Glenn L Millhauser

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Copper binding in the prion protein
    Glenn L Millhauser
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    Acc Chem Res 37:79-85. 2004
  2. pmc The octarepeat domain of the prion protein binds Cu(II) with three distinct coordination modes at pH 7.4
    Madhuri Chattopadhyay
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    J Am Chem Soc 127:12647-56. 2005
  3. pmc The elevated copper binding strength of amyloid-β aggregates allows the sequestration of copper from albumin: a pathway to accumulation of copper in senile plaques
    Dianlu Jiang
    Department of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, CA 90032, USA
    Biochemistry 52:547-56. 2013
  4. pmc Coordination of copper to the membrane-bound form of α-synuclein
    Christopher G Dudzik
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Biochemistry 52:53-60. 2013
  5. pmc The affinity of copper binding to the prion protein octarepeat domain: evidence for negative cooperativity
    Eric D Walter
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    Biochemistry 45:13083-92. 2006
  6. pmc Copper binding extrinsic to the octarepeat region in the prion protein
    Eric D Walter
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Curr Protein Pept Sci 10:529-35. 2009
  7. pmc Copper coordination in the full-length, recombinant prion protein
    Colin S Burns
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    Biochemistry 42:6794-803. 2003
  8. pmc Early onset prion disease from octarepeat expansion correlates with copper binding properties
    Daniel J Stevens
    Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California, USA
    PLoS Pathog 5:e1000390. 2009
  9. pmc The prion protein is a combined zinc and copper binding protein: Zn2+ alters the distribution of Cu2+ coordination modes
    Eric D Walter
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    J Am Chem Soc 129:15440-1. 2007
  10. ncbi request reprint Structures of the agouti signaling protein
    Joseph C McNulty
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
    J Mol Biol 346:1059-70. 2005

