M Mimeault

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. pmc Recent progress on normal and malignant pancreatic stem/progenitor cell research: therapeutic implications for the treatment of type 1 or 2 diabetes mellitus and aggressive pancreatic cancer
    M Mimeault
    Department of Biochemistry and Molecular Biology, Eppley Institute for Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Gut 57:1456-68. 2008
  2. pmc Pathobiological implications of the expression of EGFR, pAkt, NF-κB and MIC-1 in prostate cancer stem cells and their progenies
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e31919. 2012
  3. pmc Marked improvement of cytotoxic effects induced by docetaxel on highly metastatic and androgen-independent prostate cancer cells by downregulating macrophage inhibitory cytokine-1
    M Mimeault
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA
    Br J Cancer 108:1079-91. 2013
  4. pmc Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, College of Medicine, Eppley Cancer Institute, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    J Cell Mol Med 17:30-54. 2013
  5. pmc Emergence of zebrafish models in oncology for validating novel anticancer drug targets and nanomaterials
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, College of Medicine, Eppley Cancer Institute, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Drug Discov Today 18:128-40. 2013
  6. pmc Great promise of tissue-resident adult stem/progenitor cells in transplantation and cancer therapies
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Adv Exp Med Biol 741:171-86. 2012
  7. pmc New advances on critical implications of tumor- and metastasis-initiating cells in cancer progression, treatment resistance and disease recurrence
    M Mimeault
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Histol Histopathol 25:1057-73. 2010
  8. pmc Recent insights into the molecular mechanisms involved in aging and the malignant transformation of adult stem/progenitor cells and their therapeutic implications
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Ageing Res Rev 8:94-112. 2009
  9. pmc Targeting of cancer stem/progenitor cells plus stem cell-based therapies: the ultimate hope for treating and curing aggressive and recurrent cancers
    M Mimeault
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Panminerva Med 50:3-18. 2008
  10. doi request reprint Improvement of cytotoxic effects induced by mitoxantrone on hormone-refractory metastatic prostate cancer cells by co-targeting epidermal growth factor receptor and hedgehog signaling cascades
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, College of Medicine, Eppley Institute of Cancer and Allied Diseases, 985870 University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Growth Factors 25:400-16. 2007

Detail Information

Publications41

  1. pmc Recent progress on normal and malignant pancreatic stem/progenitor cell research: therapeutic implications for the treatment of type 1 or 2 diabetes mellitus and aggressive pancreatic cancer
    M Mimeault
    Department of Biochemistry and Molecular Biology, Eppley Institute for Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Gut 57:1456-68. 2008
    ..These novel targeted therapies should lead to the development of more effective treatments of locally advanced and metastatic pancreatic cancers, which remain incurable with current therapies...
  2. pmc Pathobiological implications of the expression of EGFR, pAkt, NF-κB and MIC-1 in prostate cancer stem cells and their progenies
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e31919. 2012
    ....
  3. pmc Marked improvement of cytotoxic effects induced by docetaxel on highly metastatic and androgen-independent prostate cancer cells by downregulating macrophage inhibitory cytokine-1
    M Mimeault
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA
    Br J Cancer 108:1079-91. 2013
    ..Overexpression of macrophage inhibitory cytokine-1 (MIC-1) frequently occurs during the progression of prostate cancer (PC) to androgen-independent (AI) and metastatic disease states and is associated with a poor outcome of patients...
  4. pmc Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, College of Medicine, Eppley Cancer Institute, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    J Cell Mol Med 17:30-54. 2013
    ....
  5. pmc Emergence of zebrafish models in oncology for validating novel anticancer drug targets and nanomaterials
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, College of Medicine, Eppley Cancer Institute, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Drug Discov Today 18:128-40. 2013
    ....
  6. pmc Great promise of tissue-resident adult stem/progenitor cells in transplantation and cancer therapies
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Adv Exp Med Biol 741:171-86. 2012
    ....
  7. pmc New advances on critical implications of tumor- and metastasis-initiating cells in cancer progression, treatment resistance and disease recurrence
    M Mimeault
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Histol Histopathol 25:1057-73. 2010
    ....
  8. pmc Recent insights into the molecular mechanisms involved in aging and the malignant transformation of adult stem/progenitor cells and their therapeutic implications
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Ageing Res Rev 8:94-112. 2009
    ..These diseases include premature aging diseases, hematopoietic, cardiovascular, musculoskeletal, pulmonary, ocular, urogenital, neurodegenerative and skin disorders and aggressive and recurrent cancers...
  9. pmc Targeting of cancer stem/progenitor cells plus stem cell-based therapies: the ultimate hope for treating and curing aggressive and recurrent cancers
    M Mimeault
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Panminerva Med 50:3-18. 2008
    ..These targeting and stem cell-based therapies may offer the ultimate hope for treating and even curing the patients diagnosed with locally advanced cancers at high risk of recurrence, metastatic and/or relapsed cancers in the clinics...
