Paul Mills

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Effects of placement and bereavement on psychological well-being and cardiovascular risk in Alzheimer's caregivers: a longitudinal analysis
    Brent T Mausbach
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0680, USA
    J Psychosom Res 62:439-45. 2007
  2. pmc Personal mastery is associated with reduced sympathetic arousal in stressed Alzheimer caregivers
    Susan K Roepke
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0680, USA
    Am J Geriatr Psychiatry 16:310-7. 2008
  3. pmc Brief report: Characteristics of antidepressant use in patients with heart failure
    Paul J Mills
    Department of Psychiatry
    Patient Prefer Adherence 2:333-6. 2008
  4. ncbi request reprint Race affects the decline in blood pressure with hospitalization
    P J Mills
    UCSD Medical Center, University of California, San Diego 92103 0804, USA
    Am J Hypertens 10:1091-6. 1997
  5. pmc Diurnal variability of C-reactive protein in obstructive sleep apnea
    Paul J Mills
    Department of Psychiatry, University of California, San Diego, La Jolla, 92093 0804, USA
    Sleep Breath 13:415-20. 2009
  6. pmc Effects of gender and dementia severity on Alzheimer's disease caregivers' sleep and biomarkers of coagulation and inflammation
    Paul J Mills
    Department of Psychiatry, University of California at San Diego, La Jolla, CA, USA
    Brain Behav Immun 23:605-10. 2009
  7. doi request reprint Metabolic predictors of inflammation, adhesion, and coagulability in healthy younger-aged adults
    Paul J Mills
    Department of Psychiatry, University of California San Diego, La Jolla, California, USA
    Obesity (Silver Spring) 16:2702-6. 2008
  8. pmc Predictors of fatigue in obstructive sleep apnea
    Paul J Mills
    Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
    Sleep Breath 12:397-9. 2008
  9. ncbi request reprint Immune cell CD62L and CD11a expression in response to a psychological stressor in human hypertension
    Paul J Mills
    Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
    Brain Behav Immun 17:260-7. 2003
  10. pmc Predictors of inflammation in response to anthracycline-based chemotherapy for breast cancer
    Paul J Mills
    Department of Psychiatry, University of California, San Diego, CA 92103, USA
    Brain Behav Immun 22:98-104. 2008

Detail Information

Publications97

  1. ncbi request reprint Effects of placement and bereavement on psychological well-being and cardiovascular risk in Alzheimer's caregivers: a longitudinal analysis
    Brent T Mausbach
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0680, USA
    J Psychosom Res 62:439-45. 2007
    ..We examined the impact of Alzheimer caregiver transitions (i.e., placement and bereavement) on psychological outcomes and on plasma D-dimer levels, an end product of the coagulation cascade associated with increased cardiovascular risk...
  2. pmc Personal mastery is associated with reduced sympathetic arousal in stressed Alzheimer caregivers
    Susan K Roepke
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0680, USA
    Am J Geriatr Psychiatry 16:310-7. 2008
    ..This study examines the relationship between mastery and sympathetic arousal in elderly caregivers, as measured by norepinephrine (NE) reactivity to an acute psychological stressor...
  3. pmc Brief report: Characteristics of antidepressant use in patients with heart failure
    Paul J Mills
    Department of Psychiatry
    Patient Prefer Adherence 2:333-6. 2008
    ..Depression is common in heart failure (HF), but there is little data on the characteristics of antidepressant use in patients with HF...
  4. ncbi request reprint Race affects the decline in blood pressure with hospitalization
    P J Mills
    UCSD Medical Center, University of California, San Diego 92103 0804, USA
    Am J Hypertens 10:1091-6. 1997
    ..Given that the reduction in BP with hospitalization can be similar to that attained with pharmacologic therapy, these findings may have a bearing on studies examining BP in the hospital...
  5. pmc Diurnal variability of C-reactive protein in obstructive sleep apnea
    Paul J Mills
    Department of Psychiatry, University of California, San Diego, La Jolla, 92093 0804, USA
    Sleep Breath 13:415-20. 2009
    ..The objective of this study is to examine the diurnal variability of C-reactive protein (CRP) in obstructive sleep apnea (OSA)...
  6. pmc Effects of gender and dementia severity on Alzheimer's disease caregivers' sleep and biomarkers of coagulation and inflammation
    Paul J Mills
    Department of Psychiatry, University of California at San Diego, La Jolla, CA, USA
    Brain Behav Immun 23:605-10. 2009
    ..This study examined the effects of caregiver gender and severity of the spouse's dementia on sleep, coagulation, and inflammation in the caregiver...
  7. doi request reprint Metabolic predictors of inflammation, adhesion, and coagulability in healthy younger-aged adults
    Paul J Mills
    Department of Psychiatry, University of California San Diego, La Jolla, California, USA
    Obesity (Silver Spring) 16:2702-6. 2008
    ..The findings provide insight into the adverse cardiovascular risk associated with elevated body weight in younger adults...
  8. pmc Predictors of fatigue in obstructive sleep apnea
    Paul J Mills
    Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
    Sleep Breath 12:397-9. 2008
    ..The objective of this study was to determine potential inflammatory predictors of fatigue in obstructive sleep apnea (OSA)...
  9. ncbi request reprint Immune cell CD62L and CD11a expression in response to a psychological stressor in human hypertension
    Paul J Mills
    Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
    Brain Behav Immun 17:260-7. 2003
    ..Exposure to repeated psychological stressors may further augment this potentially adverse circulatory environment...
