Li June Ming

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. ncbi request reprint Structure and function of "metalloantibiotics"
    Li June Ming
    Department of Chemistry and Institute for Biomolecular Science, University of South Florida, Tampa, Florida 33620 5250, USA
    Med Res Rev 23:697-762. 2003
  2. ncbi request reprint Assignment of the hyperfine-shifted 1H-NMR signals of the heme in the oxygen sensor FixL from Rhizobium meliloti
    C Bertolucci
    Department of Chemistry and Institute for Biomolecular Science, University of South Florida, 4202 East Fowler Avenue, CHE305, Tampa, FL 33620 5250, USA
    Chem Biol 3:561-6. 1996
  3. ncbi request reprint Metal binding and structure-activity relationship of the metalloantibiotic peptide bacitracin
    Li June Ming
    Department of Chemistry and Institute for Biomolecular Science, University of South Florida, 4202 Fowler Avenue, SCA400 Tampa, FL 33620 5250, USA
    J Inorg Biochem 91:46-58. 2002
  4. doi request reprint 1H NMR, mechanism, and mononuclear oxidative activity of the antibiotic metallopeptide bacitracin: the role of D-Glu-4, interaction with pyrophosphate moiety, DNA binding and cleavage, and bioactivity
    William M Tay
    Department of Chemistry and MBIG, University of South Florida, Tampa, Florida 33620 5250, USA
    J Am Chem Soc 132:5652-61. 2010
  5. ncbi request reprint Metallo-ROS in Alzheimer's disease: oxidation of neurotransmitters by CuII-beta-amyloid and neuropathology of the disease
    Giordano F Z da Silva
    Department of Chemistry and Institute for Biomolecular Science, University of South Florida, Tampa, FL 33620, USA
    Angew Chem Int Ed Engl 46:3337-41. 2007
  6. ncbi request reprint A "moonlighting" dizinc aminopeptidase from Streptomyces griseus: mechanisms for peptide hydrolysis and the 4 x 10(10)-fold acceleration of the alternative phosphodiester hydrolysis
    Altan Ercan
    Department of Chemistry and Institute for Biomolecular Science, University of South Florida, 4202 East Fowler Avenue, CHE205, Tampa, Florida 33620 5250, USA
    Biochemistry 45:13779-93. 2006
  7. doi request reprint Size-selective biocatalysis of myoglobin immobilized into a mesoporous metal-organic framework with hierarchical pore sizes
    Yao Chen
    Department of Chemistry, University of South Florida, 4202 E Fowler Avenue, Tampa, Florida 33620, United States
    Inorg Chem 51:9156-8. 2012
  8. ncbi request reprint Alzheimer's disease related copper(II)- beta-amyloid peptide exhibits phenol monooxygenase and catechol oxidase activities
    Giordano F Z da Silva
    Department of Chemistry and Institute for Biomolecular Science, University of South Florida, 4202 E Fowler Avenue, SCA400, Tampa, FL 33620 5250, USA
    Angew Chem Int Ed Engl 44:5501-4. 2005
  9. ncbi request reprint Mechanistic studies of the astacin-like Serratia metalloendopeptidase serralysin: highly active (>2000%) Co(II) and Cu(II) derivatives for further corroboration of a "metallotriad" mechanism
    Hyun Ik Park
    Department of Chemistry and Institute for Biomolecular Science, University of South Florida, Tampa 33620 5250, USA
    J Biol Inorg Chem 7:600-10. 2002
  10. ncbi request reprint Paramagnetic cobalt(II) as a probe for kinetic and NMR relaxation studies of phosphate binding and the catalytic mechanism of Streptomyces dinuclear aminopeptidase
    Michael N Harris
    Department of Chemistry and Institute for Biomolecular Science, University of South Florida, 4202 Fowler Avenue, Tampa, FL 33620 5250, USA
    Inorg Chem 41:5582-8. 2002

Collaborators

  • Yao Chen
  • Yong Ye
  • Randy W Larsen
  • Le Wang
  • G Gonzalez
  • M A Gilles-Gonzalez
  • Giordano F Z da Silva
  • William M Tay
  • Altan Ercan
  • William Maung Tay
  • Vasiliki Lykourinou
  • Alaa Hashim
  • Hyun Ik Park
  • Michael N Harris
  • Xi Sen Wang
  • Le Meng
  • Shengqian Ma
  • Yufen Zhao
  • Tran Hoang
  • Kashmir Juneja
  • Ronald L Musselman
  • Jon D Epperson
  • Steven H Grossman
  • Alexander Angerhofer
  • Ahmed I Hanafy
  • Craig M Bertolucci
  • C Bertolucci

