Research Topics
Species | Paul MillsSummaryAffiliation: University of California Country: USA Publications
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Publications
Effects of placement and bereavement on psychological well-being and cardiovascular risk in Alzheimer's caregivers: a longitudinal analysisBrent T Mausbach
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0680, USA
J Psychosom Res 62:439-45. 2007..We examined the impact of Alzheimer caregiver transitions (i.e., placement and bereavement) on psychological outcomes and on plasma D-dimer levels, an end product of the coagulation cascade associated with increased cardiovascular risk...
Personal mastery is associated with reduced sympathetic arousal in stressed Alzheimer caregiversSusan K Roepke
Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0680, USA
Am J Geriatr Psychiatry 16:310-7. 2008..This study examines the relationship between mastery and sympathetic arousal in elderly caregivers, as measured by norepinephrine (NE) reactivity to an acute psychological stressor...- Race affects the decline in blood pressure with hospitalizationP J Mills
UCSD Medical Center, University of California, San Diego 92103 0804, USA
Am J Hypertens 10:1091-6. 1997..Given that the reduction in BP with hospitalization can be similar to that attained with pharmacologic therapy, these findings may have a bearing on studies examining BP in the hospital... - The effects of spaceflight on adrenergic receptors and agonists and cell adhesion molecule expressionPaul J Mills
Department of Psychiatry and Medicine, University of California, San Diego, La Jolla, CA 92103, USA
J Neuroimmunol 132:173-9. 2002..05). The data suggest that spaceflight leads to an environment that would support reduced leukocyte-endothelial adhesion. Sympathetic activation may contribute to this phenomenon... - Effects of gender and dementia severity on Alzheimer's disease caregivers' sleep and biomarkers of coagulation and inflammationPaul J Mills
Department of Psychiatry, University of California at San Diego, La Jolla, CA, USA
Brain Behav Immun 23:605-10. 2009..This study examined the effects of caregiver gender and severity of the spouse's dementia on sleep, coagulation, and inflammation in the caregiver... 
Metabolic predictors of inflammation, adhesion, and coagulability in healthy younger-aged adultsPaul J Mills
Department of Psychiatry, University of California San Diego, La Jolla, California, USA
Obesity (Silver Spring) 16:2702-6. 2008..The findings provide insight into the adverse cardiovascular risk associated with elevated body weight in younger adults...- Predictors of fatigue in obstructive sleep apneaPaul J Mills
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
Sleep Breath 12:397-9. 2008..The objective of this study was to determine potential inflammatory predictors of fatigue in obstructive sleep apnea (OSA)... - Predictors of inflammation in response to anthracycline-based chemotherapy for breast cancerPaul J Mills
Department of Psychiatry, University of California, San Diego, CA 92103, USA
Brain Behav Immun 22:98-104. 2008..Inflammation in response to chemotherapy is most significantly related to inflammation that existed prior to chemotherapy but also potentially to treatment regimen and to certain disease characteristics... - Immune cell CD62L and CD11a expression in response to a psychological stressor in human hypertensionPaul J Mills
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
Brain Behav Immun 17:260-7. 2003..Exposure to repeated psychological stressors may further augment this potentially adverse circulatory environment... - Inflammation and sleep in healthy individualsPaul J Mills
Department of Psychiatry, University of California San Diego, School of Medicine, La Jolla, CA, USA
Sleep 30:729-35. 2007..Inflammation is relatively common in individuals with a sleep disorder and is associated with quality of sleep. The purpose of this study was to examine whether inflammation is associated with quality of sleep in healthy individuals... - Physical fitness attenuates leukocyte-endothelial adhesion in response to acute exercisePaul J Mills
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
J Appl Physiol 101:785-8. 2006..The findings provide evidence of how physical fitness might protect individuals from inflammatory responses to exercise... - Effects of nasal continuous positive airway pressure and oxygen supplementation on norepinephrine kinetics and cardiovascular responses in obstructive sleep apneaPaul J Mills
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
J Appl Physiol 100:343-8. 2006..01). The findings indicate that one of the mechanisms through which CPAP reduces NE levels is through an increase in the clearance of NE from the circulation... - Vulnerable caregivers of Alzheimer disease patients have a deficit in beta 2-adrenergic receptor sensitivity and densityPaul J Mills
