Arpi Minassian

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Prepulse inhibition in HIV-associated neurocognitive disorders
    Arpi Minassian
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92103 8620, USA
    J Int Neuropsychol Soc 19:709-17. 2013
  2. pmc The relationship between sensorimotor gating and clinical improvement in acutely ill schizophrenia patients
    Arpi Minassian
    Department of Psychiatry, University of California, San Diego School of Medicine, USA
    Schizophr Res 89:225-31. 2007
  3. pmc The quantitative assessment of motor activity in mania and schizophrenia
    Arpi Minassian
    University of California, Department of Psychiatry, San Diego, CA, USA
    J Affect Disord 120:200-6. 2010
  4. ncbi request reprint Adults with autism show increased sensitivity to outcomes at low error rates during decision-making
    Arpi Minassian
    Department of Psychiatry, University of California, San Diego, 200 West Arbor Drive, Mailcode 8620, San Diego, CA 92103 8620, USA
    J Autism Dev Disord 37:1279-88. 2007
  5. pmc Repeated assessment of exploration and novelty seeking in the human behavioral pattern monitor in bipolar disorder patients and healthy individuals
    Arpi Minassian
    Department of Psychiatry, University of California San Diego, San Diego, California, United States of America
    PLoS ONE 6:e24185. 2011
  6. ncbi request reprint Visual scanning deficits in schizophrenia and their relationship to executive functioning impairment
    Arpi Minassian
    Department of Psychiatry, University of California San Diego, 200 West Arbor Drive, Mailcode 8620, San Diego, CA 92103 8620, USA
    Schizophr Res 74:69-79. 2005
  7. ncbi request reprint Increased sensitivity to error during decision-making in bipolar disorder patients with acute mania
    Arpi Minassian
    Department of Psychiatry, University of California San Diego, 200 West Arbor Drive, Mailcode 8620, San Diego, CA 92103 8620, USA
    J Affect Disord 82:203-8. 2004
  8. ncbi request reprint Pupillary dilation to simple vs. complex tasks and its relationship to thought disturbance in schizophrenia patients
    Arpi Minassian
    Department of Psychiatry, University of California, 200 West Arbor Drive, Mailcode 8620, San Diego, CA 92103 8620, USA
    Int J Psychophysiol 52:53-62. 2004
  9. ncbi request reprint The category test perseveration, loss of set, and memory scales: three new scales and their relationship to executive functioning measures
    Arpi Minassian
    Department of Psychiatry, University of California, San Diego 92103 8620, USA
    Assessment 10:213-21. 2003
  10. doi request reprint A naturalistic study of intramuscular haloperidol versus intramuscular olanzapine for the management of acute agitation
    Kai MacDonald
    Department of Psychiatry, University of California, San Diego, CA 92093 0804, USA
    J Clin Psychopharmacol 32:317-22. 2012

Detail Information

Publications45

  1. pmc Prepulse inhibition in HIV-associated neurocognitive disorders
    Arpi Minassian
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92103 8620, USA
    J Int Neuropsychol Soc 19:709-17. 2013
    ..Subsequent research on the role of sensorimotor gating on decision-making and risk behaviors in HIV may be indicated...
  2. pmc The relationship between sensorimotor gating and clinical improvement in acutely ill schizophrenia patients
    Arpi Minassian
    Department of Psychiatry, University of California, San Diego School of Medicine, USA
    Schizophr Res 89:225-31. 2007
    ..Our results suggest that PPI can be improved by short-term treatment, and that improvement in sensorimotor gating is associated with treatment-related improvement of symptoms of schizophrenia...
  3. pmc The quantitative assessment of motor activity in mania and schizophrenia
    Arpi Minassian
    University of California, Department of Psychiatry, San Diego, CA, USA
    J Affect Disord 120:200-6. 2010
    ..We used an ambulatory monitoring device to quantify motor activity in BD and schizophrenia (SCZ) patients in a novel exploratory paradigm, the human Behavioral Pattern Monitor (BPM)...