Detail Information

Publications18

  1. ncbi request reprint Structure and function of "metalloantibiotics"
    Li June Ming
    Department of Chemistry and Institute for Biomolecular Science, University of South Florida, Tampa, Florida 33620 5250, USA
    Med Res Rev 23:697-762. 2003
    ..quot;..
  2. ncbi request reprint Assignment of the hyperfine-shifted 1H-NMR signals of the heme in the oxygen sensor FixL from Rhizobium meliloti
    C Bertolucci
    Department of Chemistry and Institute for Biomolecular Science, University of South Florida, 4202 East Fowler Avenue, CHE305, Tampa, FL 33620 5250, USA
    Chem Biol 3:561-6. 1996
    ..We set out to investigate the spin-state of the FixL heme and to identify the hyperfine-shifted heme-proton signals by NMR spectroscopy...
  3. ncbi request reprint Metal binding and structure-activity relationship of the metalloantibiotic peptide bacitracin
    Li June Ming
    Department of Chemistry and Institute for Biomolecular Science, University of South Florida, 4202 Fowler Avenue, SCA400 Tampa, FL 33620 5250, USA
    J Inorg Biochem 91:46-58. 2002
    ....
  4. doi request reprint 1H NMR, mechanism, and mononuclear oxidative activity of the antibiotic metallopeptide bacitracin: the role of D-Glu-4, interaction with pyrophosphate moiety, DNA binding and cleavage, and bioactivity
    William M Tay
    Department of Chemistry and MBIG, University of South Florida, Tampa, Florida 33620 5250, USA
    J Am Chem Soc 132:5652-61. 2010
    ..The binding of pyrophosphate moiety to metallobacitracin, the detachment of d-Glu-4, and the significant oxidative activity of Cu(II)-Bc provide further insights into the bioactivity of this metallopeptide and Cu-oxygen chemistry...
  5. ncbi request reprint Metallo-ROS in Alzheimer's disease: oxidation of neurotransmitters by CuII-beta-amyloid and neuropathology of the disease
    Giordano F Z da Silva
    Department of Chemistry and Institute for Biomolecular Science, University of South Florida, Tampa, FL 33620, USA
    Angew Chem Int Ed Engl 46:3337-41. 2007
  6. ncbi request reprint A "moonlighting" dizinc aminopeptidase from Streptomyces griseus: mechanisms for peptide hydrolysis and the 4 x 10(10)-fold acceleration of the alternative phosphodiester hydrolysis
    Altan Ercan
    Department of Chemistry and Institute for Biomolecular Science, University of South Florida, 4202 East Fowler Avenue, CHE205, Tampa, Florida 33620 5250, USA
    Biochemistry 45:13779-93. 2006
    ..A better understanding of enzyme catalytic promiscuity is also expected to shed light on the evolution and action of enzymes...
  7. doi request reprint Size-selective biocatalysis of myoglobin immobilized into a mesoporous metal-organic framework with hierarchical pore sizes
    Yao Chen
    Department of Chemistry, University of South Florida, 4202 E Fowler Avenue, Tampa, Florida 33620, United States
    Inorg Chem 51:9156-8. 2012
    ....
  8. ncbi request reprint Alzheimer's disease related copper(II)- beta-amyloid peptide exhibits phenol monooxygenase and catechol oxidase activities
    Giordano F Z da Silva
    Department of Chemistry and Institute for Biomolecular Science, University of South Florida, 4202 E Fowler Avenue, SCA400, Tampa, FL 33620 5250, USA
    Angew Chem Int Ed Engl 44:5501-4. 2005
  9. ncbi request reprint Mechanistic studies of the astacin-like Serratia metalloendopeptidase serralysin: highly active (>2000%) Co(II) and Cu(II) derivatives for further corroboration of a "metallotriad" mechanism
    Hyun Ik Park
    Department of Chemistry and Institute for Biomolecular Science, University of South Florida, Tampa 33620 5250, USA
    J Biol Inorg Chem 7:600-10. 2002
    ....
  10. ncbi request reprint Paramagnetic cobalt(II) as a probe for kinetic and NMR relaxation studies of phosphate binding and the catalytic mechanism of Streptomyces dinuclear aminopeptidase
    Michael N Harris