Collaborators

Detail Information

Publications34

  1. pmc Copper binding in the prion protein
    Glenn L Millhauser
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    Acc Chem Res 37:79-85. 2004
    ..The link between prion protein and copper may provide insight into the general, and recently appreciated, role of metals in neurodegenerative disease...
  2. pmc The octarepeat domain of the prion protein binds Cu(II) with three distinct coordination modes at pH 7.4
    Madhuri Chattopadhyay
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    J Am Chem Soc 127:12647-56. 2005
    ..This work provides the first complete characterization of all dominant copper coordination modes at pH 7.4...
  3. pmc The elevated copper binding strength of amyloid-β aggregates allows the sequestration of copper from albumin: a pathway to accumulation of copper in senile plaques
    Dianlu Jiang
    Department of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, CA 90032, USA
    Biochemistry 52:547-56. 2013
    ..Our work demonstrates that the copper binding affinity of Aβ(1-42) is dependent on its aggregation state and provides new insight into how and why senile plaques accumulate copper in vivo...
  4. pmc Coordination of copper to the membrane-bound form of α-synuclein
    Christopher G Dudzik
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Biochemistry 52:53-60. 2013
    ..Consideration of these results demonstrates that copper exerts its greatest conformational effect on the solution form of α-syn...
  5. pmc The affinity of copper binding to the prion protein octarepeat domain: evidence for negative cooperativity
    Eric D Walter
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    Biochemistry 45:13083-92. 2006
    ..Consideration of these findings, along with the demonstrated ability of the protein to quench copper redox activity at high occupancy, suggests that PrP may function to protect cells by scavenging excess copper...
  6. pmc Copper binding extrinsic to the octarepeat region in the prion protein
    Eric D Walter
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Curr Protein Pept Sci 10:529-35. 2009
    ..Here, we review the literature of these copper sites extrinsic to the octarepeat region and add new findings and insights from recent experiments...
  7. pmc Copper coordination in the full-length, recombinant prion protein
    Colin S Burns
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    Biochemistry 42:6794-803. 2003
    ..0. These studies seem to provide a complete profile of the copper binding sites in PrP and support the hypothesis that PrP function is related to its ability to bind copper in a pH-dependent fashion...
  8. pmc Early onset prion disease from octarepeat expansion correlates with copper binding properties
    Daniel J Stevens
    Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California, USA
    PLoS Pathog 5:e1000390. 2009
    ..Together, these findings suggest that either loss of PrP copper-dependent function or loss of copper-mediated protection against PrP polymerization makes a significant contribution to early onset prion disease...
  9. pmc The prion protein is a combined zinc and copper binding protein: Zn2+ alters the distribution of Cu2+ coordination modes
    Eric D Walter
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    J Am Chem Soc 129:15440-1. 2007
  10. ncbi request reprint Structures of the agouti signaling protein
    Joseph C McNulty
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
    J Mol Biol 346:1059-70. 2005
    ..The loop containing the heterogeneous Ala-Pro peptide bond is conserved in mammals, and suggests that ASIP is either trapped by evolution in this unusual configuration or possesses function outside of strict MCR antagonism...
  11. ncbi request reprint Chimeras of the agouti-related protein: insights into agonist and antagonist selectivity of melanocortin receptors
    Pilgrim J Jackson
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
    Peptides 26:1978-87. 2005
    ..Moreover, accessibility to the binding pocket is highly receptor specific with MC3R being the least tolerant of ligand alterations...
  12. pmc A new paradigm for enzymatic control of α-cleavage and β-cleavage of the prion protein
    Alex J McDonald
    From the Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064
    J Biol Chem 289:803-13. 2014
    ..Together, our results show that MoPrP cleavage is far more complex than previously thought and suggest a mechanism by which PrP(C) fragmentation responds to Cu(2+) and Zn(2+). ..
  13. pmc Coordination features and affinity of the Cu²+ site in the α-synuclein protein of Parkinson's disease
    Christopher G Dudzik
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, United States
    Biochemistry 50:1771-7. 2011
    ....
  14. pmc Structural and molecular evolutionary analysis of Agouti and Agouti-related proteins
    Pilgrim J Jackson
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    Chem Biol 13:1297-305. 2006
    ....
  15. pmc Zinc drives a tertiary fold in the prion protein with familial disease mutation sites at the interface
    Ann R Spevacek
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Structure 21:236-46. 2013
    ..The structural features identified here suggest mechanisms by which physiologic metal ions trigger PrP(C) trafficking and control prion disease...
  16. pmc Agouti-related protein segments outside of the receptor binding core are required for enhanced short- and long-term feeding stimulation
    Michael E Madonna
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, United States
    ACS Chem Biol 7:395-402. 2012
    ..These studies suggest new strategies for the development of potent orexigenic species and may serve as leads for the development of therapeutics for treating wasting conditions such as cachexia...
  17. pmc Copper and the prion protein: methods, structures, function, and disease
    Glenn L Millhauser
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
    Annu Rev Phys Chem 58:299-320. 2007
    ....
  18. pmc Loop-swapped chimeras of the agouti-related protein and the agouti signaling protein identify contacts required for melanocortin 1 receptor selectivity and antagonism
    Mira P Patel
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