  10. pmc Predictors of inflammation in response to anthracycline-based chemotherapy for breast cancer
    Paul J Mills
    Department of Psychiatry, University of California, San Diego, CA 92103, USA
    Brain Behav Immun 22:98-104. 2008
    ..Inflammation in response to chemotherapy is most significantly related to inflammation that existed prior to chemotherapy but also potentially to treatment regimen and to certain disease characteristics...
  11. pmc Inflammation and sleep in healthy individuals
    Paul J Mills
    Department of Psychiatry, University of California San Diego, School of Medicine, La Jolla, CA, USA
    Sleep 30:729-35. 2007
    ..Inflammation is relatively common in individuals with a sleep disorder and is associated with quality of sleep. The purpose of this study was to examine whether inflammation is associated with quality of sleep in healthy individuals...
  12. ncbi request reprint Physical fitness attenuates leukocyte-endothelial adhesion in response to acute exercise
    Paul J Mills
    Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
    J Appl Physiol (1985) 101:785-8. 2006
    ..The findings provide evidence of how physical fitness might protect individuals from inflammatory responses to exercise...
  13. ncbi request reprint Vulnerable caregivers of Alzheimer disease patients have a deficit in beta 2-adrenergic receptor sensitivity and density
    Paul J Mills
    Department of Psychiatry, University of California San Diego, 92103 0804, USA
    Am J Geriatr Psychiatry 12:281-6. 2004
    ..The authors examined the effects of being a spousal caregiver of a patient with Alzheimer disease (AD) on the lymphocyte beta(2)-adrenergic receptor...
  14. ncbi request reprint Effects of nasal continuous positive airway pressure and oxygen supplementation on norepinephrine kinetics and cardiovascular responses in obstructive sleep apnea
    Paul J Mills
    Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
    J Appl Physiol (1985) 100:343-8. 2006
    ..01). The findings indicate that one of the mechanisms through which CPAP reduces NE levels is through an increase in the clearance of NE from the circulation...
  15. ncbi request reprint Sleep apnea: a model for studying cytokines, sleep, and sleep disruption
    Paul J Mills
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Brain Behav Immun 18:298-303. 2004
    ..We believe that the study of OSA presents researchers with an excellent opportunity to tease apart the many complex and interwoven components of sleep that are relevant to PNI...
  16. ncbi request reprint The effects of standard anthracycline-based chemotherapy on soluble ICAM-1 and vascular endothelial growth factor levels in breast cancer
    Paul J Mills
    Department of Psychiatry, University of California San Diego, San Diego, California 92103, USA
    Clin Cancer Res 10:4998-5003. 2004
    ..This study examined the effects of anthracycline-based chemotherapy on plasma sICAM-1 and VEGF, as well as soluble P-selectin, von Willebrand factor, and interleukin-6 levels...
  17. ncbi request reprint The effects of spaceflight on adrenergic receptors and agonists and cell adhesion molecule expression
    Paul J Mills
    Department of Psychiatry and Medicine, University of California, San Diego, La Jolla, CA 92103, USA
    J Neuroimmunol 132:173-9. 2002
    ..05). The data suggest that spaceflight leads to an environment that would support reduced leukocyte-endothelial adhesion. Sympathetic activation may contribute to this phenomenon...
  18. pmc Sleep and health-related quality of life in heart failure
    Paul J Mills
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Congest Heart Fail 15:228-33. 2009
    ..01) (model adjusted R(2)=.732; P<.001). Findings provide evidence that in addition to functional status and ongoing fatigue, poorer quality of life in HF is independently related to the severity of sleep-disordered breathing...
  19. ncbi request reprint The relationship between fatigue and quality of life and inflammation during anthracycline-based chemotherapy in breast cancer
    Paul J Mills
    Department of Psychiatry, University of California, San Diego UCSD, Medical Center, 200 West Arbor Drive, San Diego, CA 92103 0804, USA
    Biol Psychol 69:85-96. 2005
    ..001). The findings contribute to the literature by showing that both pre-chemotherapy and chemotherapy-induced changes in inflammation are related to changes in fatigue and quality of life in response to chemotherapy...
  20. ncbi request reprint L-selectin expression affects T-cell circulation following isoproterenol infusion in humans
    P J Mills
    University of California at San Diego, La Jolla 92093, USA
    Brain Behav Immun 11:333-42. 1997
    ..The findings indicate that L-selectin expression influences T-cell trafficking in response to beta-adrenergic stimulation and help further illuminate catecholamine-mediated sympathetic and immune interactions...
  21. ncbi request reprint Leptin is related to epinephrine levels but not reproductive hormone levels in cycling African-American and Caucasian women
    P J Mills
    UCSD Medical Center, University of California, San Diego 92093, USA
    Life Sci 63:617-23. 1998
    ..38, p=0.01). No such relationship was observed in men. The findings indicate that in women leptin levels are not associated with cyclic changes in estrogen or progesterone but may be associated with catecholamine levels...
  22. ncbi request reprint Vulnerable caregivers of patients with Alzheimer's disease have a deficit in circulating CD62L- T lymphocytes
    P J Mills
    Department of Psychiatry, University of California, San Diego, USA
    Psychosom Med 61:168-74. 1999
    ..The objective of this study was to determine the effects of chronic stress on L-selectin expression on peripheral lymphocytes in elderly spousal caregivers of patients with Alzheimer's disease...