  4. ncbi request reprint Adults with autism show increased sensitivity to outcomes at low error rates during decision-making
    Arpi Minassian
    Department of Psychiatry, University of California, San Diego, 200 West Arbor Drive, Mailcode 8620, San Diego, CA 92103 8620, USA
    J Autism Dev Disord 37:1279-88. 2007
    ..Thus, behavioral paradigms that provide frequent reinforcement may be helpful in modifying decision-making abilities in AD...
  5. pmc Repeated assessment of exploration and novelty seeking in the human behavioral pattern monitor in bipolar disorder patients and healthy individuals
    Arpi Minassian
    Department of Psychiatry, University of California San Diego, San Diego, California, United States of America
    PLoS ONE 6:e24185. 2011
    ..The objective of this study was to assess the sensitivity of the hBPM to changes in manic symptoms, a necessary step towards elucidating the neurobiology underlying BD...
  6. ncbi request reprint Visual scanning deficits in schizophrenia and their relationship to executive functioning impairment
    Arpi Minassian
    Department of Psychiatry, University of California San Diego, 200 West Arbor Drive, Mailcode 8620, San Diego, CA 92103 8620, USA
    Schizophr Res 74:69-79. 2005
    ....
  7. ncbi request reprint Increased sensitivity to error during decision-making in bipolar disorder patients with acute mania
    Arpi Minassian
    Department of Psychiatry, University of California San Diego, 200 West Arbor Drive, Mailcode 8620, San Diego, CA 92103 8620, USA
    J Affect Disord 82:203-8. 2004
    ..In this study we examined whether BD patients with psychotic mania show altered patterns of decision-making as a function of the frequency of incorrect predictions or error rate...
  8. ncbi request reprint Pupillary dilation to simple vs. complex tasks and its relationship to thought disturbance in schizophrenia patients
    Arpi Minassian
    Department of Psychiatry, University of California, 200 West Arbor Drive, Mailcode 8620, San Diego, CA 92103 8620, USA
    Int J Psychophysiol 52:53-62. 2004
    ..These findings support the 'resource limitations hypothesis' of schizophrenia and underscore the utility of a simultaneous paradigm when studying the relationship between attentional deficits and thought disturbance...
  9. ncbi request reprint The category test perseveration, loss of set, and memory scales: three new scales and their relationship to executive functioning measures
    Arpi Minassian
    Department of Psychiatry, University of California, San Diego 92103 8620, USA
    Assessment 10:213-21. 2003
    ..Although future studies designed to test discriminant and convergent validity are warranted, these scales may be useful in determining specific aspects of impaired CT performance...
  10. doi request reprint A naturalistic study of intramuscular haloperidol versus intramuscular olanzapine for the management of acute agitation
    Kai MacDonald
    Department of Psychiatry, University of California, San Diego, CA 92093 0804, USA
    J Clin Psychopharmacol 32:317-22. 2012
    ..Therefore, we conducted a retrospective chart review to compare IM olanzapine and haloperidol in a "real-world" population with agitation...
  11. pmc A reverse-translational study of dysfunctional exploration in psychiatric disorders: from mice to men
    William Perry
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, MC 0804, La Jolla, CA 92093 0804, USA
    Arch Gen Psychiatry 66:1072-80. 2009
    ..Exploration is fundamental to survival and is dysregulated in these 2 disorders. Although exploratory behavior in rodents has been widely studied, surprisingly little work has examined this critical function in humans...
  12. pmc Prepulse inhibition of startle in adults with ADHD
    David Feifel
    University of California San Diego, School of Medicine, Department of Psychiatry, San Diego, CA 92103 8218, USA
    J Psychiatr Res 43:484-9. 2009
    ..This distinction may be related to a relative sparing of pre-conscious attentional functions in ADHD compared to other disorders with PPI impairment...
  13. doi request reprint Adjunctive intranasal oxytocin improves verbal memory in people with schizophrenia
    David Feifel
    Department of Psychiatry, University of California, San Diego, United States
    Schizophr Res 139:207-10. 2012
    ..Oxytocin - though it has shown promise as a novel antipsychotic in multiple clinical trials - has as-yet poorly characterized effects on cognition, with some evidence indicating an amnestic profile...
