Richard Miller

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan
    Michael J Steinbaugh
    Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Physiol Endocrinol Metab 303:E488-95. 2012
  2. doi Genes against aging
    Richard A Miller
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 67:495-502. 2012
  3. pmc Indicators of "healthy aging" in older women (65-69 years of age). A data-mining approach based on prediction of long-term survival
    William R Swindell
    Department of Pathology, University of Michigan, School of Medicine, Ann Arbor, MI 48109 2200, USA
    BMC Geriatr 10:55. 2010
  4. pmc Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
    Richard A Miller
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 66:191-201. 2011
  5. ncbi T cell subset patterns that predict resistance to spontaneous lymphoma, mammary adenocarcinoma, and fibrosarcoma in mice
    Richard A Miller
    Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, University of Michigan Institute of Gerontology, and Ann Arbor Department of Veterans Affairs Medical Center, 48109, USA
    J Immunol 169:1619-25. 2002
  6. pmc Cell stress and aging: new emphasis on multiplex resistance mechanisms
    Richard A Miller
    Department of Pathology and Geriatrics Center, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 64:179-82. 2009
  7. pmc "Dividends" from research on aging--can biogerontologists, at long last, find something useful to do?
    Richard A Miller
    Department of Pathology and Geriatrics Center, Ann Arbor VA Medical Center, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 64:157-60. 2009
  8. ncbi Detection of plasma membrane Ca(2+)-ATPase activity in mouse T lymphocytes by flow cytometry using fluo-3-loaded vesicles
    W G Telford
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109 0642, USA
    Cytometry 24:243-50. 1996
  9. ncbi An Aging Interventions Testing Program: study design and interim report
    Richard A Miller
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor VA Medical Center, Ann Arbor, MI 48109 2200, USA
    Aging Cell 6:565-75. 2007
  10. ncbi Big mice die young: early life body weight predicts longevity in genetically heterogeneous mice
    Richard A Miller
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA
    Aging Cell 1:22-9. 2002

Research Grants

  1. Activation Defects in T Cells of Aged Mice
    Richard A Miller; Fiscal Year: 2010
  2. Laboratory for Anti-Geric Testing, Evaluation and Research
    Richard Miller; Fiscal Year: 2007
  3. WILD DERIVED MOUSE STOCKS--NEW MODELS FOR AGING RESEARCH
    Richard Miller; Fiscal Year: 2004
  4. GENETICS OF AGE SENSITIVE TRAITS IN MICE
    Richard Miller; Fiscal Year: 2003
  5. Genetics of Longevity and Age-Sensitive Traits in Mice
    Richard Miller; Fiscal Year: 2007
  6. Laboratory for Anti-Geric Testing, Evaluation and Resea*
    Richard Miller; Fiscal Year: 2007
  7. Activation Defects in T Cells of Aged Mice
    Richard Miller; Fiscal Year: 2007
  8. GENETIC CONTROL OF LONGEVITY IN MICE
    Richard Miller; Fiscal Year: 2003
  9. GENETIC CONTROL OF LONGEVITY IN MICE
    Richard Miller; Fiscal Year: 1993
  10. WILD DERIVED MOUSE STOCKS--NEW MODELS FOR AGING RESEARCH
    Richard Miller; Fiscal Year: 1999

Detail Information

Publications93

  1. pmc Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan
    Michael J Steinbaugh
    Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Physiol Endocrinol Metab 303:E488-95. 2012
    ..These results suggest that elevation of phase I XMEs is a hallmark of long-lived mice and may facilitate screens for agents worth testing in intervention-based lifespan studies...
  2. doi Genes against aging
    Richard A Miller
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 67:495-502. 2012
    ..This essay compares different strategies for using genetic information to clarify questions in biogerontology, suggesting an emphasis on genes that can retard multiple forms of age-dependent dysfunction in parallel...
  3. pmc Indicators of "healthy aging" in older women (65-69 years of age). A data-mining approach based on prediction of long-term survival
    William R Swindell
    Department of Pathology, University of Michigan, School of Medicine, Ann Arbor, MI 48109 2200, USA
    BMC Geriatr 10:55. 2010
    ..The aims of this study were to identify predictors of long-term survival in older women and to develop a multivariable model based upon longitudinal data from the Study of Osteoporotic Fractures (SOF)...
  4. pmc Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
    Richard A Miller
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 66:191-201. 2011
    ....
