Research Topics
Genomes and Genes | Erin D MilliganSummaryAffiliation: University of Colorado Country: USA Publications
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Publications
Intrathecal polymer-based interleukin-10 gene delivery for neuropathic painErin D Milligan
Department of Psychology, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
Neuron Glia Biol 2:293-308. 2006..In conclusion, synthetic polymers used as i.t. gene-delivery systems are well-tolerated and improve the long-duration efficacy of pDNA-IL-10 gene therapy...
Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic painErin D Milligan
Department of Psychology and the Center for Neuroscience, University of CO at Boulder, Boulder, CO 80309, USA
Pain 126:294-308. 2006..Together, these data suggest that intrathecal IL-10 gene therapy may provide a novel approach for prolonged clinical pain control...- Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in ratsAnnemarie Ledeboer
Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO, USA
Brain Behav Immun 21:686-98. 2007..We propose that targeting the production of proinflammatory cytokines by intrathecal IL-10 gene therapy may be a promising therapeutic strategy for the relief of paclitaxel-induced neuropathic pain... - Peri-sciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in ratsCarin M Twining
Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Campus Box 345. Boulder, CO 80309-0345, USA
Pain 110:299-309. 2004..Thus these immune-derived substances can markedly alter sensory nerve function at mid-axon... - Spinal cord glia and interleukin-1 do not appear to mediate persistent allodynia induced by intramuscular acidic saline in ratsAnnemarie Ledeboer
Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, 80309 0345, USA
J Pain 7:757-67. 2006..As such, this might represent the first evidence for pain facilitation occurring in the absence of glial involvement... - Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10Erin D Milligan
Department of Psychology and the Center for Neuroscience, University of CO at Boulder, Boulder, CO 80309, USA
Eur J Neurosci 21:2136-48. 2005..These studies support that this gene therapy approach provides an alternative to neuronally focused drug and gene therapies for clinical pain control... - Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120Diana K Schoeniger-Skinner
Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 30809 0345, USA
Brain Behav Immun 21:660-7. 2007..These results would suggest that IL-6 induces pain facilitation, and may do so in part by stimulating the production and release of other pro-inflammatory cytokines... - Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10Erin D Milligan
Department of Psychology and the Center for Neuroscience, University of CO at Boulder, Boulder, CO 80309 USA
Mol Pain 1:9. 2005..Taken together, these data provide initial support that intrathecal gene therapy to drive the production of IL-10 may prove to be an efficacious treatment for neuropathic pain... - A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphineIan N Johnston
Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
J Neurosci 24:7353-65. 2004..Taken together, these results suggest that IL-1 and fractalkine are endogenous regulators of morphine analgesia and are involved in the increases in pain sensitivity that occur after chronic opiates... - Activation of the spinal cord complement cascade might contribute to mechanical allodynia induced by three animal models of spinal sensitizationCarin M Twining
Department of Psychology and the Center of Neuroscience, University of Colorado at Boulder, 80309, USA
J Pain 6:174-83. 2005..These data suggest that complement activation within the spinal cord might contribute to enhanced pain states and provide additional evidence for immune regulation of pain transmission... - Spinal gap junctions: potential involvement in pain facilitationLeah E Spataro
Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 90309-0345, USA
J Pain 5:392-405. 2004..In addition, it decreased gp120-induced proinflammatory cytokines. This suggests gap junction activation might lead to proinflammatory cytokine release by distantly activated glia... - PEGylation of interleukin-10 for the mitigation of enhanced pain statesRyan G Soderquist
Department of Chemical and Biological Engineering, University of Colorado at Boulder, Boulder, Colorado 80309, USA
J Biomed Mater Res A 93:1169-79. 2010..This suggests that PEGylation is a viable strategy for the short-term treatment or, in conjunction with other approaches, the long-term treatment of enhanced pain states... - Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioidsLinda R Watkins
Department of Psychology and the Center for Neuroscience, Muenzinger D 244, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
Brain Behav Immun 21:131-46. 2007.... - "Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioidsLinda R Watkins
Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
Brain Res Rev 56:148-69. 2007..Such changes in neuronal function would be expected to occur wherever immune-derived substances come in close contact with neurons... - Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administrationRyan Gene Soderquist
Department of Chemical and Biological Engineering, University of Colorado at Boulder, 424 UCB, Boulder, Colorado, 80309, USA
Pharm Res 27:841-54. 2010..In this work, the potential of plasmid DNA-encoding IL-10 (pDNA-IL-10) slowly released from biodegradable microparticles to provide long-term pain relief in an animal model of neuropathic pain was investigated... 
PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distributionRyan G Soderquist
Department of Chemical and Biological Engineering, University of Colorado at Boulder, 424 UCB, Boulder, Colorado 80309, USA
J Biomed Mater Res A 91:719-29. 2009..Furthermore, PEGylation may be a promising approach for enhancing intrathecal delivery of therapeutic proteins with potential for treating disease and injury in the spinal cord...- Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitationAnnemarie Ledeboer
Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309-0345, USA
Pain 115:71-83. 2005..Taken together these data highlight the importance of microglial activation in the development of exaggerated pain states... - Intrathecal injection of naked plasmid DNA provides long-term expression of secreted proteinsTravis S Hughes
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309 0347, USA
Mol Ther 17:88-94. 2009..These data suggest that naked DNA has the potential to be used as a therapeutic tool for applications that require long-term release of transgenes into the CSF... - Immunogenicity of intrathecal plasmid gene delivery: cytokine release and effects on transgene expressionTravis S Hughes
Department of Molecular, Cellular and Developmental Biology, University of CO, Boulder, CO, USA
J Gene Med 11:782-90. 2009.... - Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic painLisa C Loram
Department of Psychology and Center for Neurosciences, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
J Neurosci 29:14015-25. 2009..Activation of A(2A)Rs after intrathecal administration may be a novel, therapeutic approach for the treatment of neuropathic pain by increasing IL-10 in the immunocompetent cells of the CNS... - Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical painLinda R Watkins
Department of Psychology, Center for Neurosciences, University of Colorado at Boulder, USA
Adv Exp Med Biol 521:1-21. 2003..The take-home message is that drugs that target glia and the chemical substances that these glia release are predicted to be powerful remedies for pain problems in people... - Sciatic inflammatory neuropathy in the rat: surgical procedures, induction of inflammation, and behavioral testingErin D Milligan
Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, USA
Methods Mol Med 99:67-89. 2004..Methods for testing allodynia and for data analysis are additionally described so to provide all the steps needed for behavioral experimentation... - HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS)Adelina Holguin
Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309, USA
Pain 110:517-30. 2004..Furthermore, gp120 increases mRNA for IL1 converting enzyme and matrix metalloproteinase-9, enzymes responsible for activation and release of proinflammatory cytokines... - Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in ratsErin D Milligan
Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309 0345, USA
J Neurosci 23:1026-40. 2003..These results provide the first evidence that ipsilateral and mirror-image inflammatory neuropathy pain are created both acutely and chronically through glial and proinflammatory cytokine actions... - Spinal interleukin-10 therapy to treat peripheral neuropathic painErin D Milligan
Department of Neurosciences, University of New Mexico Health Sciences Center, School of Medicine, NM, USA
Neuromodulation 15:520-6; discussion 526. 2012..Ultimately, ongoing expression of therapeutic genes is a viable option to treat chronic neuropathic pain in the clinic... - Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effectsKevin A O'Connor
Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, CO 80309, USA
Cytokine 24:254-65. 2003..Nonetheless, these data suggest that HMGB1 may play a role as an endogenous pyrogen and support the concept that HMGB1 has proinflammatory characteristics within the central nervous system... - Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditionsGail M Verge
Neurocrine Biosciences, 12790 El Camino Real, San Diego, CA 92130, USA
Eur J Neurosci 20:1150-60. 2004..The cellular distribution of fractalkine and CX3CR1 in the spinal circuit associated with nociceptive transmission supports a potential role in the mechanisms that contribute to the exaggerated pain state in these models of neuropathy... - Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediatorsMarucia Chacur
, Instituto Butantan, Av. Vital Brazil, 1500, , SP, Brazil
Pain 111:65-76. 2004..Lastly, celecoxib, an inhibitor of cyclooxygenase-2, attenuated sPLA2 actions. These data provide the first evidence of spinal mediators involved in pain facilitation induced by subcutaneous venoms... - Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxideMarucia Chacur
Instituto Butantan, Sao Paolo, Brazil
Pain 108:180-91. 2004..As a variety of immune cells also produce and release sPLA2s during inflammatory states, the data may have general implications for the understanding of inflammatory pain... - Intrathecal gene transfer by adeno-associated virus for painAndreas S Beutler
Mount Sinai School of Medicine, Department of Medicine, Division of Hematology Oncology, New York, NY 10029, USA
Curr Opin Mol Ther 7:431-9. 2005..AAV vectors may therefore become an important tool for translational studies to validate newly identified therapeutic targets in clinical pain states... - Cannabinoids for the treatment of neuropathic pain: clinical evidenceJohn C Ashton
University of Otago, Otago School of Medical Sciences, Department of Pharmacology and Toxicology, Dunedin, New Zealand
Curr Opin Investig Drugs 9:65-75. 2008..The development of cannabinoid drugs to target neuropathic pain with improved therapeutic ratios will depend upon the development of cannabinoid treatments with reduced psychoactivity...
Research Grants
- Pain control via spinal interleukin-10 gene therapyERIN MILLIGAN; Fiscal Year: 2007..This approach to pain control represents a dramatic departure from all other available therapies. ..