Robert C Millikan

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Tumor-specific HMG-CoA reductase expression in primary premenopausal breast cancer predicts response to tamoxifen
    Donal J Brennan
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Breast Cancer Res 13:R12. 2011
  2. pmc Epidemiology of basal-like breast cancer
    Robert C Millikan
    Department of Epidemiology, CB 7435, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Breast Cancer Res Treat 109:123-39. 2008
  3. ncbi request reprint HER2 codon 655 polymorphism and breast cancer: results from kin-cohort and case-control analyses
    Robert C Millikan
    Department of Epidemiology, School of Public Health, University of North Carolina, CB 7435, Chapel Hill, NC 27599 7435, USA
    Breast Cancer Res Treat 89:309-12. 2005
  4. ncbi request reprint Polymorphisms in nucleotide excision repair genes and risk of multiple primary melanoma: the Genes Environment and Melanoma Study
    Robert C Millikan
    Department of Epidemiology, CB 7435, School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
    Carcinogenesis 27:610-8. 2006
  5. ncbi request reprint No association between the MDM2 -309 T/G promoter polymorphism and breast cancer in African-Americans or Whites
    Robert C Millikan
    Department of Epidemiology, School of Public Health and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Cancer Epidemiol Biomarkers Prev 15:175-7. 2006
  6. pmc Associations between trans fatty acid consumption and colon cancer among Whites and African Americans in the North Carolina colon cancer study I
    Lisa C Vinikoor
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
    Nutr Cancer 61:427-36. 2009
  7. pmc The estrogen receptor-alpha A908G (K303R) mutation occurs at a low frequency in invasive breast tumors: results from a population-based study
    Kathleen Conway
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Breast Cancer Res 7:R871-80. 2005
  8. pmc Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women
    Yu Li
    Department of Epidemiology, School of Public Heath and Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Breast Cancer Res 6:R460-73. 2004
  9. pmc Polychlorinated biphenyls, cytochrome P450 1A1 (CYP1A1) polymorphisms, and breast cancer risk among African American women and white women in North Carolina: a population-based case-control study
    Yu Li
    Department of Epidemiology, School of Public Heath, University of North Carolina, Chapel Hill, North Carolina, USA
    Breast Cancer Res 7:R12-8. 2005
  10. pmc Effects of polymorphisms in alcohol metabolism and oxidative stress genes on survival from head and neck cancer
    Anne M Hakenewerth
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cancer Epidemiol 37:479-91. 2013

Detail Information

Publications77

  1. pmc Tumor-specific HMG-CoA reductase expression in primary premenopausal breast cancer predicts response to tamoxifen
    Donal J Brennan
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Breast Cancer Res 13:R12. 2011
    ..Here, the predictive value of HMG-CoAR expression in relation to tamoxifen response was examined...
  2. pmc Epidemiology of basal-like breast cancer
    Robert C Millikan
    Department of Epidemiology, CB 7435, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Breast Cancer Res Treat 109:123-39. 2008
    ..Among younger African-American women, we estimate that up to 68% of basal-like breast cancer could be prevented by promoting breastfeeding and reducing abdominal adiposity...
  3. ncbi request reprint HER2 codon 655 polymorphism and breast cancer: results from kin-cohort and case-control analyses
    Robert C Millikan
    Department of Epidemiology, School of Public Health, University of North Carolina, CB 7435, Chapel Hill, NC 27599 7435, USA
    Breast Cancer Res Treat 89:309-12. 2005
    ..The results provide additional evidence that HER2 codon 655 genotype may predispose to early-onset breast cancer...
  4. ncbi request reprint Polymorphisms in nucleotide excision repair genes and risk of multiple primary melanoma: the Genes Environment and Melanoma Study
    Robert C Millikan
    Department of Epidemiology, CB 7435, School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
    Carcinogenesis 27:610-8. 2006
    ..ORs for XPD and XPC genotypes were stronger for melanoma diagnosed at an early age, but tests for interaction were not statistically significant. The results provide further evidence for a role of XPD in the etiology of melanoma...