  23. ncbi request reprint Nonselective beta blockade attenuates the recruitment of CD62L(-)T lymphocytes following exercise
    P J Mills
    Department of Psychiatry, University of California, San Diego, USA
    Eur J Appl Physiol Occup Physiol 79:531-4. 1999
    ....
  24. ncbi request reprint Menstrual cycle, race and task effects on blood pressure recovery from acute stress
    P J Mills
    UCSD Medical Center, University of California at San Diego, USA
    J Psychosom Res 46:445-54. 1999
    ..The findings support prior studies indicating racial differences in recovery from acute stress and extend these findings by suggesting that the menstrual cycle may differentially affect recovery in black versus white women...
  25. ncbi request reprint Leukocyte adhesion molecule expression and T cell naïve/memory status following isoproterenol infusion
    P J Mills
    Department of Psychiatry, UCSD Medical Center, San Diego, CA 92103 0804, USA
    J Neuroimmunol 102:137-44. 2000
    ..01), but had no significant effect on the number of circulating CD8+ CD45RA+ CD62L+ naïve T cells. beta blockade with the non-specific antagonist propranolol eliminated these isoproterenol-induced effects...
  26. ncbi request reprint Peripheral blood mononuclear cell-endothelial adhesion in human hypertension following exercise
    P J Mills
    Department of Psychiatry, University of California, San Diego 92103 0804, USA
    J Hypertens 18:1801-6. 2000
    ..To determine the effects of hypertension and exercise on interleukin-6 (IL-6) levels and mononuclear cell adhesion to endothelial cells...
  27. ncbi request reprint The effects of hypoxia and sleep apnea on isoproterenol sensitivity
    P J Mills
    Department of Psychiatry, UCSD Medical Center, University of California, San Diego 92103 0804, USA
    Sleep 21:731-5. 1998
    ..To determine the effects of both apnea and hypoxia on beta-adrenergic receptor sensitivity...
  28. ncbi request reprint Peripheral blood mononuclear cell CD62L and CD11a expression and soluble interstitial cell adhesion molecule-1 levels following infused isoproterenol in hypertension
    Paul J Mills
    Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
    J Hypertens 20:311-6. 2002
    ....
  29. ncbi request reprint Hormone replacement therapy does not affect 24-h ambulatory blood pressure in healthy non-smoking postmenopausal women
    Paul J Mills
    Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
    Blood Press Monit 8:57-61. 2003
    ..Important interindividual factors that affect blood pressure, such as smoking, body mass and sodium intake, may account for the conflicting findings seen in studies examining the effects of HRT on blood pressure...
  30. ncbi request reprint Peripheral leukocyte subpopulations and catecholamine levels in astronauts as a function of mission duration
    P J Mills
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92103 0804, USA
    Psychosom Med 63:886-90. 2001
    ..The objective of this study was to determine the effects of spaceflight duration on immune cells and their relationship to catecholamine levels...
  31. ncbi request reprint Sleep in spousal caregivers of people with Alzheimer's disease
    Christine L McKibbin
    Department of Psychiatry, University of California San Diego, CA, USA
    Sleep 28:1245-50. 2005
    ..This study examined differences in objective and subjective measures of sleep between caregivers and noncaregivers...
  32. pmc Overnight changes of immune parameters and catecholamines are associated with mood and stress
    Winfried Rief
    Department of Psychiatry, University of California, San Diego, San Diego, California, USA
    Psychosom Med 72:755-62. 2010
    ..To test the hypothesis that a nocturnal decrease of secretion of inflammation markers and catecholamines would be associated with mood and stress variables even after controlling for objective sleep variables...
  33. ncbi request reprint Coping processes and hemostatic reactivity to acute stress in dementia caregivers
    Kirstin Aschbacher
    Department of Psychiatry, School of Medicine, University of California, San Diego, California, USA
    Psychosom Med 67:964-71. 2005
    ..A hypercoagulable stress response might contribute to the increased cardiovascular risk in Alzheimer's caregivers...
  34. ncbi request reprint Association between polysomnographic measures of disrupted sleep and prothrombotic factors
    Roland von Kanel
    Department of Psychiatry, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0804, USA
    Chest 131:733-9. 2007
    ..We hypothesized that disrupted sleep as verified by polysomnography is associated with increased levels of prothrombotic hemostasis factors previously shown to predict CAD risk...
  35. ncbi request reprint Systemic vs. local cytokine and leukocyte responses to unilateral wrist flexion exercise
    Dan Nemet
    Center for the Study of Health Effects of Exercise in Children, College of Medicine, University of California, Irvine 92868, California, USA
    J Appl Physiol 93:546-54. 2002
    ..05). Brief, low-intensity exercise leads to a systemic rather than local response of mediators that could be involved in inflammation, repair, or angiogenic adaptation to physical activity...
  36. ncbi request reprint Dementia severity of the care receiver predicts procoagulant response in Alzheimer caregivers
    Kirstin Aschbacher
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Am J Geriatr Psychiatry 14:694-703. 2006
    ..Research has demonstrated that spousal dementia caregivers have elevated levels of D-dimer relative to their non-caregiving peers...