  5. ncbi T cell subset patterns that predict resistance to spontaneous lymphoma, mammary adenocarcinoma, and fibrosarcoma in mice
    Richard A Miller
    Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, University of Michigan Institute of Gerontology, and Ann Arbor Department of Veterans Affairs Medical Center, 48109, USA
    J Immunol 169:1619-25. 2002
    ....
  6. pmc Cell stress and aging: new emphasis on multiplex resistance mechanisms
    Richard A Miller
    Department of Pathology and Geriatrics Center, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 64:179-82. 2009
    ....
  7. pmc "Dividends" from research on aging--can biogerontologists, at long last, find something useful to do?
    Richard A Miller
    Department of Pathology and Geriatrics Center, Ann Arbor VA Medical Center, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 64:157-60. 2009
    ..More work is also needed to learn how timing of antiaging interventions can be used to optimize the balance between beneficial and undesirable effects...
  8. ncbi Detection of plasma membrane Ca(2+)-ATPase activity in mouse T lymphocytes by flow cytometry using fluo-3-loaded vesicles
    W G Telford
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109 0642, USA
    Cytometry 24:243-50. 1996
    ..Flow cytometric analysis, therefore, may represent a useful approach for quantifying PMCA activity in mammalian cells...
  9. ncbi An Aging Interventions Testing Program: study design and interim report
    Richard A Miller
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor VA Medical Center, Ann Arbor, MI 48109 2200, USA
    Aging Cell 6:565-75. 2007
    ..More data will be needed to determine if any of these compounds can extend maximal lifespan, but the current data show that NDGA reduces early life mortality risks in genetically heterogeneous mice at multiple test sites...
  10. ncbi Big mice die young: early life body weight predicts longevity in genetically heterogeneous mice
    Richard A Miller
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA
    Aging Cell 1:22-9. 2002
    ..The evidence that weight in 2-month-old mice is a significant predictor of life span suggests that at least some of the lethal diseases of old age can be timed by factors that influence growth rate in juvenile rodents...
  11. ncbi Genetic approaches to the study of aging
    Richard A Miller
    Department of Pathology, Geriatrics Center, University of Michigan School of Medicine, 5316 CCGCB, Box 0940, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0940, USA
    J Am Geriatr Soc 53:S284-6. 2005
    ..In this context the paltry commitment to research in biological gerontology (six cents per $100 of NIH funding, for example) seems worth reconsideration...
  12. ncbi Biomedicine. The anti-aging sweepstakes: catalase runs for the ROSes
    Richard A Miller
    Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, and Ann Arbor DVA Medical Center, Ann Arbor, MI 48109 0940, USA
    Science 308:1875-6. 2005
  13. ncbi Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance
    Richard A Miller
    Department of Pathology, Geriatrics Center, University of Michigan School of Medicine, Ann Arbor, MI 48109 0940, USA
    Aging Cell 4:119-25. 2005
    ..Studies of the cellular and molecular biology of methionine-deprived mice may, in parallel to studies of calorie-restricted mice, provide insights into the way in which nutritional factors modulate longevity and late-life illnesses...
  14. ncbi 'Accelerated aging': a primrose path to insight?
    Richard A Miller
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor VA Medical Center, Ann Arbor, MI 48103, USA
    Aging Cell 3:47-51. 2004
    ....
  15. ncbi Rebuttal to Hasty and Vijg: 'Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity'
    Richard A Miller
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor VA Medical Center, Ann Arbor, MI 48103, USA
    Aging Cell 3:53-4. 2004
  16. ncbi Longer life spans and delayed maturation in wild-derived mice
    Richard A Miller
    Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Exp Biol Med (Maywood) 227:500-8. 2002
    ..Genes present in the Id and Ma stocks may be valuable tools for the analysis of the physiology and biochemistry of aging in mice...
  17. pmc Preservation of femoral bone thickness in middle age predicts survival in genetically heterogeneous mice
    Richard A Miller
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, USA
    Aging Cell 10:383-91. 2011
    ....
  18. pmc Extending life: scientific prospects and political obstacles
    Richard A Miller
    University of Michigan, USA
    Milbank Q 80:155-74. 2002
    ....
  19. ncbi Candidate biomarkers of aging: age-sensitive indices of immune and muscle function covary in genetically heterogeneous mice
    R A Miller
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, USA
    J Gerontol A Biol Sci Med Sci 52:B39-47. 1997
    ..Further work will be needed to assess whether these tests predict either longevity or the trajectory of change in other age-sensitive molecular and physiological traits...