  5. ncbi request reprint No association between the MDM2 -309 T/G promoter polymorphism and breast cancer in African-Americans or Whites
    Robert C Millikan
    Department of Epidemiology, School of Public Health and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Cancer Epidemiol Biomarkers Prev 15:175-7. 2006
  6. pmc Associations between trans fatty acid consumption and colon cancer among Whites and African Americans in the North Carolina colon cancer study I
    Lisa C Vinikoor
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
    Nutr Cancer 61:427-36. 2009
    ..In conclusion, trans fatty acid consumption is not associated with colon cancer and does not contribute to disparities in colon cancer rates...
  7. pmc The estrogen receptor-alpha A908G (K303R) mutation occurs at a low frequency in invasive breast tumors: results from a population-based study
    Kathleen Conway
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Breast Cancer Res 7:R871-80. 2005
    ..This mutation was initially reported in one-third of hyperplastic benign breast lesions, although several recent studies failed to detect it in benign or malignant breast tissues...
  8. pmc Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women
    Yu Li
    Department of Epidemiology, School of Public Heath and Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Breast Cancer Res 6:R460-73. 2004
    ..Previous epidemiologic studies suggest that women with variant cytochrome P4501A1 (CYP1A1) genotypes who smoke cigarettes are at increased risk for breast cancer...
  9. pmc Polychlorinated biphenyls, cytochrome P450 1A1 (CYP1A1) polymorphisms, and breast cancer risk among African American women and white women in North Carolina: a population-based case-control study
    Yu Li
    Department of Epidemiology, School of Public Heath, University of North Carolina, Chapel Hill, North Carolina, USA
    Breast Cancer Res 7:R12-8. 2005
    ..However, two recent studies showed a stronger association among postmenopausal white women with the inducible M2 polymorphism in the cytochrome P450 1A1 (CYP1A1) gene...
  10. pmc Effects of polymorphisms in alcohol metabolism and oxidative stress genes on survival from head and neck cancer
    Anne M Hakenewerth
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cancer Epidemiol 37:479-91. 2013
    ..We hypothesized that polymorphisms in alcohol metabolism-related and antioxidant genes influence SCCHN survival...
  11. pmc Risk factors for breast cancer characterized by the estrogen receptor alpha A908G (K303R) mutation
    Kathleen Conway
    Department of Epidemiology, School of Public Health, CB 7435, University of North Carolina, Chapel Hill, NC 27599, USA
    Breast Cancer Res 9:R36. 2007
    ..We recently detected this mutation at a low frequency of 6% in invasive breast tumors of the Carolina Breast Cancer Study (CBCS)...
  12. ncbi request reprint Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma
    Nancy E Thomas
    Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Epidemiol Biomarkers Prev 16:991-7. 2007
    ..The association of BRAF mutations with early-life UV exposure provides evidence in support of childhood sun protection for melanoma prevention...
  13. pmc Polymorphisms in DNA repair genes, recreational physical activity and breast cancer risk
    Lauren E McCullough
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
    Int J Cancer 134:654-63. 2014
    ..46; 95% CI, 0.30-0.71). Our data show that women with minor alleles in both MSH2 and MLH1 could be at increased breast cancer risk. RPA may be modified by genes in the DNA repair pathway, and merit further investigation. ..
  14. pmc Selenium, folate, and colon cancer
    Alexandra Connelly-Frost
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    Nutr Cancer 61:165-78. 2009
    ..Importantly, weight loss, stage at diagnosis, or time from diagnosis to blood draw did not appear to produce strong bias in our study...
  15. pmc Intrinsic breast tumor subtypes, race, and long-term survival in the Carolina Breast Cancer Study
    Katie M O'Brien
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Clin Cancer Res 16:6100-10. 2010
    ....
  16. pmc Polymorphisms in methionine synthase, methionine synthase reductase and serine hydroxymethyltransferase, folate and alcohol intake, and colon cancer risk
    Susan E Steck
    Department of Nutrition, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N C, USA
    J Nutrigenet Nutrigenomics 1:196-204. 2008
    ..We examined associations among folate and alcohol intake, single nucleotide polymorphisms (SNPs) in genes involved in one-carbon metabolism, and colon cancer risk...