Department of Psychiatry, University of California San Diego, 92103 0804, USA
Am J Geriatr Psychiatry 12:281-6. 2004..The authors examined the effects of being a spousal caregiver of a patient with Alzheimer disease (AD) on the lymphocyte beta(2)-adrenergic receptor... - Sleep apnea: a model for studying cytokines, sleep, and sleep disruptionPaul J Mills
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Brain Behav Immun 18:298-303. 2004..We believe that the study of OSA presents researchers with an excellent opportunity to tease apart the many complex and interwoven components of sleep that are relevant to PNI... - The effects of standard anthracycline-based chemotherapy on soluble ICAM-1 and vascular endothelial growth factor levels in breast cancerPaul J Mills
Department of Psychiatry, University of California San Diego, San Diego, California 92103, USA
Clin Cancer Res 10:4998-5003. 2004..This study examined the effects of anthracycline-based chemotherapy on plasma sICAM-1 and VEGF, as well as soluble P-selectin, von Willebrand factor, and interleukin-6 levels... - Diurnal variability of C-reactive protein in obstructive sleep apneaPaul J Mills
Department of Psychiatry, University of California, San Diego, La Jolla, 92093 0804, USA
Sleep Breath 13:415-20. 2009..The objective of this study is to examine the diurnal variability of C-reactive protein (CRP) in obstructive sleep apnea (OSA)... - The relationship between fatigue and quality of life and inflammation during anthracycline-based chemotherapy in breast cancerPaul J Mills
Department of Psychiatry, University of California, San Diego UCSD, Medical Center, 200 West Arbor Drive, San Diego, CA 92103 0804, USA
Biol Psychol 69:85-96. 2005..001). The findings contribute to the literature by showing that both pre-chemotherapy and chemotherapy-induced changes in inflammation are related to changes in fatigue and quality of life in response to chemotherapy... - Menstrual cycle, race and task effects on blood pressure recovery from acute stressP J Mills
UCSD Medical Center, University of California at San Diego, USA
J Psychosom Res 46:445-54. 1999..The findings support prior studies indicating racial differences in recovery from acute stress and extend these findings by suggesting that the menstrual cycle may differentially affect recovery in black versus white women... - Vulnerable caregivers of patients with Alzheimer's disease have a deficit in circulating CD62L- T lymphocytesP J Mills
Department of Psychiatry, University of California, San Diego, USA
Psychosom Med 61:168-74. 1999..The objective of this study was to determine the effects of chronic stress on L-selectin expression on peripheral lymphocytes in elderly spousal caregivers of patients with Alzheimer's disease... - Leukocyte adhesion molecule expression and T cell naïve/memory status following isoproterenol infusionP J Mills
Department of Psychiatry, UCSD Medical Center, San Diego, CA 92103 0804, USA
J Neuroimmunol 102:137-44. 2000..01), but had no significant effect on the number of circulating CD8+ CD45RA+ CD62L+ naïve T cells. beta blockade with the non-specific antagonist propranolol eliminated these isoproterenol-induced effects... - Peripheral blood mononuclear cell-endothelial adhesion in human hypertension following exerciseP J Mills
Department of Psychiatry, University of California, San Diego 92103 0804, USA
J Hypertens 18:1801-6. 2000..To determine the effects of hypertension and exercise on interleukin-6 (IL-6) levels and mononuclear cell adhesion to endothelial cells... - The effects of hypoxia and sleep apnea on isoproterenol sensitivityP J Mills
Department of Psychiatry, UCSD Medical Center, University of California, San Diego 92103 0804, USA
Sleep 21:731-5. 1998..To determine the effects of both apnea and hypoxia on beta-adrenergic receptor sensitivity... - Leptin is related to epinephrine levels but not reproductive hormone levels in cycling African-American and Caucasian womenP J Mills
UCSD Medical Center, University of California, San Diego 92093, USA
Life Sci 63:617-23. 1998..38, p=0.01). No such relationship was observed in men. The findings indicate that in women leptin levels are not associated with cyclic changes in estrogen or progesterone but may be associated with catecholamine levels... - L-selectin expression affects T-cell circulation following isoproterenol infusion in humansP J Mills
University of California at San Diego, La Jolla 92093, USA
Brain Behav Immun 11:333-42. 1997..The findings indicate that L-selectin expression influences T-cell trafficking in response to beta-adrenergic stimulation and help further illuminate catecholamine-mediated sympathetic and immune interactions... - Peripheral leukocyte subpopulations and catecholamine levels in astronauts as a function of mission durationP J Mills
