Research Topics
| Mark S MillerSummaryAffiliation: University of Vermont Country: USA Publications
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Detail Information
Publications
Aging enhances indirect flight muscle fiber performance yet decreases flight ability in DrosophilaMark S Miller
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405, USA
Biophys J 95:2391-401. 2008..We also speculate that a lack of MgATP due to damaged mitochondria accounts for the decreased flight performance...
The essential light chain N-terminal extension alters force and fiber kinetics in mouse cardiac muscleMark S Miller
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405, USA
J Biol Chem 280:34427-34. 2005..Our results strongly suggest that an interaction between residues 5-14 of the ELC N terminus and the C-terminal residues of actin enhances cardiac performance...- Thick-to-thin filament surface distance modulates cross-bridge kinetics in Drosophila flight muscleBertrand C W Tanner
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont, USA
Biophys J 103:1275-84. 2012..Together, these structural changes may provide a mechanism for altering cross-bridge performance throughout a contraction-relaxation cycle... - COOH-terminal truncation of flightin decreases myofilament lattice organization, cross-bridge binding, and power output in Drosophila indirect flight muscleBertrand C W Tanner
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
Am J Physiol Cell Physiol 301:C383-91. 2011..These results indicate that the COOH terminus of flightin is necessary for normal myofilament lattice organization, thereby facilitating the cross-bridge binding required to achieve high power output for flight... - Mechanisms underlying skeletal muscle weakness in human heart failure: alterations in single fiber myosin protein content and functionMark S Miller
Departments of Molecular Physiology and Biophysics and Medicine, University of Vermont, College of Medicine, Burlington, VT, USA
Circ Heart Fail 2:700-6. 2009..Patients with chronic heart failure (HF) frequently experience skeletal muscle weakness that limits physical function. The mechanisms underlying muscle weakness, however, have not been clearly defined... - Alternative S2 hinge regions of the myosin rod affect myofibrillar structure and myosin kineticsMark S Miller
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont, USA
Biophys J 96:4132-43. 2009..Our results indicate that this hinge region plays an important role in determining myosin kinetics and in regulating thick and thin filament lengths as well as sarcomere length... - Effect of resistance training on physical disability in chronic heart failurePatrick A Savage
Department of Medicine, College of Medicine, University of Vermont, Burlington, VT 05405, USA
Med Sci Sports Exerc 43:1379-86. 2011.... - Regulatory light chain phosphorylation and N-terminal extension increase cross-bridge binding and power output in Drosophila at in vivo myofilament lattice spacingMark S Miller
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont, USA
Biophys J 100:1737-46. 2011.... - Two-state model of acto-myosin attachment-detachment predicts C-process of sinusoidal analysisBradley M Palmer
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont, USA
Biophys J 93:760-9. 2007..Experimental results from activated cardiac muscle examined at different temperatures and containing predominately alpha- or beta-myosin heavy chain isoforms were found to be consistent with the above interpretation... - Chronic heart failure decreases cross-bridge kinetics in single skeletal muscle fibres from humansMark S Miller
Department of Molecular Physiology, University of Vermont, Burlington, VT 05405, USA
J Physiol 588:4039-53. 2010..Additionally, we uncovered a unique kinetic property of MHC I fibres, a potential indication of two distinct populations of cross-bridges, which may have important physiological consequences... - Resistance training alters skeletal muscle structure and function in human heart failure: effects at the tissue, cellular and molecular levelsMichael J Toth
Health Science Research Facility 126B, 149 Beaumont Ave, University of Vermont, Burlington, VT 05405, USA
J Physiol 590:1243-59. 2012..More broadly, these data highlight novel cellular and molecular adaptations in muscle structure and function that contribute to the resistance-trained phenotype... - Chronic heart failure reduces Akt phosphorylation in human skeletal muscle: relationship to muscle size and functionMichael J Toth
Health Science Research Facility, Univ of Vermont, Burlington, VT 05405, USA
