M Million

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Susceptibility of Lewis and Fischer rats to stress-induced worsening of TNB-colitis: protective role of brain CRF
    M Million
    CURE Digestive Diseases Research Center, West Los Angeles Department of Veterans Affairs Medical Center, Los Angeles, USA
    Am J Physiol 276:G1027-36. 1999
  2. ncbi request reprint Enhanced pelvic responses to stressors in female CRF-overexpressing mice
    M Million
    CURE Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health, Department of Medicine, Division of Digestive Diseases, University of California, Los Angeles, CA 90073, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1429-38. 2007
  3. ncbi request reprint Differential Fos expression in the paraventricular nucleus of the hypothalamus, sacral parasympathetic nucleus and colonic motor response to water avoidance stress in Fischer and Lewis rats
    M Million
    CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System and Digestive Diseases Division, Department of Medicine, Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90073, USA
    Brain Res 877:345-53. 2000
  4. pmc CRF2 receptor activation prevents colorectal distension induced visceral pain and spinal ERK1/2 phosphorylation in rats
    M Million
    CURE Digestive Diseases Research Center, Department of Medicine, University of California Los Angeles, CA 90073, USA
    Gut 55:172-81. 2006
  5. ncbi request reprint Human urocortin II, a new CRF-related peptide, displays selective CRF(2)-mediated action on gastric transit in rats
    Mulugeta Million
    CURE Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System, University of California, Los Angeles 90073, USA
    Am J Physiol Gastrointest Liver Physiol 282:G34-40. 2002
  6. ncbi request reprint Peripheral injection of sauvagine prevents repeated colorectal distension-induced visceral pain in female rats
    Mulugeta Million
    Center for Neurovisceral Sciences and Women s Health, Division of Digestive Diseases, Department of Medicine, University of California Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Peptides 26:1188-95. 2005
  7. ncbi request reprint A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats
    Mulugeta Million
    CURE Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health CNS, West Los Angeles VA Medical Center, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90073, USA
    Brain Res 985:32-42. 2003
  8. pmc Cholinergic giant migrating contractions in conscious mouse colon assessed by using a novel noninvasive solid-state manometry method: modulation by stressors
    G Gourcerol
    CURE Digestive Diseases Research Center and Center for Stress Neurobiology, UCLA, VA Greater Los Angeles Healthcare System, CURE Bldg 115, Rm 118B, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 296:G992-G1002. 2009
  9. ncbi request reprint Peripheral corticotropin-releasing factor and stress-stimulated colonic motor activity involve type 1 receptor in rats
    C Maillot
    CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Gastroenterology 119:1569-79. 2000
  10. ncbi request reprint Urocortins and cholecystokinin-8 act synergistically to increase satiation in lean but not obese mice: involvement of corticotropin-releasing factor receptor-2 pathway
    G Gourcerol
    Center for Neurovisceral Sciences and Women s Health, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Endocrinology 148:6115-23. 2007