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92103 0804, USA
Psychosom Med 63:886-90. 2001..The objective of this study was to determine the effects of spaceflight duration on immune cells and their relationship to catecholamine levels... - Peripheral blood mononuclear cell CD62L and CD11a expression and soluble interstitial cell adhesion molecule-1 levels following infused isoproterenol in hypertensionPaul J Mills
Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
J Hypertens 20:311-6. 2002.... - Hormone replacement therapy does not affect 24-h ambulatory blood pressure in healthy non-smoking postmenopausal womenPaul J Mills
Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
Blood Press Monit 8:57-61. 2003..Important interindividual factors that affect blood pressure, such as smoking, body mass and sodium intake, may account for the conflicting findings seen in studies examining the effects of HRT on blood pressure... - Sleep and health-related quality of life in heart failurePaul J Mills
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
Congest Heart Fail 15:228-33. 2009..01) (model adjusted R(2)=.732; P<.001). Findings provide evidence that in addition to functional status and ongoing fatigue, poorer quality of life in HF is independently related to the severity of sleep-disordered breathing... - Nonselective beta blockade attenuates the recruitment of CD62L(-)T lymphocytes following exerciseP J Mills
Department of Psychiatry, University of California, San Diego, USA
Eur J Appl Physiol Occup Physiol 79:531-4. 1999.... - Sleep in spousal caregivers of people with Alzheimer's diseaseChristine L McKibbin
Department of Psychiatry, University of California San Diego, CA, USA
Sleep 28:1245-50. 2005..Future work is needed to examine the differences in care practices in caregivers by age and dementia severity. Perhaps more importantly, studies examining the health consequences of shortened sleep in this group are needed... - Overnight changes of immune parameters and catecholamines are associated with mood and stressWinfried Rief
Department of Psychiatry, University of California, San Diego, San Diego, California, USA
Psychosom Med 72:755-62. 2010..To test the hypothesis that a nocturnal decrease of secretion of inflammation markers and catecholamines would be associated with mood and stress variables even after controlling for objective sleep variables... - Association between polysomnographic measures of disrupted sleep and prothrombotic factorsRoland von Kanel
Department of Psychiatry, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0804, USA
Chest 131:733-9. 2007..We hypothesized that disrupted sleep as verified by polysomnography is associated with increased levels of prothrombotic hemostasis factors previously shown to predict CAD risk... - Coping processes and hemostatic reactivity to acute stress in dementia caregiversKirstin Aschbacher
Department of Psychiatry, School of Medicine, University of California, San Diego, California, USA
Psychosom Med 67:964-71. 2005..It remains to be seen whether interventions that increase approach/problem-solving processes might produce salutary effects among caregiving populations... - Systemic vs. local cytokine and leukocyte responses to unilateral wrist flexion exerciseDan Nemet
Center for the Study of Health Effects of Exercise in Children, College of Medicine, University of California, Irvine 92868, California, USA
J Appl Physiol 93:546-54. 2002..05). Brief, low-intensity exercise leads to a systemic rather than local response of mediators that could be involved in inflammation, repair, or angiogenic adaptation to physical activity... - Dementia severity of the care receiver predicts procoagulant response in Alzheimer caregiversKirstin Aschbacher
Department of Psychiatry, School of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Am J Geriatr Psychiatry 14:694-703. 2006..Effect size estimates suggest that such D-dimer increases may have clinical implications, particularly among late-stage caregivers... - In-home respite intervention reduces plasma epinephrine in stressed Alzheimer caregiversIgor Grant
Department of Psychiatry (0680, University of California, San Diego, La Jolla 92093-0680, USA
Am J Geriatr Psychiatry 11:62-72. 2003..To the extent that sympathetic activation mediates pathophysiological events, these results suggest an approach that may reduce morbidity and mortality in certain caregivers... - Combination of caregiving stress and hormone replacement therapy is associated with prolonged platelet activation to acute stress among postmenopausal womenKirstin Aschbacher
Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0680, USA
Psychosom Med 69:910-7. 2007..Both HRT and the chronic stress of caregiving have been associated with increased cardiovascular risk, potentially through a mechanism of platelet hyperactivity... - Acute psychological stress: effects on chemotaxis and cellular adhesion molecule expressionLaura Redwine