  20. ncbi Age-related changes in T cell surface markers: a longitudinal analysis in genetically heterogeneous mice
    R A Miller
    Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, Ann Arbor 48109 0642, USA
    Mech Ageing Dev 96:181-96. 1997
    ..Thus some, but not all, age-sensitive T cell subsets show correlated levels and correlated rates of change throughout the middle of the lifespan...
  21. ncbi Early activation defects in T lymphocytes from aged mice
    R A Miller
    Department of Pathology, University of Michigan, Ann Arbor, USA
    Immunol Rev 160:79-90. 1997
    ..The effect of aging on T-cell activation is not simply an overall decline in signal intensity, but a set of qualitative changes that differ among subsets and depend at least partly on the nature of the stimulus...
  22. ncbi Kleemeier award lecture: are there genes for aging?
    R A Miller
    Department of Pathology, Geriatrics Center, University of Michigan, Ann Arbor 48109 0940, USA
    J Gerontol A Biol Sci Med Sci 54:B297-307. 1999
    ....
  23. ncbi Exotic mice as models for aging research: polemic and prospectus
    R A Miller
    Department of Pathology, University of Michigan, Ann Arbor 48109 0940, USA
    Neurobiol Aging 20:217-31. 1999
    ....
  24. ncbi Effect of aging on T lymphocyte activation
    R A Miller
    Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, Institute of Gerontology, and Ann Arbor VA Medical Center, Ann Arbor, MI 48109 0940, USA
    Vaccine 18:1654-60. 2000
    ..Age-related impairment of the translocation of PKCθ from cytoplasm to the site of T-cell interaction with antigen-presenting cells may underlie downstream defects in the activation cascade...
  25. ncbi Principles of animal use for gerontological research
    R A Miller
    Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, Ann Arbor, USA
    J Gerontol A Biol Sci Med Sci 55:B117-23. 2000
    ....
  26. ncbi T cells in aging mice: genetic, developmental, and biochemical analyses
    Richard A Miller
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, 48109, USA
    Immunol Rev 205:94-103. 2005
    ....
  27. ncbi Differential longevity in mouse stocks selected for early life growth trajectory
    R A Miller
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor 48109 0940, USA
    J Gerontol A Biol Sci Med Sci 55:B455-61. 2000
    ..These size-selected mice provide useful tools for analysis of the genetic factors that influence life history parameters, including maturation and aging rates...
  28. ncbi Interpretation, design, and analysis of gene array expression experiments
    R A Miller
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor 48109 0940, USA
    J Gerontol A Biol Sci Med Sci 56:B52-7. 2001
    ....
  29. ncbi Biomarkers of aging: prediction of longevity by using age-sensitive T-cell subset determinations in a middle-aged, genetically heterogeneous mouse population
    R A Miller
    Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, Ann Arbor 48109 0940, USA
    J Gerontol A Biol Sci Med Sci 56:B180-6. 2001
    ....
  30. ncbi Gene expression patterns in calorically restricted mice: partial overlap with long-lived mutant mice
    Richard A Miller
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Endocrinol 16:2657-66. 2002
    ..These 29 genes, altered both by CR and in dwarf mice, provide a list of biochemical features common to both models of delayed aging, and thus merit confirmation and more detailed study...
  31. pmc Resistance of skin fibroblasts to peroxide and UV damage predicts hearing loss in aging mice
    Richard A Miller
    Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    Aging Cell 10:362-3. 2011
    ..Skin cell lines may provide an easily accessible surrogate index of intrinsic stress resistance that varies among individuals and influences the pace of neurosensory decline in aging mice...
  32. ncbi Coordinated genetic control of neoplastic and nonneoplastic diseases in mice
    Richard A Miller
    Department of Pathology, University of Michigan, Ann Arbor, USA
    J Gerontol A Biol Sci Med Sci 57:B3-8. 2002
    ..The data support the hypothesis that many forms of late-life disease may be influenced by shared pathophysiologic mechanisms that are under coordinated genetic control...
  33. pmc CD43-independent augmentation of mouse T-cell function by glycoprotein cleaving enzymes
    Scott B Berger
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Immunology 119:178-86. 2006
    ..The preferential ability of PNGase F and ST-Siase(2,3) to improve the function of T cells from aged mice may involve cleavage of glycoproteins containing alpha2,3-linked sialic acid residues on N-linked or O-linked glycans or both...
  34. ncbi Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress
    Adam B Salmon
    Cellular and Molecular Biology Graduate Program, University of Michigan School of Medicine, 1500 E Medical Center Dr, 5316 CCGC 0940, Ann Arbor, MI 48105 0940, USA
    Am J Physiol Endocrinol Metab 289:E23-9. 2005
    ....
