphism in the development of breast and other types of cancers...
  48. ncbi request reprint Involvement of AGO1 and AGO2 in mammalian transcriptional silencing
    Bethany A Janowski
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    Nat Struct Mol Biol 13:787-92. 2006
    ..Our data indicate key linkages and important mechanistic distinctions between transcriptional and post-transcriptional silencing pathways in mammalian cells...
  49. ncbi request reprint An ecological study of the association of metal air pollutants with lung cancer incidence in Texas
    Yvonne M Coyle
    Department of Internal Medicine, Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9103, USA
    J Thorac Oncol 1:654-61. 2006
    ..We conducted an ecological study to examine the association of metal air pollutants with lung cancer incidence in Texas...
  50. ncbi request reprint Silencing of HPV 18 oncoproteins With RNA interference causes growth inhibition of cervical cancer cells
    Jayanthi S Lea
    Division ofGynecologic Oncology, Hamon Center of Therapeutic Oncology Research, University ofTexas Southwestern Medical Center, Dallas, TX75390 9032, USA
    Reprod Sci 14:20-8. 2007
    ..RNA interference targeting the E7 portion of the bicistronic HPV 18 mRNA can silence both E6 and E7 oncoproteins and is most effective in cervical cancer growth inhibition...
  51. pmc An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone
    Erik A Bey
    Department of Pharmacology, Laboratory of Molecular Stress Responses, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:11832-7. 2007
    ..beta-Lapachone killed cells in a tumorselective manner and is indicated for use against NQO1+ NSCLC cancers...
  52. ncbi request reprint Synthetic lethal screen identification of chemosensitizer loci in cancer cells
    Angelique W Whitehurst
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nature 446:815-9. 2007
    ....
  53. pmc Differential methylation of a short CpG-rich sequence within exon 1 of TCF21 gene: a promising cancer biomarker assay
    Narayan Shivapurkar
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cancer Epidemiol Biomarkers Prev 17:995-1000. 2008
    ..We further showed similar applications with multiple other malignancies. Our assay might have important implications in early detection and surveillance of multiple malignancies...
  54. pmc ALK inhibition for non-small cell lung cancer: from discovery to therapy in record time
    David E Gerber
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Cancer Cell 18:548-51. 2010
    ..Such therapy "targeted" at oncogenic proteins provides "personalized" medicine and prompts genome-wide mutation analysis of human tumors to find other therapeutic targets...
  55. pmc Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy
    James P Sullivan
    Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, 75390, USA
    Cancer Metastasis Rev 29:61-72. 2010
    ....
  56. ncbi request reprint Loss of expression of death-inducing signaling complex (DISC) components in lung cancer cell lines and the influence of MYC amplification
    Narayan Shivapurkar
    Hamon Center for Therapeutic Oncology Research, Dallas, Texas, TX 75390 8593, USA
    Oncogene 21:8510-4. 2002
    ..These findings may have considerable clinical and therapeutic implications...
  57. pmc Radiogenomics predicting tumor responses to radiotherapy in lung cancer
    Amit K Das
    The University of Texas Southwestern Medical Center, The Hamon Center for Therapeutic Oncology Research, Dallas, TX 75390 8593, USA
    Semin Radiat Oncol 20:149-55. 2010
    ....
  58. ncbi request reprint Aberrant methylation of the cyclin D2 promoter in primary small cell, nonsmall cell lung and breast cancers
    Arvind Virmani
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Int J Cancer 107:341-5. 2003
    ..Our results confirm earlier reports in breast cancer and indicate that aberrant methylation of cyclin D2 may contribute to the pathogenesis of the 2 major types of lung cancers...
  59. ncbi request reprint Aberrant p16 methylation is a biomarker for tobacco exposure in cervical squamous cell carcinogenesis
    Jayanthi S Lea
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, and the Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Obstet Gynecol 190:674-9. 2004
    ..The purpose of this study was to determine the association between active tobacco exposure and aberrant p16 promoter methylation in primary cervical squamous cell cancer and high-grade squamous cervical dysplasia...
  60. pmc DNA damage intensity in fibroblasts in a 3-dimensional collagen matrix correlates with the Bragg curve energy distribution of a high LET particle
    Andres I Roig
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    Int J Radiat Biol 86:194-204. 2010
    ....
  61. ncbi request reprint Inactivation of tumor suppressor genes by promoter methylation is important in the pathogenesis of pancreatic cancer
    Jason B Fleming
    Department of Surgery, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 8593, USA
    Cancer Biol Ther 1:297-9. 2002
  62. pmc Lung cancer cell lines: Useless artifacts or invaluable tools for medical science?