Department of Psychiatry, University of California, San Diego, USA
Psychosom Med 65:598-603. 2003..In this study, we examine the effects of an acute psychological stress on chemotactic responses of PBMCs and on CAM expression in relation to measures of sympathetic activation... - Relation of nocturnal blood pressure dipping to cellular adhesion, inflammation and hemostasisRoland von Kanel
Department of Psychiatry, University of California San Diego, California 92093 0804, USA
J Hypertens 22:2087-93. 2004..The pathogenetic mechanisms of this relationship have not been elucidated. We investigated whether non-dipping would relate to procoagulant and proinflammatory activity... - Effects of depressive and anxious symptoms on norepinephrine and platelet P-selectin responses to acute psychological stress among elderly caregiversKirstin Aschbacher
Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla CA 92093 0680, USA
Brain Behav Immun 22:493-502. 2008.... - Effects of depressive symptoms and anxiety on hemostatic responses to acute mental stress and recovery in the elderlyRoland von Kanel
Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0680, USA
Psychiatry Res 126:253-64. 2004..The independent association of anxiety symptoms with resting and stress-induced fibrin formation (D-dimer) may be a mechanism linking mood with cardiovascular disease risk in the elderly... - Circulating levels of soluble intercellular adhesion molecule-1 (sICAM-1) independently predict depressive symptom severity after 12 months in heart failure patientsPetra H Wirtz
Department of Clinical Psychology and Psychotherapy, Psychological Institute, University of Zurich, Switzerland Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
Brain Behav Immun 24:366-9. 2010..To determine whether inflammatory markers prospectively predict depressive symptom severity 12 months later in heart failure (HF) patients... - Persistent versus transient depressive symptoms in relation to platelet hyperactivation: a longitudinal analysis of dementia caregiversKirstin Aschbacher
Department of Psychiatry, University of California, San Diego, USA
J Affect Disord 116:80-7. 2009..The primary objective was to investigate whether persistent depressive symptoms would relate to elevated platelet activation in response to acute psychological stress over a three-year period... - Pre-treatment symptom cluster in breast cancer patients is associated with worse sleep, fatigue and depression during chemotherapyLianqi Liu
Department of Psychiatry, University of California, San Diego, CA 92161, USA
Psychooncology 18:187-94. 2009..e. sleep disturbances, fatigue and depression) into one symptom cluster, to explore the associations between pre-treatment cluster categories and longitudinal profiles of these same symptoms during chemotherapy... - Effects of an exercise challenge on mobilization and surface marker expression of monocyte subsets in individuals with normal vs. elevated blood pressureSuzi Hong
Department of Psychiatry, University of California, San Diego, USA
Brain Behav Immun 22:590-9. 2008..Individuals with high BP showed greater responses to a physical challenge in some monocyte chemokine receptors and selectins, but its clinical implications need further examination... - Effects of nonspecific beta-adrenergic stimulation and blockade on blood coagulation in hypertensionRoland von Kanel
Department of Psychiatry, University of California, San Diego, California 92093, USA
J Appl Physiol 94:1455-9. 2003..However, beta-adrenergic stimulation alone may not be sufficient to trigger fibrin formation in vivo... - Interactive effects of common beta2-adrenoceptor haplotypes and age on susceptibility to hypertension and receptor functionXuping Bao
Department of Medicine, University of California, San Diego, CA, USA
Hypertension 46:301-7. 2005..05) and decreased heart rate (7%; P<0.001). Our study suggests that age is an important modifier for the effects of ADRB2 polymorphisms on ADRB2 function and the development of hypertension... - Temporal stability of acute stress-induced changes in leukocyte subsets and cellular adhesion molecules in older adultsKaren A Adler
Department of Psychiatry, University of California-San Diego, La Jolla, CA 92093, USA
Brain Behav Immun 16:262-74. 2002..The level of temporal stability achieved is comparable to that seen previously in younger adults, indicating that acute psychosocial stress produces reliable changes in circulating leukocytes and cell adhesion molecules in older adults... - Constitutive pro- and anti-inflammatory cytokine and growth factor response to exercise in leukocytesFrank Zaldivar
Department of Pediatrics, Pediatric Exercise Research Center, University Children's Hospital, University of California, Irvine, USA