  35. pmc Hormone-treated snell dwarf mice regain fertility but remain long lived and disease resistant
    Maggie Vergara
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109 0940, USA
    J Gerontol A Biol Sci Med Sci 59:1244-50. 2004
    ....
  36. pmc Fibroblasts from long-lived mutant mice show diminished ERK1/2 phosphorylation but exaggerated induction of immediate early genes
    Liou Y Sun
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109, USA
    Free Radic Biol Med 47:1753-61. 2009
    ..These alterations in kinase pathways may contribute to the resistance of these cells to lethal injury...
  37. ncbi Hormone levels and cataract scores as sex-specific, mid-life predictors of longevity in genetically heterogeneous mice
    James M Harper
    Department of Pathology, School of Medicine, University of Michigan, Ann Arbor, MI, USA
    Mech Ageing Dev 124:801-10. 2003
    ..Additional work is needed to evaluate the role of these hormones as potential modulators of the aging process, and to resolve the conflicting data obtained for cataract severity as a predictor of life span...
  38. ncbi Quantitative trait locus mapping for age-related cataract severity and synechia prevalence using four-way cross mice
    Norman Wolf
    Department of Pathology, University of Washington, Seattle 98195 7470, USA
    Invest Ophthalmol Vis Sci 45:1922-9. 2004
    ..The goal of this study was to map mouse quantitative trait loci (QTL) that influence the development of murine age-related cataract and synechia, by using a genetically heterogeneous mouse population bred by a four-way cross...
  39. ncbi Mapping tissue-specific genes correlated with age-dependent changes in protein stability and function
    Kathleen C Wisser
    Biophysics Research Division, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Arch Biochem Biophys 432:58-70. 2004
    ..Tissue specific differences in GAPDH stability may have significant consequences to these alternate functions during aging...
  40. pmc Skin-derived fibroblasts from long-lived species are resistant to some, but not all, lethal stresses and to the mitochondrial inhibitor rotenone
    James M Harper
    Department of Pathology, University of Michigan, School of Medicine, Ann Arbor, MI, USA
    Aging Cell 6:1-13. 2007
    ....
  41. pmc Cells from long-lived mutant mice exhibit enhanced repair of ultraviolet lesions
    Adam B Salmon
    Cellular and Molecular Biology Graduate Program, University of Michigan Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA
    J Gerontol A Biol Sci Med Sci 63:219-31. 2008
    ..Overall, these data suggest a mechanism for the UV resistance of Snell dwarf-derived fibroblasts that could contribute to the delay of aging and neoplasia in these mice...
  42. pmc Fibroblasts from naked mole-rats are resistant to multiple forms of cell injury, but sensitive to peroxide, ultraviolet light, and endoplasmic reticulum stress
    Adam B Salmon
    Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI, USA
    J Gerontol A Biol Sci Med Sci 63:232-41. 2008
    ..The sensitivity of both Snell dwarf and NMR cells to ER stress suggests that alterations in the unfolded protein response might modulate cell survival and aging rate...
  43. pmc Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age
    Liou Sun
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 64:711-22. 2009
    ..These results introduce new protocols that can increase maximal life span and suggest that the spectrum of metabolic changes induced by low-calorie and low-methionine diets may differ in instructive ways...
  44. ncbi Age-dependent defects in TCR-triggered cytoskeletal rearrangement in CD4+ T cells
    Gonzalo G Garcia
    Department of Pathology, School of Medicine, and Institute of Gerontology, University of Michigan, Ann Arbor 48109, USA
    J Immunol 169:5021-7. 2002
    ....
  45. ncbi Antigen-independent expansion of CD28hi CD8 cells from aged mice: cytokine requirements and signal transduction pathways
    Anavelys Ortiz-Suárez
    Cellular and Molecular Biology Graduate Program, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    J Gerontol A Biol Sci Med Sci 58:B1063-73. 2003
    ..Thus in vivo proliferation of CD28hi CD8 cells from aged mice cannot be attributed to retention of T-cell receptor signaling...
  46. ncbi A subset of CD8 memory T cells from old mice have high levels of CD28 and produce IFN-gamma
    Anavelys Ortiz-Suárez
    Cellular and Molecular Biology Graduate Program, University of Michigan School of Medicine, Ann Arbor 48109, USA
    Clin Immunol 104:282-92. 2002
    ..These studies thus document the presence in aged mice of a population of CD28(hi) CD8(+) cells whose ability to proliferate in vivo without antigenic stimulation and to produce IFN-gamma may be involved in immune regulation...