  37. ncbi request reprint In-home respite intervention reduces plasma epinephrine in stressed Alzheimer caregivers
    Igor Grant
    Department of Psychiatry 0680, University of California, San Diego, La Jolla 92093 0680, USA
    Am J Geriatr Psychiatry 11:62-72. 2003
    ..Authors tested the efficacy of an in-home respite intervention to reduce peripheral markers of SAM activation and psychological distress in spousal caregivers of patients with Alzheimer disease...
  38. ncbi request reprint Combination of caregiving stress and hormone replacement therapy is associated with prolonged platelet activation to acute stress among postmenopausal women
    Kirstin Aschbacher
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0680, USA
    Psychosom Med 69:910-7. 2007
    ..Both HRT and the chronic stress of caregiving have been associated with increased cardiovascular risk, potentially through a mechanism of platelet hyperactivity...
  39. ncbi request reprint Acute psychological stress: effects on chemotaxis and cellular adhesion molecule expression
    Laura Redwine
    Department of Psychiatry, University of California, San Diego, USA
    Psychosom Med 65:598-603. 2003
    ..In this study, we examine the effects of an acute psychological stress on chemotactic responses of PBMCs and on CAM expression in relation to measures of sympathetic activation...
  40. ncbi request reprint Relation of nocturnal blood pressure dipping to cellular adhesion, inflammation and hemostasis
    Roland von Kanel
    Department of Psychiatry, University of California San Diego, California 92093 0804, USA
    J Hypertens 22:2087-93. 2004
    ..The pathogenetic mechanisms of this relationship have not been elucidated. We investigated whether non-dipping would relate to procoagulant and proinflammatory activity...
  41. pmc Effects of depressive and anxious symptoms on norepinephrine and platelet P-selectin responses to acute psychological stress among elderly caregivers
    Kirstin Aschbacher
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla CA 92093 0680, USA
    Brain Behav Immun 22:493-502. 2008
    ....
  42. ncbi request reprint Effects of depressive symptoms and anxiety on hemostatic responses to acute mental stress and recovery in the elderly
    Roland von Kanel
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0680, USA
    Psychiatry Res 126:253-64. 2004
    ..The independent association of anxiety symptoms with resting and stress-induced fibrin formation (D-dimer) may be a mechanism linking mood with cardiovascular disease risk in the elderly...
  43. ncbi request reprint Interactive effects of common beta2-adrenoceptor haplotypes and age on susceptibility to hypertension and receptor function
    Xuping Bao
    Department of Medicine, University of California, San Diego, CA, USA
    Hypertension 46:301-7. 2005
    ..05) and decreased heart rate (7%; P<0.001). Our study suggests that age is an important modifier for the effects of ADRB2 polymorphisms on ADRB2 function and the development of hypertension...
  44. doi request reprint Circulating levels of soluble intercellular adhesion molecule-1 (sICAM-1) independently predict depressive symptom severity after 12 months in heart failure patients
    Petra H Wirtz
    Department of Clinical Psychology and Psychotherapy, Psychological Institute, University of Zurich, Switzerland Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
    Brain Behav Immun 24:366-9. 2010
    ..To determine whether inflammatory markers prospectively predict depressive symptom severity 12 months later in heart failure (HF) patients...
  45. pmc Pre-treatment symptom cluster in breast cancer patients is associated with worse sleep, fatigue and depression during chemotherapy
    Lianqi Liu
    Department of Psychiatry, University of California, San Diego, CA 92161, USA
    Psychooncology 18:187-94. 2009
    ..e. sleep disturbances, fatigue and depression) into one symptom cluster, to explore the associations between pre-treatment cluster categories and longitudinal profiles of these same symptoms during chemotherapy...
  46. ncbi request reprint Effects of nonspecific beta-adrenergic stimulation and blockade on blood coagulation in hypertension
    Roland von Kanel
    Department of Psychiatry, University of California, San Diego, California 92093, USA
    J Appl Physiol 94:1455-9. 2003
    ..However, beta-adrenergic stimulation alone may not be sufficient to trigger fibrin formation in vivo...
  47. pmc Persistent versus transient depressive symptoms in relation to platelet hyperactivation: a longitudinal analysis of dementia caregivers
    Kirstin Aschbacher
    Department of Psychiatry, University of California, San Diego, USA
    J Affect Disord 116:80-7. 2009
    ..The primary objective was to investigate whether persistent depressive symptoms would relate to elevated platelet activation in response to acute psychological stress over a three-year period...
  48. pmc Effects of an exercise challenge on mobilization and surface marker expression of monocyte subsets in individuals with normal vs. elevated blood pressure
    Suzi Hong
    Department of Psychiatry, University of California, San Diego, USA
    Brain Behav Immun 22:590-9. 2008
    ..Individuals with high BP showed greater responses to a physical challenge in some monocyte chemokine receptors and selectins, but its clinical implications need further examination...
  49. ncbi request reprint Temporal stability of acute stress-induced changes in leukocyte subsets and cellular adhesion molecules in older adults
    Karen A Adler
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    Brain Behav Immun 16:262-74. 2002
    ..The level of temporal stability achieved is comparable to that seen previously in younger adults, indicating that acute psychosocial stress produces reliable changes in circulating leukocytes and cell adhesion molecules in older adults...
  50. ncbi request reprint Constitutive pro- and anti-inflammatory cytokine and growth factor response to exercise in leukocytes
    Frank Zaldivar
    Department of Pediatrics, Pediatric Exercise Research Center, University Children s Hospital, University of California, Irvine, USA
    J Appl Physiol 100:1124-33. 2006
    ....