J Appl Physiol 100:1124-33. 2006.... - Effect of beta2-adrenergic receptor functioning and increased norepinephrine on the hypercoagulable state with mental stressRoland von Kanel
Department of Psychiatry, University of California, San Diego, Calif 92093 0804, USA
Am Heart J 144:68-72. 2002.... - Effect of water polo practice on cytokines, growth mediators, and leukocytes in girlsDan Nemet
Center for the Study of Health Effects of Exercise in Children, University of California, Irvine, CA 92868, USA
Med Sci Sports Exerc 35:356-63. 2003..The role of these frequent, almost daily immune and cytokine changes on growth and development have yet to be determined... - Effects of chronic stress on memory decline in cognitively normal and mildly impaired older adultsGuerry M Peavy
UCSD Shiley Marcos Alzheimer s Disease Research Center, University of California San Diego, 8950 Villa La Jolla Drive, La Jolla, CA 92037, USA
Am J Psychiatry 166:1384-91. 2009..The authors sought to determine the prospective association between subjective and objective measures of chronic stress and rate of memory decline in cognitively normal and mildly impaired older adults... - Hormone replacement therapy increases renal kallikrein excretion in healthy postmenopausal womenNoha H Farag
Department of Psychiatry, UCSD Medical Center, University of California, 200 West Arbor Drive, CTF A, 415, San Diego, La Jolla, CA 92103 0804, USA
Life Sci 72:1279-88. 2003.... - Autonomic responses to psychological stress: the influence of menopausal statusNoha H Farag
Department of Psychiatry, University of California, San Diego, CA 92103 0804, USA
Ann Behav Med 26:134-8. 2003..Postmenopausal women have greater sympathetic and less parasympathetic activity than premenopausal women, which may account for their increased risk of coronary artery disease... - The potential anti-inflammatory benefits of improving physical fitness in hypertensionKate M Edwards
Department of Psychiatry, UCSD Medical Center, University of California, San Diego, La Jolla, California 92093 0804, USA
J Hypertens 25:1533-42. 2007..Here, exercise is promoted as a potentially effective treatment for both the elevated blood pressure and chronic inflammation found in hypertension... - The internet for medical information about cancer: help or hindrance?Scott C Matthews
Department of Psychiatry, University of California, San Diego, USA
Psychosomatics 44:100-3. 2003..The authors tested a strategy for screening Internet sites to identify those that provide scientifically accurate information regarding complementary/alternative medicine treatments commonly used by cancer patients... - The roles of TNF-alpha and the soluble TNF receptor I on sleep architecture in OSAHerbert J Yue
Department of Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA
Sleep Breath 13:263-9. 2009..We hypothesized that the TNF receptor might play an important role in the inflammation as well as sleep architecture changes in patients with OSA... - Macrophage migratory inhibitory factor (MIF) may be a key factor in inflammation in obstructive sleep apneaKate M Edwards
Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Sleep 34:161-3. 2011.... - The effects of ethnic discrimination and socioeconomic status on endothelin-1 among blacks and whitesDenise C Cooper
Department of Psychiatry, University of California, San Diego, California, USA
Am J Hypertens 22:698-704. 2009..Stress is associated with increased endothelin-1 (ET-1). This study examined the relationship of ET-1 to socioeconomic status (SES) and to perceived ethnic discrimination among black (n = 51) and white (n = 65) adults (mean age 36.5)... - Biophoton detection and low-intensity light therapy: a potential clinical partnershipJoseph Tafur
Department of Psychiatry, Behavioral Medicine Laboratory, University of California at San Diego, San Diego, CA, USA
Photomed Laser Surg 28:23-30. 2010..In this review, we will present the case for pursuing further investigation into the potential clinical partnership between biophoton detection and LILT... - Biofield therapies: helpful or full of hype? A best evidence synthesisShamini Jain
UCLA Division of Cancer Prevention and Control Research, Los Angeles, CA, USA
Int J Behav Med 17:1-16. 2010..Biofield therapies (such as Reiki, therapeutic touch, and healing touch) are complementary medicine modalities that remain controversial and are utilized by a significant number of patients, with little information regarding their efficacy... - Adverse impact of mood on flow-mediated dilationDenise C Cooper
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0804, USA
Psychosom Med 72:122-7. 2010..Substantial literature indicates that negative mood is linked to cardiovascular disease (CVD). However, the mechanisms underlying this relationship are not well defined. CVD is often preceded by dysfunction of the endothelium... - Everyday discrimination and nocturnal blood pressure dipping in black and white americansLianne Tomfohr