  10. doi request reprint Improvement of cytotoxic effects induced by mitoxantrone on hormone-refractory metastatic prostate cancer cells by co-targeting epidermal growth factor receptor and hedgehog signaling cascades
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, College of Medicine, Eppley Institute of Cancer and Allied Diseases, 985870 University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Growth Factors 25:400-16. 2007
    ....
  11. pmc Recent advances on skin-resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti-aging and cancer therapies
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    J Cell Mol Med 14:116-34. 2010
    ....
  12. ncbi request reprint Aging of tissue-resident adult stem/progenitor cells and their pathological consequences
    M Mimeault
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Panminerva Med 51:57-79. 2009
    ....
  13. pmc Novel therapies against aggressive and recurrent epithelial cancers by molecular targeting tumor- and metastasis-initiating cells and their progenies
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology and Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Anticancer Agents Med Chem 10:137-51. 2010
    ....
  14. pmc New promising drug targets in cancer- and metastasis-initiating cells
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Drug Discov Today 15:354-64. 2010
    ..These novel targeted approaches should improve the efficacy of current therapeutic treatments against highly aggressive, metastatic, recurrent, and lethal cancers...
  15. pmc Animal models relevant to human prostate carcinogenesis underlining the critical implication of prostatic stem/progenitor cells
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, College of Medicine, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Biochim Biophys Acta 1816:25-37. 2011
    ....
  16. pmc Complex oncogenic signaling networks regulate brain tumor-initiating cells and their progenies: pivotal roles of wild-type EGFR, EGFRvIII mutant and hedgehog cascades and novel multitargeted therapies
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, College of Medicine, Eppley Cancer Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Neb 68198 5870, USA
    Brain Pathol 21:479-500. 2011
    ....
  17. pmc Functions of normal and malignant prostatic stem/progenitor cells in tissue regeneration and cancer progression and novel targeting therapies
    Murielle Mimeault
    and Surinder K Batra, Ph D, Department of Biochemistry and Molecular Biology, Eppley Institute for Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Endocr Rev 29:234-52. 2008
    ....
  18. pmc Recent progress on tissue-resident adult stem cell biology and their therapeutic implications
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198 5870, USA
    Stem Cell Rev 4:27-49. 2008
    ....
  19. ncbi request reprint Recent advances in cancer stem/progenitor cell research: therapeutic implications for overcoming resistance to the most aggressive cancers
    M Mimeault
    Department of Biochemistry and Molecular Biology, Eppley Institute of Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA
    J Cell Mol Med 11:981-1011. 2007
    ..These new targeted therapies should improve the efficacy of current therapeutic treatments against aggressive cancers, and thereby preventing disease relapse and enhancing patient survival...
  20. ncbi request reprint Concise review: recent advances on the significance of stem cells in tissue regeneration and cancer therapies
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, Eppley Institute of Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 5870, USA
    Stem Cells 24:2319-45. 2006
    ....
  21. pmc Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, College of Medicine, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Chin Med 6:31. 2011
    ....
  22. ncbi request reprint Functions of tumorigenic and migrating cancer progenitor cells in cancer progression and metastasis and their therapeutic implications
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, Eppley Institute of Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Cancer Metastasis Rev 26:203-14. 2007
    ....
  23. ncbi request reprint New advances on the functions of epidermal growth factor receptor and ceramides in skin cell differentiation, disorders and cancers
    M Mimeault
    Department of Biochemistry and Molecular Biology, UNMC Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198 4525, USA
    Skin Pharmacol Physiol 17:153-66. 2004
    ..New progress in understanding of skin organization, which might provide the basis for the design of new transcutaneous drug delivery techniques as well as for the development of new therapies of skin disorders and cancers, are reported...
  24. ncbi request reprint Interplay of distinct growth factors during epithelial mesenchymal transition of cancer progenitor cells and molecular targeting as novel cancer therapies
    M Mimeault
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Ann Oncol 18:1605-19. 2007
    ....
  25. ncbi request reprint Stem cells: a revolution in therapeutics-recent advances in stem cell biology and their therapeutic applications in regenerative medicine and cancer therapies
    M Mimeault
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Clin Pharmacol Ther 82:252-64. 2007
    ..A particular emphasis is made on the therapeutic potential of different tissue-resident adult stem cell types and their in vivo modulation for treating and curing specific pathological disorders...
  26. pmc Recent advances on the molecular mechanisms involved in the drug resistance of cancer cells and novel targeting therapies
    M Mimeault
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Clin Pharmacol Ther 83:673-91. 2008
    ....
