Research Topics
| Arpi MinassianSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
The quantitative assessment of motor activity in mania and schizophreniaArpi Minassian
University of California, Department of Psychiatry, San Diego, CA, USA
J Affect Disord 120:200-6. 2010..We used an ambulatory monitoring device to quantify motor activity in BD and schizophrenia (SCZ) patients in a novel exploratory paradigm, the human Behavioral Pattern Monitor (BPM)...
Adults with autism show increased sensitivity to outcomes at low error rates during decision-makingArpi Minassian
Department of Psychiatry, University of California, San Diego, 200 West Arbor Drive, Mailcode 8620, San Diego, CA 92103 8620, USA
J Autism Dev Disord 37:1279-88. 2007..Thus, behavioral paradigms that provide frequent reinforcement may be helpful in modifying decision-making abilities in AD...- The relationship between sensorimotor gating and clinical improvement in acutely ill schizophrenia patientsArpi Minassian
Department of Psychiatry, University of California, San Diego School of Medicine, USA
Schizophr Res 89:225-31. 2007..Our results suggest that PPI can be improved by short-term treatment, and that improvement in sensorimotor gating is associated with treatment-related improvement of symptoms of schizophrenia... - Visual scanning deficits in schizophrenia and their relationship to executive functioning impairmentArpi Minassian
Department of Psychiatry, University of California San Diego, 200 West Arbor Drive, Mailcode 8620, San Diego, CA 92103 8620, USA
Schizophr Res 74:69-79. 2005.... - Repeated assessment of exploration and novelty seeking in the human behavioral pattern monitor in bipolar disorder patients and healthy individualsArpi Minassian
Department of Psychiatry, University of California San Diego, San Diego, California, United States of America
PLoS ONE 6:e24185. 2011..The objective of this study was to assess the sensitivity of the hBPM to changes in manic symptoms, a necessary step towards elucidating the neurobiology underlying BD... - Increased sensitivity to error during decision-making in bipolar disorder patients with acute maniaArpi Minassian
Department of Psychiatry, University of California San Diego, 200 West Arbor Drive, Mailcode 8620, San Diego, CA 92103 8620, USA
J Affect Disord 82:203-8. 2004..In this study we examined whether BD patients with psychotic mania show altered patterns of decision-making as a function of the frequency of incorrect predictions or error rate... - Pupillary dilation to simple vs. complex tasks and its relationship to thought disturbance in schizophrenia patientsArpi Minassian
Department of Psychiatry, University of California, 200 West Arbor Drive, Mailcode 8620, San Diego, CA 92103 8620, USA
Int J Psychophysiol 52:53-62. 2004..These findings support the 'resource limitations hypothesis' of schizophrenia and underscore the utility of a simultaneous paradigm when studying the relationship between attentional deficits and thought disturbance... - The category test perseveration, loss of set, and memory scales: three new scales and their relationship to executive functioning measuresArpi Minassian
Department of Psychiatry, University of California, San Diego 92103 8620, USA
Assessment 10:213-21. 2003..Although future studies designed to test discriminant and convergent validity are warranted, these scales may be useful in determining specific aspects of impaired CT performance... 