  47. ncbi Gene expression profile of long-lived snell dwarf mice
    Igor Dozmorov
    Department of Pathology, University of Michigan, Ann Arbor 48109 0940, USA
    J Gerontol A Biol Sci Med Sci 57:B99-108. 2002
    ....
  48. ncbi Multiplex stress resistance in cells from long-lived dwarf mice
    Shin Murakami
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    FASEB J 17:1565-6. 2003
    ..The findings suggest that increases in cellular resistance to stress may mediate extended longevity in mammals...
  49. ncbi Age-related defects in CD4+ T cell activation reversed by glycoprotein endopeptidase
    Gonzalo G Garcia
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, USA
    Eur J Immunol 33:3464-72. 2003
    ..These data support a model in which O-glycosylated forms of T cell surface molecules, including CD43, are largely responsible for age-related defects in TCR signaling and function...
  50. ncbi Body weight, hormones and T cell subsets as predictors of life span in genetically heterogeneous mice
    James M Harper
    Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, MI, USA
    Mech Ageing Dev 125:381-90. 2004
    ....
  51. pmc Three-locus and four-locus QTL interactions influence mouse insulin-like growth factor-I
    Philip Hanlon
    Department of Mathematics, University of Michigan, Ann Arbor, Michigan 48109 0618, USA
    Physiol Genomics 26:46-54. 2006
    ..The analysis method can detect multilocus interactions in a genome scan experiment and may provide new ways to explore the genetic architecture of complex physiological phenotypes...
  52. ncbi Biochemical and genetic analyses of T cell aging in mice
    Richard A Miller
    University of Michigan, 1500 East Medical Center Drive, Room 5316 CCGCB, Box 0940, Ann Arbor, MI 48109 0940, USA
    Springer Semin Immunopathol 24:61-73. 2002
  53. ncbi Quantitative trait loci for insulin-like growth factor I, leptin, thyroxine, and corticosterone in genetically heterogeneous mice
    James M Harper
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, USA
    Physiol Genomics 15:44-51. 2003
    ..These results show that the genetic controls over late-life hormone levels are complex and dependent on effects of genes that act both early and late in the life course...
  54. pmc Nrf2 signaling, a mechanism for cellular stress resistance in long-lived mice
    Scott F Leiser
    University of Michigan, Ann Arbor, MI 48109 2200, USA
    Mol Cell Biol 30:871-84. 2010
    ..Augmented activity of Nrf2 and ARE-responsive genes may coordinate many of the stress resistance traits seen in cells from these long-lived mutant mice...
  55. pmc Age-related defects in moesin/ezrin cytoskeletal signals in mouse CD4 T cells
    Gonzalo G Garcia
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    J Immunol 179:6403-9. 2007
    ..In addition, CD4 T cells from aged mice show defects in the Rho GTPase activities known to control ERM function...
  56. pmc Genetic modulation of hormone levels and life span in hybrids between laboratory and wild-derived mice
    James M Harper
    University of Michigan, 190 Zina Pitcher Pl, Room 3005, BSRB Box 2200, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 61:1019-29. 2006
    ..Overall, these finding suggest that wild-derived mice harbor alleles that increase longevity, perhaps through effects on growth, maturation, and early-life hormone levels...
  57. ncbi Inhibition of retinoic acid-induced skin irritation in calorie-restricted mice
    James Varani
    Department of Pathology, The University of Michigan, 1301 Catherine Road, Box 0602, Ann Arbor, MI 48109, USA
    Arch Dermatol Res 300:27-35. 2008
    ..CR appears to exert a protective effect at the target tissue level rather than by a reduction in pro-inflammatory events, per se...
  58. pmc How long will my mouse live? Machine learning approaches for prediction of mouse life span
    William R Swindell
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 63:895-906. 2008
    ..Future work in this direction can provide tools for aging research and will shed light on associations between phenotypic traits and longevity...
  59. ncbi Mouse loci associated with life span exhibit sex-specific and epistatic effects
    Anne U Jackson
    Department of Human Genetics, University of Michigan School of Medicine, Institute of Gerontology, University of Michigan, Ann Arbor 48109 0940, USA
    J Gerontol A Biol Sci Med Sci 57:B9-B15. 2002
    ..Our results show that the common laboratory mouse strains are polymorphic at loci that produce substantial differences in life span and that these effects can be sex specific and conditional on alleles inherited at other loci...
