Alexandra H Minn

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis
    Alexandra H Minn
    Department of Medicine, University of Wisconsin Madison, Madison, Wisconsin 53792, USA
    Endocrinology 146:2397-405. 2005
  2. ncbi Increased insulin translation from an insulin splice-variant overexpressed in diabetes, obesity, and insulin resistance
    Alexandra H Minn
    Department of Medicine, University of Wisconsin Madison, H4 526 Clinical Science Center, 600 Highland Avenue, Madison, Wisconsin 53792, USA
    Mol Endocrinol 19:794-803. 2005
  3. ncbi Gene expression profiling in INS-1 cells overexpressing thioredoxin-interacting protein
    Alexandra H Minn
    Department of Medicine, University of Wisconsin Madison, WI, USA
    Biochem Biophys Res Commun 336:770-8. 2005
  4. ncbi Exenatide blocks JAK1-STAT1 in pancreatic beta cells
    Francesca M Couto
    Department of Medicine, University of Wisconsin, Madison, WI, USA
    Metabolism 56:915-8. 2007
  5. ncbi Metabolism-independent sugar effects on gene transcription: the role of 3-O-methylglucose
    Alexandra H Minn
    Department of Medicine, University of Wisconsin, Madison, Wisconsin 53792, USA
    Biochemistry 45:11047-51. 2006
  6. ncbi Insulinomas and expression of an insulin splice variant
    Alexandra H Minn
    Department of Medicine, Endocrinology Section, University of Wisconsin Madison, Madison, WI 53792, USA
    Lancet 363:363-7. 2004
  7. ncbi Exenatide inhibits beta-cell apoptosis by decreasing thioredoxin-interacting protein
    Junqin Chen
    Department of Medicine, University of Wisconsin, Madison, WI 53792, USA
    Biochem Biophys Res Commun 346:1067-74. 2006
  8. ncbi Resistin is expressed in pancreatic islets
    Alexandra H Minn
    Endocrinology Section, Department of Medicine, University of Wisconsin, Madison, WI 53792, USA
    Biochem Biophys Res Commun 310:641-5. 2003

Collaborators

Detail Information

Publications8

  1. ncbi Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis
    Alexandra H Minn
    Department of Medicine, University of Wisconsin Madison, Madison, Wisconsin 53792, USA
    Endocrinology 146:2397-405. 2005
    ..Thus, TXNIP is a novel proapoptotic beta-cell gene elevated in insulin resistance/diabetes and up-regulated by glucose through a unique ChoRE and may link glucotoxicity and beta-cell apoptosis...
  2. ncbi Increased insulin translation from an insulin splice-variant overexpressed in diabetes, obesity, and insulin resistance
    Alexandra H Minn
    Department of Medicine, University of Wisconsin Madison, H4 526 Clinical Science Center, 600 Highland Avenue, Madison, Wisconsin 53792, USA
    Mol Endocrinol 19:794-803. 2005
    ..This raises the possibility that the mSPV may represent a compensatory beta-cell mechanism to enhance insulin biosynthesis when insulin requirements are elevated by hyperglycemia/insulin resistance...
  3. ncbi Gene expression profiling in INS-1 cells overexpressing thioredoxin-interacting protein
    Alexandra H Minn
    Department of Medicine, University of Wisconsin Madison, WI, USA
    Biochem Biophys Res Commun 336:770-8. 2005
    ..Thus, aside from regulating the cellular redox, TXNIP does modulate overall gene transcription and thereby may further enhance beta-cell death and impair insulin secretion...
  4. ncbi Exenatide blocks JAK1-STAT1 in pancreatic beta cells
    Francesca M Couto
    Department of Medicine, University of Wisconsin, Madison, WI, USA
    Metabolism 56:915-8. 2007
    ..Thus, these findings suggest that Ex-4 treatment may also be beneficial in type 1 diabetes mellitus, where it may help protect beta cells from cytokine-induced cell death by inhibiting JAK1-STAT1...
  5. ncbi Metabolism-independent sugar effects on gene transcription: the role of 3-O-methylglucose
    Alexandra H Minn
    Department of Medicine, University of Wisconsin, Madison, Wisconsin 53792, USA
    Biochemistry 45:11047-51. 2006
    ....
  6. ncbi Insulinomas and expression of an insulin splice variant
    Alexandra H Minn
    Department of Medicine, Endocrinology Section, University of Wisconsin Madison, Madison, WI 53792, USA
    Lancet 363:363-7. 2004
    ..This splice variant has increased translation efficiency in vitro and in vivo compared with native insulin mRNA. However, splice variant expression is less than 1% of native insulin mRNA in normal islets...
  7. ncbi Exenatide inhibits beta-cell apoptosis by decreasing thioredoxin-interacting protein
    Junqin Chen
    Department of Medicine, University of Wisconsin, Madison, WI 53792, USA
    Biochem Biophys Res Commun 346:1067-74. 2006
    ..Thus, Ex-4 inhibits apoptosis by reducing TXNIP expression and early initiation of Ex-4 treatment may help preserve endogenous beta-cell mass, protect against oxidative stress, and delay type 2 diabetes progression...
  8. ncbi Resistin is expressed in pancreatic islets
    Alexandra H Minn
    Endocrinology Section, Department of Medicine, University of Wisconsin, Madison, WI 53792, USA
    Biochem Biophys Res Commun 310:641-5. 2003
    ..Our results demonstrate that resistin is expressed in islets and up-regulated in insulin resistance and thereby shed new light on the role of resistin in mice and humans...