A naturalistic study of intramuscular haloperidol versus intramuscular olanzapine for the management of acute agitationKai MacDonald
Department of Psychiatry, University of California, San Diego, CA 92093 0804, USA
J Clin Psychopharmacol 32:317-22. 2012..Therefore, we conducted a retrospective chart review to compare IM olanzapine and haloperidol in a "real-world" population with agitation...- A reverse-translational study of dysfunctional exploration in psychiatric disorders: from mice to menWilliam Perry
Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, MC 0804, La Jolla, CA 92093 0804, USA
Arch Gen Psychiatry 66:1072-80. 2009..Exploration is fundamental to survival and is dysregulated in these 2 disorders. Although exploratory behavior in rodents has been widely studied, surprisingly little work has examined this critical function in humans... - Adjunctive intranasal oxytocin improves verbal memory in people with schizophreniaDavid Feifel
Department of Psychiatry, University of California, San Diego, United States
Schizophr Res 139:207-10. 2012..Oxytocin - though it has shown promise as a novel antipsychotic in multiple clinical trials - has as-yet poorly characterized effects on cognition, with some evidence indicating an amnestic profile... - Cross-species assessments of motor and exploratory behavior related to bipolar disorderBrook L Henry
University of California San Diego, Department of Psychiatry, La Jolla, CA, USA
Neurosci Biobehav Rev 34:1296-306. 2010.... - The mania-like exploratory profile in genetic dopamine transporter mouse models is diminished in a familiar environment and reinstated by subthreshold psychostimulant administrationJared W Young
Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA 92093 0804, United States
Pharmacol Biochem Behav 96:7-15. 2010..These mice may provide a model of BD from mania to euthymia and back again with stimulant treatment. Acute blockade of the DAT by GBR 12909 however, may provide a consistent model for BD mania... - GBR 12909 administration as a mouse model of bipolar disorder mania: mimicking quantitative assessment of manic behaviorJared W Young
Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA 92093 0804, USA
Psychopharmacology (Berl) 208:443-54. 2010.... - Prepulse inhibition of startle in adults with ADHDDavid Feifel
University of California San Diego, School of Medicine, Department of Psychiatry, San Diego, CA 92103 8218, USA
J Psychiatr Res 43:484-9. 2009..This distinction may be related to a relative sparing of pre-conscious attentional functions in ADHD compared to other disorders with PPI impairment... - Olanzapine in ED patients: differential effects on oxygenation in patients with alcohol intoxicationMichael P Wilson
Department of Emergency Medicine, UC San Diego Health System, San Diego, CA 92103, USA
Am J Emerg Med 30:1196-201. 2012..Use of SGAs such as olanzapine in alcohol-intoxicated (ETOH+) patients or with benzodiazepines is not well studied and may be associated with vital sign abnormalities... - Information processing deficits in acutely psychotic schizophrenia patients medicated and unmedicated at the time of admissionWilliam Perry
Neuropsychiatry and Behavioral Medicine Service, Department of Psychiatry, University of California San Diego, La Jolla 92093 8620, USA
Am J Psychiatry 159:1375-81. 2002..The present study investigated the effects of antipsychotics on prepulse inhibition and startle habituation in acutely hospitalized patients with schizophrenia... - Heart rate variability in bipolar mania and schizophreniaBrook L Henry
University of California San Diego, Department of Psychiatry, La Jolla, CA 92103 0851, United States
J Psychiatr Res 44:168-76. 2010..We recorded cardiac activity and assessed HRV in acutely hospitalized manic bipolar (BD) and schizophrenia (SCZ) patients compared to age- and gender-matched healthy comparison (HC) subjects... - A reverse-translational approach to bipolar disorder: rodent and human studies in the Behavioral Pattern MonitorJared W Young
University of California San Diego, Department of Psychiatry, 9500 Gilman Dr, La Jolla, CA 92093 0603, USA
Neurosci Biobehav Rev 31:882-96. 2007..This unique approach to modeling BD provides an opportunity to identify the neurobiology underlying BD mania and test novel antimanic agents... - Intact visual latent inhibition in schizophrenia patients in a within-subject paradigmNeal R Swerdlow
Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
Schizophr Res 72:169-83. 2005..LI deficits in schizophrenia may be paradigm-specific and are not detected by a paradigm that we previously reported to be sensitive to disruption by dopamine agonists... - Sensorimotor gating deficits in adults with autismWilliam Perry
Department of Psychiatry, University of California, San Diego, California, USA