Department of Psychology, University of California, San Diego, 9500 Gilman Drive, Mail Code 0804, La Jolla, CA 92093 0804, USA
Psychosom Med 72:266-72. 2010..Attenuated nocturnal BP dipping is closely linked to cardiovascular morbidity and mortality. Self-reported experiences of everyday discrimination have also been associated with negative cardiovascular health outcomes... - Association between chronic caregiving stress and impaired endothelial function in the elderlyBrent T Mausbach
Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0680, USA
J Am Coll Cardiol 55:2599-606. 2010..We examined the relationship between chronic caregiving stress and endothelial function... - The effects of prolonged stress and APOE genotype on memory and cortisol in older adultsGuerry M Peavy
Department of Neurosciences, University of California, San Diego, California, USA
Biol Psychiatry 62:472-8. 2007..Combined effects of stress and APOE status on memory and cortisol in humans have not been studied... - Correlates of physical activity level in breast cancer survivors participating in the Women's Healthy Eating and Living (WHEL) StudySuzi Hong
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
Breast Cancer Res Treat 101:225-32. 2007..The purpose of this study was to examine factors that are associated with physical activity or inactivity among breast cancer survivors... - Sleep disturbance, norepinephrine, and D-dimer are all related in elderly caregivers of people with Alzheimer diseaseBrent T Mausbach
Department of Psychiatry, University of California, San Diego, CA 92093 0682, USA
Sleep 29:1347-52. 2006..In this study, we examined if sleep disturbance of elderly caregivers was associated with physiologic markers of cardiovascular risk, including plasma norepinephrine, epinephrine, and the hemostasis marker D-dimer... - Effects of perceived stress and uplifts on inflammation and coagulabilityShamini Jain
Joint Doctoral Program, Clinical Psychology, University of California San Diego San Diego State University, San Diego, California, USA
Psychophysiology 44:154-60. 2007.... - Cardiac-related hospitalization and/or death associated with immune dysregulation and symptoms of depression in heart failure patientsLaura S Redwine
Department of Medicine, University of California, San Diego, CA, USA
Psychosom Med 69:23-9. 2007..This study examined in CHF patients the relationship of depressive symptoms with cellular immune activity measured by Th1/Th2 ratios and cardiac rehospitalization and/or death... - Effects of continuous positive airway pressure versus supplemental oxygen on 24-hour ambulatory blood pressureDaniel Norman
Department of Medicine, School of Medicine, University of California, San Diego, CA, USA
Hypertension 47:840-5. 2006..We conclude that CPAP therapy reduces both daytime and nighttime blood pressure in patients with OSA, perhaps through mechanisms other than improvement of nocturnal oxyhemoglobin saturation... - The association of social status and blood pressure with markers of vascular inflammationSuzi Hong
Department of Psychiatry, University of California, San Diego, San Diego, California, USA
Psychosom Med 68:517-23. 2006..We examined the associations among BP, social status, and sICAM-1 and ET-1 levels in 121 European American and African American men and women... - Ethnicity, social class and hostility: effects on in vivo beta-adrenergic receptor responsivenessShamini Jain
Department of Psychiatry, University of California, San Diego, CA, USA
Biol Psychol 65:89-100. 2004..Thus, decreased beta-adrenergic receptor responsiveness in African-Americans does not appear to be due to differences in current social class, age, or smoking status, nor to higher reports of hostility... - Avoidant coping partially mediates the relationship between patient problem behaviors and depressive symptoms in spousal Alzheimer caregiversBrent T Mausbach
Department of Psychiatry, University of California at San Diego, San Diego, California 92093 0680, USA
Am J Geriatr Psychiatry 14:299-306. 2006..The purpose of this study was to test a mediational model of the associations between patient problem behaviors, escape-avoidance coping, and depressive symptoms in Alzheimer caregivers... - Depressive symptoms predict norepinephrine response to a psychological stressor task in Alzheimer's caregiversBrent T Mausbach
Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0680, USA
Psychosom Med 67:638-42. 2005..The current study examined the relations between the level of depressive symptoms in spousal caregivers and the physiological response to a psychological stress task... - Negative mood endures after completion of high-altitude military trainingWayne A Bardwell
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