    Department of Chemistry and Institute for Biomolecular Science, University of South Florida, 4202 Fowler Avenue, Tampa, FL 33620 5250, USA
    Inorg Chem 41:5582-8. 2002
    ..These results strongly support that the phosphate binding site is Arg202 and that this residue plays an important role in the action of sAP...
  11. doi request reprint How can proteins enter the interior of a MOF? Investigation of cytochrome c translocation into a MOF consisting of mesoporous cages with microporous windows
    Yao Chen
    Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, Florida 33620, USA
    J Am Chem Soc 134:13188-91. 2012
    ..Mechanistic studies suggest that the Cyt c molecules must undergo a significant conformational change during translocation into the MOF interior through the relatively small nanopores...
  12. doi request reprint A plausible role of salivary copper in antimicrobial activity of histatin-5--metal binding and oxidative activity of its copper complex
    William M Tay
    Department of Chemistry and MBIG, University of South Florida, Tampa, FL 33620 5250, USA
    Bioorg Med Chem Lett 19:6709-12. 2009
    ..011 and 0.060 s(-1) and k(cat)/K(m)=19 and 50 M(-1)s(-1) without and with 12.8mM H(2)O(2), respectively). The significant oxidative activity may contribute to the biological activity of this antibiotic metallopeptide...
  13. ncbi request reprint Catechol oxidase activity of di-Cu2+-substituted aminopeptidase from Streptomyces griseus
    Giordano F Z da Silva
    Department of Chemistry and Institute for Biomolecular Science, University of South Florida, 4202 East Fowler Avenue, Tampa, Florida 33620 525, USA
    J Am Chem Soc 127:16380-1. 2005
    ..The multifunctionality of this enzyme suggests that it is a unique system for further exploration of protein structure and function and a template for design of enzymes of diverse activities...
  14. doi request reprint Metal binding of flavonoids and their distinct inhibition mechanisms toward the oxidation activity of Cu2+-β-amyloid: not just serving as suicide antioxidants!
    William Maung Tay
    Department of Chemistry, University of South Florida, Tampa, Florida 33620 5250, United States
    Inorg Chem 52:679-90. 2013
    ....
  15. doi request reprint Mechanistic role of each metal ion in Streptomyces dinuclear aminopeptidase: PEPTIDE hydrolysis and 7x10(10)-fold rate enhancement of phosphodiester hydrolysis
    Altan Ercan
    Department of Chemistry and Institute for Biomolecular Science, University of South Florida, 4202 E Fowler Avenue, CHE205, Tampa, FL 33620 5250, USA
    J Inorg Biochem 104:19-29. 2010
    ....
  16. ncbi request reprint Catechol oxidase-like oxidation chemistry of the 1-20 and 1-16 fragments of Alzheimer's disease-related beta-amyloid peptide: their structure-activity correlation and the fate of hydrogen peroxide
    Giordano F Z da Silva
    Department of Chemistry and Institute for Biomolecular Science, University of South Florida, Tampa, Florida 33620 5250, USA
    J Biol Chem 280:16601-9. 2005
    ..The results presented here are expected to add further insight into the chemistry of metallo-Abeta, which may assist better understanding of the neuropathology of Alzheimer's disease...
  17. doi request reprint Immobilization of MP-11 into a mesoporous metal-organic framework, MP-11@mesoMOF: a new platform for enzymatic catalysis
    Vasiliki Lykourinou
    Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, Florida 33620, USA
    J Am Chem Soc 133:10382-5. 2011
    ....
  18. doi request reprint Vitamin B6s inhibit oxidative stress caused by Alzheimer's disease-related Cu(II)-β-amyloid complexes-cooperative action of phospho-moiety
    Alaa Hashim
    Department of Chemistry, University of South Florida, 4202 E Fowler Ave, Tampa, FL 33612, USA
    Bioorg Med Chem Lett 21:6430-2. 2011
    ..4, 8.3, 1.2, and 0.2mM, respectively. The phospho-moiety in PLP seems to exhibit cooperative inhibition, affording a clue for future design of inhibitors...