    Adi F Gazdar
    UT Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Lung Cancer 68:309-18. 2010
    ..Finally the issue of cell line contamination must be addressed and safeguarded against. A full understanding of the advantages and shortcomings of cell lines is required for the investigator to derive the maximum benefit from their use...
  63. ncbi request reprint Mutations and addiction to EGFR: the Achilles 'heal' of lung cancers?
    Adi F Gazdar
    Hamon Centre for Therapeutic Oncology Research, University of Texas Southwestern Medical Centre, Dallas, TX 75390, USA
    Trends Mol Med 10:481-6. 2004
    ..Cancer cells with mutant EGFR genes might become physiologically dependent on the continued activity of the gene for the maintenance of their malignant phenotype; however, this might also be a target for therapy...
  64. pmc Inhibition of EGFR signaling: all mutations are not created equal
    Adi F Gazdar
    Hamon Center for Therapeutic Oncology Research and in the Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS Med 2:e377. 2005
  65. pmc Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene
    Narayan Shivapurkar
    Hamon Center for Therapeutic Oncology Research, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cancer Res 68:7448-56. 2008
    ..Our data constitute the first direct functional evidence for CYGB, the newest member of the globin family, as a tumor suppressor gene...
  66. pmc Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines
    Jeet Gandhi
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS ONE 4:e4576. 2009
    ..Mutations of EGFR (mEGFR) and copy number gains (CNGs) of EGFR (gEGFR) and HER2 (gHER2) have been reported to predict for TKI response. Mutations in KRAS (mKRAS) are associated with primary resistance to TKIs...
  67. ncbi request reprint Survival in small cell lung cancer is independent of tumor expression of VEGF and COX-2
    Jonathan E Dowell
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8852, USA
    Anticancer Res 24:2367-73. 2004
    ..Little is known about the frequency of tumor expression of VEGF and COX-2 in SCLC or the prognostic significance of this expression...
  68. pmc miR-93, miR-98, and miR-197 regulate expression of tumor suppressor gene FUS1
    Liqin Du
    Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390 8591, USA
    Mol Cancer Res 7:1234-43. 2009
    ..Finally, we found that elevated miR-93 and miR-197 expression is correlated with reduced Fus1 expression in NSCLC tumor specimens. These results suggest that the three miRNAs are negative regulators of Fus1 expression in lung cancers...
  69. pmc Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells
    Junichi Soh
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 4:e7464. 2009
    ..However, mutant allele specific imbalance (MASI) has been observed in tumors and cell lines harboring mutations of oncogenes...
  70. pmc Lung cancer cell lines as tools for biomedical discovery and research
    Adi F Gazdar
    University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 8593, USA
    J Natl Cancer Inst 102:1310-21. 2010
    ..However, major problems including misidentification or cell line contamination remain. Ongoing studies and new approaches are expected to reveal the full potential of the lung cancer cell line panel...
  71. pmc Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy
    Noriaki Sunaga
    Hamon Center for Therapeutic Oncology Research, Simmons Cancer Center, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Mol Cancer Ther 10:336-46. 2011
    ..Our findings suggest that targeting oncogenic KRAS by itself will not be sufficient treatment, but may offer possibilities of combining anti-KRAS strategies with other targeted drugs...
  72. pmc Characterizing the cancer genome in lung adenocarcinoma
    Barbara A Weir
    Department of Medical Oncology and Center for Cancer Genome Discovery, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 450:893-8. 2007
    ..More generally, our results indicate that many of the genes that are involved in lung adenocarcinoma remain to be discovered...
  73. pmc Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS
    Udayan Guha
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 105:14112-7. 2008
    ..Bayesian network analysis of these and other datasets revealed that PTRF might be a potentially important component of the ERBB signaling network...
  74. pmc Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo
    Lin Ji
    Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 62:2715-20. 2002
    ..3 120-kb chromosomal region may exhibit tumor suppressor activity in vitro and in vivo...
  75. pmc Predicting the future for people with lung cancer
    Yang Xie
    Nat Med 14:812-3. 2008
  76. pmc Epidermal growth factor receptor pathway analysis identifies amphiregulin as a key factor for cisplatin resistance of human breast cancer cells
    Niels Eckstein
    Stiftung Center of Advanced European Studies and Research, Ludwig Erhard Allee 2, 53175 Bonn, Germany
    J Biol Chem 283:739-50. 2008
    ..We have thus identified a novel function of amphiregulin for cisplatin resistance in human breast cancer cells...