  14. pmc Behavioral effects of chronic methamphetamine treatment in HIV-1 gp120 transgenic mice
    Brook L Henry
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92103 8620, United States
    Behav Brain Res 236:210-20. 2013
    ..These findings illustrate the need to improve our knowledge about the combined effects of HIV and substance use and facilitate improved treatment methods for comorbid disease and drug dependence...
  15. pmc GBR 12909 administration as a mouse model of bipolar disorder mania: mimicking quantitative assessment of manic behavior
    Jared W Young
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 208:443-54. 2010
    ....
  16. pmc The mania-like exploratory profile in genetic dopamine transporter mouse models is diminished in a familiar environment and reinstated by subthreshold psychostimulant administration
    Jared W Young
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA 92093 0804, United States
    Pharmacol Biochem Behav 96:7-15. 2010
    ..These mice may provide a model of BD from mania to euthymia and back again with stimulant treatment. Acute blockade of the DAT by GBR 12909 however, may provide a consistent model for BD mania...
  17. pmc Cross-species assessments of motor and exploratory behavior related to bipolar disorder
    Brook L Henry
    University of California San Diego, Department of Psychiatry, La Jolla, CA, USA
    Neurosci Biobehav Rev 34:1296-306. 2010
    ....
  18. pmc Quantifying over-activity in bipolar and schizophrenia patients in a human open field paradigm
    William Perry
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 8218, USA
    Psychiatry Res 178:84-91. 2010
    ..The current study extends our methodology for quantifying exploration and over-activity in a controlled laboratory setting and aids in assessing the overlap and distinguishing characteristics of BD and SCZ...
  19. doi request reprint Olanzapine in ED patients: differential effects on oxygenation in patients with alcohol intoxication
    Michael P Wilson
    Department of Emergency Medicine, UC San Diego Health System, San Diego, CA 92103, USA
    Am J Emerg Med 30:1196-201. 2012
    ..Use of SGAs such as olanzapine in alcohol-intoxicated (ETOH+) patients or with benzodiazepines is not well studied and may be associated with vital sign abnormalities...
  20. pmc Heart rate variability in bipolar mania and schizophrenia
    Brook L Henry
    University of California San Diego, Department of Psychiatry, La Jolla, CA 92103 0851, United States
    J Psychiatr Res 44:168-76. 2010
    ..We recorded cardiac activity and assessed HRV in acutely hospitalized manic bipolar (BD) and schizophrenia (SCZ) patients compared to age- and gender-matched healthy comparison (HC) subjects...
  21. ncbi request reprint Intact visual latent inhibition in schizophrenia patients in a within-subject paradigm
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Schizophr Res 72:169-83. 2005
    ..LI deficits in schizophrenia may be paradigm-specific and are not detected by a paradigm that we previously reported to be sensitive to disruption by dopamine agonists...
  22. ncbi request reprint Information processing deficits in acutely psychotic schizophrenia patients medicated and unmedicated at the time of admission
    William Perry
    Neuropsychiatry and Behavioral Medicine Service, Department of Psychiatry, University of California San Diego, La Jolla 92093 8620, USA
    Am J Psychiatry 159:1375-81. 2002
    ..The present study investigated the effects of antipsychotics on prepulse inhibition and startle habituation in acutely hospitalized patients with schizophrenia...
  23. ncbi request reprint Sensorimotor gating deficits in adults with autism
    William Perry
    Department of Psychiatry, University of California, San Diego, California, USA
    Biol Psychiatry 61:482-6. 2007
    ..Adults with autistic disorder (AD) exhibit clinical features of inhibitory deficits, such as restrictive and repetitive behaviors, that may be explained by deficits in sensorimotor gating...
  24. pmc A reverse-translational approach to bipolar disorder: rodent and human studies in the Behavioral Pattern Monitor
    Jared W Young
    University of California San Diego, Department of Psychiatry, 9500 Gilman Dr, La Jolla, CA 92093 0603, USA
    Neurosci Biobehav Rev 31:882-96. 2007
    ..This unique approach to modeling BD provides an opportunity to identify the neurobiology underlying BD mania and test novel antimanic agents...