J Appl Physiol 110:892-900. 2011..Because patients and controls were similar for age, muscle mass, and physical activity, we ascribe the observed alterations in Akt phosphorylation and its relationship to myosin protein content to the unique effects of the HF syndrome... - Comparative biomechanics of thick filaments and thin filaments with functional consequences for muscle contractionMark S Miller
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
J Biomed Biotechnol 2010:473423. 2010..Here we review information on the material properties of thick filaments, thin filaments, and their primary constituents; we also discuss ways in which mechanical properties of filaments impact muscle performance... - Reduced knee extensor function in heart failure is not explained by inactivityMichael J Toth
Department of Medicine, University of Vermont, College of Medicine Burlington, VT 05405, United States
Int J Cardiol 143:276-82. 2010..The goal of this study was to determine if heart failure alters knee extensor muscle torque, power production or contractile velocity... - Skeletal muscle mitochondrial density, gene expression, and enzyme activities in human heart failure: minimal effects of the disease and resistance trainingMichael J Toth
Department of Medicine, College of Medicine, University of Vermont, Burlington, VT, USA
J Appl Physiol 112:1864-74. 2012..Moreover, the beneficial effects of resistance training on physical function in HF patients and controls are likely not related to alterations in mitochondrial biology... - Distribution of myosin attachment times predicted from viscoelastic mechanics of striated muscleBradley M Palmer
Department of Molecular Physiology and Biophysics, University of Vermont, 122 HSRF, Beaumont Avenue, Burlington, VT 05405, USA
J Biomed Biotechnol 2011:592343. 2011.... 
Myofilament protein alterations promote physical disability in aging and diseaseMark S Miller
Department of Molecular Physiology and Biophysics, University of Vermont, College of Medicine, Burlington, VT 05405, USA
Exerc Sport Sci Rev 41:93-9. 2013..Based on these data, we propose that age- and disease-related alterations in myofilament proteins represent one molecular mechanism contributing to the development of physical disability...- Molecular mechanisms underlying skeletal muscle weakness in human cancer: reduced myosin-actin cross-bridge formation and kineticsMichael J Toth
Department of Medicine, University of Vermont, College of Medicine, Burlington, Vermont
J Appl Physiol 114:858-68. 2013..Collectively, our results suggest reductions in myofilament protein function as a potential molecular mechanism contributing to muscle weakness and physical disability in human cancer... - An infrared system for monitoring Drosophila motility during microgravityMark S Miller
Department of Mechanical Engineering, University of Vermont, Burlington, VT 05405, USA
J Gravit Physiol 9:83-91. 2002..DIMMS is also lightweight, compact, and power efficient. DIMMS has been flight tested onboard NASA's KC-135 reduced gravity research aircraft and a Nike-Orion sounding rocket... - Paramyosin phosphorylation site disruption affects indirect flight muscle stiffness and power generation in Drosophila melanogasterHongjun Liu
Department of Biology and Molecular Biology Institute, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182 4614, USA
Proc Natl Acad Sci U S A 102:10522-7. 2005.... - Passive stiffness in Drosophila indirect flight muscle reduced by disrupting paramyosin phosphorylation, but not by embryonic myosin S2 hinge substitutionYudong Hao
Department of Bioengineering, University of Washington, Seattle, WA, USA
Biophys J 91:4500-6. 2006.... - Chlamydomonas IFT172 is encoded by FLA11, interacts with CrEB1, and regulates IFT at the flagellar tipLotte B Pedersen
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
Curr Biol 15:262-6. 2005..Therefore, IFT172 is involved in the control of flagellar assembly/disassembly at the tip... - Diphtheria toxin fused to variant interleukin-3 provides enhanced binding to the interleukin-3 receptor and more potent leukemia cell cytotoxicityTie Fu Liu
Department of Medicine and Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA
Exp Hematol 32:277-81. 2004..One or both of these variant fusion proteins merit further development for therapy of chemotherapy refractory AML... - Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in miceZheng Cui
Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Proc Natl Acad Sci U S A 100:6682-7. 2003..The mice are healthy and cancer-free and have a normal life span. These observations suggest a previously unrecognized mechanism of immune surveillance, which may have potential for therapy or prevention of cancer...