  27. ncbi request reprint Combined targeting of epidermal growth factor receptor and hedgehog signaling by gefitinib and cyclopamine cooperatively improves the cytotoxic effects of docetaxel on metastatic prostate cancer cells
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, 985870 Nebraska Medical Center, Eppley Cancer Institute, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Mol Cancer Ther 6:967-78. 2007
    ..These findings indicate that the combined use of inhibitors of EGF-EGFR and hedgehog signaling with docetaxel could represent a more promising strategy for treatment in patients with metastatic and androgen-independent prostate cancer...
  28. pmc Cytotoxic effects induced by docetaxel, gefitinib, and cyclopamine on side population and nonside population cell fractions from human invasive prostate cancer cells
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5870, USA
    Mol Cancer Ther 9:617-30. 2010
    ....
  29. ncbi request reprint Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, College of Medicine, Omaha, NE 68198 5870, USA
    Int J Cancer 118:1022-31. 2006
    ....
  30. ncbi request reprint Novel combination therapy against metastatic and androgen-independent prostate cancer by using gefitinib, tamoxifen and etoposide
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, University of Nebraska College of Medicine, 985870 Medical Center, Omaha, Nebraska 68198, USA
    Int J Cancer 120:160-9. 2007
    ....
  31. ncbi request reprint Synergistic antiproliferative and apoptotic effects induced by mixed epidermal growth factor receptor inhibitor ZD1839 and nitric oxide donor in human prostatic cancer cell lines
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Prostate 62:187-99. 2005
    ....
  32. pmc Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer, and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Pharmacol Rev 62:497-524. 2010
    ....
  33. pmc MUC4 down-regulation reverses chemoresistance of pancreatic cancer stem/progenitor cells and their progenies
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Cancer Lett 295:69-84. 2010
    ..These data suggest that the MUC4 down-regulation may constitute a potential therapeutic strategy for improving the efficacy of gemcitabine to eradicate the total PC cell mass, and thereby preventing disease relapse...
  34. doi request reprint Characterization of nonmalignant and malignant prostatic stem/progenitor cells by Hoechst side population method
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA
    Methods Mol Biol 568:139-49. 2009
    ....
  35. ncbi request reprint Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapies
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Carcinogenesis 27:1-22. 2006
    ..Of therapeutic interest, new strategies for the diagnosis and treatment of localized and metastatic forms of prostate cancer by targeting multiple tumorigenic signaling elements are also reported...
  36. pmc Divergent molecular mechanisms underlying the pleiotropic functions of macrophage inhibitory cytokine-1 in cancer
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 5870, USA
    J Cell Physiol 224:626-35. 2010
    ....
  37. ncbi request reprint Recent advances on the molecular mechanisms involved in pancreatic cancer progression and therapies
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Pancreas 31:301-16. 2005
    ..The molecular mechanisms associated with antitumoral properties and the clinical benefits of gemcitabine alone or in combination with other cytotoxic agents for the treatment of pancreatic cancer are discussed...
  38. ncbi request reprint New advances on prostate carcinogenesis and therapies: involvement of EGF-EGFR transduction system
    Murielle Mimeault
    Institut de Chimie Pharmaceutique Albert Lespagnol, Faculte de Pharmacie, 3 rue du Professeur Laguesse, BP83, 59006 Lille, Cedex, France
    Growth Factors 21:1-14. 2003
    ..Of therapeutic interest, recent advances and prospects for development of new treatments against incurable forms of metastatic PC forms are also discussed...
  39. ncbi request reprint Synergistic antiproliferative and apoptotic effects induced by epidermal growth factor receptor and protein kinase a inhibitors in human prostatic cancer cell lines
    Murielle Mimeault
    Institut de Chimie Pharmaceutique Albert Lespagnol, Lille, France
    Int J Cancer 106:116-24. 2003
    ....
  40. ncbi request reprint Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production
    Murielle Mimeault
    Institut de Chimie Pharmaceutique Albert Lespagnol, 3 rue du Professeur Laguesse, BP83, Lille, France
    Prostate 56:1-12. 2003
    ..Anandamide (ANA) is an endogenous lipid which acts as a cannabinoid receptor ligand and with potent anticarcinogenic activity in several cancer cell types...
  41. ncbi request reprint New advances on structural and biological functions of ceramide in apoptotic/necrotic cell death and cancer
    Murielle Mimeault
    Institut de Chimie Pharmaceutique Albert Lespagnol, Faculte de Pharmacie, Laboratoire de Toxicologie, 3 rue du Professeur Laguesse, P O Box 83, 59006 Lille Cedex, France
    FEBS Lett 530:9-16. 2002
    ..Information on the deregulated functions of ceramide and caspase signaling pathways in several metastatic cancer types is also presented...