  25. pmc Inhibitory deficits in euthymic bipolar disorder patients assessed in the human behavioral pattern monitor
    Brook L Henry
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA
    J Affect Disord 150:948-54. 2013
    ..The objective of this study was to determine if euthymic BD individuals demonstrate inhibitory deficits in the hBPM, supporting disinhibition as an endophenotype for the disorder...
  26. doi request reprint Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patients
    David Feifel
    Department of Psychiatry, University of California, San Diego Medical Center, San Diego, California 92103 8218, USA
    Biol Psychiatry 68:678-80. 2010
    ..Both human and animal studies suggest oxytocin may have antipsychotic properties. Therefore, we conducted a clinical trial to directly test this notion...
  27. doi request reprint A retrospective analysis of intramuscular haloperidol and intramuscular olanzapine in the treatment of agitation in drug- and alcohol-using patients
    Kai MacDonald
    Department of Psychiatry, University of California, San Diego, San Diego, CA 92093, USA
    Gen Hosp Psychiatry 32:443-5. 2010
    ..The treatment of agitation in drug- and alcohol-using emergency patients is understudied...
  28. pmc Effect of methamphetamine dependence on inhibitory deficits in a novel human open-field paradigm
    Brook L Henry
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Psychopharmacology (Berl) 215:697-707. 2011
    ..Previous work demonstrated that manic bipolar subjects exhibit a disinhibited pattern of behavior in the hBPM characterized by increased object interactions...
  29. pmc Further evidence for ClockΔ19 mice as a model for bipolar disorder mania using cross-species tests of exploration and sensorimotor gating
    Jordy van Enkhuizen
    Department of Psychiatry, University of California, San Diego UCSD, 9500 Gilman Drive MC 0804, La Jolla, CA 92093 0804, United States
    Behav Brain Res 249:44-54. 2013
    ..Future studies will extend the characterization of these mice in measures with cross-species translational relevance to human testing...
  30. ncbi request reprint Frequent emergency department visits are more prevalent in psychiatric, alcohol abuse, and dual diagnosis conditions than in chronic viral illnesses such as hepatitis and human immunodeficiency virus
    Arpi Minassian
    Department of Psychiatry, University of California San Diego, San Diego, California Center of Excellence for Stress and Mental Health CESAMH, Veteran s Administration, San Diego, California
    J Emerg Med 45:520-5. 2013
    ..The illness features of frequent visitors have not been well defined, though chronic medical and psychiatric illness and substance abuse are implicated...
  31. pmc Prepulse inhibition in HIV-1 gp120 transgenic mice after withdrawal from chronic methamphetamine
    Brook L Henry
    aDepartment of Psychiatry, University of California, San Diego bResearch Service, VA San Diego Healthcare System cCenter of Excellence for Stress and Mental Health, CESAMH, Veteran s Administration, San Diego, California, USA
    Behav Pharmacol 25:12-22. 2014
    ..In summary, PPI impairment in HIV could depend on factors such as sex, whereas changes in PPI following METH withdrawal may depend on the quantity and duration of drug exposure. ..
  32. pmc Effect of methamphetamine dependence on heart rate variability
    Brook L Henry
    Department of Psychiatry, University of California San Diego, USA
    Addict Biol 17:648-58. 2012
    ..We discuss and review evidence that impaired HRV may be related to the cardiotoxic or neurotoxic effects of prolonged METH use...
  33. pmc Effect of methamphetamine dependence on everyday functional ability
    Brook L Henry
    University of California San Diego, Department of Psychiatry, La Jolla, CA, United States
    Addict Behav 35:593-8. 2010
    ..We assessed the effect of METH dependence on everyday functioning using the UCSD Performance-Based Skills Assessment (UPSA-2), a performance-based measure designed to evaluate real-life skills...
  34. ncbi request reprint Prepulse inhibition in patients with non-psychotic major depressive disorder
    William Perry
    Department of Psychiatry, University of California San Diego, 200 West Arbor Drive, Mailcode 8218, San Diego, CA 92103 8218, USA
    J Affect Disord 81:179-84. 2004
    ..Therefore, we assessed PPI in non-psychotic MDD patients and compared their results to schizophrenia patients and non-patients...
