Gregg Milligan

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. ncbi request reprint Entry of inflammatory cells into the mouse vagina following application of candidate microbicides: comparison of detergent-based and sulfated polymer-based agents
    Gregg N Milligan
    Department of Pediatrics and the Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas 77555 0436, USA
    Sex Transm Dis 29:597-605. 2002
  2. ncbi request reprint Efficacy of genital T cell responses to herpes simplex virus type 2 resulting from immunization of the nasal mucosa
    Gregg N Milligan
    Sealy Center for Vaccine Development, University of Texas Medical Branch Galveston, TX 77555 0436, USA
    Virology 318:507-15. 2004
  3. ncbi request reprint T-cell-mediated mechanisms involved in resolution of genital herpes simplex virus type 2 (HSV-2) infection of mice
    Gregg N Milligan
    Department of Pediatrics, Children s Hospital Research Foundation, Cincinnati, OH, USA
    J Reprod Immunol 61:115-27. 2004
  4. ncbi request reprint Effect of candidate vaginally-applied microbicide compounds on recognition of antigen by CD4+ and CD8+ T lymphocytes
    Gregg N Milligan
    Sealy Center for Vaccine Development, 301 University Blvd, Galveston, Texas 77555 0436, USA
    Biol Reprod 71:1638-45. 2004
  5. ncbi request reprint Effects of candidate vaginally-applied microbicide compounds on innate immune cells
    Gregg N Milligan
    Sealy Center for Vaccine Development, 301 University Boulevard, Galveston, TX 77555 0436, USA
    J Reprod Immunol 66:103-16. 2005
  6. pmc Long-term presence of virus-specific plasma cells in sensory ganglia and spinal cord following intravaginal inoculation of herpes simplex virus type 2
    Gregg N Milligan
    Sealy Center for Vaccine Development, Department of Pediatrics, University of Texas Medical Branch, Galveston, 77555 0436, USA
    J Virol 79:11537-40. 2005
  7. pmc Herpes simplex virus (HSV)-specific T cells activated in the absence of IFN-gamma express alternative effector functions but are not protective against genital HSV-2 infection
    Alison J Johnson
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Reprod Immunol 84:8-15. 2010
  8. doi request reprint 3,4-Methylenedioxymethamphetamine increases susceptibility to genital herpes simplex virus infection in mice
    Jeffry W Pennock
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston 77555, USA
    J Infect Dis 200:1247-50. 2009
  9. doi request reprint Influence of methamphetamine on genital herpes simplex virus type 2 infection in a mouse model
    Frances Valencia
    Department of Experimental Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Sex Transm Dis 39:720-5. 2012
  10. pmc Antibody-mediated protection against genital herpes simplex virus type 2 disease in mice by Fc gamma receptor-dependent and -independent mechanisms
    Chin Fun Chu
    Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555 0436, USA
    J Reprod Immunol 78:58-67. 2008

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Entry of inflammatory cells into the mouse vagina following application of candidate microbicides: comparison of detergent-based and sulfated polymer-based agents
    Gregg N Milligan
    Department of Pediatrics and the Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas 77555 0436, USA
    Sex Transm Dis 29:597-605. 2002
    ..A murine model was developed to test for induction of inflammatory responses following application of candidate microbicides...
  2. ncbi request reprint Efficacy of genital T cell responses to herpes simplex virus type 2 resulting from immunization of the nasal mucosa
    Gregg N Milligan
    Sealy Center for Vaccine Development, University of Texas Medical Branch Galveston, TX 77555 0436, USA
    Virology 318:507-15. 2004
    ..These results have implications for immunization strategies to elicit high levels of cell-mediated protection of the genital tract and sensory ganglia...
  3. ncbi request reprint T-cell-mediated mechanisms involved in resolution of genital herpes simplex virus type 2 (HSV-2) infection of mice
    Gregg N Milligan
    Department of Pediatrics, Children s Hospital Research Foundation, Cincinnati, OH, USA
    J Reprod Immunol 61:115-27. 2004
    ..Together, these results suggest that non-lytic mechanisms mediated by alphabeta T cells were responsible for resolution of a genital HSV-2 infection...
  4. ncbi request reprint Effect of candidate vaginally-applied microbicide compounds on recognition of antigen by CD4+ and CD8+ T lymphocytes
    Gregg N Milligan
    Sealy Center for Vaccine Development, 301 University Blvd, Galveston, Texas 77555 0436, USA
    Biol Reprod 71:1638-45. 2004
    ..The assays described in this study represent a useful means to screen candidate topical microbicide compounds for inappropriate interactions with immune cells and may be useful for prioritization of candidate microbicide compounds...