  17. pmc Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case-control study of African Americans and whites
    Robert C Millikan
    Department of Epidemiology, School of Public Health, and Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Breast Cancer Res 6:R264-74. 2004
    ..Results suggest that the Ala allele increases the risk of breast cancer and modifies the effects of environmental exposures that produce oxidative damage to DNA...
  18. pmc trans-Fatty acid consumption and its association with distal colorectal cancer in the North Carolina Colon Cancer Study II
    Lisa C Vinikoor
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Cancer Causes Control 21:171-80. 2010
    ..98 (95%CI: 0.47, 2.05) and 0.87 (95%CI 0.42, 1.81), respectively]. In conclusion, high consumption of trans-fatty acids was positively associated with distal colorectal cancer among Whites...
  19. pmc Common genetic variation in adiponectin, leptin, and leptin receptor and association with breast cancer subtypes
    Sarah J Nyante
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    Breast Cancer Res Treat 129:593-606. 2011
    ..Replication in additional studies where breast cancer subtypes have been defined is necessary to confirm these potential associations...
  20. ncbi request reprint Polymorphisms in DNA repair genes, medical exposure to ionizing radiation, and breast cancer risk
    Robert C Millikan
    Department of Epidemiology, School of Public Health, University of North Carolina, CB 7400, Chapel Hill, NC 27599 7400, USA
    Cancer Epidemiol Biomarkers Prev 14:2326-34. 2005
    ..Prospective studies are needed to address whether common polymorphisms in DNA repair genes modify the effects of low-dose radiation exposure from medical sources...
  21. ncbi request reprint The effect of physician permission versus notification on research recruitment through cancer registries (United States)
    Laura M Beskow
    Department of Health Policy and Administration, School of Public Health, University of North Carolina, Chapel Hill, USA
    Cancer Causes Control 17:315-23. 2006
    ..To determine how physicians responded when investigators inquired about contacting patients identified through a central cancer registry, and to examine participation rates under physician permission versus notification approaches...
  22. ncbi request reprint XRCC1 genotype and breast cancer: functional studies and epidemiologic data show interactions between XRCC1 codon 280 His and smoking
    Brian F Pachkowski
    Department of Environmental Sciences, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Cancer Res 66:2860-8. 2006
    ..0) and 399Arg (D' = 1.0). These data suggest that less common, functional polymorphisms may lie within common haplotypes and drive gene-environment interactions...
  23. pmc Distance to diagnosing provider as a measure of access for patients with melanoma
    Karyn B Stitzenberg
    Department of Surgery, School of Medicine, University of North Carolina at Chapel Hill, 3010 Old Clinic Bldg, CB 7213, Chapel Hill, NC 27599 7213, USA
    Arch Dermatol 143:991-8. 2007
    ..To examine the effect of travel distance and other sociodemographic factors on access to a diagnosing provider for patients with melanoma...
  24. pmc Association of germline microRNA SNPs in pre-miRNA flanking region and breast cancer risk and survival: the Carolina Breast Cancer Study
    Jeannette T Bensen
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Cancer Causes Control 24:1099-109. 2013
    ..Common germline variation in the 5' region proximal to precursor (pre-) miRNA gene sequences is evaluated for association with breast cancer risk and survival among African Americans and Caucasians...
  25. ncbi request reprint Identification of a basal-like subtype of breast ductal carcinoma in situ
    Chad A Livasy
    Department of Pathology and Lab Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Hum Pathol 38:197-204. 2007
    ..0001), p53 overexpression (P < .0001), and elevated Ki-67 index (P < .0001). These studies demonstrate the presence of a basal-like in situ carcinoma, a potential precursor lesion to invasive basal-like carcinoma...
  26. pmc Mammographic density and breast cancer risk in White and African American Women
    Hilda Razzaghi
    Department of Epidemiology, Gillings Global School of Public Health, University of North Carolina, 2104 McGavran Greenberg, 135 Dauer Drive, Campus Box 7435, Chapel Hill, NC 27599 7435, USA
    Breast Cancer Res Treat 135:571-80. 2012
    ..However, exposures such as BMI and hormone therapy may be important modifiers of this association and merit further investigation...