  51. ncbi request reprint Effect of water polo practice on cytokines, growth mediators, and leukocytes in girls
    Dan Nemet
    Center for the Study of Health Effects of Exercise in Children, University of California, Irvine, CA 92868, USA
    Med Sci Sports Exerc 35:356-63. 2003
    ....
  52. ncbi request reprint Effect of beta2-adrenergic receptor functioning and increased norepinephrine on the hypercoagulable state with mental stress
    Roland von Kanel
    Department of Psychiatry, University of California, San Diego, Calif 92093 0804, USA
    Am Heart J 144:68-72. 2002
    ....
  53. ncbi request reprint The internet for medical information about cancer: help or hindrance?
    Scott C Matthews
    Department of Psychiatry, University of California, San Diego, USA
    Psychosomatics 44:100-3. 2003
    ..The authors tested a strategy for screening Internet sites to identify those that provide scientifically accurate information regarding complementary/alternative medicine treatments commonly used by cancer patients...
  54. ncbi request reprint Hormone replacement therapy increases renal kallikrein excretion in healthy postmenopausal women
    Noha H Farag
    Department of Psychiatry, UCSD Medical Center, University of California, 200 West Arbor Drive, CTF A, 415, San Diego, La Jolla, CA 92103 0804, USA
    Life Sci 72:1279-88. 2003
    ....
  55. ncbi request reprint Autonomic responses to psychological stress: the influence of menopausal status
    Noha H Farag
    Department of Psychiatry, University of California, San Diego, CA 92103 0804, USA
    Ann Behav Med 26:134-8. 2003
    ..Postmenopausal women have greater sympathetic and less parasympathetic activity than premenopausal women, which may account for their increased risk of coronary artery disease...
  56. ncbi request reprint The potential anti-inflammatory benefits of improving physical fitness in hypertension
    Kate M Edwards
    Department of Psychiatry, UCSD Medical Center, University of California, San Diego, La Jolla, California 92093 0804, USA
    J Hypertens 25:1533-42. 2007
    ..Here, exercise is promoted as a potentially effective treatment for both the elevated blood pressure and chronic inflammation found in hypertension...
  57. pmc The roles of TNF-alpha and the soluble TNF receptor I on sleep architecture in OSA
    Herbert J Yue
    Department of Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA
    Sleep Breath 13:263-9. 2009
    ..We hypothesized that the TNF receptor might play an important role in the inflammation as well as sleep architecture changes in patients with OSA...
  58. pmc The effects of ethnic discrimination and socioeconomic status on endothelin-1 among blacks and whites
    Denise C Cooper
    Department of Psychiatry, University of California, San Diego, California, USA
    Am J Hypertens 22:698-704. 2009
    ..Stress is associated with increased endothelin-1 (ET-1). This study examined the relationship of ET-1 to socioeconomic status (SES) and to perceived ethnic discrimination among black (n = 51) and white (n = 65) adults (mean age 36.5)...
  59. pmc Biophoton detection and low-intensity light therapy: a potential clinical partnership
    Joseph Tafur
    Department of Psychiatry, Behavioral Medicine Laboratory, University of California at San Diego, San Diego, CA, USA
    Photomed Laser Surg 28:23-30. 2010
    ..In this review, we will present the case for pursuing further investigation into the potential clinical partnership between biophoton detection and LILT...
  60. pmc Effects of chronic stress on memory decline in cognitively normal and mildly impaired older adults
    Guerry M Peavy
    UCSD Shiley Marcos Alzheimer s Disease Research Center, University of California San Diego, 8950 Villa La Jolla Drive, La Jolla, CA 92037, USA
    Am J Psychiatry 166:1384-91. 2009
    ..The authors sought to determine the prospective association between subjective and objective measures of chronic stress and rate of memory decline in cognitively normal and mildly impaired older adults...
  61. pmc Adverse impact of mood on flow-mediated dilation
    Denise C Cooper
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0804, USA
    Psychosom Med 72:122-7. 2010
    ..Substantial literature indicates that negative mood is linked to cardiovascular disease (CVD). However, the mechanisms underlying this relationship are not well defined. CVD is often preceded by dysfunction of the endothelium...
  62. pmc Everyday discrimination and nocturnal blood pressure dipping in black and white americans
    Lianne Tomfohr
    Department of Psychology, University of California, San Diego, 9500 Gilman Drive, Mail Code 0804, La Jolla, CA 92093 0804, USA
    Psychosom Med 72:266-72. 2010
    ..Attenuated nocturnal BP dipping is closely linked to cardiovascular morbidity and mortality. Self-reported experiences of everyday discrimination have also been associated with negative cardiovascular health outcomes...
  63. pmc Association between chronic caregiving stress and impaired endothelial function in the elderly
    Brent T Mausbach
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0680, USA
    J Am Coll Cardiol 55:2599-606. 2010
    ..We examined the relationship between chronic caregiving stress and endothelial function...
  64. pmc Macrophage migratory inhibitory factor (MIF) may be a key factor in inflammation in obstructive sleep apnea
    Kate M Edwards
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Sleep 34:161-3. 2011
    ....
