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Genomes and GenesSpecies | Glenn L MillhauserSummaryAffiliation: University of California Country: USA Publications
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Copper binding in the prion proteinGlenn L Millhauser
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
Acc Chem Res 37:79-85. 2004..The link between prion protein and copper may provide insight into the general, and recently appreciated, role of metals in neurodegenerative disease...- The octarepeat domain of the prion protein binds Cu(II) with three distinct coordination modes at pH 7.4Madhuri Chattopadhyay
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
J Am Chem Soc 127:12647-56. 2005..This work provides the first complete characterization of all dominant copper coordination modes at pH 7.4... - The affinity of copper binding to the prion protein octarepeat domain: evidence for negative cooperativityEric D Walter
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
Biochemistry 45:13083-92. 2006..Consideration of these findings, along with the demonstrated ability of the protein to quench copper redox activity at high occupancy, suggests that PrP may function to protect cells by scavenging excess copper... - Copper binding extrinsic to the octarepeat region in the prion proteinEric D Walter
Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
Curr Protein Pept Sci 10:529-35. 2009..Here, we review the literature of these copper sites extrinsic to the octarepeat region and add new findings and insights from recent experiments... - Copper coordination in the full-length, recombinant prion proteinColin S Burns
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
Biochemistry 42:6794-803. 2003..0. These studies seem to provide a complete profile of the copper binding sites in PrP and support the hypothesis that PrP function is related to its ability to bind copper in a pH-dependent fashion... 
Chimeras of the agouti-related protein: insights into agonist and antagonist selectivity of melanocortin receptorsPilgrim J Jackson
Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
Peptides 26:1978-87. 2005..Moreover, accessibility to the binding pocket is highly receptor specific with MC3R being the least tolerant of ligand alterations...- Structures of the agouti signaling proteinJoseph C McNulty
Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
J Mol Biol 346:1059-70. 2005..The loop containing the heterogeneous Ala-Pro peptide bond is conserved in mammals, and suggests that ASIP is either trapped by evolution in this unusual configuration or possesses function outside of strict MCR antagonism... - Early onset prion disease from octarepeat expansion correlates with copper binding propertiesDaniel J Stevens
Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California, USA
PLoS Pathog 5:e1000390. 2009..Together, these findings suggest that either loss of PrP copper-dependent function or loss of copper-mediated protection against PrP polymerization makes a significant contribution to early onset prion disease... - Coordination features and affinity of the Cu²+ site in the α-synuclein protein of Parkinson's diseaseChristopher G Dudzik
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, United States
Biochemistry 50:1771-7. 2011.... - The prion protein is a combined zinc and copper binding protein: Zn2+ alters the distribution of Cu2+ coordination modesEric D Walter
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
J Am Chem Soc 129:15440-1. 2007 - Structural and molecular evolutionary analysis of Agouti and Agouti-related proteinsPilgrim J Jackson
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
Chem Biol 13:1297-305. 2006.... - Agouti-related protein segments outside of the receptor binding core are required for enhanced short- and long-term feeding stimulationMichael E Madonna
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, United States
ACS Chem Biol 7:395-402. 2012..These studies suggest new strategies for the development of potent orexigenic species and may serve as leads for the development of therapeutics for treating wasting conditions such as cachexia... - Loop-swapped chimeras of the agouti-related protein and the agouti signaling protein identify contacts required for melanocortin 1 receptor selectivity and antagonismMira P Patel
Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
J Mol Biol 404:45-55. 2010..Comparison with previously published molecular models suggests that this loop makes contact with the first extracellular loop of MC1R through a series of key hydrophobic interactions... - Copper and the prion protein: methods, structures, function, and diseaseGlenn L Millhauser
Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
Annu Rev Phys Chem 58:299-320. 2007.... - Peptoid mimics of agouti related proteinDarren A Thompson
Department of Chemistry and Biochemistry, University of California, Santa Cruz 95064, USA
Bioorg Med Chem Lett 13:1409-13. 2003..1 microM) and AGRP (86-132) (IC(50)=1.9 microM) from the human melanocortin-4 receptor and functioned as an antagonist of alpha-MSH stimulated cAMP generation, thus providing an important lead in the development of AGRP mimetics... - Copper redox cycling in the prion protein depends critically on binding modeLin Liu