  60. pmc Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice
    William R Swindell
    University of Michigan, Department of Pathology and Geriatrics Center, Ann Arbor, MI 48109 2200, USA
    Mech Ageing Dev 130:393-400. 2009
    ..Contributions of chaperones to longevity in mice may be more complex than those inferred from C. elegans...
  61. pmc Age-related changes in lck-Vav signaling pathways in mouse CD4 T cells
    Gonzalo G Garcia
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan 48105, USA
    Cell Immunol 259:100-4. 2009
    ..These changes in lck-Vav signals in resting CD4 cells may contribute in turn to age-related increases in Rac1 activity and declines in phosphorylation of cytoskeletal proteins including Ezrin and Moesin...
  62. pmc Macrophage migration inhibitory factor-knockout mice are long lived and respond to caloric restriction
    James M Harper
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, Michigan, USA
    FASEB J 24:2436-42. 2010
    ..Overall, these data refute the suggestion that MIF is required for the CR effect on life span, but raise the possibility that MIF may limit life span in normal mice...
  63. pmc Quantitative trait loci modulate vertebral morphology and mechanical properties in a population of 18-month-old genetically heterogeneous mice
    Grant M Reeves
    Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Bone 40:433-43. 2007
    ..Genetic markers were associated with traits on at least 13 different chromosomes, demonstrating the complexity of genetic control over vertebral form, function and aging...
  64. ncbi Correlated resistance to glucose deprivation and cytotoxic agents in fibroblast cell lines from long-lived pituitary dwarf mice
    Scott F Leiser
    Cellular and Molecular Biology Graduate Program, University of Michigan School of Medicine, Ann Arbor, MI 48109 2200, USA
    Mech Ageing Dev 127:821-9. 2006
    ..Further analysis of the basis for metabolic abnormalities in these cell lines may provide insights into the cause of stress resistance in dwarf-derived cultures and to the longevity and disease-resistance of these long-lived mutant mice...
  65. pmc Hyperglycemia, impaired glucose tolerance and elevated glycated hemoglobin levels in a long-lived mouse stock
    James M Harper
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109 0940, USA
    Exp Gerontol 40:303-14. 2005
    ..Taken together, these findings suggest that neither a reduction of blood glucose levels nor an increase in glucose tolerance is necessary for life span extension in mice...
  66. ncbi Age-associated changes in glycosylation of CD43 and CD45 on mouse CD4 T cells
    Gonzalo G Garcia
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA
    Eur J Immunol 35:622-31. 2005
    ..These data support the idea that changes in T cell surface glycosylation could play an important role in immune senescence...
  67. pmc Ex vivo enzymatic treatment of aged CD4 T cells restores antigen-driven CD69 expression and proliferation in mice
    Gonzalo G Garcia
    Department of Pathology, University of Michigan School of Medicine, USA
    Immunobiology 216:66-71. 2011
    ..OSGE treatment also repairs the age-dependent loss of CD69 expression after in vivo activation...
  68. ncbi Comparison of gene expression of 2-mo denervated, 2-mo stimulated-denervated, and control rat skeletal muscles
    Tatiana Y Kostrominova
    Institute of Gerontology, Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109 2007, USA
    Physiol Genomics 22:227-43. 2005
    ....
  69. ncbi A glycoprotein endopeptidase enhances calcium influx and cytokine production by CD4+ T cells of old and young mice
    Scott B Berger
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, USA
    Int Immunol 17:983-91. 2005
    ..These data support a model in which O-glycosylated surface proteins inhibit CD4+ lymphocyte activation in both young and old mice, and in which such glycoproteins contribute to the age-related decline in cytokine production...
  70. pmc Stress resistance and aging: influence of genes and nutrition
    James M Harper
    Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, Ann Arbor, MI, United States
    Mech Ageing Dev 127:687-94. 2006
    ..These data thus suggest that while resistance to stress is a common characteristic of experimental life span extension in mice, the cell types showing resistance may differ among the various models of delayed or decelerated aging...
  71. pmc Enhancement of CD8 T-cell function through modifying surface glycoproteins in young and old mice
    Amir A Sadighi Akha
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Immunology 119:187-94. 2006
    ....
  72. pmc Age-related defects in the cytoskeleton signaling pathways of CD4 T cells
    Gonzalo G Garcia
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, United States
    Ageing Res Rev 10:26-34. 2011
    ..Here we discuss recent progress in the understanding of how aging alters F-actin and ERM proteins in mouse CD4 T cells, and the implications of these changes for the T cell activation process...