  5. ncbi request reprint Effects of candidate vaginally-applied microbicide compounds on innate immune cells
    Gregg N Milligan
    Sealy Center for Vaccine Development, 301 University Boulevard, Galveston, TX 77555 0436, USA
    J Reprod Immunol 66:103-16. 2005
    ....
  6. pmc Long-term presence of virus-specific plasma cells in sensory ganglia and spinal cord following intravaginal inoculation of herpes simplex virus type 2
    Gregg N Milligan
    Sealy Center for Vaccine Development, Department of Pediatrics, University of Texas Medical Branch, Galveston, 77555 0436, USA
    J Virol 79:11537-40. 2005
    ....
  7. pmc Herpes simplex virus (HSV)-specific T cells activated in the absence of IFN-gamma express alternative effector functions but are not protective against genital HSV-2 infection
    Alison J Johnson
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Reprod Immunol 84:8-15. 2010
    ....
  8. doi request reprint 3,4-Methylenedioxymethamphetamine increases susceptibility to genital herpes simplex virus infection in mice
    Jeffry W Pennock
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston 77555, USA
    J Infect Dis 200:1247-50. 2009
    ..We also demonstrate that MDMA has an effect on the cytokines of the innate immune system-both systemically and, for the first time, in the genital tract. These data suggest that MDMA may play an important biological role in infection...
  9. doi request reprint Influence of methamphetamine on genital herpes simplex virus type 2 infection in a mouse model
    Frances Valencia
    Department of Experimental Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Sex Transm Dis 39:720-5. 2012
    ..METH is known to have immune modulatory properties. However, the impact of METH on normal immune responses and disease pathogenesis with STIs has not been fully examined...
  10. pmc Antibody-mediated protection against genital herpes simplex virus type 2 disease in mice by Fc gamma receptor-dependent and -independent mechanisms
    Chin Fun Chu
    Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555 0436, USA
    J Reprod Immunol 78:58-67. 2008
    ..These studies suggest that HSV vaccines might need to elicit multiple, diverse antibody effector mechanisms to achieve optimal protection...
  11. pmc Estradiol improves genital herpes vaccine efficacy in mice
    Jeffry W Pennock
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Vaccine 27:5830-6. 2009
    ....
  12. pmc Clearance of herpes simplex virus type 2 by CD8+ T cells requires gamma interferon and either perforin- or Fas-mediated cytolytic mechanisms
    Melanie E Dobbs
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Virol 79:14546-54. 2005
    ..However, either perforin- or Fas-mediated cytolytic mechanisms were required to achieve complete clearance of HSV-2 from the genital epithelium...
  13. pmc Early resolution of herpes simplex virus type 2 infection of the murine genital tract involves stimulation of genital parenchymal cells by gamma interferon
    Melanie D Bird
    Department of Pathology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0436, USA
    J Virol 81:423-6. 2007
    ..Together, these results suggest that early IFN-gamma-mediated protection was manifested mainly by stimulation of genital parenchymal cells...
  14. pmc Efficacy and toxicity of zinc salts as candidate topical microbicides against vaginal herpes simplex virus type 2 infection
    Nigel Bourne
    Department of Pediatrics, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas, 77555 0436, USA
    Antimicrob Agents Chemother 49:1181-3. 2005
    ....
  15. ncbi request reprint A soluble divalent class I MHC/IgG1 fusion protein activates CD8+ T cells in vivo
    Brenna Carey
    William S Rowe Division of Rheumatology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Clin Immunol 116:65-76. 2005
    ..These data suggest that antigen-loaded MHC/IgG fusion proteins may enhance T cell immunity in conditions where antigen presentation is altered...
  16. pmc Effector CD4+ T-cell involvement in clearance of infectious herpes simplex virus type 1 from sensory ganglia and spinal cords
    Alison J Johnson
    University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0436, USA
    J Virol 82:9678-88. 2008
    ....
  17. pmc T lymphocytes contribute to antiviral immunity and pathogenesis in experimental human metapneumovirus infection
    Deepthi Kolli
    Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas, USA
    J Virol 82:8560-9. 2008
    ..Whether these findings have implications for naturally acquired human infections remains to be determined...
  18. ncbi request reprint Impact of immunization with glycoprotein D2/AS04 on herpes simplex virus type 2 shedding into the genital tract in guinea pigs that become infected
    Nigel Bourne
    Department of Pediatrics, University of Texas Medical Branch, Galveston, 77555, USA
    J Infect Dis 192:2117-23. 2005
    ..However, the amount of virus shed was significantly reduced, as measured by qPCR. These data suggest that immunization could affect transmission by altering viral shedding patterns...