Research Grants

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Susceptibility of Lewis and Fischer rats to stress-induced worsening of TNB-colitis: protective role of brain CRF
    M Million
    CURE Digestive Diseases Research Center, West Los Angeles Department of Veterans Affairs Medical Center, Los Angeles, USA
    Am J Physiol 276:G1027-36. 1999
    ..These data show that central CRF restrains the proinflammatory action of stress in experimental colitis...
  2. ncbi request reprint Enhanced pelvic responses to stressors in female CRF-overexpressing mice
    M Million
    CURE Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health, Department of Medicine, Division of Digestive Diseases, University of California, Los Angeles, CA 90073, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1429-38. 2007
    ....
  3. ncbi request reprint Differential Fos expression in the paraventricular nucleus of the hypothalamus, sacral parasympathetic nucleus and colonic motor response to water avoidance stress in Fischer and Lewis rats
    M Million
    CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System and Digestive Diseases Division, Department of Medicine, Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90073, USA
    Brain Res 877:345-53. 2000
    ....
  4. pmc CRF2 receptor activation prevents colorectal distension induced visceral pain and spinal ERK1/2 phosphorylation in rats
    M Million
    CURE Digestive Diseases Research Center, Department of Medicine, University of California Los Angeles, CA 90073, USA
    Gut 55:172-81. 2006
    ..We hypothesised that CRF2 receptor activation may influence visceral pain induced by colorectal distension (CRD) in conscious rats, and assessed the possible sites and mechanisms of action...
  5. ncbi request reprint Human urocortin II, a new CRF-related peptide, displays selective CRF(2)-mediated action on gastric transit in rats
    Mulugeta Million
    CURE Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System, University of California, Los Angeles 90073, USA
    Am J Physiol Gastrointest Liver Physiol 282:G34-40. 2002
    ..The distinct profile of hUcn II, only on gastric transit, is linked to its CRF(2) selectivity...
  6. ncbi request reprint Peripheral injection of sauvagine prevents repeated colorectal distension-induced visceral pain in female rats
    Mulugeta Million
    Center for Neurovisceral Sciences and Women s Health, Division of Digestive Diseases, Department of Medicine, University of California Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Peptides 26:1188-95. 2005
    ..5+/-23.3% and 63.5+/-7.2%, respectively in Fisher rats. These data suggest that peripheral CRF2 receptor activation exerts antinociceptive effects on CRD-induced visceral pain, whereas CRF1 contributes to visceral sensitization...
  7. ncbi request reprint A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats
    Mulugeta Million
    CURE Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health CNS, West Los Angeles VA Medical Center, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90073, USA
    Brain Res 985:32-42. 2003
    ....
  8. pmc Cholinergic giant migrating contractions in conscious mouse colon assessed by using a novel noninvasive solid-state manometry method: modulation by stressors
    G Gourcerol
    CURE Digestive Diseases Research Center and Center for Stress Neurobiology, UCLA, VA Greater Los Angeles Healthcare System, CURE Bldg 115, Rm 118B, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 296:G992-G1002. 2009
    ..Noninvasive colonic manometry opens new venues to investigate colonic motor function in genetically modified mice relevant to diseases that involve colonic motility alterations...
  9. ncbi request reprint Peripheral corticotropin-releasing factor and stress-stimulated colonic motor activity involve type 1 receptor in rats
    C Maillot
    CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Gastroenterology 119:1569-79. 2000
    ..CRF has preferential affinity for CRF-R1, whereas urocortin displays high affinity for both. We investigated changes in colonic motor function after intraperitoneal (IP) injection of CRF-related peptides...
  10. ncbi request reprint Urocortins and cholecystokinin-8 act synergistically to increase satiation in lean but not obese mice: involvement of corticotropin-releasing factor receptor-2 pathway
    G Gourcerol
    Center for Neurovisceral Sciences and Women s Health, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Endocrinology 148:6115-23. 2007
    ..Such synergy is lost in DIO mice, suggesting a resistance to the satiety signaling that may contribute to maintain obesity...
  11. ncbi request reprint Lack of interaction between peripheral injection of CCK and obestatin in the regulation of gastric satiety signaling in rodents
    G Gourcerol
    CURE Digestive Diseases Research Center, Department of Medicine, Division of Digestive Diseases, University of California Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Peptides 27:2811-9. 2006
    ..These data show that obestatin neither influences cumulative food intake, gastric motility or vagal afferent activity nor CCK-induced satiety signaling...
  12. ncbi request reprint Peripheral corticotropin releasing factor (CRF) and a novel CRF1 receptor agonist, stressin1-A activate CRF1 receptor expressing cholinergic and nitrergic myenteric neurons selectively in the colon of conscious rats
    P Q Yuan
    CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, Digestive Diseases Division, Department of Medicine and Brain Research Institute, University of California Los Angeles 90073, USA
    Neurogastroenterol Motil 19:923-36. 2007
    ..These data support that one mechanism through which peripherally injected CRF ligands stimulate colonic function involves a direct action on colonic cholinergic and nitrergic myenteric neurons expressing CRF(1) receptor...
  13. ncbi request reprint Corticotropin-releasing factor and the brain-gut motor response to stress
    Y Tache
    CURE Digestive Diseases Research Center, West Los Angeles VA Medical Center, Los Angeles 90073, USA
    Can J Gastroenterol 13:18A-25A. 1999
    ..Hypersecretion of CRF in the brain may contribute to the pathophysiology of stress-related exacerbation of irritable bowel syndrome...
  14. ncbi request reprint Colitis induces CRF expression in hypothalamic magnocellular neurons and blunts CRF gene response to stress in rats
    A E Kresse
    CURE: Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Am J Physiol Gastrointest Liver Physiol 281:G1203-13. 2001
    ..These data show that colitis upregulates CRF gene synthesis in magnocellular hypothalamic neurons but dampens CRF gene transcription in the pPVN and plasma corticosterone responses to environmental acute stressors...
  15. pmc Intracisternal urocortin inhibits vagally stimulated gastric motility in rats: role of CRF(2)
    C Y Chen
    CURE Digestive Diseases Research Center, Veterans Affairs Greater Los Angeles Healthcare System, California 90073, USA
    Br J Pharmacol 136:237-47. 2002
    ..rUcn action was antagonized by astressin(2)-B. 7. These data show that i.c. rUcn acts through CRF(2) receptors to inhibit central vagal gastric contractile response and postoprandial emptying...
  16. pmc CRF1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: implications for irritable bowel syndrome
    Y Tache
    CURE Digestive Diseases Research Center, and Center for Neurovisceral Sciences and Woman s Health, West Los Angeles VA Medical Center, University of California Los Angeles, 1130 Wilshire Boulevard, Los Angeles, CA 90073, U S A
    Br J Pharmacol 141:1321-30. 2004
    ..Targeting CRF(1)-dependent pathways may have potential benefit against stress or anxiety-/depression-related functional bowel disorders...
  17. pmc Visceral analgesia induced by acute and repeated water avoidance stress in rats: sex difference in opioid involvement
    M Larauche
    Department of Medicine, CURE Digestive Diseases Research Center and Oppenheimer Family Center for Neurobiology of Stress, Digestive Diseases Division at the University of California Los Angeles, CA 90073, USA
    Neurogastroenterol Motil 24:1031-e547. 2012
    ....
  18. ncbi request reprint Stress and the gastrointestinal tract III. Stress-related alterations of gut motor function: role of brain corticotropin-releasing factor receptors
    Y Tache
    CURE Digestive Diseases Research Center, Department of Veterans Affairs Greater Los Angeles Healthcare System, Bldg 115, Rm 203, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 280:G173-7. 2001
    ..CRF subtype 1 receptors are involved in the colonic and anxiogenic responses to stress and may have clinical relevance in the comorbidity of anxiety/depression and irritable bowel syndrome...

Research Grants4

  1. CRF2 Receptor Modulation of Colonic Response to Stress
    MILLION MULUGETA; Fiscal Year: 2006
    ..abstract_text> ..
  2. Modulation of Colonic Response to Stress by Peripheral CRF2 Receptors
    MILLION MULUGETA; Fiscal Year: 2010
    ....