  65. ncbi request reprint Ethnicity, social class and hostility: effects on in vivo beta-adrenergic receptor responsiveness
    Shamini Jain
    Department of Psychiatry, University of California, San Diego, CA, USA
    Biol Psychol 65:89-100. 2004
    ..Thus, decreased beta-adrenergic receptor responsiveness in African-Americans does not appear to be due to differences in current social class, age, or smoking status, nor to higher reports of hostility...
  66. pmc The effects of prolonged stress and APOE genotype on memory and cortisol in older adults
    Guerry M Peavy
    Department of Neurosciences, University of California, San Diego, California, USA
    Biol Psychiatry 62:472-8. 2007
    ..Combined effects of stress and APOE status on memory and cortisol in humans have not been studied...
  67. ncbi request reprint Effects of perceived stress and uplifts on inflammation and coagulability
    Shamini Jain
    Joint Doctoral Program, Clinical Psychology, University of California San Diego San Diego State University, San Diego, California, USA
    Psychophysiology 44:154-60. 2007
    ....
  68. ncbi request reprint Sleep disturbance, norepinephrine, and D-dimer are all related in elderly caregivers of people with Alzheimer disease
    Brent T Mausbach
    Department of Psychiatry, University of California, San Diego, CA 92093 0682, USA
    Sleep 29:1347-52. 2006
    ..In this study, we examined if sleep disturbance of elderly caregivers was associated with physiologic markers of cardiovascular risk, including plasma norepinephrine, epinephrine, and the hemostasis marker D-dimer...
  69. ncbi request reprint Correlates of physical activity level in breast cancer survivors participating in the Women's Healthy Eating and Living (WHEL) Study
    Suzi Hong
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Breast Cancer Res Treat 101:225-32. 2007
    ..The purpose of this study was to examine factors that are associated with physical activity or inactivity among breast cancer survivors...
  70. ncbi request reprint The association of social status and blood pressure with markers of vascular inflammation
    Suzi Hong
    Department of Psychiatry, University of California, San Diego, San Diego, California, USA
    Psychosom Med 68:517-23. 2006
    ..We examined the associations among BP, social status, and sICAM-1 and ET-1 levels in 121 European American and African American men and women...
  71. ncbi request reprint Effects of continuous positive airway pressure versus supplemental oxygen on 24-hour ambulatory blood pressure
    Daniel Norman
    Department of Medicine, School of Medicine, University of California, San Diego, CA, USA
    Hypertension 47:840-5. 2006
    ..We conclude that CPAP therapy reduces both daytime and nighttime blood pressure in patients with OSA, perhaps through mechanisms other than improvement of nocturnal oxyhemoglobin saturation...
  72. pmc Biofield therapies: helpful or full of hype? A best evidence synthesis
    Shamini Jain
    UCLA Division of Cancer Prevention and Control Research, Los Angeles, CA, USA
    Int J Behav Med 17:1-16. 2010
    ..Biofield therapies (such as Reiki, therapeutic touch, and healing touch) are complementary medicine modalities that remain controversial and are utilized by a significant number of patients, with little information regarding their efficacy...
  73. ncbi request reprint Negative mood endures after completion of high-altitude military training
    Wayne A Bardwell
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    Ann Behav Med 29:64-9. 2005
    ..Most research in this area has focused on immediate effects of stress on mood...
  74. ncbi request reprint Depressive symptoms predict norepinephrine response to a psychological stressor task in Alzheimer's caregivers
    Brent T Mausbach
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0680, USA
    Psychosom Med 67:638-42. 2005
    ..The current study examined the relations between the level of depressive symptoms in spousal caregivers and the physiological response to a psychological stress task...
  75. ncbi request reprint Cardiac-related hospitalization and/or death associated with immune dysregulation and symptoms of depression in heart failure patients
    Laura S Redwine
    Department of Medicine, University of California, San Diego, CA, USA
    Psychosom Med 69:23-9. 2007
    ..This study examined in CHF patients the relationship of depressive symptoms with cellular immune activity measured by Th1/Th2 ratios and cardiac rehospitalization and/or death...
  76. ncbi request reprint Avoidant coping partially mediates the relationship between patient problem behaviors and depressive symptoms in spousal Alzheimer caregivers
    Brent T Mausbach
    Department of Psychiatry, University of California at San Diego, San Diego, California 92093 0680, USA
    Am J Geriatr Psychiatry 14:299-306. 2006
    ..The purpose of this study was to test a mediational model of the associations between patient problem behaviors, escape-avoidance coping, and depressive symptoms in Alzheimer caregivers...
  77. ncbi request reprint Keeping it simple: encouraging walking as a means to active living
    Gregory J Norman
    Department of Family and Preventive Medicine, University of California, San Diego, CA 92037, USA
    Ann Behav Med 28:149-51. 2004
  78. pmc Recruiting research participants at community education sites
    Georgia Robins Sadler
    Rebecca and John Moores Cancer Center, La Jolla, CA, USA
    J Cancer Educ 20:235-9. 2005
    ..In this study, we explored whether community-based cancer education sites and educators serving the African American community could be used to recruit minority participants to research...
  79. pmc Higher population-based incidence rates of triple-negative breast cancer among young African-American women : Implications for breast cancer screening recommendations
    Kathryn C Amirikia
    Department of Surgery, University of California San Francisco, Fresno, California, USA
    Cancer 117:2747-53. 2011
    ..The objective of the current study was to evaluate age-specific breast cancer stage distributions and incidence rates of triple-negative breast cancer (TNBC) in a population-based tumor registry...