  27. pmc Smoking and selected DNA repair gene polymorphisms in controls: systematic review and meta-analysis
    M Elizabeth Hodgson
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
    Cancer Epidemiol Biomarkers Prev 19:3055-86. 2010
    ..Few studies have examined the occurrence of G-E association in published control group data...
  28. pmc Consumption of trans-fatty acid and its association with colorectal adenomas
    Lisa C Vinikoor
    Department of Epidemiology, Center for Gastrointestinal Biology and Disease, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7555, USA
    Am J Epidemiol 168:289-97. 2008
    ..These results suggest that consumption of high amounts of trans-fatty acid may increase the risk of colorectal neoplasia, and they provide additional support to recommendations to limit trans-fatty acid consumption...
  29. pmc Associations of cumulative sun exposure and phenotypic characteristics with histologic solar elastosis
    Nancy E Thomas
    Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Epidemiol Biomarkers Prev 19:2932-41. 2010
    ..Solar elastosis adjacent to melanomas in histologic sections is regarded as an indicator of sun exposure, although the associations of UV exposure and phenotype with solar elastosis are yet to be fully explored...
  30. ncbi request reprint Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study
    Lisa A Carey
    Division of Hematology Oncology, School of Public Health, Department of Epidemiology, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599 7305, USA
    JAMA 295:2492-502. 2006
    ..Gene expression analysis has identified several breast cancer subtypes, including basal-like, human epidermal growth factor receptor-2 positive/estrogen receptor negative (HER2+/ER-), luminal A, and luminal B...
  31. pmc Polymorphisms in oxidative stress genes, physical activity, and breast cancer risk
    Lauren E McCullough
    Department of Epidemiology, University of North Carolina, CB 7435, McGavran Greenberg Hall, Chapel Hill, NC 27599 7435, USA
    Cancer Causes Control 23:1949-58. 2012
    ..Given the paradoxical effects of physical activity, the oxidative stress pathway is of interest. Genetic variation in CAT or antioxidant-related polymorphisms may mediate the physical activity-breast cancer association...
  32. pmc Birthweight, parental age, birth order and breast cancer risk in African-American and white women: a population-based case-control study
    M Elizabeth Hodgson
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Breast Cancer Res 6:R656-67. 2004
    ..Much recent work has focused on hypotheses that very early life exposures influence adult cancer risk. For breast cancer it has been hypothesized that high in utero estrogen exposure may increase risk...
  33. pmc ADIPOQ, ADIPOR1, and ADIPOR2 polymorphisms in relation to serum adiponectin levels and BMI in black and white women
    Sarah S Cohen
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
    Obesity (Silver Spring) 19:2053-62. 2011
    ....
  34. ncbi request reprint Patient perspectives on research recruitment through cancer registries
    Laura M Beskow
    Department of Health Policy and Administration, School of Public Health, University of North Carolina, CB 7411, McGavran Greenberg Hall, Chapel Hill, NC 27599 7411, USA
    Cancer Causes Control 16:1171-5. 2005
    ..To gain preliminary insight into patients' levels of awareness and preferences about research recruitment through cancer registries...
  35. ncbi request reprint Radiation clastogenesis and cell cycle checkpoint function as functional markers of breast cancer risk
    William K Kaufmann
    Lineberger Comprehensive Cancer Center, Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Carcinogenesis 27:2519-27. 2006
    ..This study tested whether sporadic breast cancer was associated with constitutive radiation hypersensitivity...
  36. ncbi request reprint Constipation, laxative use, and colon cancer in a North Carolina population
    Malcolm C Roberts
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7080, USA
    Am J Gastroenterol 98:857-64. 2003
    ..The aim of this study was to determine whether bowel movement frequency and laxative use and type were associated with risk of colon cancer in white and black men and women...