  35. pmc Effects of chronic, heavy cannabis use on executive functions
    Rebecca D Crean
    Committee on the Neurobiology of Addictive Disorders The Scripps Research Institute La Jolla, CA, 92037, USA
    J Addict Med 5:9-15. 2011
    ..It should be of particular interest to clinicians who work with people with cannabis use disorders...
  36. pmc Disentangling working memory processes during spatial span assessment: a modeling analysis of preferred eye movement strategies
    Virginie M Patt
    a Department of Psychiatry, University of California, San Diego, CA, USA
    J Clin Exp Neuropsychol 36:186-204. 2014
    ....
  37. pmc Evaluation of the clinical efficacy of asenapine in schizophrenia
    Arpi Minassian
    University of California San Diego, Department of Psychiatry, La Jolla, California 92093 0804, USA
    Expert Opin Pharmacother 11:2107-15. 2010
    ..Sublingual administration may have positive and negative effects on patient compliance. Potential 'pro-cognitive' effects of asenapine are preliminary and require more investigation...
  38. ncbi request reprint The use of the Ego Impairment Index across the schizophrenia spectrum
    William Perry
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 8620, USA
    J Pers Assess 80:50-7. 2003
    ....
  39. ncbi request reprint Despite Expert Recommendations, Second-generation Antipsychotics Are Not Often Prescribed in the Emergency Department
    Michael P Wilson
    Department of Emergency Medicine Behavioral Emergencies Research Lab, UC San Diego, San Diego, California Department of Emergency Medicine, UC San Diego Health System, San Diego, California
    J Emerg Med 46:808-13. 2014
    ..However, little is known about how these meds are used in the ED or how often SGAs are prescribed...
  40. pmc Everyday functional ability across different phases of bipolar disorder
    Brook L Henry
    University of California San Diego, Department of Psychiatry, La Jolla, CA, USA Electronic address
    Psychiatry Res 210:850-6. 2013
    ..Poor WCST performance was also associated with worse UPSA-2 function. In summary, BD functional deficits occur across different phases of the disorder and may be impacted by symptom severity and associated with executive dysfunction. ..
  41. doi request reprint Literature-based recommendations for suicide assessment in the emergency department: a review
    Linda Ronquillo
    Alliant International University, California School of Professional Psychology, San Diego, California 92122, USA
    J Emerg Med 43:836-42. 2012
    ..The Joint Commission established a National Patient Safety Goal that requires screening for suicidal ideation to identify patients at risk for suicide...
  42. pmc Heart rate variability characteristics in a large group of active-duty marines and relationship to posttraumatic stress
    Arpi Minassian
    From the Center of Excellence for Stress and Mental Health A M, M A G, D G B, C M N, V B R, Veteran s Administration, San Diego, California Departments of Psychiatry A M, M A G, D G B, C M N, V B R and Medicine D T O, University of California San Diego, La Jolla, California and VA San Diego Healthcare System M A G, D G B, C M N, V B R, San Diego, California
    Psychosom Med 76:292-301. 2014
    ..Here we describe HRV associations with stress disorder symptoms in a large study of Marines while accounting for well-known covariates of HRV and PTSD including TBI and depression...
  43. doi request reprint Reduction of suboptimal prescribing and clinical outcome for dementia patients in a senior behavioral health inpatient unit
    Virginia T Chan
    Department of Psychiatry, University of California, San Diego, CA 92103 8631, USA
    Int Psychogeriatr 21:195-9. 2009
    ....
  44. ncbi request reprint Stability of attention deficits in schizophrenia
    Josette G Harris
    University of Colorado School of Medicine, Department of Psychiatry, C268 71, 4200 E 9th Avenue, Denver, CO 80262, United States
    Schizophr Res 91:107-11. 2007
    ..Attention and concentration were significantly enhanced after two weeks in the previously unmedicated group. However, improvement failed to reach the level of performance of comparison subjects...
  45. ncbi request reprint A process approach to verbal fluency in patients with schizophrenia
    Leeza M Maron
    Schizophr Res 68:105-6. 2004