Ann Behav Med 29:64-9. 2005..Most research in this area has focused on immediate effects of stress on mood... - Keeping it simple: encouraging walking as a means to active livingGregory J Norman
Department of Family and Preventive Medicine, University of California, San Diego, CA 92037, USA
Ann Behav Med 28:149-51. 2004 - Recruiting research participants at community education sitesGeorgia Robins Sadler
Rebecca and John Moores Cancer Center, La Jolla, CA, USA
J Cancer Educ 20:235-9. 2005..In this study, we explored whether community-based cancer education sites and educators serving the African American community could be used to recruit minority participants to research... - Higher population-based incidence rates of triple-negative breast cancer among young African-American women : Implications for breast cancer screening recommendationsKathryn C Amirikia
Department of Surgery, University of California San Francisco, Fresno, California, USA
Cancer 117:2747-53. 2011..The objective of the current study was to evaluate age-specific breast cancer stage distributions and incidence rates of triple-negative breast cancer (TNBC) in a population-based tumor registry... - An unanticipated effect of meditation on cardiovascular pharmacology and physiologyJoel E Dimsdale
Department of Psychiatry, University of California, San Diego, La Jolla, California 92093, USA
Am J Cardiol 90:908-9. 2002 - What's next in behavioral hypertension research?Noha H Farag
Ann Behav Med 27:1-2. 2004 - Vascular profile, delayed recovery, inflammatory process, and ambulatory blood pressure: laboratory-to-life generalizabilityCristina Ottaviani
Department of Psychology, University of Bologna, Italy
Int J Psychophysiol 66:56-65. 2007..The results suggest a link between recovery hemodynamics and cardiovascular risk... - Poor sleep is associated with higher plasma proinflammatory cytokine interleukin-6 and procoagulant marker fibrin D-dimer in older caregivers of people with Alzheimer's diseaseRoland von Kanel
Department of General Internal Medicine, University Hospital, Berne, Switzerland
J Am Geriatr Soc 54:431-7. 2006..To determine whether objective measures of sleep correlate with plasma levels of the proinflammatory cytokine interleukin (IL)-6 and the procoagulant marker fibrin D-dimer in caregivers of patients with dementia... - Effects of regular exercise on lymphocyte subsets and CD62L after psychological vs. physical stressSuzi Hong
Department of Psychiatry, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA, USA
J Psychosom Res 56:363-70. 2004..To examine the effects of regular physical activity on lymphocyte responses to a speech stressor and an exercise challenge... - Relationship between central obesity and cardiovascular hemodynamic indices in postmenopausal womenNoha H Farag
Fertil Steril 81:465-7. 2004..In a sample of healthy postmenopausal women, greater central body fat distribution was associated with higher peripheral resistance, triglycerides, and total cholesterol as well as lower cardiac and stroke indexes... - Does obstructive sleep apnea increase hematocrit?Jong Bae Choi
Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Kyunggi Do, South Korea
Sleep Breath 10:155-60. 2006..05). The severity of OSA is significantly associated with increased hematocrit, even after controlling for possible confounding variables. However, nocturnal hypoxemia in OSA does not usually lead to clinical polycythemia... - Relation of autonomic activity to plasminogen activator inhibitor-1 plasma concentration and the role of body mass indexRoland von Kanel
Department of General Internal Medicine, University Hospital Berne, Switzerland
Blood Coagul Fibrinolysis 18:353-9. 2007..More apparent, higher BMI explained a significant proportion of the variance in the relationship between depressed sympathetic and parasympathetic activity and elevated plasma PAI-1 concentration... - Mood states, sympathetic activity, and in vivo beta-adrenergic receptor function in a normal populationBum Hee Yu
Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Depress Anxiety 25:559-64. 2008..These findings replicate previous reports that anxiety is related to decreased (i.e., desensitized) beta-adrenergic receptor sensitivity, even after controlling for age, gender, ethnicity, and body mass index... - Autonomic and cardiovascular function in postmenopausal women: the effects of estrogen versus combination therapyNoha H Farag
Department of Psychiatry, University of California, San Diego, UCSD Medical Center, 92103 0804, USA
Am J Obstet Gynecol 186:954-61. 2002..This study examined the effects of oral estrogen (ERT) alone versus oral estrogen/medroxyprogesterone acetate (HRT) therapy on cardiovascular function, as controlled by the autonomic nervous system... - Relationship between heart rate variability, interleukin-6, and soluble tissue factor in healthy subjectsRoland von Kanel