  73. ncbi Differential effects of ageing on cytokine and chemokine responses during type-1 (mycobacterial) and type-2 (schistosomal) pulmonary granulomatous inflammation in mice
    Bo Chin Chiu
    Department of Pathology, University of Michigan Medical School, 113 Ann Arbor Veterans Affairs Healthcare System, 2215 Fuller Road, Ann Arbor, MI 48105, USA
    Mech Ageing Dev 123:313-26. 2002
    ..These findings suggest that cytokine and chemokine responses degrade differentially with age shifting Th1/Th2 crossregulatory pressures and local expression of chemokines...
  74. ncbi Fibroblasts from long-lived Snell dwarf mice are resistant to oxygen-induced in vitro growth arrest
    Scott P Maynard
    Department of Pathology and Geriatrics Center, University of Michigan, and Ann Arbor VA Medical Center, Ann Arbor, MI 48109 0940, USA
    Aging Cell 5:89-96. 2006
    ....
  75. ncbi Quantitative trait loci for femoral size and shape in a genetically heterogeneous mouse population
    Suzanne K Volkman
    Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Bone Miner Res 18:1497-505. 2003
    ..Genotypes from 487 mice were compared with geometric traits obtained from microCT. We found 14 genetic markers that associate with geometric traits, showing the complexity of genetic control over bone geometry...
  76. ncbi Quantitative trait loci that modulate femoral mechanical properties in a genetically heterogeneous mouse population
    Suzanne K Volkman
    Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Bone Miner Res 19:1497-505. 2004
    ..We found evidence for QTL on eight chromosomes that affect mechanical traits. Some of these QTL may have primary effects on body weight or femoral geometry, and others seem to affect bone quality directly...
  77. ncbi Signal transduction in the aging immune system
    Amir A Sadighi Akha
    Department of Veterans Affairs Medical Center, Ann Arbor, Michigan 48109 0940, USA
    Curr Opin Immunol 17:486-91. 2005
    ..Evidence for intrinsic signal defects in aged B cells is more limited, but might involve pathways that activate the transcription factor E47, which has been implicated in somatic hypermutation and class-switch recombination...
  78. pmc Hepatic response to oxidative injury in long-lived Ames dwarf mice
    Liou Y Sun
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109 0940, USA
    FASEB J 25:398-408. 2011
    ..Thus, livers of Ames dwarf mice differ systematically from controls in multiple stress resistance pathways before and after exposure to diquat, suggesting mechanisms for stress resistance and extended longevity in Ames dwarf mice...
  79. pmc Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
    Randy Strong
    Geriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, San Antonio, TX 78229, USA
    Aging Cell 7:641-50. 2008
    ..Further studies are warranted to find whether NDGA or aspirin, over a range of doses,might prove to postpone death and various age-related outcomes reproducibly in mice...
  80. ncbi Altered growth characteristics of skin fibroblasts from wild-derived mice, and genetic loci regulating fibroblast clone size
    Rong Yuan
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Aging Cell 5:203-12. 2006
    ..These enzymes may protect Pohn TSFs from oxidation...
  81. ncbi Genetic loci that influence cause of death in a heterogeneous mouse stock
    Ruth Lipman
    Division on Aging, Harvard Medical School, Boston, Massachusetts, USA
    J Gerontol A Biol Sci Med Sci 59:977-83. 2004
    ..The collection of normal and neoplastic tissues from 1004 terminal necropsies, together with genetic information, provides a valuable resource for further studies of the genetic influences on late-life diseases in mice...
  82. ncbi Dietary restriction and life-span
    Andrzej Bartke
    Science 296:2141-2; author reply 2141-2. 2002
  83. ncbi Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines
    Philip S Lecane
    Pharmacyclics, Inc, Sunnyvale, CA 94085, USA
    Cancer Res 65:11676-88. 2005
    ..These data provide insights into the molecular changes that accompany the disruption of intracellular zinc homeostasis and support a role for MGd in treatment of B-cell hematologic malignancies...
  84. ncbi An EM algorithm for mapping binary disease loci: application to fibrosarcoma in a four-way cross mouse family
    Shizhong Xu
    Department of Botany and Plant Sciences, University of California, Riverside, CA 92521, USA
    Genet Res 82:127-38. 2003
    ..All the QTLs detected primarily show dominance effects...
