Stephen C Miller

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi Profiling sulfonate ester stability: identification of complementary protecting groups for sulfonates
    Stephen C Miller
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, Massachusetts 01605, USA
    J Org Chem 75:4632-5. 2010
  2. ncbi Synthesis of near-IR fluorescent oxazine dyes with esterase-labile sulfonate esters
    Steven M Pauff
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Org Lett 13:6196-9. 2011
  3. ncbi A trifluoroacetic acid-labile sulfonate protecting group and its use in the synthesis of a near-IR fluorophore
    Steven M Pauff
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    J Org Chem 78:711-6. 2013
  4. ncbi Design and application of esterase-labile sulfonate protecting groups
    Laert Rusha
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA
    Chem Commun (Camb) 47:2038-40. 2011

Research Grants

  1. Delivery and Triggered Activation of Near-IR Fluorophores for Live Cell Imaging
    Stephen C Miller; Fiscal Year: 2010

Collaborators

  • Steven M Pauff
  • Laert Rusha

Detail Information

Publications4

  1. ncbi Profiling sulfonate ester stability: identification of complementary protecting groups for sulfonates
    Stephen C Miller
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, Massachusetts 01605, USA
    J Org Chem 75:4632-5. 2010
    ..This work compares the intrinsic lability of different sulfonate esters, identifying new sulfonate protecting groups and mild, selective cleavage conditions...
  2. ncbi Synthesis of near-IR fluorescent oxazine dyes with esterase-labile sulfonate esters
    Steven M Pauff
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Org Lett 13:6196-9. 2011
    ....
  3. ncbi A trifluoroacetic acid-labile sulfonate protecting group and its use in the synthesis of a near-IR fluorophore
    Steven M Pauff
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    J Org Chem 78:711-6. 2013
    ..The use of this protecting group improved the synthesis of a sulfonated near-IR fluorophore and the mild deprotection conditions allowed isolation of the product without requiring chromatography...
  4. ncbi Design and application of esterase-labile sulfonate protecting groups
    Laert Rusha
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA
    Chem Commun (Camb) 47:2038-40. 2011
    ..Three esterase-labile, but chemically-stable sulfonate protecting groups have been designed and synthesized. One of these sulfonate esters allowed the cytoplasmic delivery and unmasking of a sulfonated dye in live cells...

Research Grants3

  1. Delivery and Triggered Activation of Near-IR Fluorophores for Live Cell Imaging
    Stephen C Miller; Fiscal Year: 2010
    ..This study will improve the ability of light-based imaging to be used for the study and diagnosis of disease. ..