Department of General Internal Medicine, University Hospital Berne, Switzerland
Brain Behav Immun 22:461-8. 2008..Inflammation and related hypercoagulability might particularly contribute to atherothrombotic events in a setting of decreased HRV... - Relationship of systolic blood pressure with plasma homocysteine: importance of smoking statusBrian P Kennedy
Department of Medicine, University of California, San Diego Medical Center, California 92103 8341, USA
J Hypertens 21:1307-12. 2003..Elevated plasma homocysteine is a risk factor for cardiovascular disease. Elevations in plasma homocysteine occur in both smokers and hypertensives, but the combined effect of smoking and hypertension on homocysteine is unknown... - Sleepiness in obstructive sleep apnea: a harbinger of impaired cardiac function?Jong Bae Choi
Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Kyunggi Do, South Korea
Sleep 29:1531-6. 2006..The purpose of this study was to assess the relationship between degree of subjective daytime sleepiness and cardiac performance in patients with obstructive sleep apnea... - Increased Framingham Coronary Heart Disease Risk Score in dementia caregivers relative to non-caregiving controlsRoland von Kanel
Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital, Berne, Switzerland
Gerontology 54:131-7. 2008..Elderly individuals who provide care to a spouse suffering from dementia bear an increased risk of coronary heart disease (CHD)... - Serum aminotransferase levels are associated with markers of hypoxia in patients with obstructive sleep apneaDaniel Norman
Department of Pulmonary and Critical Care Medicine, University of California at San Diego, San Diego, CA 92103 8383, USA
Sleep 31:121-6. 2008.... - Effects of estrogen and psychological stress on plasma homocysteine levelsNoha H Farag
Department of Psychiatry, University of California, San Diego, San Diego, California 92093, USA
Fertil Steril 79:256-60. 2003..To investigate the effects of estrogen (E) and psychological stress on plasma total homocysteine levels in relation to menopausal status... - Effect of Alzheimer caregiving stress and age on frailty markers interleukin-6, C-reactive protein, and D-dimerRoland von Kanel
Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital, Switzerland
J Gerontol A Biol Sci Med Sci 61:963-9. 2006..We hypothesized that, compatible with premature frailty, chronic stress and age are related in predicting inflammation and coagulation activity in Alzheimer caregivers... - Association of blood pressure and fitness with levels of atherosclerotic risk markers pre-exercise and post-exerciseRoland von Kanel
Division of General Internal Medicine and Cardiovascular Prevention and Rehabilitation, Swiss Cardiovascular Center Berne, Department of Cardiology, University Hospital Berne, Berne, Switzerland
Am J Hypertens 20:670-5. 2007..We investigated the association of screening blood pressure (BP) and cardiorespiratory fitness with baseline levels and exercise-induced changes in levels of soluble atherosclerotic risk markers...
Research Grants
- American Psychosomatic Society Meeting GrantPaul Mills; Fiscal Year: 2007..Across five years of funding, the Advisory Committee comprised of senior scientists will oversee trainee abstract selection, the trainee program, and APS's commitment to research training within the context of the annual conference. ..
- SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESIONPaul J Mills; Fiscal Year: 2010..abstract_text> ..
- SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESIONPaul Mills; Fiscal Year: 2007..Changes in cardiovascular fitness, weight, neuroendocrine activation (catecholamine and cortisol levels), and insulin sensitivity will be examined as possible mechanisms for the anticipated reductions in inflammation and cell adhesion. ..
- SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESIONPaul Mills; Fiscal Year: 1999..The project will help elucidate the effects of sympathetic activation on CAMs and the degree to which this physiology is altered in individuals with hypertensive disease. ..
- UCSD Hillcrest Flow CytometerPaul Mills; Fiscal Year: 2003..It will also be the centerpiece for an environment of shared ideas and collaboration among investigators who now utilize cytometry for their research. ..
- SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESIONPaul Mills; Fiscal Year: 2004..The overarching hypothesis of the proposal is that hypertension combined with sympathetic activation results in enhanced effects on leukocyte, platelet and endothelial adhesion that are of likely clinical significance. ..
- BNP and Neuroimmune Characteristics of CHF & DepressionPaul Mills; Fiscal Year: 2009..The overarching hypothesis of this study is that neuroimmune and adhesion molecule activation constitute an important pathophysiological pathway linking depression to worse outcomes in CHF. ..