  77. ncbi request reprint Tumor suppressor 101F6 and ascorbate synergistically and selectively inhibit non-small cell lung cancer growth by caspase-independent apoptosis and autophagy
    Shoichiro Ohtani
    Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 67:6293-303. 2007
    ....
  78. ncbi request reprint Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers
    David Chi Leung Lam
    Department of Medicine, University of Hong Kong, HKSAR, China
    Cancer Res 67:4638-47. 2007
    ..These results further implicate nicotine in bronchial carcinogenesis and suggest targeting nAChRs for prevention and therapy in lung cancer...
  79. ncbi request reprint Discovery of frequent homozygous deletions in chromosome 3p21.3 LUCA and AP20 regions in renal, lung and breast carcinomas
    Vera N Senchenko
    Microbiology and Tumor Biology Center, Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm 17177 Sweden
    Oncogene 23:5719-28. 2004
    ..Mapping of 19 HDs in the AP20 region resulted in the localization of the minimal region to the interval flanked by D3S1298 and D3S3623 markers. Only four genes were discovered in this interval, namely, APRG1, ITGA9, HYA22 and VILL...
  80. ncbi request reprint Dose effect of smoking on aberrant methylation in non-small cell lung cancers
    Shinichi Toyooka
    Int J Cancer 110:462-4. 2004
  81. pmc RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies
    Vladimir I Kashuba
    Microbiology and Tumor Biology Center and Center for Genomics and Bioinformatics, Karolinska Institute, 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 101:4906-11. 2004
    ....
  82. ncbi request reprint Loss of heterozygosity of chromosome 12p does not correlate with KRAS mutation in non-small cell lung cancer
    Mika Uchiyama
    Department of Clinical Preventive Medicine, Nagoya University School of Medicine, Tsurumai 65, Showa Ku, Nagoya 466 8560, Japan
    Int J Cancer 107:962-9. 2003
    ....
  83. ncbi request reprint A training-testing approach to the molecular classification of resected non-small cell lung cancer
    Noboru Yamagata
    Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6838, USA
    Clin Cancer Res 9:4695-704. 2003
    ....
  84. pmc Identification of novel gene expression targets for the Ras association domain family 1 (RASSF1A) tumor suppressor gene in non-small cell lung cancer and neuroblastoma
    Angelo Agathanggelou
    Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Cancer Res 63:5344-51. 2003
    ..The identified targets are involved in diverse cellular processes; this should help toward understanding mechanisms that contribute to RASSF1A biological activity...
  85. ncbi request reprint Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU in human cancers
    Angelo Agathanggelou
    Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, The Medical School, Edgbaston, Birmingham B15 2TT, UK
    Oncogene 22:1580-8. 2003
    ..Together, these data suggest a significant role for epigenetic inactivation of BLU in the pathogenesis of common human cancers and that methylation inactivation of BLU occurs independent of RASSF1A in SCLC and neuroblastoma tumours...
  86. pmc CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity
    Giovanni L Carboni
    Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Oncogene 22:615-26. 2003
    ....
  87. ncbi request reprint SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers
    Ashraf Dallol
    Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, University of Birmingham, United Kingdom
    Cancer Res 62:5874-80. 2002
    ..2...
  88. pmc MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer
    Michiho Nishioka
    National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Proc Natl Acad Sci U S A 99:12269-74. 2002
    ..These results indicate that the MYO18B gene is a strong candidate for a novel tumor suppressor gene whose inactivation is involved in lung cancer progression...
  89. ncbi request reprint Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma
    Yoshio Tomizawa
    Biology Division, Pathology Division, National Cancer Center Hospital, Tokyo 104 0045, Japan
    Clin Cancer Res 8:2362-8. 2002
    ..In this study, we investigated the pathogenetic and clinicopathological significances of RASSF1A methylation in the development and/or progression of lung adenocarcinoma...
  90. ncbi request reprint The expression of DNA methyltransferases and methyl-CpG-binding proteins is not associated with the methylation status of p14(ARF), p16(INK4a) and RASSF1A in human lung cancer cell lines
    Mitsuo Sato
    Department of Clinical Preventive Medicine, Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Oncogene 21:4822-9. 2002
    ..Our results suggest that upregulation of DNMTs and MBPs probably reflects an increased cell proliferation in human lung cancers and that there are likely to exist gene-specific mechanisms for epigenetic gene silencing...