  19. pmc Differential virological and immunological outcome of severe acute respiratory syndrome coronavirus infection in susceptible and resistant transgenic mice expressing human angiotensin-converting enzyme 2
    Naoko Yoshikawa
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    J Virol 83:5451-65. 2009
    ..Collectively, our data revealed a more intense viral infection and immunosuppression in AC70 mice than in AC22 mice, thereby providing us with an immunopathogenic basis for the fatal outcome of SARS-CoV infection in the AC70 mice...
  20. ncbi request reprint Estrogen receptor alpha (ERalpha) deficiency in macrophages results in increased stimulation of CD4+ T cells while 17beta-estradiol acts through ERalpha to increase IL-4 and GATA-3 expression in CD4+ T cells independent of antigen presentation
    K Chad Lambert
    Department of Molecular Microbiology and Immunology, University of Missouri, Columbia, MO 65211, USA
    J Immunol 175:5716-23. 2005
    ..However, the addition of E2 significantly increased IL-4 secretion, as well as increased GATA-3 mRNA levels from ERalpha-replete CD4+ T cells, while this effect was abrogated in ERalpha-deficient CD4+ T cells...

Research Grants17

  1. PROTECTION OF GENITAL MUCOSA AND GANGLIA AGAINST HSV-2
    Gregg Milligan; Fiscal Year: 1999
    ..abstract_text> ..
  2. PROTECTION OF GENITAL MUCOSA AND GANGLIA AGAINST HSV-2
    Gregg Milligan; Fiscal Year: 2009
    ..The results of these studies should be important for the rational development of HSV vaccines as well as understanding the cellular interactions and specific molecular mechanisms required for resolution of HSV lesions. ..
  3. Vaccine-elicited genital and neuronal T cell responses
    Gregg Milligan; Fiscal Year: 2007
    ....
  4. PROTECTION OF GENITAL MUCOSA AND GANGLIA AGAINST HSV-2
    Gregg Milligan; Fiscal Year: 2007
    ..The results of these studies should be important for the rational development of HSV vaccines as well as understanding the cellular interactions and specific molecular mechanisms required for resolution of HSV lesions. ..
  5. PROTECTION OF GENITAL MUCOSA AND GANGLIA AGAINST HSV-2
    Gregg Milligan; Fiscal Year: 2006
    ..The results of these studies should be important for the rational development of HSV vaccines as well as understanding the cellular interactions and specific molecular mechanisms required for resolution of HSV lesions. ..
  6. Vaccine-elicited genital and neuronal T cell responses
    Gregg Milligan; Fiscal Year: 2006
    ....
  7. PROTECTION OF GENITAL MUCOSA AND GANGLIA AGAINST HSV-2
    Gregg Milligan; Fiscal Year: 2005
    ..The results of these studies should be important for the rational development of HSV vaccines as well as understanding the cellular interactions and specific molecular mechanisms required for resolution of HSV lesions. ..
  8. Vaccine-elicited genital and neuronal T cell responses
    Gregg Milligan; Fiscal Year: 2005
    ....
  9. Vaccine-elicited genital and neuronal T cell responses
    Gregg Milligan; Fiscal Year: 2004
    ....
  10. PROTECTION OF GENITAL MUCOSA AND GANGLIA AGAINST HSV-2
    Gregg Milligan; Fiscal Year: 2003
    ..abstract_text> ..
  11. Vaccine-elicited genital and neuronal T cell responses
    Gregg Milligan; Fiscal Year: 2003
    ....
  12. PROTECTION OF GENITAL MUCOSA AND GANGLIA AGAINST HSV-2
    Gregg Milligan; Fiscal Year: 2001
    ..abstract_text> ..
  13. PROTECTION OF GENITAL MUCOSA AND GANGLIA AGAINST HSV-2
    Gregg Milligan; Fiscal Year: 2002
    ..abstract_text> ..
  14. PROTECTION OF GENITAL MUCOSA AND GANGLIA AGAINST HSV-2
    Gregg Milligan; Fiscal Year: 2001
    ..abstract_text> ..
  15. PROTECTION OF GENITAL MUCOSA AND GANGLIA AGAINST HSV-2
    Gregg Milligan; Fiscal Year: 2000
    ..abstract_text> ..
  16. PROTECTION OF GENITAL MUCOSA AND GANGLIA AGAINST HSV-2
    Gregg N Milligan; Fiscal Year: 2010
    ..The results of these studies should be important for the rational development of HSV vaccines as well as understanding the cellular interactions and specific molecular mechanisms required for resolution of HSV lesions. ..