  37. ncbi request reprint Reproductive factors and breast cancer risk among older women
    Sumitra Shantakumar
    Department of Epidemiology, CB 7435 McGavran Greenberg Hall, University of North Carolina School of Public Health, Chapel Hill, NC 27599 7435, USA
    Breast Cancer Res Treat 102:365-74. 2007
    ..Moreover, breastfeeding, one of the few potentially modifiable risk factors for breast cancer, was an important factor in decreasing risk among older parous postmenopausal women...
  38. pmc Genome-wide association study of age at menarche in African-American women
    Ellen W Demerath
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    Hum Mol Genet 22:3329-46. 2013
    ..The findings provide the first evidence of cross-ethnic generalization of menarche loci identified to date, and suggest a number of novel biological links to menarche timing in AA women. ..
  39. pmc μ-Opioid receptor gene A118G polymorphism predicts survival in patients with breast cancer
    Andrey V Bortsov
    Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7010, USA
    Anesthesiology 116:896-902. 2012
    ..In this study we assessed the association between six common polymorphisms in the μ-opioid receptor gene, including the well known A118G polymorphism, and breast cancer survival...
  40. pmc Joint effects of alcohol consumption and polymorphisms in alcohol and oxidative stress metabolism genes on risk of head and neck cancer
    Anne M Hakenewerth
    Department of Epidemiology, University of North Carolina at Chapel Hill, 100 Market Street, Chapel Hill, NC 27516, USA
    Cancer Epidemiol Biomarkers Prev 20:2438-49. 2011
    ..Genetic variation in the oxidative stress pathway may impact the carcinogenic effect of reactive oxygen species produced by ethanol metabolism. We hypothesized that alcohol interacts with these pathways to affect SCCHN incidence...
  41. ncbi request reprint Consumption of the epidermis: a criterion in the differential diagnosis of melanoma and dysplastic nevi that is associated with increasing breslow depth and ulceration
    Ruth Fulghum Walters
    Department of Pathology, University of North Carolina Hospitals, Chapel Hill, NC 27599 7287, USA
    Am J Dermatopathol 29:527-33. 2007
    ..Furthermore, the process leading to COE may be the first step in a progression to ulceration...
  42. ncbi request reprint 5,10-methylenetetrahydrofolate reductase 677 and 1298 polymorphisms, folate intake, and microsatellite instability in colon cancer
    Allison M Eaton
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7555, USA
    Cancer Epidemiol Biomarkers Prev 14:2023-9. 2005
    ..These results indicate that the relationship between MTHFR genotypes and MSI is influenced by folate status...
  43. pmc Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium
    Bogdan Pasaniuc
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    PLoS Genet 7:e1001371. 2011
    ..Our methods and our publicly available software are broadly applicable to GWAS in admixed populations...
  44. pmc Trends in stage-specific incidence rates for urothelial carcinoma of the bladder in the United States: 1988 to 2006
    Matthew E Nielsen
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina Department of Urology, University of North Carolina School of Medicine, Chapel Hill, North Carolina Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina
    Cancer 120:86-95. 2014
    ..Given the suggestion of an increasing percentage of low-risk cases in hospital-based registry data in recent years, the authors hypothesized that population-based data may reveal changes in the stage distribution of early-stage cases...
  45. pmc Determinants of breast cancer treatment delay differ for African American and White women
    SASHA A MCGEE
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cancer Epidemiol Biomarkers Prev 22:1227-38. 2013
    ..We used interview and medical record data from the Carolina Breast Cancer Study (CBCS) to identify determinants of delay and assess whether disparities exist between White and African American women (n = 601)...
  46. ncbi request reprint Selenium, apoptosis, and colorectal adenomas
    Alexandra Connelly-Frost
    R Stuart Dickson Institute for Health Studies, 720 East Morehead Street, Charlotte, NC 28232, USA
    Cancer Epidemiol Biomarkers Prev 15:486-93. 2006
    ..Selenium is an essential trace element found in cereals, wheat, dairy products, meat, and fish. This micronutrient may prevent carcinogenesis through several biochemical pathways; one suggested pathway is enhanced apoptosis...