    J Mol Biol 404:45-55. 2010
    ..Comparison with previously published molecular models suggests that this loop makes contact with the first extracellular loop of MC1R through a series of key hydrophobic interactions...
  19. ncbi request reprint Peptoid mimics of agouti related protein
    Darren A Thompson
    Department of Chemistry and Biochemistry, University of California, Santa Cruz 95064, USA
    Bioorg Med Chem Lett 13:1409-13. 2003
    ..1 microM) and AGRP (86-132) (IC(50)=1.9 microM) from the human melanocortin-4 receptor and functioned as an antagonist of alpha-MSH stimulated cAMP generation, thus providing an important lead in the development of AGRP mimetics...
  20. pmc Molecular and functional analysis of human β-defensin 3 action at melanocortin receptors
    Matthew A Nix
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Chem Biol 20:784-95. 2013
    ....
  21. pmc Copper redox cycling in the prion protein depends critically on binding mode
    Lin Liu
    Department of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, California 90032, USA
    J Am Chem Soc 133:12229-37. 2011
    ..The observed production of hydrogen peroxide suggests a mechanism that could explain PrP's putative role in cellular signaling...
  22. pmc Molecular features of the copper binding sites in the octarepeat domain of the prion protein
    Colin S Burns
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    Biochemistry 41:3991-4001. 2002
    ....
  23. ncbi request reprint Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers
    Taha Rezai
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, 95064, USA
    J Am Chem Soc 128:2510-1. 2006
    ..The most permeable diastereomer, cyclo[d-Leu-d-Leu-Leu-d-Leu-Pro-Tyr] (1), exhibited a passive membrane diffusion rate comparable to that of the orally available drug cyclosporine A...
  24. pmc Electron spin relaxation of copper(II) complexes in glassy solution between 10 and 120 K
    Alistair J Fielding
    Department of Chemistry and Biochemistry, University of Denver, Denver, CO 80208, USA
    J Magn Reson 179:92-104. 2006
    ..Near 10 K Tm was dominated by proton spins in the surroundings. As temperature was increased motion and spin-lattice relaxation made increasing contributions to Tm. Near 100 K spin-lattice relaxation dominated Tm...
  25. pmc Chemical disulfide mapping identifies an inhibitor cystine knot in the agouti signaling protein
    Bin Yu
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
    FEBS Lett 581:5561-5. 2007
    ..The results demonstrate unequivocally that ASIP adopts the ICK fold and thereby supports a recent evolution structure function analysis, which proposes that ASIP and AgRP arose from a common antagonist ligand...
  26. ncbi request reprint Design, pharmacology, and NMR structure of a minimized cystine knot with agouti-related protein activity
    Pilgrim J Jackson
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    Biochemistry 41:7565-72. 2002
    ..and may also find use as a new reagent for probing melanocortin receptor structure and function...
  27. ncbi request reprint Dap-SL: a new site-directed nitroxide spin labeling approach for determining structure and motions in synthesized peptides and proteins
    Joe C McNulty
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
    FEBS Lett 529:243-8. 2002
    ..In addition, the technique is readily modified for incorporation of any biophysical probe...
  28. pmc Melanocortin-1 receptor-mediated signalling pathways activated by NDP-MSH and HBD3 ligands
    Kimberley A Beaumont
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia
    Pigment Cell Melanoma Res 25:370-4. 2012
    ..We suggest that β-defensin 3 may be a novel melanocortin-1 receptor agonist involved in regulating melanocyte responses in humans...
  29. ncbi request reprint Loops and links: structural insights into the remarkable function of the agouti-related protein
    Glenn L Millhauser
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    Ann N Y Acad Sci 994:27-35. 2003
    ..Based on these design and structure studies, we propose that the N-terminal loop of AGRP(87-132) makes contact with a receptor exoloop and helps confer AGRP's selectivity for the central MCRs...
  30. pmc Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synuclein
    Katerina Levitan
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
    J Mol Biol 411:329-33. 2011
    ..Therefore, C-terminal charge is kinetically and thermodynamically protective against α-syn polymerization and may provide a target for the treatment of PD...
  31. ncbi request reprint Inverse agonist activity of agouti and agouti-related protein
    Biao Xin Chai
    Department of Surgery, University of Michigan Medical Center, Ann Arbor 48109 0682, USA
    Peptides 24:603-9. 2003
    ..These data shed new light on the determinants and mechanism of inverse agonism at the MC4R...
  32. pmc Probing the role of PrP repeats in conformational conversion and amyloid assembly of chimeric yeast prions
    Jijun Dong
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    J Biol Chem 282:34204-12. 2007
    ..It also reveals new features of the yeast prion protein, and provides a level of control over yeast prion assembly that will be useful for future structural studies and for creating amyloid-based biomaterials...
  33. ncbi request reprint Functional analysis of the Ala67Thr polymorphism in agouti related protein associated with anorexia nervosa and leanness
    Corine E de Rijke
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Utrecht, The Netherlands
    Biochem Pharmacol 70:308-16. 2005
    ..Taken together, no evidence was found for a functional defect of Thr67 AgRP related to MC4R interactions...
  34. ncbi request reprint Melanoma prevention strategy based on using tetrapeptide alpha-MSH analogs that protect human melanocytes from UV-induced DNA damage and cytotoxicity
    Zalfa A Abdel-Malek
    Department of Dermatology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio 45267 0592, USA
    FASEB J 20:1561-3. 2006
    ..Analogs, such as 4-Phenylbutyryl-His-D-Phe-Arg-Trp-NH2 with prolonged and reversible effects, can potentially be developed into topical agents to prevent skin photocarcinogenesis, particularly melanoma...