Department of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, California 90032, USA
J Am Chem Soc 133:12229-37. 2011..The observed production of hydrogen peroxide suggests a mechanism that could explain PrP's putative role in cellular signaling... - Chemical disulfide mapping identifies an inhibitor cystine knot in the agouti signaling proteinBin Yu
Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
FEBS Lett 581:5561-5. 2007..The results demonstrate unequivocally that ASIP adopts the ICK fold and thereby supports a recent evolution structure function analysis, which proposes that ASIP and AgRP arose from a common antagonist ligand... - Molecular features of the copper binding sites in the octarepeat domain of the prion proteinColin S Burns
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
Biochemistry 41:3991-4001. 2002.... - Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomersTaha Rezai
Department of Chemistry and Biochemistry, University of California, Santa Cruz, 95064, USA
J Am Chem Soc 128:2510-1. 2006..The most permeable diastereomer, cyclo[d-Leu-d-Leu-Leu-d-Leu-Pro-Tyr] (1), exhibited a passive membrane diffusion rate comparable to that of the orally available drug cyclosporine A... - Electron spin relaxation of copper(II) complexes in glassy solution between 10 and 120 KAlistair J Fielding
Department of Chemistry and Biochemistry, University of Denver, Denver, CO 80208, USA
J Magn Reson 179:92-104. 2006..Near 10 K Tm was dominated by proton spins in the surroundings. As temperature was increased motion and spin-lattice relaxation made increasing contributions to Tm. Near 100 K spin-lattice relaxation dominated Tm... - Design, pharmacology, and NMR structure of a minimized cystine knot with agouti-related protein activityPilgrim J Jackson
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
Biochemistry 41:7565-72. 2002..and may also find use as a new reagent for probing melanocortin receptor structure and function... - Coordination of copper to the membrane-bound form of α-synucleinChristopher G Dudzik
Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
Biochemistry 52:53-60. 2013..Consideration of these results demonstrates that copper exerts its greatest conformational effect on the solution form of α-syn... - Dap-SL: a new site-directed nitroxide spin labeling approach for determining structure and motions in synthesized peptides and proteinsJoe C McNulty
Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
FEBS Lett 529:243-8. 2002..In addition, the technique is readily modified for incorporation of any biophysical probe... 
Melanocortin-1 receptor-mediated signalling pathways activated by NDP-MSH and HBD3 ligandsKimberley A Beaumont
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia
Pigment Cell Melanoma Res 25:370-4. 2012..We suggest that β-defensin 3 may be a novel melanocortin-1 receptor agonist involved in regulating melanocyte responses in humans...- Loops and links: structural insights into the remarkable function of the agouti-related proteinGlenn L Millhauser
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
Ann N Y Acad Sci 994:27-35. 2003..Based on these design and structure studies, we propose that the N-terminal loop of AGRP(87-132) makes contact with a receptor exoloop and helps confer AGRP's selectivity for the central MCRs... - Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synucleinKaterina Levitan
Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
J Mol Biol 411:329-33. 2011..Therefore, C-terminal charge is kinetically and thermodynamically protective against α-syn polymerization and may provide a target for the treatment of PD... - Inverse agonist activity of agouti and agouti-related proteinBiao Xin Chai
Department of Surgery, University of Michigan Medical Center, Ann Arbor 48109 0682, USA
Peptides 24:603-9. 2003..These data shed new light on the determinants and mechanism of inverse agonism at the MC4R... - Functional analysis of the Ala67Thr polymorphism in agouti related protein associated with anorexia nervosa and leannessCorine E de Rijke
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Utrecht, The Netherlands
Biochem Pharmacol 70:308-16. 2005..Taken together, no evidence was found for a functional defect of Thr67 AgRP related to MC4R interactions... - Melanoma prevention strategy based on using tetrapeptide alpha-MSH analogs that protect human melanocytes from UV-induced DNA damage and cytotoxicityZalfa A Abdel-Malek
Department of Dermatology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio 45267 0592, USA
FASEB J 20:1561-3. 2006..Analogs, such as 4-Phenylbutyryl-His-D-Phe-Arg-Trp-NH2 with prolonged and reversible effects, can potentially be developed into topical agents to prevent skin photocarcinogenesis, particularly melanoma... - Probing the role of PrP repeats in conformational conversion and amyloid assembly of chimeric yeast prionsJijun Dong
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
J Biol Chem 282:34204-12. 2007..It also reveals new features of the yeast prion protein, and provides a level of control over yeast prion assembly that will be useful for future structural studies and for creating amyloid-based biomaterials...