  47. ncbi request reprint Commentary: the Human Genome: philosopher's stone or magic wand?
    Robert C Millikan
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA
    Int J Epidemiol 35:578-81; discussion 593-6. 2006
  48. ncbi request reprint Family history of colon cancer: what does it mean and how is it useful?
    Temitope O Keku
    Center for Gastrointestinal Biology and Disease, CB 7555, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7555, USA
    Am J Prev Med 24:170-6. 2003
    ..Family history of colon cancer can be deconstructed into causal and noncausal explanations, which include genetic factors, environmental factors, gene-environment interactions, misclassification, and differences in screening...
  49. ncbi request reprint High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype
    Amy L Lark
    Department of Pathology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Mod Pathol 18:1289-94. 2005
    ..The presence of strong FAK expression in many high grade, estrogen- and progesterone-negative breast carcinomas indicates that FAK may be an attractive target for therapeutic intervention...
  50. pmc Genomics and the public health code of ethics
    James C Thomas
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 2799 7435, USA
    Am J Public Health 95:2139-43. 2005
    ..In addition, the concerns raised by genomics highlight areas of our understanding of the ethical principles of public health in which further refinement may be necessary...
  51. ncbi request reprint Tandem BRAF mutations in primary invasive melanomas
    Nancy E Thomas
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    J Invest Dermatol 122:1245-50. 2004
    ..The finding of tandem mutations in thin melanomas makes it more likely that they arise as a simultaneous rather than sequential event...
  52. pmc Review of state Comprehensive Cancer Control plans for genomics content
    Debra E Irwin
    North Carolina Center for Genomics and Public Health, Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Prev Chronic Dis 2:A08. 2005
    ..The goals of this study were to determine U.S. states with Comprehensive Cancer Control plans that include genomics in some capacity and to review successes with and barriers to implementation of genomics-related cancer control initiatives...
  53. ncbi request reprint Glutathione-S-transferase genotypes, smoking, and their association with markers of inflammation, hemostasis, and endothelial function: the atherosclerosis risk in communities (ARIC) study
    Eric A Miller
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    Atherosclerosis 171:265-72. 2003
    ..The results of this study provide some limited evidence that GSTM1 and GSTT1 polymorphisms modify the effect of smoking on inflammation, hemostasis, and endothelial function...
  54. ncbi request reprint Urbanization and breast cancer incidence in North Carolina, 1995-1999
    Susan A Hall
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7439, USA
    Ann Epidemiol 15:796-803. 2005
    ..We investigated the relationship between urbanization and breast cancer in North Carolina (1995-1999), and considered hospital characteristics as an explanation...
  55. ncbi request reprint Genomics and public health practice: a survey of nurses in local health departments in North Carolina
    Debra E Irwin
    North Carolina Center for Genomics and Public Health, Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Public Health Manag Pract 10:539-44. 2004
    ..1%) acknowledged their need for training in order to achieve these competencies. Information collected by taking a family history can indicate a combination of genetic and environmental susceptibilities for chronic diseases...
  56. ncbi request reprint Comparative analysis of breast cancer risk factors among African-American women and White women
    Ingrid J Hall
    Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 161:40-51. 2005
    ..Hence, racial variations in both prevalences of and risks associated with particular factors may contribute to the higher incidence of breast cancer among younger African-American women...
  57. ncbi request reprint Familial aggregation of melanoma risks in a large population-based sample of melanoma cases
    Colin B Begg
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Causes Control 15:957-65. 2004
    ..In this study we use information from a large series of incident cases of melanoma from an international population-based study to examine the patterns of incidence of melanoma in the first-degree relatives of these cases...
  58. ncbi request reprint Association between non-steroidal anti-inflammatory drugs (NSAIDs) and invasive breast cancer and carcinoma in situ of the breast
    Patricia G Moorman
    Cancer Prevention, Detection, and Control Research Program, Department of Community and Family Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Causes Control 14:915-22. 2003
    ..This study's objective was to examine the relationship between use of non-prescription and prescription NSAIDs and breast cancer and carcinoma in situ of the breast...