  85. ncbi PohnB6F1: a cross of wild and domestic mice that is a new model of extended female reproductive life span
    Kevin Flurkey
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Gerontol A Biol Sci Med Sci 62:1187-98. 2007
    ..Possibly, out-crossing Pohn mice unmasked cryptic alleles that promote extended female reproduction. This work establishes the PohnB6F1 hybrid as a new model for delayed reproductive aging...
  86. pmc Synthesis and biologic properties of hydrophilic sapphyrins, a new class of tumor-selective inhibitors of gene expression
    Zhong Wang
    Pharmacyclics, Inc, Sunnyvale, California, USA
    Mol Cancer 6:9. 2007
    ..However, the mechanisms for their anticancer activity have not been fully elucidated...
  87. pmc Science fact and the SENS agenda. What can we reasonably expect from ageing research?
    Huber Warner
    Buck Institute for Age Research, Novato, CA, USA
    EMBO Rep 6:1006-8. 2005
  88. ncbi Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines
    Darren Magda
    Pharmacyclics, Inc, Sunnyvale, California, USA
    Cancer Res 65:3837-45. 2005
    ..This class of compounds may provide insight into the development of novel cancer drugs targeting control of intracellular free zinc and the roles that zinc and other metal cations play in biochemical pathways relevant to cancer...
  89. ncbi Meeting report--National Institute on Aging Workshop on the Comparative Biology of Aging
    Huber Warner
    Biology of Aging Program at the National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Sci Aging Knowledge Environ 2002:pe5. 2002
    ..The aim of the workshop was to stimulate new approaches to understanding the molecular bases for differences in aging rates and life expectancy among species...
  90. pmc Extended longevity of wild-derived mice is associated with peroxidation-resistant membranes
    A J Hulbert
    Metabolic Research Centre, University of Wollongong, Wollongong, NSW 2522, Australia
    Mech Ageing Dev 127:653-7. 2006
    ..It is suggested that peroxidation-resistant membranes may be an important component of extended longevity...
  91. ncbi The aging factor in health and disease: the promise of basic research on aging
    Robert N Butler
    International Longevity Center USA, Alliance for Health and the Future, and Department of Geriatrics, Mount Sinai Medical Center, New York, NY 10028, USA
    Aging Clin Exp Res 16:104-11; discussion 111-2. 2004
  92. ncbi Evaluating evidence for aging
    Richard A Miller
    Science 310:441-3; author reply 441-3. 2005
  93. ncbi Pursuing the longevity dividend: scientific goals for an aging world
    S Jay Olshansky
    University of Illinois at Chicago, 1603 West Taylor Street, Room 885, Chicago, IL 60612, USA
    Ann N Y Acad Sci 1114:11-3. 2007
    ..The time has arrived for governments and national and international healthcare organizations to make research into healthy aging a major research priority...

Research Grants44

  1. Activation Defects in T Cells of Aged Mice
    Richard A Miller; Fiscal Year: 2010
    ....
  2. Laboratory for Anti-Geric Testing, Evaluation and Research
    Richard Miller; Fiscal Year: 2007
    ..abstract_text> ..
  3. WILD DERIVED MOUSE STOCKS--NEW MODELS FOR AGING RESEARCH
    Richard Miller; Fiscal Year: 2004
    ....
  4. GENETICS OF AGE SENSITIVE TRAITS IN MICE
    Richard Miller; Fiscal Year: 2003
    ..The Genotyping, Animal, and Analysis cores will be directed respectively by David Burke, Richard Miller, and Andrzej Galecki...
  5. Genetics of Longevity and Age-Sensitive Traits in Mice
    Richard Miller; Fiscal Year: 2007
    ..abstract_text> ..
  6. Laboratory for Anti-Geric Testing, Evaluation and Resea*
    Richard Miller; Fiscal Year: 2007
    ..abstract_text> ..
  7. Activation Defects in T Cells of Aged Mice
    Richard Miller; Fiscal Year: 2007
    ....
  8. GENETIC CONTROL OF LONGEVITY IN MICE
    Richard Miller; Fiscal Year: 2003
    ....
  9. GENETIC CONTROL OF LONGEVITY IN MICE
    Richard Miller; Fiscal Year: 1993
    ....
  10. WILD DERIVED MOUSE STOCKS--NEW MODELS FOR AGING RESEARCH
    Richard Miller; Fiscal Year: 1999
    ..Secondly, it will provide extremely valuable new mouse strains for testing biochemical, physiological, and genetic hypotheses about the mechanisms of aging. ..