  80. ncbi request reprint Relation of autonomic activity to plasminogen activator inhibitor-1 plasma concentration and the role of body mass index
    Roland von Kanel
    Department of General Internal Medicine, University Hospital Berne, Switzerland
    Blood Coagul Fibrinolysis 18:353-9. 2007
    ..More apparent, higher BMI explained a significant proportion of the variance in the relationship between depressed sympathetic and parasympathetic activity and elevated plasma PAI-1 concentration...
  81. ncbi request reprint Poor sleep is associated with higher plasma proinflammatory cytokine interleukin-6 and procoagulant marker fibrin D-dimer in older caregivers of people with Alzheimer's disease
    Roland von Kanel
    Department of General Internal Medicine, University Hospital, Berne, Switzerland
    J Am Geriatr Soc 54:431-7. 2006
    ..To determine whether objective measures of sleep correlate with plasma levels of the proinflammatory cytokine interleukin (IL)-6 and the procoagulant marker fibrin D-dimer in caregivers of patients with dementia...
  82. ncbi request reprint Effects of regular exercise on lymphocyte subsets and CD62L after psychological vs. physical stress
    Suzi Hong
    Department of Psychiatry, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA, USA
    J Psychosom Res 56:363-70. 2004
    ..To examine the effects of regular physical activity on lymphocyte responses to a speech stressor and an exercise challenge...
  83. ncbi request reprint Association of blood pressure and fitness with levels of atherosclerotic risk markers pre-exercise and post-exercise
    Roland von Kanel
    Division of General Internal Medicine and Cardiovascular Prevention and Rehabilitation, Swiss Cardiovascular Center Berne, Department of Cardiology, University Hospital Berne, Berne, Switzerland
    Am J Hypertens 20:670-5. 2007
    ..We investigated the association of screening blood pressure (BP) and cardiorespiratory fitness with baseline levels and exercise-induced changes in levels of soluble atherosclerotic risk markers...
  84. ncbi request reprint Vascular profile, delayed recovery, inflammatory process, and ambulatory blood pressure: laboratory-to-life generalizability
    Cristina Ottaviani
    Department of Psychology, University of Bologna, Italy
    Int J Psychophysiol 66:56-65. 2007
    ..The results suggest a link between recovery hemodynamics and cardiovascular risk...
  85. pmc Mood states, sympathetic activity, and in vivo beta-adrenergic receptor function in a normal population
    Bum Hee Yu
    Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Depress Anxiety 25:559-64. 2008
    ..These findings replicate previous reports that anxiety is related to decreased (i.e., desensitized) beta-adrenergic receptor sensitivity, even after controlling for age, gender, ethnicity, and body mass index...
  86. ncbi request reprint What's next in behavioral hypertension research?
    Noha H Farag
    Ann Behav Med 27:1-2. 2004
  87. ncbi request reprint An unanticipated effect of meditation on cardiovascular pharmacology and physiology
    Joel E Dimsdale
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093, USA
    Am J Cardiol 90:908-9. 2002
  88. ncbi request reprint Does obstructive sleep apnea increase hematocrit?
    Jong Bae Choi
    Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Kyunggi Do, South Korea
    Sleep Breath 10:155-60. 2006
    ..05). The severity of OSA is significantly associated with increased hematocrit, even after controlling for possible confounding variables. However, nocturnal hypoxemia in OSA does not usually lead to clinical polycythemia...
  89. pmc Serum aminotransferase levels are associated with markers of hypoxia in patients with obstructive sleep apnea
    Daniel Norman
    Department of Pulmonary and Critical Care Medicine, University of California at San Diego, San Diego, CA 92103 8383, USA
    Sleep 31:121-6. 2008
    ....
  90. doi request reprint Increased Framingham Coronary Heart Disease Risk Score in dementia caregivers relative to non-caregiving controls
    Roland von Kanel
    Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital, Berne, Switzerland
    Gerontology 54:131-7. 2008
    ..Elderly individuals who provide care to a spouse suffering from dementia bear an increased risk of coronary heart disease (CHD)...
  91. ncbi request reprint Relationship of systolic blood pressure with plasma homocysteine: importance of smoking status
    Brian P Kennedy
    Department of Medicine, University of California, San Diego Medical Center, California 92103 8341, USA
    J Hypertens 21:1307-12. 2003
    ..Elevated plasma homocysteine is a risk factor for cardiovascular disease. Elevations in plasma homocysteine occur in both smokers and hypertensives, but the combined effect of smoking and hypertension on homocysteine is unknown...
  92. ncbi request reprint Effects of estrogen and psychological stress on plasma homocysteine levels
    Noha H Farag
    Department of Psychiatry, University of California, San Diego, San Diego, California 92093, USA
    Fertil Steril 79:256-60. 2003
    ..To investigate the effects of estrogen (E) and psychological stress on plasma total homocysteine levels in relation to menopausal status...
  93. ncbi request reprint Autonomic and cardiovascular function in postmenopausal women: the effects of estrogen versus combination therapy
    Noha H Farag
    Department of Psychiatry, University of California, San Diego, UCSD Medical Center, 92103 0804, USA
    Am J Obstet Gynecol 186:954-61. 2002
    ..This study examined the effects of oral estrogen (ERT) alone versus oral estrogen/medroxyprogesterone acetate (HRT) therapy on cardiovascular function, as controlled by the autonomic nervous system...