  91. ncbi request reprint Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers
    Ashraf Dallol
    Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, The Medical School, Edgbaston, Birmingham B15 2TT, UK
    Oncogene 21:3020-8. 2002
    ..Our findings suggest that DUTT1 warrants further analysis as a candidate for the tumour suppressor gene (TSG) at 3p12, a region defined by hemi and homozygous deletions and functional analysis...
  92. ncbi request reprint Functional characterization of the candidate tumor suppressor gene NPRL2/G21 located in 3p21.3C
    Jingfeng Li
    Microbiology and Tumor Biology Center, Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, Sweden
    Cancer Res 64:6438-43. 2004
    ..This study, together with previously obtained results, indicates that NPRL2 is a multiple tumor suppressor gene...
  93. pmc Conserved transcription factor binding sites of cancer markers derived from primary lung adenocarcinoma microarrays
    Yee Leng Yap
    HKU Pasteur Research Centre Dexter H C Man Building, 8 Sassoon Road Pokfulam, Hong Kong, China
    Nucleic Acids Res 33:409-21. 2005
    ..This study searched beyond phenotypic gene expression profiles in cancer cells, in order to identify the more important regulatory transcription factors that caused these aberrations in gene expression...
  94. ncbi request reprint Establishment and expression profiling of new lung cancer cell lines from Chinese smokers and lifetime never-smokers
    David C L Lam
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong SAR, China
    J Thorac Oncol 1:932-42. 2006
    ..Lung cancer cell lines established from patients with known clinical characteristics such as gender and smoking habit would be useful for future research on lung cancer...
  95. ncbi request reprint Methylation and gene silencing of the Ras-related GTPase gene in lung and breast cancers
    Makoto Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Surg Oncol 14:1397-404. 2007
    ..Although loss of expression of RRAD in breast cancer cells has been reported and it may act as an oncogene, the mechanism of silencing is unknown...
  96. ncbi request reprint Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer
    Makoto Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Inohana, Chiba, Japan
    Cancer 106:2200-7. 2006
    ..Both genetic and epigenetic changes in nonsmall cell lung cancer (NSCLC) are known to be a common event...
  97. ncbi request reprint 3p21.3 tumor suppressor cluster: prospects for translational applications
    Lin Ji
    Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Unit 445, PO Box 301402, Houston, Texas, TX 77230 1402, USA
    Future Oncol 1:79-92. 2005
    ..3 genes for future development as biomarkers for the early detection and diagnosis of cancer, and as prognostic and therapeutic tools for cancer prevention and molecular cancer therapy...
  98. ncbi request reprint Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features
    Issan Yee San Tam
    Department of Pathology, Dental Public Health, Medicine, University of Hong Kong
    Clin Cancer Res 12:1647-53. 2006
    ..This study evaluated the mutational profile of epidermal growth factor receptor (EGFR) and KRAS in non-small cell lung cancers in Hong Kong and determined their relation with smoking history and other clinicopathologic features...
  99. ncbi request reprint Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines
    Samir E Witta
    Department of Medicine Medical Oncology, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Campus Box 8117, PO Box 6511, Aurora, CO 80045, USA
    Cancer Res 66:944-50. 2006
    ..Thus, combined HDAC inhibitor and gefitinib treatment represents a novel pharmacologic strategy for overcoming resistance to EGFR inhibitors in patients with lung cancer...
  100. ncbi request reprint The growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathway
    Anna Moshnikova
    Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908, USA
    J Biol Chem 281:8143-52. 2006
    ..Our studies suggest that association of NORE1A with cytoskeletal elements is essential for NORE1A-induced growth suppression and that the ERK pathway is a target for NORE1A growth-suppressive activities...
  101. ncbi request reprint High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor
    Nobukazu Fujimoto
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 65:11478-85. 2005
    ..Thus, lung adenocarcinoma cells that depend on EGFR for survival constitutively activate the receptor through a combination of genetic mutations and overexpression of EGFR dimeric partners and their ligands...

Research Grants13

  1. Molecular Pathology of Lung Cancer
    John Minna; Fiscal Year: 2005
    ..The group of speakers who have agreed to participate are some of the leading transdisciplinary investigators in these fields and are active in seeking to translate their findings to and from the clinic and the laboratory. ..
  2. Characterization of Human 3p Recessive Oncogenes
    John Minna; Fiscal Year: 2004
    ..The characterization of these gene(s) should ultimately have translational benefit for the development of new cancer diagnostics and therapeutics, including use in cancer early detection, prevention, and treatment. ..
  3. HUMAN 3P RECESSIVE ONCOGENES
    John Minna; Fiscal Year: 1999
    ....