Biol Psychiatry 61:482-6. 2007..Adults with autistic disorder (AD) exhibit clinical features of inhibitory deficits, such as restrictive and repetitive behaviors, that may be explained by deficits in sensorimotor gating... - Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patientsDavid Feifel
Department of Psychiatry, University of California, San Diego Medical Center, San Diego, California 92103 8218, USA
Biol Psychiatry 68:678-80. 2010..Both human and animal studies suggest oxytocin may have antipsychotic properties. Therefore, we conducted a clinical trial to directly test this notion... - Effect of methamphetamine dependence on inhibitory deficits in a novel human open-field paradigmBrook L Henry
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
Psychopharmacology (Berl) 215:697-707. 2011..Previous work demonstrated that manic bipolar subjects exhibit a disinhibited pattern of behavior in the hBPM characterized by increased object interactions... - A retrospective analysis of intramuscular haloperidol and intramuscular olanzapine in the treatment of agitation in drug- and alcohol-using patientsKai MacDonald
Department of Psychiatry, University of California, San Diego, San Diego, CA 92093, USA
Gen Hosp Psychiatry 32:443-5. 2010..The treatment of agitation in drug- and alcohol-using emergency patients is understudied... - Behavioral effects of chronic methamphetamine treatment in HIV-1 gp120 transgenic miceBrook L Henry
Department of Psychiatry, University of California San Diego, La Jolla, CA 92103 8620, United States
Behav Brain Res 236:210-20. 2013..These findings illustrate the need to improve our knowledge about the combined effects of HIV and substance use and facilitate improved treatment methods for comorbid disease and drug dependence... - Effect of methamphetamine dependence on heart rate variabilityBrook L Henry
Department of Psychiatry, University of California San Diego, USA
Addict Biol 17:648-58. 2012..We discuss and review evidence that impaired HRV may be related to the cardiotoxic or neurotoxic effects of prolonged METH use... - Prepulse inhibition in patients with non-psychotic major depressive disorderWilliam Perry
Department of Psychiatry, University of California San Diego, 200 West Arbor Drive, Mailcode 8218, San Diego, CA 92103 8218, USA
J Affect Disord 81:179-84. 2004..Therefore, we assessed PPI in non-psychotic MDD patients and compared their results to schizophrenia patients and non-patients... - Effect of methamphetamine dependence on everyday functional abilityBrook L Henry
University of California San Diego, Department of Psychiatry, La Jolla, CA, United States
Addict Behav 35:593-8. 2010..We assessed the effect of METH dependence on everyday functioning using the UCSD Performance-Based Skills Assessment (UPSA-2), a performance-based measure designed to evaluate real-life skills... - Effects of chronic, heavy cannabis use on executive functionsRebecca D Crean
Committee on the Neurobiology of Addictive Disorders The Scripps Research Institute La Jolla, CA, 92037, USA
J Addict Med 5:9-15. 2011..It should be of particular interest to clinicians who work with people with cannabis use disorders... - The use of the Ego Impairment Index across the schizophrenia spectrumWilliam Perry
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 8620, USA
J Pers Assess 80:50-7. 2003.... - Evaluation of the clinical efficacy of asenapine in schizophreniaArpi Minassian
University of California San Diego, Department of Psychiatry, La Jolla, California 92093 0804, USA
Expert Opin Pharmacother 11:2107-15. 2010..Sublingual administration may have positive and negative effects on patient compliance. Potential 'pro-cognitive' effects of asenapine are preliminary and require more investigation... - Quantifying over-activity in bipolar and schizophrenia patients in a human open field paradigmWilliam Perry
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 8218, USA
Psychiatry Res 178:84-91. 2010..The current study extends our methodology for quantifying exploration and over-activity in a controlled laboratory setting and aids in assessing the overlap and distinguishing characteristics of BD and SCZ... - Reduction of suboptimal prescribing and clinical outcome for dementia patients in a senior behavioral health inpatient unitVirginia T Chan
Department of Psychiatry, University of California, San Diego, CA 92103 8631, USA
Int Psychogeriatr 21:195-9. 2009.... - Stability of attention deficits in schizophreniaJosette G Harris
University of Colorado School of Medicine, Department of Psychiatry, C268 71, 4200 E 9th Avenue, Denver, CO 80262, United States
Schizophr Res 91:107-11. 2007..Attention and concentration were significantly enhanced after two weeks in the previously unmedicated group. However, improvement failed to reach the level of performance of comparison subjects... - A process approach to verbal fluency in patients with schizophreniaLeeza M Maron
Schizophr Res 68:105-6. 2004