  94. ncbi request reprint Effect of Alzheimer caregiving stress and age on frailty markers interleukin-6, C-reactive protein, and D-dimer
    Roland von Kanel
    Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital, Switzerland
    J Gerontol A Biol Sci Med Sci 61:963-9. 2006
    ..We hypothesized that, compatible with premature frailty, chronic stress and age are related in predicting inflammation and coagulation activity in Alzheimer caregivers...
  95. pmc Relationship between heart rate variability, interleukin-6, and soluble tissue factor in healthy subjects
    Roland von Kanel
    Department of General Internal Medicine, University Hospital Berne, Switzerland
    Brain Behav Immun 22:461-8. 2008
    ..Inflammation and related hypercoagulability might particularly contribute to atherothrombotic events in a setting of decreased HRV...
  96. ncbi request reprint Relationship between central obesity and cardiovascular hemodynamic indices in postmenopausal women
    Noha H Farag
    Fertil Steril 81:465-7. 2004
    ..In a sample of healthy postmenopausal women, greater central body fat distribution was associated with higher peripheral resistance, triglycerides, and total cholesterol as well as lower cardiac and stroke indexes...
  97. ncbi request reprint Sleepiness in obstructive sleep apnea: a harbinger of impaired cardiac function?
    Jong Bae Choi
    Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Kyunggi Do, South Korea
    Sleep 29:1531-6. 2006
    ..The purpose of this study was to assess the relationship between degree of subjective daytime sleepiness and cardiac performance in patients with obstructive sleep apnea...

Research Grants20

  1. BNP and Neuroimmune Characteristics of CHF & Depression
    Paul Mills; Fiscal Year: 2007
    ..The overarching hypothesis of this study is that neuroimmune and adhesion molecule activation constitute an important pathophysiological pathway linking depression to worse outcomes in CHF. ..
  2. American Psychosomatic Society Meeting Grant
    Paul Mills; Fiscal Year: 2007
    ..Across five years of funding, the Advisory Committee comprised of senior scientists will oversee trainee abstract selection, the trainee program, and APS's commitment to research training within the context of the annual conference. ..
  3. SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESION
    Paul Mills; Fiscal Year: 2007
    ..abstract_text> ..
  4. SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESION
    Paul Mills; Fiscal Year: 2009
    ..abstract_text> ..
  5. SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESION
    Paul J Mills; Fiscal Year: 2010
    ..abstract_text> ..
  6. SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESION
    Paul Mills; Fiscal Year: 2007
    ..Changes in cardiovascular fitness, weight, neuroendocrine activation (catecholamine and cortisol levels), and insulin sensitivity will be examined as possible mechanisms for the anticipated reductions in inflammation and cell adhesion. ..
  7. BNP and Neuroimmune Characteristics of CHF & Depression
    Paul Mills; Fiscal Year: 2006
    ..The overarching hypothesis of this study is that neuroimmune and adhesion molecule activation constitute an important pathophysiological pathway linking depression to worse outcomes in CHF. ..
  8. SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESION
    Paul Mills; Fiscal Year: 1999
    ..The project will help elucidate the effects of sympathetic activation on CAMs and the degree to which this physiology is altered in individuals with hypertensive disease. ..
  9. SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESION
    Paul Mills; Fiscal Year: 2001
    ..The overarching hypothesis of the proposal is that hypertension combined with sympathetic activation results in enhanced effects on leukocyte, platelet and endothelial adhesion that are of likely clinical significance. ..
  10. SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESION
    Paul Mills; Fiscal Year: 2002
    ..The overarching hypothesis of the proposal is that hypertension combined with sympathetic activation results in enhanced effects on leukocyte, platelet and endothelial adhesion that are of likely clinical significance. ..
  11. UCSD Hillcrest Flow Cytometer
    Paul Mills; Fiscal Year: 2003
    ..It will also be the centerpiece for an environment of shared ideas and collaboration among investigators who now utilize cytometry for their research. ..
  12. SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESION
    Paul Mills; Fiscal Year: 2003
    ..The overarching hypothesis of the proposal is that hypertension combined with sympathetic activation results in enhanced effects on leukocyte, platelet and endothelial adhesion that are of likely clinical significance. ..
  13. SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESION
    Paul Mills; Fiscal Year: 2004
    ..The overarching hypothesis of the proposal is that hypertension combined with sympathetic activation results in enhanced effects on leukocyte, platelet and endothelial adhesion that are of likely clinical significance. ..
  14. BNP and Neuroimmune Characteristics of CHF & Depression
    Paul Mills; Fiscal Year: 2005
    ..The overarching hypothesis of this study is that neuroimmune and adhesion molecule activation constitute an important pathophysiological pathway linking depression to worse outcomes in CHF. ..
  15. SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESION
    Paul Mills; Fiscal Year: 2006
    ..Changes in cardiovascular fitness, weight, neuroendocrine activation (catecholamine and cortisol levels), and insulin sensitivity will be examined as possible mechanisms for the anticipated reductions in inflammation and cell adhesion. ..
  16. BNP and Neuroimmune Characteristics of CHF & Depression
    Paul Mills; Fiscal Year: 2009
    ..The overarching hypothesis of this study is that neuroimmune and adhesion molecule activation constitute an important pathophysiological pathway linking depression to worse outcomes in CHF. ..