  59. ncbi request reprint Roles of religious involvement and social support in the risk of colon cancer among Blacks and Whites
    Anita Yeomans Kinney
    Huntsman Cancer Institute, Division of Cancer Control and Population Sciences, University of Utah, Salt Lake City, UT 84112, USA
    Am J Epidemiol 158:1097-107. 2003
    ..These results suggest that certain characteristics of social ties are associated with both risk of and prognostic indicators for colon cancer...
  60. ncbi request reprint Antidepressant medications and their association with invasive breast cancer and carcinoma in situ of the breast
    Patricia G Moorman
    Cancer Prevention, Detection, and Control Research Program, Department of Community and Family Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Epidemiology 14:307-14. 2003
    ..Experimental studies in animals have suggested that antidepressants may promote the growth of mammary tumors, but epidemiologic data have not shown consistent associations between antidepressant use and breast cancer...
  61. ncbi request reprint Joint effects between UDP-glucuronosyltransferase 1A7 genotype and dietary carcinogen exposure on risk of colon cancer
    Lesley M Butler
    Department of Public Health Sciences, Division of Epidemiology, University of California, Davis, California, USA
    Cancer Epidemiol Biomarkers Prev 14:1626-32. 2005
    ..2-4.8), compared with less than the median daily intake and UGT1A7 high/intermediate genotypes. These data suggest that the associations among cooked meat-derived compound exposure, and colon cancer are modified by the UGT1A7 genotype...
  62. ncbi request reprint Use of nonsteroidal antiinflammatory drugs and risk of colon cancer in a population-based, case-control study of African Americans and Whites
    Leah B Sansbury
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 8325, USA
    Am J Epidemiol 162:548-58. 2005
    ..These results add new knowledge suggesting that the protective effect of NSAIDs against colon cancer is similar among African Americans and Whites...
  63. ncbi request reprint CA IX is an independent prognostic marker in premenopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance
    Donal J Brennan
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College, Dublin, and Department of Pathology and Laboratory Medicine, St Vincent s University Hospital, Ireland
    Clin Cancer Res 12:6421-31. 2006
    ..We examined the potential prognostic and predictive role of CA IX in premenopausal breast cancer patients...
  64. ncbi request reprint CENP-F expression is associated with poor prognosis and chromosomal instability in patients with primary breast cancer
    Sallyann L O'Brien
    UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Int J Cancer 120:1434-43. 2007
    ..036) and overall survival (p=0.040). In conclusion, we identified CENP-F as a biomarker associated with poor outcome in breast cancer and showed several novel associations of biological significance...
  65. ncbi request reprint Ambient UV, personal sun exposure and risk of multiple primary melanomas
    Anne Kricker
    School of Public Health, University of Sydney, Edward Ford Building A27, NSW, 2006, Australia, and Women s College Hospital, Toronto, ON, Canada
    Cancer Causes Control 18:295-304. 2007
    ..Sun exposure is the main cause of melanoma in populations of European origin. No previous study has examined the effect of sun exposure on risk of multiple primary melanomas compared with people who have one melanoma...
  66. ncbi request reprint CDKN2A germline mutations in individuals with cutaneous malignant melanoma
    Irene Orlow
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Invest Dermatol 127:1234-43. 2007
    ..With the exception of the variant in position -34 of CDKN2A of known functional consequence, the remaining rare variants in the non-coding region have no apparent impact on risk...
  67. ncbi request reprint GSTM1 and GSTT1 polymorphisms, cigarette smoking, and risk of colon cancer: a population-based case-control study in North Carolina (United States)
    Kui Huang
    Global Epidemiology, Pfizer Inc, Mail stop 150 3 80, 235 East 42nd Street, New York City, NY 10017 575, USA
    Cancer Causes Control 17:385-94. 2006
    ..GSTT1 and GSTM1 polymorphisms may be weakly related to colon cancer risk and there may be racial differences in gene-smoking interactions...
  68. ncbi request reprint A design for cancer case-control studies using only incident cases: experience with the GEM study of melanoma
    Colin B Begg
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Epidemiol 35:756-64. 2006
    ..The use of a novel case-control design in which cases have second primaries and controls are cancer survivors has been proposed for this purpose...
  69. ncbi request reprint COX-2 polymorphism, use of nonsteroidal anti-inflammatory drugs, and risk of colon cancer in African Americans (United States)
    Leah B Sansbury
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 8325, USA
    Cancer Causes Control 17:257-66. 2006
    ..We explored the association between the COX-2 Val511Ala SNP and risk of colon cancer among 240 African American cases and 326 African American controls in a population-based, case-control study in North Carolina...
  70. pmc Modification by N-acetyltransferase 1 genotype on the association between dietary heterocyclic amines and colon cancer in a multiethnic study
    Lesley M Butler
    University of California Davis, Department of Public Health Sciences, Division of Epidemiology, Davis, CA 95616, USA
    Mutat Res 638:162-74. 2008
    ....
  71. doi request reprint Altered cytoplasmic-to-nuclear ratio of survivin is a prognostic indicator in breast cancer
    Donal J Brennan
    UCD School of Biomolecular and Biomedical Science and UCD School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Clin Cancer Res 14:2681-9. 2008
    ..Quantitative determination of survivin expression using image analysis offers the opportunity to develop alternative scoring models for survivin immunohistochemistry. Here, we present such a model...
  72. ncbi request reprint Polymorphisms in nucleotide excision repair genes, smoking and breast cancer in African Americans and whites: a population-based case-control study
    Leah E Mechanic
    Laboratory of Human Carcinogenesis, NCI NIH, 37 Convent Drive MSC 4255, Bldg 37 Rm 3060, Bethesda, MD 20892 4255, USA
    Carcinogenesis 27:1377-85. 2006
    ..These results are consistent with previous evidence of exposure-specific p53 mutations in breast tumors from current and former smokers, suggesting that smoking may play a role in breast cancer etiology...
  73. pmc UGT1A1 and UGT1A9 functional variants, meat intake, and colon cancer, among Caucasians and African-Americans
    Hugo Girard
    Pharmacogenomics Laboratory, CHUQ Research Center and Faculty of Pharmacy, Laval University, G1V 4G2 Quebec, Canada
    Mutat Res 644:56-63. 2008
    ..7 ng/day and combined high/intermediate genotypes. These data support a hypothesis that UGTs modify the association between meat-derived PAH exposure and colon cancer by their role in the elimination of dietary carcinogens...
  74. ncbi request reprint Lifetime risk of melanoma in CDKN2A mutation carriers in a population-based sample
    Colin B Begg
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Natl Cancer Inst 97:1507-15. 2005
    ..In this study, we examined lifetime melanoma risk among CDKN2A mutation carriers using carriers who were identified in a population-based study of melanoma...
  75. ncbi request reprint Mitochondrial DNA G10398A polymorphism and invasive breast cancer in African-American women
    Jeffrey A Canter
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University Medical Center, Nasshville, Tennessee 37212, USA
    Cancer Res 65:8028-33. 2005
    ..31; P = 0.81). This study provides novel epidemiologic evidence that the mtDNA 10398A allele influences breast cancer susceptibility in African-American women. mtDNA polymorphisms may be underappreciated factors in breast carcinogenesis...
  76. ncbi request reprint The prevalence of CDKN2A germ-line mutations and relative risk for cutaneous malignant melanoma: an international population-based study
    Marianne Berwick
    University of New Mexico, Department of Internal Medicine, New Mexico Cancer Research Facility, MSC08 4630, Room 103A, 1 University of New Mexico, Albuquerque, NM 87131, USA
    Cancer Epidemiol Biomarkers Prev 15:1520-5. 2006
    ..The results suggest that the relative risk of mutation carriers in the population may be lower than currently believed and that different mutations on the CDKN2A gene may confer substantially different risks of melanoma...
  77. ncbi request reprint Population-based study of natural variation in the melanocortin-1 receptor gene and melanoma
    Peter A Kanetsky
    Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
    Cancer Res 66:9330-7. 2006
    ....